Biomarkers, Omics, and Species Comparisons

REFERENCES

• Banajamali , A R , Xu , Y Strunk , R J . 1999 . Identification of metabolites of 13C -labeled propargyl alcohol in rat urine by 13C NMR and mass spectrometry . J Ag Food Chem , 47 : 1717 – 29 .
   PubMed Web of Science ®Google Scholar
• Brindle , J T , Antti , H Holmes , E . 2002 . Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics . Nature Med , 8 ( 12 ) : 1439 – 46 .
   PubMed Web of Science ®Google Scholar
• Colatsky , T and Sumner , S CJ . 2003 . Metabolic Profiling and Biomarker Discovery . Current Opinions in Investigational Drugs , 4 ( 3 ) : 1 – 3 .
   Google Scholar
• Dettmer , K and Hammock , B D . 2004 . Metabolomics—a new exciting field within the “omics” sciences . Environ Health Perspect , 112 ( 7 ) : A396 – A397 .
   PubMed Web of Science ®Google Scholar
• Fennell , T R , Sumner , S and Nuclear Magnetic Resonance Spectroscopy . 2000 . “ Application of NMR spectroscopy and labels in the study of metabolism ” . In Encyclopedia of Spectroscopy and Spectrometry
   Google Scholar
• Fennell , T R , Kedderis , G K and Sumner , S J . 1991 . Urinary metabolites of [1,2,3-13C]acrylonitrile in rats and mice detected by 13C nuclear magnetic resonance spectroscopy . Chem Res Toxicol , 4 ( 6 ) : 678 – 87 .
   PubMed Web of Science ®Google Scholar
• Fennell , T R , Sumner , S C Snyder , R W . 2005 . Metabolism and hemoglobin adduct formation of acrylamide in humans . Toxicol Sci Advance Access , doi:10.1093/toxsci/kfi069
   Google Scholar
• Goodacre , R , Vaidyanathan , S Dunn , W B . 2004 . Metabolomics by numbers: Acquiring and understanding global metabolite data . Trends in Biotechnology , 2 ( 5 ) : 245 – 52 .
   Web of Science ®Google Scholar
• Holmes , E , Nicholson , J K Nicholls , A W . 1998 . The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine . Chemomet & Intel Lab Systems , 44 : 245 – 55 .
   Web of Science ®Google Scholar
• Holmes , E , Nicholls , A W Lindon , J C . 2000 . Chemometric models for toxicity classification based on NMR spectra of biofluids . Chem Res Toxicol , 13 : 471 – 8 .
   PubMed Web of Science ®Google Scholar
• Johanson , G , Ernstrad , L Löf , A . 2000 . Toxicokinetics of styrene and styrene-7,8-oxide, and determination of urinary metabolites and hemoglobin adducts in human volunteers exposed to styrene vapors . Toxicol Appl Pharmacol , 168 ( 1 ) : 36 – 49 .
   PubMed Web of Science ®Google Scholar
• Kenney , N and Shockcor , J P . 2003 . Complementary NMR and LC-MS technologies for metabonomic studies . PharmaGenomics , Nov/Dec : 56 – 63 .
   Google Scholar
• Keun , H C , Ebbels , T MD Bollard , M E . 2004 . Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles . Chem Res Toxicol , 17 ( 5 ) : 579 – 87 .
   PubMed Web of Science ®Google Scholar
• Lenz , E M , Bright , J Knight , R . 2004 . A metabonomic investigation of the biochemical effects of mercuric chloride in the rat using 1H NMR and HPLC-TOF/MS: time dependant changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity . Analyst , 129 ( 6 ) : 535 – 41 .
   PubMed Web of Science ®Google Scholar
• Nauhaus , S K , Fennell , T R Asgharian , B . 1996 . Characterization of urinary metabolites in rats and mice exposed to [1,2,3,4-13C]butadiene . Chem Res Toxicol , 9 : 764 – 73 .
   PubMed Web of Science ®Google Scholar
• Nicholson , J K , Lindon , J C and Holmes , E . 1999 . ‘Metabonomics’: Understanding the metaboloic response of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopy dat . Xenobiotica , 29 ( 11 ) : 1181 – 9 .
   PubMed Web of Science ®Google Scholar
• Nicholson , J K , Connelly , J Lindon , J C . 2002 . Metabonomics: A platform for studying drug toxicity and gene function . Nature Reviews Drug Discovery , 1 : 153 – 61 .
   PubMed Web of Science ®Google Scholar
• Nihlén , S , Sumner , S Löf , A . 1999 . 13C-Labelled Methyl tertiary-butyl ether (13C2-MTBE): Toxicokinetics and Characterization of Urinary Metabolites in Humans . Chem Res Toxicol , 12 : 822 – 30 .
   PubMed Web of Science ®Google Scholar
• NRC (National Research Council) . 1989 . Biologic Markers in Pulmonary Toxicology , Washington, DC, , USA : National Academy Press .
   Google Scholar
• Plumb , R S , Stumpf , C L Gorenstein , M V . 2003 . Use of LC-TOF-MS and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids . Rapid Commun Mass Spectrom , 17 : 2632 – 8 .
   PubMed Web of Science ®Google Scholar
• Robertson , D G , Reily , M D Sigler , R E . 2000 . Metabonomics: Evaluation of nuclear magnetic resonance (NMR) and pattern recognition for liver toxicity . Toxicol Sci , 57 : 326 – 37 .
   PubMed Web of Science ®Google Scholar
• Sumner , S CJ and Liu , G . 2002 . Pathway Linkage and Data Integration . Genetics and Engineering News , 22 ( 19 ) November 7
   Google Scholar
• Sumner , S CJ , MacNeela , J P and Fennell , T R . 1992a . Characterization and quantitation of urinary metabolites of [1,2,3-13C]acrylamide in rats and in mice using 13C nuclear magnetic resonance spectroscopy . Chem Res Toxicol , 5 ( 1 ) : 81 – 9 .
   PubMed Web of Science ®Google Scholar
• Sumner , S CJ , Stedman , D B Clarke , D O . 1992b . Characterization of urinary metabolites from [1,2,methoxy-13C]2-methoxyethanol in mice using 13C NMR spectroscopy . Chem Res Toxicol , 5 ( 4 ) : 553 – 60 .
   PubMed Web of Science ®Google Scholar
• Walker , V E , Fennell , T R Boucheron , J A . 1990 . Macromolecular adducts of ethylene oxide: A literature review and a time-course study on the formation of 7-(2- hydroxyethyl)guanine following exposures of rats by inhalation . Mutat Res , 233 : 151 – 64 .
   PubMed Web of Science ®Google Scholar
• Walker , V E , Fennell , T R Upton , P B . 1992 . Molecular dosimetry of ethylene oxide: formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice . Cancer Res , 52 : 4328 – 34 .
   PubMed Web of Science ®Google Scholar
• Walker , V E , Fennell , T R Upton , P B . 1993 . Molecular dosimetry of DNA and hemoglobin adducts in mice and rats exposed to ethylene oxide . Environ Health Perspect , 99 : 11 – 7 .
   PubMed Web of Science ®Google Scholar
• Watkins , S M . 2004 . Lipomic profiling in drug discovery, development and clinical trail evaluation . Curr Opin Drug Discov Devel , 7 ( 1 ) : 112 – 7 .
   PubMed Web of Science ®Google Scholar
• Watkins , S M and German , J B . 2002 . Toward the implementation of metabolomic assessments of human health and nutrition . Curr Opin Biotechnol , 13 ( 5 ) : 512 – 16 .
   PubMed Web of Science ®Google Scholar
• Watkins , S M , Reifsnyder , P R Pan , H J . 2002 . Lipid metabolome-wide effects of the PPAR gamma agonist rosiglitazone . J Lipid Res , 43 ( 11 ) : 1809 – 17 .
   PubMed Web of Science ®Google Scholar
• Weis , B K , Balshaw , D Barr , J R . 2005 . Personalized Exposure Assessment: Promising Approaches for Human Environmental Health Research . Environ Health Perspect , http://dx.doi.org/ doi: 10.1289/ehp.7651 available at
   Web of Science ®Google Scholar
• Xirasager , S , Gustafason Merrick , A Tomer , K . 2004 . CEBS Object Model for Systems Biology Data. CEBS MAGE SysBio-Om . Bioinformatics , 20 ( 13 ) : 2004 – 15 .
   PubMed Web of Science ®Google Scholar
• Yates , J M , Fennell , T R Turner , M J . 1994 . Characterization of phosphodiester adducts produced by the reaction of cyanoethylene oxide with nucleotides . Carcinogenesis , 15 : 277 – 83 .
   PubMed Web of Science ®Google Scholar