Neuroprotective Effects of Alpha-Lipoic Acid in Experimental Spinal Cord Injury in Rats

REFERENCES

• Azbill RD, Mu X, Bruce-Keller AJ, Mattson MP, Springer JE. Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury. Brain Res. 1997; 765(2): 283–290.
   PubMed Web of Science ®Google Scholar
• Park E, Velumian AA, Fehlings MG. The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J Neurotrauma. 2004; 21 (6): 754–774.
   PubMed Web of Science ®Google Scholar
• Hall ED, Springer JE. Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx. Jan 2004; 1(1): 80–100.
   PubMedGoogle Scholar
• Slemmer JE, Shacka JJ, Sweeney Ml, Weber JT. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem. 2008; 15(4): 404–414.
   PubMed Web of Science ®Google Scholar
• Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med. 1997; 22(1-2): 359–378.
   PubMed Web of Science ®Google Scholar
• Roy S, Packer L. Redox regulation of cell functions by alphalipoate: biochemical and molecular aspects. Biofactors. 1998; 8(1 -2): 17–21.
   PubMed Web of Science ®Google Scholar
• Suzuki Y), Tsuchiya M, Packer L. Antioxidant activities of dihydrolipoic acid and its structural homologues. Free Radic Res Commun. 1993; 18(2): 115–122.
   PubMed Web of Science ®Google Scholar
• Kagan VE, Shvedova A, Serbinova E, et al. Dihydrolipoic acid—a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol. 1992; 44(8): 1637–1649.
   PubMed Web of Science ®Google Scholar
• Han D, Handelman C, Marcocci L, et al. Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization. Biofactors. 1997; 6(3): 321–338.
   PubMed Web of Science ®Google Scholar
• Glantzounis GK, Yang W, Koti RS, Mikhailidis DP, Seifalian AM, Davidson BR. The role of thiols in liver ischemia-reperfusion injury. Curr Pharm Des. 2006; 12(23): 2891–2901.
   PubMed Web of Science ®Google Scholar
• Biewenga G, Haenen GR, Bast A. The role of lipoic acid in the treatment of diabetic polyneuropathy. Drug Metab Rev. Nov 1997; 29(4): 1025–1054.
   PubMed Web of Science ®Google Scholar
• Sehirli O, Sener E, Cetinel S, Yuksel M, Gedik N, Sener G. Alpha-lipoic acid protects against renal ischaemia-reperfusion injury in rats. Clin Exp Pharmacol Physiol. 2008; 35(3): 249–255.
   PubMed Web of Science ®Google Scholar
• Bilska A, Wlodek L. Lipoic acid—the drug of the future? Pharmacol Rep. Sep-Oct 2005; 57(5): 570–577.
   PubMed Web of Science ®Google Scholar
• Foster TS. Efficacy and safety of alpha-lipoic acid supplementation in the treatment of symptomatic diabetic neuropathy. Diabetes Educ. 2007; 33(1): 111–117.
   PubMed Web of Science ®Google Scholar
• Manda K, Ueno M, Moritake T, Anzai K. Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: protective effect of alpha-lipoic acid. Behav Brain Res. 2007; 177(1): 7–14.
   PubMed Web of Science ®Google Scholar
• Salinthone S, Yadav V, Bourdette DN, Carr DW. Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS. Endocr Metab Immune Disord Drug Targets. 2008; 8(2): 132–142.
   PubMedGoogle Scholar
• Maczurek A, Hager K, Kenklies M, Sharman M, Martins R, Engel J, Carlsonn DA, Munch G: Lipoic acid as an antiinflammatory and neuroprotective treatment for Alzheimer's disease. Adv Drug Deliv Rev. 2008; 60(13-14): 1463–1470.
   PubMed Web of Science ®Google Scholar
• Toklu HZ, Hakan T, Biber N, Solakoglu S, Ogunc AV, Sener G. The protective effect of alpha lipoic acid against traumatic brain injury in rats. Free Radic Res. 2009; 43(7): 658–667.
   PubMed Web of Science ®Google Scholar
• Ersahin M, Toklu HZ, Cetinel S, et al. Alpha lipoic acid alleviates oxidative stress and preserves blood brain permeability in rats with subarachnoid hemorrhage. Neurochem Res. 2010; 35(3): 418–428.
   PubMed Web of Science ®Google Scholar
• Allen AR. Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column. A preliminary report. JAMA. 1911; 57: 878–880.
   Google Scholar
• Gale K, Kerasidis H, Wrathall JR. Spinal cord contusion in the rat: behavioral analysis of functional neurologic impairment. Exp Neurol. 1985; 88(1): 123–134.
   PubMed Web of Science ®Google Scholar
• Davies GR, Simmonds NJ, Stevens TR, Grandison A, Blake DR, Rampton DS. Mucosal reactive oxygen metabolite production in duodenal ulcer disease. Gut. 1992; 33(11): 1467–1472.
   PubMed Web of Science ®Google Scholar
• Haklar G, Yuksel, M., Yalcin, A.S. Chemiluminescence in the measurement of free radicals: theory and application on a tissue injury model. Marmara Med J. 1998; 11: 55–60.
   Google Scholar
• Hillegass LM, Griswold DE, Brickson B, Albrightson-Winslow C. Assessment of myeloperoxidase activity in whole rat kidney. J Pharmacol Methods. 1990; 24(4): 285–295.
   PubMedGoogle Scholar
• Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. 1978; 52: 302–310.
   PubMedGoogle Scholar
• Beutler E, Duran O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med. 1963; 61: 882–888.
   PubMed Web of Science ®Google Scholar
• Burton K. Determination of DNA concentration with diphenylamine. Methods Enzymol. 1968; 12: 163–166.
   Google Scholar
• Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG. Multiple sclerosis. N Engl J Med. 2000; 343(13): 938–952.
   PubMed Web of Science ®Google Scholar
• Emerit J, Edeas M, Bricaire F. Neurodegenerative diseases and oxidative stress. Biomed Pharmacother. 2004; 58(1): 39–46.
   PubMed Web of Science ®Google Scholar
• Tilleux S, Hermans E. Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J Neurosci Res. 2007; 85(10): 2059–2070.
   PubMed Web of Science ®Google Scholar
• Adibhatla RM, Hatcher JF. Phospholipase A(2), reactive oxygen species, and lipid peroxidation in CNS pathologies. BMB Rep. 2008; 41 (8): 560–567.
   PubMed Web of Science ®Google Scholar
• Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004; 134(3): 489–492.
   PubMed Web of Science ®Google Scholar
• Biewenga GP, Haenen GR, Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol. 1997; 29(3): 315–331.
   PubMedGoogle Scholar
• Moini H, Packer L, Saris NE. Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol Appl Pharmacol. 2002; 182(1): 84–90.
   PubMed Web of Science ®Google Scholar
• Dulundu E, Ozel Y, Topaloglu U, et al. Alpha-lipoic acid protects against hepatic ischemia-reperfusion injury in rats. Pharmacology. 2007; 79(3): 163–170.
   PubMed Web of Science ®Google Scholar
• Sehirli O, Tatlidede E, Yuksel M, Sehirli O, Ercan F, Gedik N, Sener G. Antioxidant effect of alpha-lipoic acid against ethanol-induced gastric mucosal erosion in rats. Pharmacology. 2008; 81 (2): 173–180.
   PubMed Web of Science ®Google Scholar
• Gris D, Hamilton EF, Weaver LC. The systemic inflammatory response after spinal cord injury damages lungs and kidneys. Exp Neurol. 2008; 211(1): 259–270.
   PubMed Web of Science ®Google Scholar
• Bernards CM, Akers T. Effect of postinjury intravenous or intrathecal methylprednisolone on spinal cord excitatory amino-acid release, nitric oxide generation, PGE2 synthesis, and myeloperoxidase content in a pig model of acute spinal cord injury. Spinal Cord. 2006; 44(10): 594–604.
   PubMed Web of Science ®Google Scholar
• Taoka Y, Okajima K, Uchiba M, Johno M. Methylprednisolone reduces spinal cord injury in rats without affecting tumor necrosis factor-alpha production. J Neurotrauma. 2001; 18(5): 533–543.
   PubMed Web of Science ®Google Scholar
• Zhang WJ, Wei H, Hagen T, Frei B. Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. Proc Natl Acad Sci USA. 2007; 104(10): 4077–4082.
   PubMed Web of Science ®Google Scholar
• Kolgazi M, Jahovic N, Yuksel M, Ercan F, Alican I. Alpha- lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats. J Gastroenterol Hepatol. 2007; 22(11): 1859–1865.
   PubMed Web of Science ®Google Scholar
• Jia Z, Zhu H, Vitto MJ, Misra BR, Li Y, Misra HP. Alpha- lipoic acid potently inhibits peroxynitrite-mediated DNA strand breakage and hydroxyl radical formation: implications for the neuroprotective effects of alpha-lipoic acid. Mol Cell Biochem. 2009; 323(1-2): 131–138.
   PubMed Web of Science ®Google Scholar