Ciprofloxacin-induces free radical production in rat cerebral microsomes

References

• Ichikawa N, Naora K, Iwamoto K. Comparative study of permeability into rat cerebrospinal fluid of the quinolones: dependency on their lipophilicities. Biol Pharm Bull. 1994;17(1):152–155.
   PubMed Web of Science ®Google Scholar
• Kucers A, Bennett N, Mc K. The use of antibiotics. Avon: The Bath Press; 1997.
   Google Scholar
• Tomé AM, Filipe A. Quinolones: review of psychiatric and neurological adverse reactions. Drug Saf. 2011;34(6):465–488.
   PubMed Web of Science ®Google Scholar
• Bacci C, Galli L, de Martino M, et al. Fluoroquinolones in children: update of the literature. J Chemother. 2015;27(5):257–265.
   PubMed Web of Science ®Google Scholar
• Hayem G, Petit PX, Levacher M, et al. Cytofluorometric analysis of chondrotoxicity of fluoroquinolone antimicrobial agents. Antimicrob Agents Chemother. 1994;38(2):243–247.
   PubMed Web of Science ®Google Scholar
• Pouzaud F, Bernard-Beaubois K, Thevenin M, et al. In vitro discrimination of fluoroquinolones toxicity on tendon cells: involvement of oxidative stress. J Pharmacol Exp Ther. 2004;308(1):394–402.
   PubMed Web of Science ®Google Scholar
• Wagai N, Tawara K. Quinolone antibacterial-agent-induced cutaneous phototoxicity: ear swelling reactions in BALB/c mice. Toxicol Lett. 1991;58(2):215–223.
   PubMed Web of Science ®Google Scholar
• Gürbay A, Garrel C, Osman M, et al. Cytotoxicity in ciprofloxacin-treated human fibroblast cells and protection by vitamin E. Hum Exp Toxicol. 2002;21(12):635–641.
   PubMed Web of Science ®Google Scholar
• Gürbay A, Gonthier B, Barret L, et al. Cytotoxic effect of ciprofloxacin in primary culture of rat astrocytes and protection by vitamin E. Toxicology. 2007;229(1–2):54–61.
   PubMed Web of Science ®Google Scholar
• Gürbay A, Gonthier B, Daveloose D, et al. Microsomal metabolism of ciprofloxacin generates free radicals. Free Radic Biol Med. 2001;30(10):1118–1121.
   PubMed Web of Science ®Google Scholar
• Gürbay A, Hıncal F. Ciprofloxacin-induced glutathione redox status alterations in rat tissues. Drug Chem Toxicol. 2004;27(3):233–242.
   PubMed Web of Science ®Google Scholar
• Rawi SM, Mourad IM, Arafa NMS, et al. Effect of ciprofloxacin and levofloxacin on some oxidative stress parameters in brain regions of male albino rats. Afr J Pharm Pharmacol. 2011;5(16):1888–1897.
   Google Scholar
• Talla V, Veerareddy P. Oxidative stress induced by fluoroquinolones on treatment for complicated urinary tract infections in Indian patients. J Young Pharm. 2011;3(4):304–309.
   PubMedGoogle Scholar
• Qin P, Liu R. Oxidative stress response of two fluoroquinolones with catalase and erythrocytes: A combined molecular and cellular study. J Hazard Mater. 2013;252–253:321–329.
   PubMed Web of Science ®Google Scholar
• Buettner GR. In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals. J Biochem Biophys Methods. 1988;16(1):27–40.
   PubMedGoogle Scholar
• Cederbaum AI, Cohen G. Microsomal oxidation of hydroxyl radical scavenging agents. In: Greenwald RA, editor. CRC handbook of methods for oxygen radical research. New York: CRC Press Incorporated; 1986. p. 81–87.
   Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193(1):265–275.
   PubMed Web of Science ®Google Scholar
• Richard MJ, Portal B, Meo J, et al. Malondialdehyde kit evaluated for determining plasma and lipoprotein fractions that react with thiobarbituric acid. Clin Chem. 1992;38(5):704–709.
   PubMed Web of Science ®Google Scholar
• Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82(1):70–77.
   PubMed Web of Science ®Google Scholar
• Gasser TC, Ebert SC, Graversen PH, et al. Ciprofloxacin pharmacokinetics in patients with normal and impaired renal function. Antimicrob Agents Chemother. 1987;31(5):709–712.
   PubMed Web of Science ®Google Scholar
• Naora K, Ichikawa N, Hirano H, et al. Distribution of ciprofloxacin into the central nervous system in rats with acute renal or hepatic failure. J Pharm Pharmacol. 1999;51(5):609–616.
   PubMed Web of Science ®Google Scholar
• Gerding DN, Hitt JA. Tissue penetration of the new quinolones in humans. Rev Infect Dis. 1989;11(Suppl 5):S1046–S1057.
   PubMedGoogle Scholar
• Wolff M, Boutron L, Singlas E, et al. Penetration of ciprofloxacin into cerebrospinal fluid of patients with bacterial meningitis. Antimicrob Agents Chemother. 1987;31(6):899–902.
   PubMed Web of Science ®Google Scholar
• Davey PG, Charter M, Kelly S, et al. Ciprofloxacin and sparfloxacin penetration into human brain tissue and their activity as antagonists of GABAA receptor of rat vagus nerve. Antimicrob Agents Chemother. 1994;38(6):1356–1362.
   PubMed Web of Science ®Google Scholar
• Bassaris HP, Papadakis N, Gogos C, et al., editors. Penetration of ciprofloxacin into human cerebrospinal fluid. Proceedings of the First International Ciprofloxacin Workshop; 1986 Nov 6–8. p. 204–205.
   Google Scholar
• Dodd PR, Davies LP, Watson WEJ, et al. Neurochemical studies on quinolone antibiotics: effects on glutamate, GABA and adenosine systems in mammalian CNS. Pharmacol Toxicol. 1989;64(5):404–411.
   PubMedGoogle Scholar
• Takayama S, Hirohashi M, Kato M, et al. Toxicity of quinolone antimicrobial agents. J Toxicol Environ Health. 1995;45(1):1–45.
   PubMed Web of Science ®Google Scholar
• Green MA, Halliwell RF. Selective antagonism of the GABAA receptor by ciprofloxacin and biphenylacetic acid. Br J Pharmacol. 1997;122(3):584–590.
   PubMed Web of Science ®Google Scholar
• North JA, Spector AA, Buettner GR. Detection of lipid radicals by electron paramagnetic resonance spin trapping using intact cells enriched with polyunsaturated fatty acid. J Biol Chem. 1992;267(9):5743–5746.
   PubMed Web of Science ®Google Scholar
• Buettner GR, Kelley EE, Burns CP. Membrane lipid free radicals produced from L1210 murine leukemia cells by photofrin photosensitization: an electron paramagnetic resonance spin trapping study. Cancer Res. 1993;53(16):3670–3673.
   PubMed Web of Science ®Google Scholar
• Barclay LRC, Ingold KU. Autoxidation of biological molecules. 2. Autoxidation of a model membrane. Comparison of the autoxidation of egg lecithin phosphatidylcholine in water and in chlorobenzene. J Am Chem Soc. 1981;103(21):6478–6485.
   Web of Science ®Google Scholar
• Hincal F, Taskin T. The mechanism of convulsions induced by ciprofloxacin may involve the generation of free radicals and the activation of excitatory amino acid receptors. Abstracts of the international congress of toxicology – VII; 1995; Seattle, WA. p. 27:(abstract 99).
   Google Scholar
• Arafa NM, Abdel-Rahman M, El-khadragy MF, et al. Evaluation of the possible epileptogenic activity of ciprofloxacin: the role of Nigella sativa on amino acids neurotransmitters. Neurochem Res. 2013;38(1):174–185.
   PubMed Web of Science ®Google Scholar
• Sörgel F. Metabolism of gyrase inhibitors. Rev Infect Dis. 1989;11(Suppl 5):S1119–S1129.
   PubMedGoogle Scholar
• Vance-Bryan K, Guay DR, Rotschafer JC. Clinical pharmacokinetics of ciprofloxacin. Clin Pharmacokinet. 1990;19(6):434–461.
   PubMed Web of Science ®Google Scholar
• Chidiac C, SPILF working group. Update on a proper use of systemic fluoroquinolones in adult patients (ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin, pefloxacin). Med Mal Infect. 2015;45(9):348–373.
   PubMed Web of Science ®Google Scholar
• Warner M, Köhler C, Hansson T, et al. Regional distribution of cytochrome P-450 in the rat brain: spectral quantitation and contribution of P-450b,e, and P-450c,d. J Neurochem. 1988;50(4):1057–1065.
   PubMed Web of Science ®Google Scholar
• Miksys S, Tyndale RF. Cytochrome P450-mediated drug metabolism in the brain. J Psychiatry Neurosci. 2013;38(3):152–163.
   PubMed Web of Science ®Google Scholar
• Jeffery EH. The effect of zinc on NADPH oxidation and monooxygenase activity in rat hepatic microsomes. Mol Pharmacol. 1983;23(2):467–473.
   PubMed Web of Science ®Google Scholar
• Chvapil M, Ludwig JC, Sipes IG, et al. Inhibition of NADPH oxidation and related drug oxidation in liver microsomes by zinc. Biochem Pharmacol. 1976;25(15):1787–1791.
   PubMed Web of Science ®Google Scholar
• Hida H, Coudray C, Calop J, et al. Effect of antioxidants on adriamycin-induced microsomal lipid peroxidation. Biol Trace Elem Res. 1995;47(1–3):111–116.
   PubMed Web of Science ®Google Scholar
• Minotti G. The role of an endogenous nonheme iron in microsomal redox reactions. Arch Biochem Biophys. 1992;297(2):189–198.
   PubMed Web of Science ®Google Scholar
• Miller DM, Buettner GR, Aust SD. Transition metals as catalysts of “autoxidation” reactions. Free Radic Biol Med. 1990;8(1):95–108.
   PubMed Web of Science ®Google Scholar
• Hartley A, Davies M, Rice-Evans C. Desferrioxamine as a lipid chain-breaking antioxidant in sickle erythrocyte membranes. FEBS Lett. 1990;264(1):145–148.
   PubMed Web of Science ®Google Scholar
• Chvapil M, Ryan JN, Elias SL, et al. Protective effect of zinc on carbon tetrachloride-induced liver injury in rats. Exp Mol Pathol. 1973;19(2):186–196.
   PubMed Web of Science ®Google Scholar
• Bettger WJ, O’Dell BL. A critical physiological role of zinc in the structure and function of biomembranes. Life Sci. 1981;28(13):1425–1438.
   PubMed Web of Science ®Google Scholar
• Coppen DE, Richardson DE, Cousins RJ. Zinc suppression of free radicals induced in cultures of rat hepatocytes by iron, t-butyl hydroperoxide, and 3-methylindole. Proc Soc Exp Biol Med. 1988;189(1):100–109.
   PubMed Web of Science ®Google Scholar
• Oliveira VA, Oliveira CS, Ineu RP, et al. Lactating and non-lactating rats differ in sensitivity to HgCl(2): protective effect of ZnCl(2). J Trace Elem Med Biol. 2014;28(2):240–246.
   PubMed Web of Science ®Google Scholar
• Ueda Y, Yokoyama H, Niwa R, et al. Generation of lipid radicals in the hippocampal extracellular space during kainic acid-induced seizures in rats. Epilepsy Res. 1997;26(2):329–333.
   PubMed Web of Science ®Google Scholar
• Kawakami Y, Monobe M, Kuwabara K, et al. A comparative study of nitric oxide, glutathione, and glutathione peroxidase activities in cerebrospinal fluid from children with convulsive diseases/children with aseptic meningitis. Brain Dev. 2006;28(4):243–246.
   PubMed Web of Science ®Google Scholar
• Abdel-Zaher AO, Afify AH, Kamel SM, et al. Involvement of glutamate, oxidative stress and inducible nitric oxide synthase in the convulsant activity of ciprofloxacin in mice. Eur J Pharmacol. 2012;685(1–3):30–37.
   PubMed Web of Science ®Google Scholar