DEVELOPMENT OF A VALIDATED HIGH PERFORMANCE LIQUID CHROMATOGRAPHY ASSAY FOR THE DETECTION AND QUANTIFICATION OF METHOXYCHLOR AND ITS MONO- AND BIS-HYDROXY METABOLITES FROM OVARIAN FOLLICLE CULTURE MEDIA

REFERENCES

• Cummings , A. M. Methoxychlor as a Model for Environmental Estrogens . Crit. Rev. Toxicol. 1997 , 27 , 367 – 379 .
   PubMed Web of Science ®Google Scholar
• Miller , K. P. ; Gupta , R. K. ; Greenfeld , C. R. ; Babus , J. K. ; Flaws , J. A. Methoxychlor Directly Affects Ovarian Antral Follicle Growth and Atresia Through Bcl-2- and Bax-Mediated Pathways . Toxicol. Sci. 2005 , 88 , 213 – 221 .
   PubMed Web of Science ®Google Scholar
• Miller , K. P. ; Gupta , R. K. ; Flaws , J. A. Methoxychlor Metabolites May Cause Ovarian Toxicity Through Estrogen Regulated Pathways. Toxicol. Sci. 2006, 93, 180–188.
   PubMed Web of Science ®Google Scholar
• Kapoor , I. P. ; Metcalf , R. L. ; Nystrom , R. F. ; Sangha G. K. Comparative Metabolism of Methoxychlor, Methiochlor, and DDT in Mouse, Insects, and in a Model Ecosystem . J. Agric. Food Chem. 1970 , 18 , 1145 – 1152 .
   PubMed Web of Science ®Google Scholar
• Bulger , W. H. ; Muccitelli , R. M. ; Kupfer , D. Studies on the In vivo and In vitro Estrogenic Activities of Methoxychlor and Its Metabolites. Role of Hepatic Mono-Oxygenase in Methoxychlor Activation . Biochem. Pharmacol. 1978 , 27 , 2417 – 2423 .
   PubMed Web of Science ®Google Scholar
• Bulger , W. H. ; Feil , V. J. ; Kupfer , D. Role of Hepatic Monooxygenases in Generating Estrogenic Metabolites from Methoxychlor and From Its Identified Contaminants . Mol. Pharmacol. 1985 , 27 , 115 – 124 .
   PubMed Web of Science ®Google Scholar
• Laws , S. C. ; Carey , S. A. ; Ferrell , J. M. ; Bodman , G. J. ; Cooper , R. L. Estrogenic Activity of Octylphenol, Nonylphenol, Bisphenol A and Methoxychlor in Rats . Toxicol. Sci. 2000 , 54 , 154 – 167 .
   PubMed Web of Science ®Google Scholar
• Ousterhout , J. ; Struck , R. F. ; Nelson , J. A. Estrogenic Activities on Methoxychlor Metabolites . Biochem. Pharmacol. 1981 , 30 , 2869 – 2871 .
   PubMed Web of Science ®Google Scholar
• Gaido , K. W. ; Leonard , L. S. ; Maness , S. C. ; Hall , J. M. ; McDonnell , D. P. ; Saville , B. ; Safe , S. Differential Interaction of the Methoxychlor Metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with Estrogen Receptors α and β . Endocrinology 1999 , 140 , 5746 – 5753 .
   PubMed Web of Science ®Google Scholar
• Gaido , K. W. ; Maness , S. C. ; McDonnell , D. P. ; Dehal , S. S. ; Kupfer , D. ; Safe , S. Interaction of Methoxychlor and Related Compounds with Estrogen Receptor α and β, Andandrogen Receptor: Structure Activity Studies . Mol. Pharmacol. 2000 , 58 , 852 – 858 .
   PubMed Web of Science ®Google Scholar
• Symonds , D. A. ; Miller , K. P. ; Tomic , D. ; Flaws , J. A. Effect of Methoxychlor and Estradiol on Cytochrome P450 Enzymes in the Mouse Ovarian Surface Epithelium . Toxicol. Sci. 2006 , 89 , 510 – 514 .
   PubMed Web of Science ®Google Scholar
• Borgeest , C. ; Miller , K. P. ; Gupta , R. ; Greenfeld , C. ; Hruska , K. S. ; Hoyer , P. ; Flaws , J. A. Methoxychlor-Induced Atresia in the Mouse Involves Bcl-2 Family Members, But Not Gonadotropins or Estradiol . Biol. Reprod. 2004 , 70 , 1828 – 1835 .
   PubMed Web of Science ®Google Scholar
• Kupfer , D. ; Bulger , W. H. ; Theoharides , A. D. Metabolism of Methoxychlor by Hepatic P-450 Monooxygenases in Rat and Human. 1. Characterization of a Novel Catechol Metabolite . Chem. Res. Toxicol. 1990 , 3 , 8 – 16 .
   PubMed Web of Science ®Google Scholar
• Gupta , R. K. ; Meachum , S. ; Hernandez-Ochoa , I. ; Peretz , J. ; Yao , H. H. ; Flaws , J. A. Methoxychlor In hibits Growth of Antral Follicles by Altering Cell Cycle Regulators . Toxicol. Appl. Pharmacol. 2009 , 240 , 1 – 7 .
   PubMed Web of Science ®Google Scholar
• Hu , Y. ; Kupfer , D. Enantioselective Metabolism of the Endocrine Disruptor Pesticide Methoxychlor by Human Cytochromes P450 (P450 s): Major Differences in Selective Enantiomer Formation by Various p450 Isoforms . Drug Metab. Dispos. 2002 , 30 , 1329 – 1336 .
   PubMed Web of Science ®Google Scholar
• Imo , S. T. ; Sheikh , M. A. ; Hirosawa , E. ; Oomori , T. ; Tamaki , F. Contamination by Organochlorine Pesticides from Rivers . Int. J. Environ. Sci. Tech. 2007 , 4 , 1 – 9 .
   Web of Science ®Google Scholar
• Savabieasfahani , M. ; Kannan , K. ; Astapova , O. ; Evans , N. P. ; Padmanabhan , V. Developmental Programming: Differential Effects of Prenatal Exposure to Bisphenol-A or Methoxychlor on Reproductive Function . Endocrinology 2006 , 147 , 5956 – 5966 .
   PubMed Web of Science ®Google Scholar
• Hazai , E. ; Gagne , P. V. ; Kupfer , D. Glucoronidation of the Oxidative Cytochrome P450-Mediated Phenolic Metabolites of the Endocrine Disruptor Pesticide: Methoxychlor by Human Hepatic UDP-Glucoronosyl Transferases . Drug Metab. Dispos. 2004 , 32 , 742 – 751 .
   PubMed Web of Science ®Google Scholar