Neutrophil Recruitment under Shear Flow: It's All about Endothelial Cell Rings and Gaps

References

• Adamson P, Etienne S, Couraud PO, Calder V, Greenwood J. Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a Rho-dependent pathway. J Immunol 1999; 162: 2964–2973
   PubMed Web of Science ®Google Scholar
• Albelda SM, Muller WA, Buck CA, Newman PJ. Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule. J Cell Biol 1991; 114: 1059–1068
   PubMed Web of Science ®Google Scholar
• Allingham MJ, van Buul JD, Burridge K. ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. J Immunol 2007; 179: 4053–4064
   Web of Science ®Google Scholar
• Allport JR, Ding H, Collins T, Gerritsen ME, Luscinskas FW. Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions. J Exp Med 1997; 186: 517–527
   PubMed Web of Science ®Google Scholar
• Allport JR, Muller WA, Luscinskas FW. Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow. J Cell Biol 2000; 148: 203–216
   Google Scholar
• Anastasiadis PZ, Reynolds AB. Regulation of Rho GTPases by p120-catenin. Curr Opin Cell Biol 2001; 13: 604–610
   PubMedGoogle Scholar
• Ariel A, Serhan CN. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 2007; 28: 176–183
   PubMed Web of Science ®Google Scholar
• Barreiro O, Vicente-Manzanares M, Urzainqui A, Yanez-Mo M, Sanchez-Madrid F. Interactive protrusive structures during leukocyte adhesion and transendothelial migration. Front Biosci 2004; 9: 1849–1863
   Google Scholar
• Barreiro O, Yanez-Mo M, Serrador JM, Montoya MC, Vicente-Manzanares M, Tejedor R, Furthmayr H, Sanchez-Madrid F. Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J Cell Biol 2002; 157: 1233–1245
   PubMed Web of Science ®Google Scholar
• Barret C, Roy C, Montcourrier P, Mangeat P, Niggli V. Mutagenesis of the phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding site in the NH(2)-terminal domain of ezrin correlates with its altered cellular distribution. J Cell Biol 2000; 151: 1067–1080
   PubMed Web of Science ®Google Scholar
• Bokoch GM, Wang Y, Bohl BP, Sells MA, Quilliam LA, Knaus UG. Interaction of the Nck adapter protein with p21-activated kinase (PAK1). J Biol Chem 1996; 271: 25746–25749
   PubMed Web of Science ®Google Scholar
• Burns AR, Bowden RA, Abe Y, Walker DC, Simon SI, Entman ML, Smith CW. P-selectin mediates neutrophil adhesion to endothelial cell borders. J Leuk Biol 1999; 65: 299–306
   PubMed Web of Science ®Google Scholar
• Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 1991; 67: 1033–1036
   PubMed Web of Science ®Google Scholar
• Carman CV, Sage PT, Sciuto TE, de la Fuente MA, Geha RS, Ochs HD, Dvorak HF, Dvorak AM, Springer TA. Transcellular diapedesis is initiated by invasive podosomes. Immunity 2007; 26: 784–797
   PubMed Web of Science ®Google Scholar
• Carman CV, Springer TA. A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J Cell Biol 2004; 167: 377–388
   PubMed Web of Science ®Google Scholar
• Carpen O, Pallai P, Staunton DE, Springer TA. Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin. J Cell Biol 1992; 118: 1223–1234
   PubMed Web of Science ®Google Scholar
• Celli L, Ryckewaert JJ, Delachanal E, Duperray A. Evidence of a functional role for interaction between ICAM-1 and nonmuscle {alpha}-actinins in leukocyte diapedesis. J Immunol 2006; 177: 4113–4121
   PubMedGoogle Scholar
• Cernuda-Morollon E, Ridley AJ. Rho GTPases and leukocyte adhesion receptor expression and function in endothelial cells. Circ Res 2006; 98: 757–767
   PubMed Web of Science ®Google Scholar
• Cinamon G, Shinder V, Alon R. Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines. Nat Immunol 2001; 2: 515–522
   PubMed Web of Science ®Google Scholar
• Cinamon G, Shinder V, Shamri R, Alon R. Chemoattractant signals and {beta}2 integrin occupancy at apical endothelial contacts combine with shear stress signals to promote transendothelial neutrophil migration. J Immunol 2004; 173: 7282–7291
   PubMedGoogle Scholar
• Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-kB and cytokine-inducible enhancers. FASEB J 1995; 9: 899–909
   PubMed Web of Science ®Google Scholar
• Davies PF, Zilberberg J, Helmke BP. Spatial microstimuli in endothelial mechanosignaling. Circ Res 2003; 92: 359–370
   PubMed Web of Science ®Google Scholar
• Del Maschio A, Zanetti A, Corada M, Rival Y, Ruco L, Lampugnani MG, Dejana E. Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions. J Cell Biol 1996; 135: 497–510
   PubMed Web of Science ®Google Scholar
• Dudek SM, Jacobson JR, Chiang ET, Birukov KG, Wang P, Zhan X, Garcia JG. Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase. J Biol Chem 2004; 279: 24692–24700
   PubMed Web of Science ®Google Scholar
• Engelhardt B, Wolburg H. Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house?. Eur J Immunol 2004; 34: 2955–2963
   PubMed Web of Science ®Google Scholar
• Feng D, Nagy JA, Pyne K, Dvorak HF, Dvorak AM. Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP. J Exp Med 1998; 187: 903–915
   PubMedGoogle Scholar
• Garcia-Cardena G, Comander J, Anderson KR, Blackman BR, Gimbrone MA, Jr. Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proc Natl Acad Sci U S A 2001; 98: 4478–4485
   PubMed Web of Science ®Google Scholar
• Gavard J, Gutkind JS. VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Nat Cell Biol 2006; 8: 1223–1234
   PubMed Web of Science ®Google Scholar
• Gopalan PK, Burns AR, Simon SI, Sparks S, Mcintire LV, Smith CW. Preferential sites for stationary adhesion of neutrophils to cytokine-stimulated HUVEC under flow conditions. J Leukoc Biol 2000; 68: 47–57
   PubMed Web of Science ®Google Scholar
• Gotsch U, Borges E, Bosse R, Boggemeyer E, Simon M, Mossmann H, Vestweber D. VE-cadherin antibody accelerates neutrophil recruitment in vivo. J Cell Sci 1997; 110: 583–588
   PubMed Web of Science ®Google Scholar
• Grosheva I, Shtutman M, Elbaum M, Bershadsky AD. p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion. J Cell Sci 2001; 114: 695–707
   PubMed Web of Science ®Google Scholar
• Guilford WH, Lantz RC, Gore RW. Locomotive forces produced by single leukocytes in vivo and in vitro. Am J Physiol 1995; 268: C1308–C1312
   PubMed Web of Science ®Google Scholar
• Harris TA, Yamakuchi M, Ferlito M, Mendell JT, Lowenstein CJ. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. PNAS 2008; 105: 1516–1521
   PubMed Web of Science ®Google Scholar
• Heiska L, Alfthan K, Gronholm M, Vilja P, Vaheri A, Carpen O. Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4,5-bisphosphate. J Biol Chem 1998; 273: 21893–21900
   PubMed Web of Science ®Google Scholar
• Hu G, Place AT, Minshall RD. Regulation of endothelial permeability by Src kinase signaling: vascular leakage versus transcellular transport of drugs and macromolecules. Chem Biol Interact 2008; 171: 177–189
   PubMed Web of Science ®Google Scholar
• Huang C, Liu J, Haudenschild CC, Zhan X. The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells. J Biol Chem 1998; 273: 25770–25776
   PubMed Web of Science ®Google Scholar
• Ingley E. Src family kinases: regulation of their activities, levels, and identification of new pathways. Biochim Biophys Acta (BBA) Prot Proteom 2008; 1784: 56–65
   PubMed Web of Science ®Google Scholar
• Jacobson JR, Dudek SM, Singleton PA, Kolosova IA, Verin AD, Garcia JG. Endothelial cell barrier enhancement by ATP is mediated by the small GTPase Rac and Cortactin. Am J Physiol Lung Cell Mol Physiol 2006; 291: L289–L295
   Google Scholar
• Kaibuchi K, Kuroda S, Amano M. Regulation of the cytoskeletal and cell adhesion by the Rho family of GTPases in mammalian cells. Annu Rev Biochem 1999; 68: 459–486
   PubMed Web of Science ®Google Scholar
• Kanner SB, Reynolds AB, Parsons JT. Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor stimulation and in polymovirus middle-T-antigen-transformed cells. Mol Cell Biol 1991; 11: 713–720
   PubMedGoogle Scholar
• Kvietys PR, Sandig M. Neutrophil diapedesis: paracellular or transcellular?. News Physiol Sci 2001; 16: 15–19
   Google Scholar
• Lampugnani MG, Orsenigo F, Gagliani MC, Tacchetti C, Dejana E. Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol 2006; 174: 593–604
   PubMed Web of Science ®Google Scholar
• Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 2007; 7: 678–689
   PubMed Web of Science ®Google Scholar
• Luster AD, Alon R, von Andrian UH. Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol 2005; 6: 1182–1190
   PubMed Web of Science ®Google Scholar
• Makino A, Shin HY, Komai Y, Fukuda S, Coughlin MF, Sugihara-Seki M, Schmid-Schoenbein GW. Mechanotransduction in leukocyte activation: a review. Biorheology 2007; 44: 221–240
   PubMed Web of Science ®Google Scholar
• Mamdouh Z, Chen X, Pierini LM, Maxfield FR, Muller WA. Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis. Nature 2003; 421: 748–753
   Google Scholar
• Mamdouh Z, Kreitzer GE, Muller WA. Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the lateral border recycling compartment. J Exp Med 2008; 205: 951–966
   PubMed Web of Science ®Google Scholar
• Millan J, Hewlett L, Glyn M, Toomre D, Clark P, Ridley AJ. Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains. Nat Cell Biol 2006; 8: 113–123
   PubMed Web of Science ®Google Scholar
• Moazzam F, DeLano FA, Zweifach BW, Schmid-Schonbein GW. The leukocyte response to fluid stress. Proc Natl Acad Sci U S A 1997; 94: 5338–5343
   Google Scholar
• Moll T, Dejana E, Vestweber D. In vitro degradation of endothelial catenins by a neutrophil protease. J Cell Biol 1998; 140: 403–407
   PubMedGoogle Scholar
• Muller WA. Migration of leukocytes across endothelial junctions: some concepts and controversies. Microcirculation 2001; 8: 181–193
   PubMed Web of Science ®Google Scholar
• Muller WA. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol 2003; 24: 327–334
   PubMed Web of Science ®Google Scholar
• Muller WA, Weigl SA, Deng X, Phillips DM. PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 1993; 178: 449–460
   PubMed Web of Science ®Google Scholar
• Nathan C. Points of control in inflammation. Nature 2002; 420: 846
   PubMed Web of Science ®Google Scholar
• Nawroth R, Poell G, Ranft A, Kloep S, Samulowitz U, Fachinger G, Golding M, Shima DT, Deutsch U, Vestweber D. VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J 2002; 21: 4885–4895
   PubMed Web of Science ®Google Scholar
• Noren NK, Niessen CM, Gumbiner BM, Burridge K. Cadherin engagement regulates Rho-family GTPases. J Biol Chem 2001; 276: 33305–33308
   PubMed Web of Science ®Google Scholar
• Oh HM, Lee S, Na BR, Wee H, Kim SH, Choi SC, Lee KM, Jun CD. RKIKK motif in the intracellular domain is critical for spatial and dynamic organization of ICAM-1: functional implication for the leukocyte adhesion and transmigration. Mol Biol Cell 2007; 18: 2322–2335
   Google Scholar
• Phillipson M, Heit B, Colarusso P, Liu L, Ballantyne CM, Kubes P. Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade. J Exp Med 2006; 203: 2569–2575
   PubMed Web of Science ®Google Scholar
• Potter MD, Barbero S, Cheresh DA. Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and {beta}-catenin and maintains the cellular mesenchymal state. J Biol Chem 2005; 280: 31906–31912
   PubMed Web of Science ®Google Scholar
• Rabodzey, R, Alcaide P, Luscinskas FW, Ladoux B. 2008. Mechanical forces induced by the transendothelial migration of human neutrophils. Biophys J In press.
   Google Scholar
• Ramirez SH, Heilman D, Morsey B, Potula R, Haorah J, Persidsky Y. Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1-infected monocytes. J Immunol 2008; 180: 1854–1865
   PubMed Web of Science ®Google Scholar
• Rao RM, Yang L, Garcia-Cardena G, Luscinskas FW. Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res 2007; 101: 234–247
   PubMed Web of Science ®Google Scholar
• Reynolds AB. p120-catenin: past and present. Biochim Biophys Acta 2007; 1773: 2–7
   PubMedGoogle Scholar
• Sachs UJH, Andrei-Selmer CL, Maniar A, Weiss T, Paddock C, Orlova VV, Choi EY, Newman PJ, Preissner KT, Chavakis T, Santoso S. The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31). J Biol Chem 2007; 282: 23603–23612
   PubMed Web of Science ®Google Scholar
• Schenkel AR, Chew TW, Muller WA. Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strains. J Immunol 2004; 173: 6403–6408
   PubMed Web of Science ®Google Scholar
• Schenkel AR, Mamdouh Z, Muller WA. Locomotion of monocytes on endothelium is a critical step during extravasation. Nat Immunol 2004; 5: 393–400
   PubMed Web of Science ®Google Scholar
• Scott DL, Diez G, Goldmann WH. Protein-lipid interactions: correlation of a predictive algorithm for lipid-binding sites with three-dimensional structural data. Theor Biol Med Mod 2006; 3: 17
   Google Scholar
• Shaw SK, Bamba PS, Perkins BN, Luscinskas FW. Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium. J Immunol 2001; 167: 2323–2330
   PubMed Web of Science ®Google Scholar
• Shaw SK, Ma S, Kim M, Rao RM, Hartman CU, Froio R, Liu Y, Yang L, Jones T., Nusrat A, Parkos CA, Luscinskas FW. Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompanies neutrophil transmigration. J Exp Med 2004; 200: 1571–1580
   PubMed Web of Science ®Google Scholar
• Shin HY, Simon SI, Schmid-Schonbein GW. Fluid shear-induced activation and cleavage of CD18 during pseudopod retraction by human neutrophils. J Cell Physiol 2008; 214: 528–536
   Google Scholar
• Smith CW, Kishimoto TK, Abbassi O, Hughes B, Rothlein R, Mcintire LV, Butcher EC, Anderson DC. Chemotactic factors regulate lectin adhesion molecule-1 (LECAM-1)-dependent neutrophil adhesion to cytokine-stimulated endothlial cells in vitro. J Clin Invest 1991; 87: 609–618
   PubMed Web of Science ®Google Scholar
• Smith CW, Marlin SD, Rothlein R, Toman C, Anderson DC. Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J Clin Invest 1989; 83: 2008–2017
   PubMed Web of Science ®Google Scholar
• Smith LA, Aranda-Espinoza H, Haun JB, Dembo M, Hammer DA. Neutrophil traction stresses are concentrated in the uropod during migration. Biophys J 2007; 92: L58–L60
   Google Scholar
• Sparks AB, Rider JE, Hoffman NG, Fowlkes DM, Quillam LA, Kay BK. Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCgamma, Crk, and Grb2. Proc Natl Acad Sci U S A 1996; 93: 1540–1544
   PubMed Web of Science ®Google Scholar
• Sparks AB, Rider JE, Kay BK. Mapping the specificity of SH3 domains with phage-displayed random-peptide libraries. Meth Mol Biol 1998; 84: 87–103
   Google Scholar
• Su WH, Chen H-I, Jen CJ. Differential movements of VE-cadherin and PECAM-1 during transmigration of polymorphonuclear leukocytes through human umbilical vein endothelium. Blood 2002; 100: 3597–3603
   Google Scholar
• Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 1997; 13: 513–609
   PubMed Web of Science ®Google Scholar
• Tilghman RW, Hoover RL. The Src-cortactin pathway is required for clustering of E-selectin and ICAM-1 in endothelial cells. FASEB J 2002; 16: 1257–1259
   PubMedGoogle Scholar
• Tsukita S, Yonemura S. Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins. J Biol Chem 1999; 274: 34507–34510
   PubMed Web of Science ®Google Scholar
• Turowski P, Martinelli R, Crawford R, Wateridge D, Papageorgiou AP, Lampugnani MG, Gamp AC, Vestweber D, Adamson P, Dejana E, Greenwood J. Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration. J Cell Sci 2008; 121: 29–37
   PubMed Web of Science ®Google Scholar
• Turowski P, Adamson P, Greenwood J. Pharmacological targeting of ICAM-1 signaling in brain endothelial cells: potential for treating neuroinflammation. Cell Mol Neurobiol 2005; 25: 153–170
   PubMed Web of Science ®Google Scholar
• van Buul JD, Allingham MJ, Samson T, Meller J, Boulter E, Garcia-Mata R, Burridge K. Rho G regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte transendothelial migration. J Cell Biol 2007; 178: 1279–1293
   PubMed Web of Science ®Google Scholar
• Vestweber D. Adhesion and signaling molecules controlling the transmigration of leukocytes through endothelium. Immunol Rev 2007; 218: 178–196
   PubMed Web of Science ®Google Scholar
• Vestweber D. VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol 2008; 28: 223–232
   PubMed Web of Science ®Google Scholar
• Vincent PA, Xiao K, Buckley KM, Kowalczyk AP. VE-cadherin: adhesion at arm's length. Am J Physiol Cell Physiol 2004; 286: C987–C997
   PubMed Web of Science ®Google Scholar
• Wang S, Voisin MB, Larbi KY, Dangerfield J, Scheiermann C, Tran M, Maxwell PH, Sorokin L, Nourshargh S. Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils. J Exp Med 2006; 203: 1519–1532
   PubMed Web of Science ®Google Scholar
• Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, Parsons JT. Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex. J Cell Biol 2000; 151: 29–40
   PubMedGoogle Scholar
• Weed SA, Parsons JT. Cortactin: coupling membrane dynamics to cortical actin assembly. Oncogene 2001; 20: 6418–6434
   PubMed Web of Science ®Google Scholar
• Weis WI, Nelson WJ. Resolving the cadherin-catenin-actin conundrum. J Biol Chem 2006; 281: 35593–35597
   PubMedGoogle Scholar
• Wildenberg GA, Dohn MR, Carnahan RH, Davis MA, Lobdell NA, Settleman J, Reynolds AB. p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell 2006; 127: 1027–1039
   PubMedGoogle Scholar
• Wojciak-Stothard B, Williams L, Ridley AJ. Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering. J Cell Biol 1999; 145: 1293–1307
   PubMed Web of Science ®Google Scholar
• Wojciechowski JC, Sarelius IH. Preferential binding of leukocytes to the endothelial cell junction region in venules in situ. Microcirculation 2005; 12: 349–359
   Web of Science ®Google Scholar
• Xiao K, Allison DF, Buckley KM, Kottke MD, Vincent PA, Faundez V, Kowalczyk AP. Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells. J Cell Biol 2003; 163: 535–545
   PubMed Web of Science ®Google Scholar
• Xiao K, Garner J, Buckley KM, Vincent PA, Chiasson CM, Dejana E, Faundez V, Kowalczyk AP. p120-catenin regulates clathrin-dependent endocytosis of VE-cadherin. Mol Biol Cell 2005; 16: 5141–5151
   PubMed Web of Science ®Google Scholar
• Yamada S, Pokutta S, Drees F, Weis WI, Nelson WJ. Deconstructing the cadherin-catenin-actin complex. Cell 2005; 123: 889–901
   PubMed Web of Science ®Google Scholar
• Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW. ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-α-activated vascular endothelium under flow. Blood 2005; 106: 584–592
   PubMed Web of Science ®Google Scholar
• Yang L, Kowalski JR, Yacono P, Bajmoczi M, Shaw SK, Froio RM, Golan DE, Thomas SM, Luscinskas FW. Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration. J Immunol 2006; 177: 6440–6449
   PubMed Web of Science ®Google Scholar
• Yang L, Kowalski JR, Zhan X, Thomas SM, Luscinskas FW. Endothelial Cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro. Circ Res 2006; 98: 394–402
   Google Scholar
• Yang Y, Jun CD, Liu JH, Zhang R, Joachimiak A, Springer TA, Wang JH. Structural basis for dimerization of ICAM-1 on the cell surface. Mol Cell 2004; 14: 269–276
   Google Scholar
• Yap B, Kamm RD. Mechanical deformation of neutrophils into narrow channels induces pseudopod projection and changes in biomechanical properties. J Appl Physiol 2005; 98: 1930–1939
   PubMed Web of Science ®Google Scholar