163
Views
1
CrossRef citations to date
0
Altmetric
Research Article

A systems biology approach for elucidating the interaction of curcumin with Fanconi anemia FANC G protein and the key disease targets of leukemia

, , &
Pages 276-282 | Received 11 Mar 2016, Accepted 03 Aug 2016, Published online: 08 Sep 2016

References

  • Wang W. Emergence of a DNA-damage response network consisting of Fanconi anemia and BRCA proteins. Nat Rev Genet 2007;8:735–48.
  • de Winter JP, Joenje H. The genetic and molecular basis of Fanconi anemia. Mutat Res 2009;668:11–9.
  • Solomon PJ, Margaret P, Rajendran R, et al. A case report and literature review of Fanconi Anemia (FA) diagnosed by genetic testing. Ital J Pediatr 2015;41:38.
  • Joo W, Xu G, Persky NS, et al. Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway. Science 2011;333:312–6.
  • Terrie F, Kathleen N, Lewing K, Jignesh Dalal J. Successful treatment of Fanconi Anemia and T-cell acute lymphoblastic leukemia. Case Rep Hematol 2012;2012. doi: 10.1155/2012/396395.
  • Mathew CG. Fanconi anaemia genes and susceptibility to cancer. Oncogene 2006;25:5875–84.
  • Auerbach AD, Allen RG. Leukemia and preleukemia in Fanconi anemia patients. A review of the literature and report of the International Fanconi Anemia Registry. Cancer Genet Cytogenet 1991;51. doi: 10.1016/0165-4608(91)90002-C.
  • Auerbach AD. Fanconi anemia and leukemia: tracking the genes. Leukemia 1992;6.
  • Hussain S, Witt E, Huber PA, et al. Direct interaction of the Fanconi anemia protein FANCG with BRCA2/FANCD1. Hum Mol Genet 2003;12:2503–10.
  • Al-Hussaini M, Di Persio JF. Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinic. Expert Rev Hematol 2014;7:439–64.
  • Hatzimichael E, Georgiou G, Benetatos L, Briasoulis E. Gene mutations and molecularly targeted therapies in acute myeloid leukemia. Am J Blood Res 2013;3:29–51.
  • Landais I, Hiddingh S, McCarroll M, et al. Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors. Mol Cancer 2009;8:133.
  • Jacquemont C, Taniguchi T. Proteasome function is required for DNA damage response and Fanconi anemia pathway activation. Cancer Res 2007;67:7395–405.
  • Kuo ML, Huang TS, Lin JK. Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Biochim Biophys Acta 1996;1317:95–100.
  • Atsumi T, Murakami Y, Shibuya K, et al. Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression, by curcumin and its analog, alpha-diisoeugenol. Anticancer Res 2005;25:4029–36.
  • Sali A, Blundell TL. Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 1993;234:779–815.
  • Bairoch A, Apweiler R. The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. Nucleic Acids Res 2000;28:45–8.
  • Altschul SF, Madden TL, Schaffer AA, et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997;25:3389–402.
  • Berman H, Henrick K, Nakamura H. Announcing the worldwide Protein Data Bank. Nat Struc Biol 2003;10:980.
  • Ramachandran GN, Ramakrishnan C, Sasisekharan V. Stereochemistry of polypeptide chain configurations. J Mol Biol 1963;7:95–9.
  • The PyMOL Molecular Graphics System, Version 1.2r3pre, Schrödinger, LLC.
  • Trott O, Olson AJ, AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading. J Comput Chem 2010;31:455–61.
  • Henikoff S, Henikoff JG. Amino acid substitution matrices from protein blocks. PNAS 1992;89:10915–9.
  • Rice P, Longden I, Bleasby A. EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet 2000;16:276–7.
  • Huang X, Miller W. LALIGN finds the best local alignments between two sequences. Adv Appl Math 1991;12:373–81.
  • Shukla P, Ghosh K, Vundinti BR. Current and emerging therapeutic strategies for Fanconi anemia. Hugo J 2012;6. doi: 10.1186/1877-6566-6-1.
  • Navarro S, Río P, Bueren JA. Perspectives on gene therapy for Fanconi anemia. Exp Opin Orphan Drugs 2015;3:8 99–910.
  • Rose SR. Hormone therapy in Fanconi anemia. Exp Opin Orphan Drugs 2015;3:831–42.
  • MacMillan ML, Wagner JE. Haematopoeitic cell transplantation for Fanconi anaemia – when and how? Br J Haematol 2010;149:14–21.
  • Zhang QS, Benedetti E, Deater M, et al. Oxymetholone therapy of Fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling. Stem Cell Rep 2015;4:90–102.
  • Moldvay J, Schaff Z, Lapis K. Hepatocellular carcinoma in Fanconi’s anemia treated with androgen and corticosteroid. Zentralbl Pathol 1991;137:167–70.
  • Mulvihill JJ, Ridolfi RL, Schultz FR, et al. Hepatic adenoma in Fanconi anemia treated with oxymetholone. J Pediatr 1975;87: 122–12.
  • Touraine RL, Bertrand Y, Foray P, et al. Hepatic tumours during androgen therapy in Fanconi anaemia. Eur J Pediatr 1993;152: 691–3.
  • Rackoff WR, Orazi A, Robinson CA, et al. Prolonged administration of granulocyte colony-stimulating factor (filgrastim) to patients with Fanconi anemia: a pilot study. Blood 1996;88: 1588–93.
  • Pang Q, Fagerlie S, Christianson TA, et al. The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors. Mol Cell Biol 2000;20:4724–35.
  • Jun DW, Hwang M, Kim HJ, et al. Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. PLoS One 2013;8:e75905.
  • Tsai YS, Lin CS, Chiang SL, et al. Areca nut induces miR-23a and inhibits repair of DNA double-strand breaks by targeting FANCG. Toxicol Sci 2011;123:480–90.
  • Landais I, Sobeck A, Stone S, et al. A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway. Int J Cancer 2009;124:783–92.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.