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Research Article

A Rationally Designed Synthetic Mimic of the Discontinuous CD4-Binding Site of HIV-1 gp120

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Pages 453-460 | Published online: 10 Oct 2008

REFERENCES

  • Eichler J. synthetic peptide arrays and peptide combinatorial libraries for the exploration of protein-protein interactions and the design of protein inhibitors. Comb Chem High Throughput Screen 2005; 8: 135–143
  • Franke R, Doll C, Wray V, Eichler J. Solid-phase synthesis of structurally diverse scaffolded peptides for the mimicry of discontinuous protein binding sites. Protein Pept Lett 2003; 10: 531–539
  • Turner B G, Summers M F. Structural biology of HIV. J Mol Biol 1999; 285: 1–32
  • Cordonnier A, Montagnier L, Emerman M. Single amino-acid changes in HIV envelope affect viral tropism and receptor binding. Nature 1989; 340: 571–574
  • Cordonnier A, Riviere Y, Montagnier L, Emerman M. Effects of mutations in hyperconserved regions of the extracellular glycoprotein of human immunodeficiency virus type 1 on receptor binding. J Virol 1989; 63: 4464–4468
  • Burton D R, Pyati J, Koduri R, Sharp S J, Thornton G B, Parren P WHI, Sawyer L SW, Hendry R M, Dunlop N, Nara P L, Lamacchia M, Garratty E, Stiehm E R, Bryson Y J, Cao Y J, Moore J P, Ho D D, Barbas C FI. Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody. Science 1994; 266: 1024–1027
  • Saphire E O, Parren P W, Pantophlet R, Zwick M B, Morris G M, Rudd P M, Dwek R A, Stanfield R L, Burton D R, Wilson I A. Crystal structure of a neutralizing human IgG against HIV-1: A template for vaccine design. Science 2001; 293: 1155–1159
  • Huang C C, Tang M, Zhang M Y, Majeed S, Montabana E, Stanfield R L, Dimitrov D S, Korber B, Sodroski J, Wilson I A, Wyatt R, Kwong P D. Structure of a V3-containing HIV-1 gp120 core. Science 2005; 310: 1025–1028
  • Huang C C, Venturi M, Majeed S, Moore M J, Phogat S, Zhang M Y, Dimitrov D S, Hendrickson W A, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong P D. Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120. Proc Natl Acad Sci USA 2004; 101: 2706–2711
  • Kwong P D, Wyatt R, Majeed S, Robinson J, Sweet R W, Sodroski J, Hendrickson W A. Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates. Structure 2000; 8: 1329–1339
  • Kwong P D, Wyatt R, Robinson J, Sweet R W, Sodroski J, Hendrickson W A. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 1998; 393: 648–659
  • Franke R, Doll C, Wray V, Eichler J. Loops on loops: Generation of complex scaffolded peptides presenting multiple cyclic fragments. Org Biomol Chem 2004; 2: 2847–2851
  • Franke R, Doll C, Eichler J. Peptide ligation through click chemistry for the generation of assembled and scaffolded peptides. Tetrahedron Lett 2005; 46: 4479–4482
  • Packman L C. N-2-hydroxy-4-methoxybenzyl (Hmb) backbone protection strategy prevents double aspartimide formation in a difficult peptide sequence. Tetrahedron Lett 1995; 36: 7523–7526

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