Medical Cannabis Patients Report Improvements in Health Functioning and Reductions in Opiate Use

References

• Aviram, J., & Samuelly-Leichtag, G. (2017). Efficacy of cannabis-based medicines for pain management: A systematic review and meta-analysis of randomized controlled trials. Pain Physician, 20(6), E755–E796. https://pubmed.ncbi.nlm.nih.gov/28934780
   PubMed Web of Science ®Google Scholar
• Boehnke, K. F., Litinas, E., & Clauw, D. J. (2016). Medical cannabis use is associated with decreased opiate medication use in a retrospective cross-sectional survey of patients with chronic pain. The Journal of Pain, 17(6), 739–744. https://doi.org/10.1016/j.jpain.2016.03.002
   PubMed Web of Science ®Google Scholar
• Bonn-Miller, M. O., Boden, M. T., Bucossi, M. M., & Babson, K. A. (2014). Self-reported cannabis use characteristics, patterns and helpfulness among medical cannabis users. The American Journal of Drug and Alcohol Abuse, 40(1), 23–30. https://doi.org/10.3109/00952990.2013.821477
   PubMed Web of Science ®Google Scholar
• Boston Roybal Center for Active Lifestyle Interventions. (n.d.). Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36). https://www.brandeis.edu/roybal/docs/SF-36_website_PDF.pdf
   Google Scholar
• Busse, J. W., Wang, L., Kamaleldin, M., Craigie, S., Riva, J. J., Montoya, L., Mulla, S. M., Lopes, L. C., Vogel, N., Chen, E., Kirmayr, K., De Oliveira, K., Olivieri, L., Kaushal, A., Chaparro, L. E., Oyberman, I., Agarwal, A., Couban, R., Tsoi, L., … Guyatt, G. H. (2018). Opioids for chronic noncancer pain: A systematic review and meta-analysis. JAMA, 320(23), 2448–2460. https://doi.org/10.1001/jama.2018.18472
   PubMed Web of Science ®Google Scholar
• CDC/National Center for Health Statistics. (2020). Wide-ranging online data for epidemiologic research (WONDER)
   Google Scholar
• CDC/National Center for Health Statistics. (2021). Drug overdose deaths in the U.S. Top 100,000 Annually.
   Google Scholar
• Florence, C., Luo, F., & Rice, K. (2021). The economic burden of opioid use disorder and fatal opioid overdose in the United States, 2017. Drug and Alcohol Dependence, 218, 108350. https://doi.org/10.1016/j.drugalcdep.2020.108350
   PubMed Web of Science ®Google Scholar
• Haroutounian, S., Ratz, Y., Ginosar, Y., Furmanov, K., Saifi, F., Meidan, R., & Davidson, E. (2016). The effect of medicinal cannabis on pain and quality-of-life outcomes in chronic pain: A prospective open-label study. The Clinical Journal of Pain, 32(12), 1036–1043. https://doi.org/10.1097/AJP.0000000000000364
   PubMed Web of Science ®Google Scholar
• Häuser, W., Petzke, F., & Fitzcharles, M. A. (2018). Efficacy, tolerability and safety of cannabis-based medicines for chronic pain management – An overview of systematic reviews. European Journal of Pain (London, England), 22(3), 455–470. https://doi.org/10.1002/ejp.1118
   PubMed Web of Science ®Google Scholar
• Jugl, S., Okpeku, A., Costales, B., Morris, E. J., Alipour-Haris, G., Hincapie-Castillo, J. M., Stetten, N. E., Sajdeya, R., Keshwani, S., Joseph, V., Zhang, Y., Shen, Y., Adkins, L., Winterstein, A. G., & Goodin, A. (2021). A mapping literature review of medical cannabis clinical outcomes and quality of evidence in approved conditions in the USA from 2016 to 2019. Medical Cannabis and Cannabinoids, 4(1), 21–42. https://doi.org/10.1159/000515069
   PubMedGoogle Scholar
• Kosiba, J. D., Maisto, S. A., & Ditre, J. W. (2019). Patient-reported use of medical cannabis for pain, anxiety, and depression symptoms: Systematic review and meta-analysis. Social Science & Medicine (1982), 233, 181–192. https://doi.org/10.1016/j.socscimed.2019.06.005
   PubMed Web of Science ®Google Scholar
• Lake, S., Walsh, Z., Kerr, T., Cooper, Z. D., Buxton, J., Wood, E., Ware, M. A., & Milloy, M. J. (2019). Frequency of cannabis and illicit opioid use among people who use drugs and report chronic pain: A longitudinal analysis. PLOS Medicine, 16(11), e1002967–e1002967. https://doi.org/10.1371/journal.pmed.1002967
   Web of Science ®Google Scholar
• Lee, C., Lin, M., Martins, K. J. B., Dyck, J. R. B., Klarenbach, S., Richer, L., Jess, E., Hanlon, J. G., Hyshka, E., & Eurich, D. T. (2021). Opioid use in medical cannabis authorization adult patients from 2013 to 2018: Alberta, Canada. BMC Public Health, 21(1), 843. https://doi.org/10.1186/s12889-021-10867-w
   PubMed Web of Science ®Google Scholar
• Lee, G., Grovey, B., Furnish, T., & Wallace, M. (2018). Medical cannabis for neuropathic pain. Current Pain and Headache Reports, 22(1), 8. https://doi.org/10.1007/s11916-018-0658-8
   PubMed Web of Science ®Google Scholar
• Lopez, C. D., Boddapati, V., Jobin, C. M., & Hickernell, T. R. (2021). State medical cannabis laws associated with reduction in opioid prescriptions by orthopaedic surgeons in medicare part D cohort. JAAOS - Journal of the American Academy of Orthopaedic Surgeons, 29(4), e188–e197. https://doi.org/10.5435/JAAOS-D-19-00767
   PubMed Web of Science ®Google Scholar
• Lucas, P., Boyd, S., Milloy, M.-J., & Walsh, Z. (2021). Cannabis significantly reduces the use of prescription opioids and improves quality of life in authorized patients: Results of a large prospective study. Pain Medicine (Malden, Mass.), 22(3), 727–739. https://doi.org/10.1093/pm/pnaa396
   PubMed Web of Science ®Google Scholar
• Luo, F., Li, M., & Florence, C. (2021). State-level economic costs of opioid use disorder and fatal opioid overdose - United States, 2017. MMWR. Morbidity and Mortality Weekly Report, 70(15), 541–546. https://doi.org/10.15585/mmwr.mm7015a1
   PubMed Web of Science ®Google Scholar
• Mahabir, V. K., Merchant, J. J., Smith, C., & Garibaldi, A. (2020). Medical cannabis use in the United States: A retrospective database study. Journal of Cannabis Research, 2(1), 32. https://doi.org/10.1186/s42238-020-00038-w
   PubMedGoogle Scholar
• Maharajan, M. K., Yong, Y. J., Yip, H. Y., Woon, S. S., Yeap, K. M., Yap, K. Y., Yip, S. C., & Yap, K. X. (2020). Medical cannabis for chronic pain: Can it make a difference in pain management? Journal of Anesthesia, 34(1), 95–103. https://doi.org/10.1007/s00540-019-02680-y
   PubMed Web of Science ®Google Scholar
• Marijuana Policy Project. (2020). Medical marijuana patient numbers. https://www.mpp.org/issues/medical-marijuana/state-by-state-medical-marijuana-laws/medical-marijuana-patient-numbers/
   Google Scholar
• Miller, R. J., & Miller, R. E. (2017). Is cannabis an effective treatment for joint pain? Clinical and Experimental Rheumatology, 35 (1), 5), 59–67. https://pubmed.ncbi.nlm.nih.gov/28967368
   Google Scholar
• Mücke, M., Phillips, T., Radbruch, L., Petzke, F., & Häuser, W. (2018). Cannabis-based medicines for chronic neuropathic pain in adults. The Cochrane Database of Systematic Reviews, 3(3), CD012182–CD012182. https://doi.org/10.1002/14651858.CD012182.pub2
   PubMedGoogle Scholar
• Mutubuki, E. N., Beljon, Y., Maas, E. T., Huygen, F. J. P. M., Ostelo, R. W. J. G., van Tulder, M. W., & van Dongen, J. M. (2020). The longitudinal relationships between pain severity and disability versus health-related quality of life and costs among chronic low back pain patients. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 29(1), 275–287. https://doi.org/10.1007/s11136-019-02302-w
   PubMed Web of Science ®Google Scholar
• National Academies of Sciences Engineering and Medicine. (2017). The health effects of cannabis and cannabinoids: The current state of evidence and recommendations for research. National Academies Press.
   Google Scholar
• National Institute on Drug Abuse. (n.d.). Florida: Opioid-involved deaths and related harms. Retrieved June 2, 2021, from https://www.drugabuse.gov/drug-topics/opioids/opioid-summaries-by-state/florida-opioid-involved-deaths-related-harms
   Google Scholar
• Nielsen, S., Sabioni, P., Trigo, J. M., Ware, M. A., Betz-Stablein, B. D., Murnion, B., Lintzeris, N., Khor, K. E., Farrell, M., Smith, A., & le Foll, B. (2017). Opioid-sparing effect of cannabinoids: A systematic review and meta-analysis. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 42(9), 1752–1765. https://doi.org/10.1038/npp.2017.51
   PubMed Web of Science ®Google Scholar
• Okusanya, B. O., Asaolu, I. O., Ehiri, J. E., Kimaru, L. J., Okechukwu, A., & Rosales, C. (2020). Medical cannabis for the reduction of opioid dosage in the treatment of non-cancer chronic pain: A systematic review. Systematic Reviews, 9(1), 167. https://doi.org/10.1186/s13643-020-01425-3
   PubMed Web of Science ®Google Scholar
• Perneger, T. v., Etter, J. F., & Rougemont, A. (1997). Prospective versus retrospective measurement of change in health status: A community based study in Geneva, Switzerland. Journal of Epidemiology and Community Health, 51(3), 320–325. https://doi.org/10.1136/jech.51.3.320
   PubMed Web of Science ®Google Scholar
• Piper, B. J., DeKeuster, R. M., Beals, M. L., Cobb, C. M., Burchman, C. A., Perkinson, L., Lynn, S. T., Nichols, S. D., & Abess, A. T. (2017). Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep. Journal of Psychopharmacology, 31(5), 569–575. https://doi.org/10.1177/0269881117699616
   PubMed Web of Science ®Google Scholar
• Rabgay, K., Waranuch, N., Chaiyakunapruk, N., Sawangjit, R., Ingkaninan, K., & Dilokthornsakul, P. (2020). The effects of cannabis, cannabinoids, and their administration routes on pain control efficacy and safety: A systematic review and network meta-analysis. Journal of the American Pharmacists Association: JAPhA, 60(1), 225–234.e6. https://doi.org/10.1016/j.japh.2019.07.015
   PubMed Web of Science ®Google Scholar
• Rand Health Care. (n.d.-a). 36-Item short form survey (SF-36). https://www.rand.org/health-care/surveys_tools/mos/36-item-short-form.html
   Google Scholar
• Rand Health Care. (n.d.-b). 36-Item short form survey (SF-36) scoring instructions. https://www.rand.org/health-care/surveys_tools/mos/36-item-short-form/scoring.html
   Google Scholar
• Reiman, A., Welty, M., & Solomon, P. (2017). Cannabis as a substitute for opioid-based pain medication: Patient self-report. Cannabis and Cannabinoid Research, 2(1), 160–166. https://doi.org/10.1089/can.2017.0012
   PubMedGoogle Scholar
• Reinarman, C., Nunberg, H., Lanthier, F., & Heddleston, T. (2011). Who are medical marijuana patients? Population characteristics from nine California assessment clinics. Journal of Psychoactive Drugs, 43(2), 128–135. https://doi.org/10.1080/02791072.2011.587700
   PubMed Web of Science ®Google Scholar
• Salazar, C. A., Tomko, R. L., Akbar, S. A., Squeglia, L. M., & McClure, E. A. (2019). Medical cannabis use among adults in the Southeastern United States. Cannabis (Research Society on Marijuana), 2(1), 53–65. https://doi.org/10.26828/cannabis.2019.01.005
   PubMedGoogle Scholar
• Schlienz, N. J., Scalsky, R., Martin, E. L., Jackson, H., Munson, J., Strickland, J. C., Bonn-Miller, M. O., Loflin, M., & Vandrey, R. (2021). A cross-sectional and prospective comparison of medicinal cannabis users and controls on self-reported health. Cannabis and Cannabinoid Research, 6(6), 548–558. https://doi.org/10.1089/can.2019.0096
   PubMedGoogle Scholar
• Schmier, J. K., & Halpern, M. T. (2004). Patient recall and recall bias of health state and health status. Expert Review of Pharmacoeconomics & Outcomes Research, 4(2), 159–163. https://doi.org/10.1586/14737167.4.2.159
   PubMedGoogle Scholar
• Segura, L. E., Mauro, C. M., Levy, N. S., Khauli, N., Philbin, M. M., Mauro, P. M., & Martins, S. S. (2019). Association of US medical marijuana laws with nonmedical prescription opioid use and prescription opioid use disorder. JAMA Network Open, 2(7), e197216–e197216. https://doi.org/10.1001/jamanetworkopen.2019.7216
   Web of Science ®Google Scholar
• Sexton, M., Cuttler, C., Finnell, J. S., & Mischley, L. K. (2016). A cross-sectional survey of medical cannabis users: Patterns of use and perceived efficacy. Cannabis and Cannabinoid Research, 1(1), 131–138. https://doi.org/10.1089/can.2016.0007
   PubMedGoogle Scholar
• Sohler, N. L., Starrels, J. L., Khalid, L., Bachhuber, M. A., Arnsten, J. H., Nahvi, S., Jost, J., & Cunningham, C. O. (2018). Cannabis use is associated with lower odds of prescription opioid analgesic use among HIV-infected individuals with chronic pain. Substance Use & Misuse, 53(10), 1602–1607. https://doi.org/10.1080/10826084.2017.1416408
   PubMed Web of Science ®Google Scholar
• Stockings, E., Campbell, G., Hall, W. D., Nielsen, S., Zagic, D., Rahman, R., Murnion, B., Farrell, M., Weier, M., & Degenhardt, L. (2018). Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: A systematic review and meta-analysis of controlled and observational studies. Pain, 159(10), 1932–1954. https://doi.org/10.1097/j.pain.0000000000001293
   PubMed Web of Science ®Google Scholar
• Takakuwa, K. M., Hergenrather, J. Y., Shofer, F. S., & Schears, R. M. (2020). The impact of medical cannabis on intermittent and chronic opioid users with back pain: How cannabis diminished prescription opioid usage. Cannabis and Cannabinoid Research, 5(3), 263–270. https://doi.org/10.1089/can.2019.0039
   PubMedGoogle Scholar
• Topp, J., Andrees, V., Heesen, C., Augustin, M., & Blome, C. (2019). Recall of health-related quality of life: how does memory affect the SF-6D in patients with psoriasis or multiple sclerosis? A prospective observational study in Germany. BMJ Open, 9(11), e032859. https://doi.org/10.1136/bmjopen-2019-032859
   PubMed Web of Science ®Google Scholar
• Troutt, W. D., & DiDonato, M. D. (2015). Medical cannabis in Arizona: Patient characteristics, perceptions, and impressions of medical cannabis legalization. Journal of Psychoactive Drugs, 47(4), 259–266. https://doi.org/10.1080/02791072.2015.1074766
   PubMed Web of Science ®Google Scholar
• Vigil, J. M., Stith, S. S., Adams, I. M., & Reeve, A. P. (2017). Associations between medical cannabis and prescription opioid use in chronic pain patients: A preliminary cohort study. Plos One, 12(11), e0187795–e0187795. https://doi.org/10.1371/journal.pone.0187795
   PubMed Web of Science ®Google Scholar
• Vulfsons, S., Minerbi, A., & Sahar, T. (2020). Cannabis and pain treatment-A review of the clinical utility and a practical approach in light of uncertainty. Rambam Maimonides Medical Journal, 11(1), e0002. https://doi.org/10.5041/RMMJ.10385
   PubMed Web of Science ®Google Scholar
• Woodhams, S. G., Sagar, D. R., Burston, J. J., & Chapman, V. (2015). The role of the endocannabinoid system in pain. Handbook of Experimental Pharmacology, 227, 119–143. https://doi.org/10.1007/978-3-662-46450-2_7
   PubMedGoogle Scholar
• Yanes, J. A., McKinnell, Z. E., Reid, M. A., Busler, J. N., Michel, J. S., Pangelinan, M. M., Sutherland, M. T., Younger, J. W., Gonzalez, R., & Robinson, J. L. (2019). Effects of cannabinoid administration for pain: A meta-analysis and meta-regression. Experimental and Clinical Psychopharmacology, 27(4), 370–382. https://doi.org/10.1037/pha0000281
   PubMed Web of Science ®Google Scholar