1,837
Views
9
CrossRef citations to date
0
Altmetric
RESEARCH ARTICLE

Innovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro/in vivo evaluation

, , , , , , & show all
Pages 2058-2071 | Received 26 Apr 2022, Accepted 14 Jun 2022, Published online: 08 Jul 2022

References

  • Abd-Elal RM, Shamma RN, Rashed HM, Bendas E. (2016). Trans-nasal zolmitriptan novasomes: in-vitro preparation, optimization and in-vivo evaluation of brain targeting efficiency. Drug Deliv. 23:3374–86.
  • Abdelbary AA, AbouGhaly MH. (2015). Design and optimization of topical methotrexate loaded niosomes for enhanced management of psoriasis: application of Box–Behnken design, in-vitro evaluation and in-vivo skin deposition study. Int J Pharm 485:235–43.
  • Abdelrahim ME, Plant P, Chrystyn H. (2010). In-vitro characterisation of the nebulised dose during non-invasive ventilation. J Pharm Pharmacol 62:966–72.
  • Aboud HM, Ali AA, El-Menshawe SF, Elbary AA. (2016). Nanotransfersomes of carvedilol for intranasal delivery: formulation, characterization and in vivo evaluation. Drug Deliv 23:2471–81.
  • Aboud HM, Hassan AH, Ali AA, Abdel-Razik A-RH. (2018). Novel in situ gelling vaginal sponges of sildenafil citrate-based cubosomes for uterine targeting. Drug Deliv 25:1328–39.
  • Aboud HM, Hussein AK, Zayan AZ, et al. (2022). Tailoring of selenium-plated novasomes for fine-tuning pharmacokinetic and tumor uptake of quercetin: in vitro optimization and in vivo radiobiodistribution assessment in ehrlich tumor-bearing mice. Pharmaceutics 14:875.
  • Aboud HM, Mahmoud MO, Abdeltawab Mohammed M, et al. (2020). Preparation and appraisal of self-assembled valsartan-loaded amalgamated Pluronic F127/Tween 80 polymeric micelles: boosted cardioprotection via regulation of Mhrt/Nrf2 and Trx1 pathways in cisplatin-induced cardiotoxicity. J Drug Target 28:282–18.
  • Abou-Taleb HA, Khallaf RA, Abdel-Aleem JA. (2018). Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation. Drug Des Devel Ther 12:3501–16.
  • Ahad A, Aqil M, Kohli K, et al. (2012). Formulation and optimization of nanotransfersomes using experimental design technique for accentuated transdermal delivery of valsartan. Nanomedicine 8:237–49.
  • Ali MH, Kirby DJ, Mohammed AR, Perrie Y. (2010). Solubilisation of drugs within liposomal bilayers: alternatives to cholesterol as a membrane stabilising agent. J Pharm Pharmacol 62:1646–55.
  • Al-mahallawi AM, Khowessah OM, Shoukri RA. (2014). Nano-transfersomal ciprofloxacin loaded vesicles for non-invasive trans-tympanic ototopical delivery: in-vitro optimization, ex-vivo permeation studies, and in-vivo assessment. Int J Pharm 472:304–14.
  • Annadurai G, Ling LY, Lee J-F. (2008). Statistical optimization of medium components and growth conditions by response surface methodology to enhance phenol degradation by Pseudomonas putida. J Hazard Mater 151:171–8.
  • Arafa MG, Ayoub BM. (2018). Bioavailability study of niosomal salbutamol sulfate in metered dose inhaler: controlled pulmonary drug delivery. J Aerosol Med Pulm Drug Deliv 31:114–5.
  • Araujo J, Gonzalez-Mira E, Egea M, et al. (2010). Optimization and physicochemical characterization of a triamcinolone acetonide-loaded NLC for ocular antiangiogenic applications. Int J Pharm 393:168–76.
  • Atef B, Ishak RA, Badawy SS, Osman R. (2022). Exploring the potential of oleic acid in nanotechnology-mediated dermal drug delivery: an up-to-date review. J Drug Delivery Sci Technol. 67:103032.
  • Baig MS, Ahad A, Aslam M, et al. (2016). Application of Box–Behnken design for preparation of levofloxacin-loaded stearic acid solid lipid nanoparticles for ocular delivery: optimization, in vitro release, ocular tolerance, and antibacterial activity. Int J Biol Macromol 85:258–70.
  • Bancroft JD, Gamble M. (2008). Theory and practice of histological techniques. Churchill Livingstone. Elsevier Health Sciences.
  • Bivas-Benita M, Zwier R, Junginger HE, Borchard G. (2005). Non-invasive pulmonary aerosol delivery in mice by the endotracheal route. Eur J Pharm Biopharm 61:214–8.
  • Chaurasiya B, Zhao Y-Y. (2020). Dry powder for pulmonary delivery: a comprehensive review. Pharmaceutics 13:31.
  • Chen C-C, Tsai T-H, Huang Z-R, Fang J-Y. (2010). Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics. Eur J Pharm Biopharm 74:474–82.
  • Chen X, Huang W, Wong BC, et al. (2012). Liposomes prolong the therapeutic effect of anti-asthmatic medication via pulmonary delivery. Int J Nanomed 7:1139–48.
  • Deniz A, Sade A, Severcan F, et al. (2010). Celecoxib-loaded liposomes: effect of cholesterol on encapsulation and in vitro release characteristics. Biosci Rep 30:365–73.
  • Domínguez-Romero JC, García-Reyes JF, Martínez-Romero R, et al. (2013). Detection of main urinary metabolites of β2-agonists clenbuterol, salbutamol and terbutaline by liquid chromatography high resolution mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 923–924:128–35.
  • Doroudian M, O’Neill A, Mac Loughlin R, et al. (2021). Nanotechnology in pulmonary medicine. Curr Opin Pharmacol 56:85–92.
  • El Menshawe SF, Nafady MM, Aboud HM, et al. (2019). Transdermal delivery of fluvastatin sodium via tailored spanlastic nanovesicles: mitigated Freund’s adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway. Drug Deliv 26:1140–54.
  • Elkomy MH, Khallaf RA, Mahmoud MO, et al. (2021). Intratracheally inhalable nifedipine-loaded chitosan-PLGA nanocomposites as a promising nanoplatform for lung targeting: snowballed protection via regulation of TGF-β/β-catenin pathway in bleomycin-induced pulmonary fibrosis. Pharmaceuticals 14:1225.
  • Fetih G. (2016). Fluconazole-loaded niosomal gels as a topical ocular drug delivery system for corneal fungal infections. J Drug Delivery Sci Technol 35:8–15.
  • Goyal G, Garg T, Malik B, et al. (2015). Development and characterization of niosomal gel for topical delivery of benzoyl peroxide. Drug Deliv 22:1027–42.
  • Gulsun T, Cayli YA, Izat N, et al. (2018). Development and evaluation of terbutaline sulfate orally disintegrating tablets by direct compression and freeze drying methods. J Drug Delivery Sci Technol 46:251–8.
  • Hami Z. (2021). A brief review on advantages of nano-based drug delivery systems. Ann Mil Health Sci Res 19:e112274.
  • Hamzawy MA, Abo-youssef AM, Salem HF, Mohammed SA. (2017). Antitumor activity of intratracheal inhalation of temozolomide (TMZ) loaded into gold nanoparticles and/or liposomes against urethane-induced lung cancer in BALB/c mice. Drug Deliv 24:599–607.
  • Hassan A, Rabea H, Hussein RR, et al. (2016). In-vitro characterization of the aerosolized dose during non-invasive automatic continuous positive airway pressure ventilation. Pulm Ther 2:115–26.
  • Hathout RM, Mansour S, Mortada ND, Guinedi AS. (2007). Liposomes as an ocular delivery system for acetazolamide: in vitro and in vivo studies. Aaps Pharmscitech 8:1–E12.
  • Hochhaus G, Möllmann H. (2019). ß2-agonists: terbutaline, albuterol, and fenoterol. In: Handbook of pharmacokinetic/pharmacodynamic correlation. New York: CRC Press.
  • Jinturkar KA, Anish C, Kumar MK, et al. (2012). Liposomal formulations of Etoposide and Docetaxel for p53 mediated enhanced cytotoxicity in lung cancer cell lines. Biomaterials 33:2492–507.
  • Joshi MR, Misra A. (1999). Liposomes of terbutaline sulphate: in vitro and in vivo studies. Indian J Exp Biol 37:881–7.
  • Kanicky JR, Shah DO. (2002). Effect of degree, type, and position of unsaturation on the pKa of long-chain fatty acids. J Colloid Interface Sci 256:201–7.
  • Kaushik R, Saran S, Isar J, Saxena R. (2006). Statistical optimization of medium components and growth conditions by response surface methodology to enhance lipase production by Aspergillus carneus. J Mol Catal B: Enzym 40:121–6.
  • Khalil RM, Abdelbary A, Kocova El-Arini S, et al. (2019). Evaluation of bilosomes as nanocarriers for transdermal delivery of tizanidine hydrochloride: in vitro and ex vivo optimization. J Liposome Res 29:171–82.
  • Khallaf RA, Aboud HM, Sayed OM. (2020). Surface modified niosomes of olanzapine for brain targeting via nasal route; preparation, optimization, and in vivo evaluation. J Liposome Res 30:163.
  • Kuzmov A, Minko T. (2015). Nanotechnology approaches for inhalation treatment of lung diseases. J Control Release 219:500–18.
  • Levinsky HV, Procter BG, Malmfors T, et al. (1978). A three month inhalation toxicity study in the squirrel monkey (Saimiri sciureus) with terbutaline sulfate (Bricanyl®). Toxicology 11:325–8.
  • Li Q, Zhan S, Liu Q, et al. (2018). Preparation of a sustained-release nebulized aerosol of R-terbutaline hydrochloride liposome and evaluation of its anti-asthmatic effects via pulmonary delivery in guinea pigs. AAPS PharmSciTech 19:232–41.
  • Mahmoud MO, Aboud HM, Hassan AH, et al. (2017). Transdermal delivery of atorvastatin calcium from novel nanovesicular systems using polyethylene glycol fatty acid esters: ameliorated effect without liver toxicity in poloxamer 407-induced hyperlipidemic rats. J Controlled Release 254:10–22.
  • Mehanna MM, Mneimneh AT. (2021). Formulation and applications of lipid-based nanovehicles: spotlight on self-emulsifying systems. Adv Pharm Bull 11:56–67.
  • Mitchell JP, Nagel MW. (2003). Cascade impactors for the size characterization of aerosols from medical inhalers: their uses and limitations. J Aerosol Med 16:341–77.
  • Mohammed H, Roberts DL, Copley M, et al. (2012). Effect of sampling volume on dry powder inhaler (DPI)-emitted aerosol aerodynamic particle size distributions (APSDs) measured by the Next-Generation Pharmaceutical Impactor (NGI) and the Andersen Eight-Stage Cascade Impactor (ACI). Aaps Pharmscitech 13:875–82.
  • Mosallam S, Ragaie MH, Moftah NH, et al. (2021). Use of novasomes as a vesicular carrier for improving the topical delivery of terconazole: in vitro characterization, in vivo assessment and exploratory clinical experimentation. Int J Nanomed. 16:119–32.
  • Nahar K, Gupta N, Gauvin R, et al. (2013). In vitro, in vivo and ex vivo models for studying particle deposition and drug absorption of inhaled pharmaceuticals. Eur J Pharm Sci 49:805–18.
  • Nasr M, Mansour S, Mortada ND, Elshamy A. (2008). Vesicular aceclofenac systems: a comparative study between liposomes and niosomes. J Microencapsul 25:499–512.
  • Patlolla RR, Chougule M, Patel AR, et al. (2010). Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers. J Control Release 144:233–41.
  • Salem HF, Ali AA, Hegazy AM, et al. (2022). Harnessing of doxylamine succinate/pyridoxine hydrochloride-dual laden bilosomes as a novel combinatorial nanoparadigm for intranasal delivery: in vitro optimization and in vivo pharmacokinetic appraisal. J Pharm Sci 111:794–809.
  • Salem HF, Kharshoum RM, Abdel Hakim LF, Abdelrahim ME. (2016). Edge activators and a polycationic polymer enhance the formulation of porous voriconazole nanoagglomerate for the use as a dry powder inhaler. J Liposome Res 26:324–35.
  • Salem HF, Kharshoum RM, Abou-Taleb HA, et al. (2019). Progesterone-loaded nanosized transethosomes for vaginal permeation enhancement: formulation, statistical optimization, and clinical evaluation in anovulatory polycystic ovary syndrome. J Liposome Res 29:183–94.
  • Salem HF, Kharshoum RM, Sayed OM, Abdel Hakim LF. (2018). Abdel Hakim LF. Formulation design and optimization of novel soft glycerosomes for enhanced topical delivery of celecoxib and cupferron by Box–Behnken statistical design. Drug Dev Ind Pharm 44:1871–84.
  • Schneider CS, Xu Q, Boylan NJ, et al. (2017). Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation. Sci Adv. 3:e1601556.
  • Stern J, Pier J, Litonjua AA. (2020). Asthma epidemiology and risk factors. Semin Immunopathol 42(1):5–15.
  • Tawfik MA, Mohamed MI, Tadros MI, El-Helaly SN. (2021). Low-frequency sonophoresis as an active approach to potentiate the transdermal delivery of agomelatine-loaded novasomes: design, optimization, and pharmacokinetic profiling in rabbits. AAPS PharmSciTech 22:1–15.
  • Yoshioka T, Sternberg B, Florence AT. (1994). Preparation and properties of vesicles (niosomes) of sorbitan monoesters (Span 20, 40, 60 and 80) and a sorbitan triester (Span 85). Int J Pharm 105:1–6.
  • Yu F, Li C, Liu M, et al. (2021). Aerosol inhalation of ambroxol hydrochloride combined with terbutaline can promote recovery of children with severe pneumonia. Am J Transl Res 13:5019–26.
  • Zhang M, Li M, Du L, et al. (2020). Paclitaxel-in-liposome-in-bacteria for inhalation treatment of primary lung cancer. Int J Pharm 578:119177.