4-octyl itaconate inhibits high glucose induced renal tubular epithelial cell fibrosis through TGF-β-ROS pathway

References

• Sun H, Saeedi P, Karuranga S, et al. IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. doi:10.1016/j.diabres.2021.109119.
   PubMed Web of Science ®Google Scholar
• Ma X, Ma J, Leng T, et al. Advances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention. Ren Fail. 2023;45(1):2146512. doi:10.1080/0886022X.2022.2146512.
   PubMed Web of Science ®Google Scholar
• Kuenz A, Krull S. Biotechnological production of itaconic acid-things you have to know. Appl Microbiol Biotechnol. 2018;102(9):3901–3914. doi:10.1007/s00253-018-8895-7.
   PubMed Web of Science ®Google Scholar
• Shin JH, Yang JY, Jeon BY, et al. (1)H NMR-based metabolomic profiling in mice infected with Mycobacterium tuberculosis. J Proteome Res. 2011;10(5):2238–2247. doi:10.1021/pr101054m.
   PubMed Web of Science ®Google Scholar
• Agarwal R, Filippatos G, Pitt B, et al. Cardiovascular and kidney outcomes with finerenone in patients with type 2 diabetes and chronic kidney disease: the FIDELITY pooled analysis. Eur Heart J. 2022;43(6):474–484. Erratum in: eur Heart J. 2022 May 21;43(20):1989. doi:10.1093/eurheartj/ehab777.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Jiang L, Wang J, et al. Network meta-analysis on the effects of finerenone versus SGLT2 inhibitors and GLP-1 receptor agonists on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus and chronic kidney disease. Cardiovasc Diabetol. 2022;21(1):232. doi:10.1186/s12933-022-01676-5.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Jin D, Kang X, et al. Signaling pathways involved in diabetic renal fibrosis. Front Cell Dev Biol. 2021;9:696542. doi:10.3389/fcell.2021.696542.
   PubMed Web of Science ®Google Scholar
• Wu W, Huang XR, You Y, et al. Latent TGF-β1 protects against diabetic kidney disease via arkadia/Smad7 signaling. Int J Biol Sci. 2021;17(13):3583–3594. Aug 19 doi:10.7150/ijbs.61647.
   PubMed Web of Science ®Google Scholar
• Peace CG, O'Neill LA. The role of itaconate in host defense and inflammation. J Clin Invest. 2022;132(2):e148548. doi:10.1172/JCI148548.
   PubMed Web of Science ®Google Scholar
• Hersch SJ, Navarre WW. The Salmonella LysR family regulator RipR activates the SPI-13-Encoded itaconate degradation cluster. Infect Immun. 2020;88(10):e00303-20. doi:10.1128/IAI.00303-20.
   PubMed Web of Science ®Google Scholar
• Daniels BP, Kofman SB, Smith JR, et al. The nucleotide sensor ZBP1 and kinase RIPK3 induce the enzyme IRG1 to promote an antiviral metabolic state in neurons. Immunity. 2019;50(1):64–76. e4. Jan 15Epub 2019 Jan 8. doi:10.1016/j.immuni.2018.11.017.
   PubMed Web of Science ®Google Scholar
• Olagnier D, Farahani E, Thyrsted J, et al. SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. Nat Commun. 2020;11(1):5419. Oct 2;11(1):4938. Erratum in: nat Commun. 2020 Oct 21 doi:10.1038/s41467-020-19363-y.
   PubMed Web of Science ®Google Scholar
• Sohail A, Iqbal AA, Sahini N, et al. Itaconate and derivatives reduce interferon responses and inflammation in influenza a virus infection. PLoS Pathog. 2022;18(1):e1010219. Erratum in: PLoS Pathog. 2022 Nov 2918(11):e1011002. doi:10.1371/journal.ppat.1011002.
   PubMed Web of Science ®Google Scholar
• Chen F, Lukat P, Iqbal AA, et al. Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis. Proc Natl Acad Sci U S A. 2019;116(41):20644–20654. doi:10.1073/pnas.1908770116.
   PubMed Web of Science ®Google Scholar
• Mills EL, Ryan DG, Prag HA, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018;556(7699):113–117. doi:10.1038/nature25986.
   PubMed Web of Science ®Google Scholar
• Domínguez-Andrés J, Novakovic B, Li Y, et al. The itaconate pathway is a Central regulatory node linking innate immune tolerance and trained immunity. Cell Metab. 2019;29(1):211–220.e5. doi:10.1016/j.cmet.2018.09.003.
   PubMed Web of Science ®Google Scholar
• Ogger PP, Albers GJ, Hewitt RJ, et al. Itaconate controls the severity of pulmonary fibrosis. Sci Immunol. 2020;5(52):eabc1884. doi:10.1126/sciimmunol.abc1884.
   PubMed Web of Science ®Google Scholar
• Puchalska P, Huang X, Martin SE, et al. Isotope tracing untargeted metabolomics reveals macrophage Polarization-State-specific metabolic coordination across intracellular compartments. iScience. 2018;9:298–313. doi:10.1016/j.isci.2018.10.029.
   PubMed Web of Science ®Google Scholar
• Li R, Zhang P, Wang Y, et al. Itaconate: a metabolite regulates inflammation response and oxidative stress. Oxid Med Cell Longev. 2020;2020:5404780. doi:10.1155/2020/5404780.
   PubMed Web of Science ®Google Scholar
• Rittenhouse JW, McFadden BA. Inhibition of isocitrate lyase from Pseudomonas indigofera by itaconate. Arch Biochem Biophys. 1974;163(1):79–86. doi:10.1016/0003-9861(74)90456-1.
   PubMed Web of Science ®Google Scholar
• Raghu G, Berk M, Campochiaro PA, et al. The multifaceted therapeutic role of N-Acetylcysteine (NAC) in disorders characterized by oxidative stress. Curr Neuropharmacol. 2021;19(8):1202–1224.
   PubMed Web of Science ®Google Scholar
• Nair S, Huynh JP, Lampropoulou V, et al. Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection. J Exp Med. 2018;215(4):1035–1045. doi:10.1084/jem.20180118.
   PubMed Web of Science ®Google Scholar
• Zhao C, Jiang P, He Z, et al. Dimethyl itaconate protects against lippolysacchride-induced mastitis in mice by activating MAPKs and Nrf2 and inhibiting NF-κB signaling pathways. Microb Pathog. 2019;133:103541. doi:10.1016/j.micpath.2019.05.024.
   PubMed Web of Science ®Google Scholar
• Lampropoulou V, Sergushichev A, Bambouskova M, et al. Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation. Cell Metab. 2016;24(1):158–166. doi:10.1016/j.cmet.2016.06.004.
   PubMed Web of Science ®Google Scholar
• Shen H, Campanello GC, Flicker D, et al. The human knockout gene CLYBL connects itaconate to vitamin B (12). Cell. 2017;171(4):771–782.e711. doi:10.1016/j.cell.2017.09.051.
   PubMed Web of Science ®Google Scholar
• Sporn MB, Liby KT. NRF2 and cancer: the good, the bad and the importance of context. Nat Rev Cancer. 2012;12(8):564–571. doi:10.1038/nrc3278.
   PubMed Web of Science ®Google Scholar
• Shan Q, Li X, Zheng M, et al. Protective effects of dimethyl itaconate in mice acute cardiotoxicity induced by doxorubicin. Biochem Biophys Res Commun. 2019;517(3):538–544. doi:10.1016/j.bbrc.2019.07.046.
   PubMed Web of Science ®Google Scholar
• Liu H, Feng Y, Xu M, et al. Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide. Cell Commun Signal. 2018;16(1):81. doi:10.1186/s12964-018-0294-2.
   PubMedGoogle Scholar
• Bambouskova M, Gorvel L, Lampropoulou V, et al. Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Nature. 2018;556(7702):501–504. doi:10.1038/s41586-018-0052-z.
   PubMed Web of Science ®Google Scholar
• Tang C, Tan S, Zhang Y, et al. Activation of Keap1-Nrf2 signaling by 4-octyl itaconate protects human umbilical vein endothelial cells from high glucose. Biochem Biophys Res Commun. 2019;508(3):921–927. doi:10.1016/j.bbrc.2018.12.032.
   PubMed Web of Science ®Google Scholar
• Cordes T, Lucas A, Divakaruni AS, et al. Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury. Mol Metab. 2020;32:122–135. doi:10.1016/j.molmet.2019.11.019.
   PubMed Web of Science ®Google Scholar
• Zhang D, Lu Z, Zhang Z, et al. A likely protective effect of dimethyl itaconate on cerebral ischemia/reperfusion injury. Int Immunopharmacol. 2019;77:105924. doi:10.1016/j.intimp.2019.105924.
   PubMed Web of Science ®Google Scholar
• Tian F, Wang Z, He J, et al. 4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/smad pathway, autophagy and reducing generation of reactive oxygen species. Eur J Pharmacol. 2020;873:172989. doi:10.1016/j.ejphar.2020.172989.
   PubMed Web of Science ®Google Scholar
• Tryfonidis K, Basaran G, Bogaerts J, et al. A european organisation for research and treatment of cancer randomized, double-blind, placebo-controlled, multicentre phase II trial of anastrozole in combination with gefitinib or placebo in hormone receptor-positive advanced breast cancer (NCT00066378). Eur J Cancer. 2016;53:144–154. doi:10.1016/j.ejca.2015.10.012.
   PubMed Web of Science ®Google Scholar
• Weiss JM, Davies LC, Karwan M, et al. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. J Clin Invest. 2018;128(9):3794–3805. doi:10.1172/JCI99169.
   PubMed Web of Science ®Google Scholar
• Pan J, Zhao XY, Lin CN, et al. Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma. Oncol Rep. 2014;32(5):1957–1966. doi:10.3892/or.2014.3474.
   PubMed Web of Science ®Google Scholar
• Shi HZ, Wang D, Sun XN, et al. MicroRNA-378 acts as a prognosis marker and inhibits cell migration, invasion and epithelial-mesenchymal transition in human glioma by targeting IRG1. Eur Rev Med Pharmaco. 2018;22(12):3837–3846.
   PubMed Web of Science ®Google Scholar
• Wang Q, Li XL, Mei Y, et al. The anti-inflammatory drug dimethyl itaconate protects against colitis-associated colorectal cancer. J Mol Med (Berl). 2020;98(10):1457–1466. doi:10.1007/s00109-020-01963-2.
   PubMed Web of Science ®Google Scholar
• Kobayashi EH, Suzuki T, Funayama R, et al. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun. 2016;7(1):11624. doi:10.1038/ncomms11624.
   PubMed Web of Science ®Google Scholar
• McFadden BA, Purohit S. Itaconate, an isocitrate lyase-directed inhibitor in Pseudomonas indigofera. J Bacteriol. 1977;131(1):136–144. doi:10.1128/jb.131.1.136-144.1977.
   PubMed Web of Science ®Google Scholar
• Huang Q, Liu Z, Yang Y, et al. Selenium nanodots (SENDs) as antioxidants and antioxidant-prodrugs to rescue islet β cells in type 2 diabetes mellitus by restoring mitophagy and alleviating endoplasmic reticulum stress. Adv Sci (Weinh). 2023;10(19):e2300880.
   PubMedGoogle Scholar