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ORIGINAL ARTICLE

Cardiovascular and Respiratory Effects of Cannabis Use by Route of Administration: A Systematic Review

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References

  • Abouchedid, R., Ho, J. H., Hudson, S., Dines, A., Archer, J. R., Wood, D. M., & Dargan, P. I. (2016). Acute toxicity associated with use of 5F-derivations of synthetic cannabinoid receptor agonists with analytical confirmation. Journal of Medical Toxicology, 12(4), 396–401. https://doi.org/10.1007/s13181-016-0571-7
  • Abramovici, H. (2013). Information for health care professionals: Cannabis (marihuana, marijuana) and the cannabinoids. Controlled Substances and Tobacco Directorate at Health Canada. https://www.canada.ca/content/dam/hc-sc/documents/services/drugs-medication/cannabis/information-medical-practitioners/information-health-care-professionals-cannabis-cannabinoids-eng.pdf
  • Abrams, D. I., Vizoso, H. P., Shade, S. B., Jay, C., Kelly, M. E., & Benowitz, N. L. (2007). Vaporization as a smokeless cannabis delivery system: A pilot study. Clinical Pharmacology and Therapeutics, 82(5), 572–578. https://doi.org/10.1038/sj.clpt.6100200
  • Ahumada, G., Araneda, J. C., Clarke, P., Cumsille, F., & Hynes, M. (2019). Report on drug use in the Americas 2019. http://www.cicad.oas.org/main/pubs/Report%20on%20Drug%20Use%20in%20the%20Americas%202019.pdf
  • Alhadi, S., Tiwari, A., Vohra, R., Gerona, R., Acharya, J., & Bilello, K. (2013). High times, low sats: Diffuse pulmonary infiltrates associated with chronic synthetic cannabinoid use. Journal of Medical Toxicology, 9(2), 199–206. https://doi.org/10.1007/s13181-013-0288-9
  • Bene-Alhasan, Y., Osei, A. D., Tammara, A., Almaadawy, O., Dwumah-Agyen, M., Mensah, S., & Woldu, B. (2023). Daily marijuana use is associated with incident heart failure: “All of Us” research program. American Heart Association Scientific Sessions. https://s3.amazonaws.com/cms.ipressroom.com/67/files/20239/Y.+Bene-Alhasan+abstract+MDP250.pdf
  • Berkman, N. D., Lohr, K. N., Ansari, M. T., Balk, E. M., Kane, R., McDonagh, M., Morton, S. C., Viswanathan, M., Bass, E. B., Butler, M., Gartlehner, G., Hartling, L., McPheeters, M., Morgan, L. C., Reston, J., Sista, P., Whitlock, E., & Chang, S. (2015). Grading the strength of a body of evidence when assessing health care interventions: An EPC update. Journal of Clinical Epidemiology, 68(11), 1312–1324. https://doi.org/10.1016/j.jclinepi.2014.11.023
  • Black, E., Hocum, B., & Black, K. (2018). Ethics and science, cannabinoids and healthcare. Primary care reports. https://www.reliasmedia.com/articles/141970-ethics-and-science-cannabinoids-and-healthcare
  • Black, N., Stockings, E., Campbell, G., Tran, L. T., Zagic, D., Hall, W. D., Farrell, M., & Degenhardt, L. (2019). Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: A systematic review and meta-analysis. The Lancet. Psychiatry, 6(12), 995–1010. https://doi.org/10.1016/S2215-0366(19)30401-8
  • Cao, D., Srisuma, S., Bronstein, A. C., & Hoyte, C. O. (2016). Characterization of edible marijuana product exposures reported to United States poison centers. Clinical Toxicology, 54(9), 840–846. https://doi.org/10.1080/15563650.2016.1209761
  • Cascini, F., Aiello, C., & Di Tanna, G. (2012). Increasing Delta-9-Tetrahydrocannabinol (Δ-9-THC) content in herbal cannabis over time: Systematic review and meta-analysis. Current Drug Abuse Reviews, 5(1), 32–40. https://doi.org/10.2174/1874473711205010032
  • Castelaz, E. (2020). Cannabis 101: Routes of administration. https://www.pointsevengroup.com/post/cannabis-101-routes-of-administration
  • Cavazos-Rehg, P. A., Sowles, S. J., Krauss, M. J., Agbonavbare, V., Grucza, R., & Bierut, L. (2016). A content analysis of tweets about high-potency marijuana. Drug and Alcohol Dependence, 166, 100–108. https://doi.org/10.1016/j.drugalcdep.2016.06.034
  • Centers for Disease Control and Prevention (2020). Marijuana and public health: Cancer. National Center for Injury Prevention and Control, Centers for Disease Control and Prevention. Retrieved January 30, 2020, from https://www.cdc.gov/marijuana/health-effects/cancer.html#:∼:text=Is%20there%20a%20link%20between,the%20lungs%20and%20cardiovascular%20system
  • Chaiton, M., Kundu, A., Rueda, S., & Di Ciano, P. (2022). Are vaporizers a lower-risk alternative to smoking cannabis? Canadian Journal of Public Health, 113(2), 293–296. https://doi.org/10.17269/s41997-021-00565-w
  • Chatkin, J. M., Zani-Silva, L., Ferreira, I., & Zamel, N. (2019). Cannabis-associated asthma and allergies. Clinical Reviews in Allergy & Immunology, 56(2), 196–206. https://doi.org/10.1007/s12016-017-8644-1
  • Cooper, Z. D., & Haney, M. (2009). Comparison of subjective, pharmacokinetic, and physiological effects of marijuana smoked as joints and blunts. Drug and Alcohol Dependence, 103(3), 107–113. https://doi.org/10.1016/j.drugalcdep.2009.01.023
  • Dahdouh, Z., Roule, V., Lognoné, T., Sabatier, R., & Grollier, G. (2012). Cannabis and coronary thrombosis: What is the role of platelets? Platelets, 23(3), 243–245. https://doi.org/10.3109/09537104.2011.601824
  • Drummer, O. H., Gerostamoulos, D., & Woodford, N. W. (2019). Cannabis as a cause of death: A review. Forensic Science International, 298, 298–306. https://doi.org/10.1016/j.forsciint.2019.03.007
  • Ducros, A., Boukobza, M., Porcher, R., Sarov, M., Valade, D., & Bousser, M. G. (2007). The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients. Brain: A Journal of Neurology, 130(Pt 12), 3091–3101. https://doi.org/10.1093/brain/awm256
  • Fiorelli, A., Accardo, M., Vicidomini, G., Messina, G., Laperuta, P., & Santini, M. (2013). Does cannabis smoking predispose to lung bulla formation? Asian Cardiovascular & Thoracic Annals, 22(1), 65–71. https://doi.org/10.1177/0218492313478954
  • Ghasemiesfe, M., Barrow, B., Leonard, S., Keyhani, S., & Korenstein, D. (2019). Association between marijuana use and risk of cancer: A systematic review and meta-analysis. JAMA Network Open, 2(11), e1916318. https://doi.org/10.1001/jamanetworkopen.2019.16318
  • Ghasemiesfe, M., Ravi, D., Casino, T., Korenstein, D., & Keyhani, S. (2020). Acute cardiovascular effects of marijuana use. Journal of General Internal Medicine, 35(3), 969–974. https://doi.org/10.1007/s11606-019-05235-9
  • Ghosh, M., & Naderi, S. (2019). Cannabis and cardiovascular disease. Current Atherosclerosis Reports, 21(21), 1–6. https://doi.org/10.1007/s11883-019-0783-9
  • Goyal, H., Awad, H. H., & Ghali, J. K. (2017). Role of cannabis in cardiovascular disorders. Journal of Thoracic Disease, 9(7), 2079–2092. https://doi.org/10.21037/jtd.2017.06.104
  • Hancox, R. J., Poulton, R., Ely, M., Welch, D., Taylor, D. R., McLachlan, C. R., Greene, J. M., Moffitt, T. E., Caspi, A., & Sears, M. R. (2010). Effects of cannabis on lung function: A population-based cohort study. The European Respiratory Journal, 35(1), 42–47. https://doi.org/10.1183/09031936.00065009
  • Hoch, E., Bonnet, U., Thomasius, R., Ganzer, F., Havemann-Reinecke, U., & Preuss, U. W. (2015). Risks associated with the non-medicinal use of cannabis. Deutsches Arzteblatt International, 112(16), 271–278. https://doi.org/10.3238/arztebl.2015.0271
  • Hodcroft, C. J., Rossiter, M. C., & Buch, A. N. (2014). Cannabis-associated myocardial infarction in a young man with normal coronary arteries. The Journal of Emergency Medicine, 47(3), 277–281. https://doi.org/10.1016/j.jemermed.2013.11.077
  • Jones, R. T. (2002). Cardiovascular system effects of marijuana. Journal of Clinical Pharmacology, 42(S1), 58s–63s. https://doi.org/10.1002/j.1552-4604.2002.tb06004.x
  • Joshi, M., Joshi, A., & Bartter, T. (2014). Marijuana and lung diseases. Current Opinion in Pulmonary Medicine, 20(2), 173–179. https://doi.org/10.1097/mcp.0000000000000026
  • Joshi, M., Joshi, A., & Bartter, T. (2022). Marijuana and the lung: Evolving understandings. The Medical Clinics of North America, 106(6), 1093–1107. https://doi.org/10.1016/j.mcna.2022.07.010
  • Jouanjus, E., Lapeyre-Mestre, M., & Micallef, J. (2014). Cannabis use: Signal of increasing risk of serious cardiovascular disorders. Journal of the American Heart Association, 3(2), e000638. https://doi.org/10.1161/jaha.113.000638
  • Kaczor, E. E., Mathews, B., LaBarge, K., Chapman, B. P., & Carreiro, S. (2021). Cannabis product ingestions in pediatric patients: Ranges of exposure, effects, and outcomes. Journal of Medical Toxicology, 17(4), 386–396. https://doi.org/10.1007/s13181-021-00849-0
  • Karila, L., Roux, P., Rolland, B., Benyamina, A., Reynaud, M., Aubin, H. J., & Lançon, C. (2014). Acute and long-term effects of cannabis use: A review. Current Pharmaceutical Design, 20(25), 4112–4118. https://doi.org/10.2174/13816128113199990620
  • Kempker, J. A., Honig, E. G., & Martin, G. S. (2015). The effects of marijuana exposure on expiratory airflow. A study of adults who participated in the U.S. national health and nutrition examination study. Annals of the American Thoracic Society, 12(2), 135–141. https://doi.org/10.1513/AnnalsATS.201407-333OC
  • Kyaw, W. P., Win, M. S., & Naing, T. W. (2017). Cannabis induced broncho pneumonitis leading to fatal cardiac arrhythmia [Conference Abstract]. American Journal of Respiratory and Critical Care Medicine, 195(A2064), 1. https://doi.org/10.1164/ajrccm-conference.2017.A60
  • LaFrance, E. M., Stueber, A., Glodosky, N. C., Mauzay, D., & Cuttler, C. (2020). Overbaked: Assessing and predicting acute adverse reactions to cannabis. Journal of Cannabis Research, 2(1), 3. https://doi.org/10.1186/s42238-019-0013-x
  • Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLOS Medicine, 6(7), e1000100. https://doi.org/10.1371/journal.pmed.1000100
  • MacPherson, P., Munthali, C., Ferguson, J., Armstrong, A., Kranzer, K., Ferrand, R. A., & Ross, D. A. (2015). Service delivery interventions to improve adolescents’ linkage, retention and adherence to antiretroviral therapy and HIV care. Tropical Medicine & International Health, 20(8), 1015–1032. https://doi.org/10.1111/tmi.12517
  • Manolis, T. A., Manolis, A. A., & Manolis, A. S. (2019). Cannabis associated “high” cardiovascular morbidity and mortality: Marijuana smoke like tobacco smoke? A Déjà Vu/Déjà Vécu story? Mini Reviews in Medicinal Chemistry, 19(11), 870–879. https://doi.org/10.2174/1389557518666181114113947
  • Marcu, J. (2020). The legalization of cannabinoid products and standardizing cannabis-drug development in the United States: A brief report. Dialogues in Clinical Neuroscience, 22(3), 289–293. https://doi.org/10.31887/DCNS.2020.22.3/jmarcu
  • Martinasek, M. P., McGrogan, J. B., & Maysonet, A. (2016). A systematic review of the respiratory effects of inhalational marijuana. Respiratory Care, 61(11), 1543–1551. https://doi.org/10.4187/respcare.04846
  • McClure, E. A., Walters, K. J., Tomko, R. L., Dahne, J., Hill, E. G., & McRae-Clark, A. L. (2023). Cannabis use prevalence, patterns, and reasons for use among patients with cancer and survivors in a state without legal cannabis access. Supportive Care in Cancer, 31(7), 429. https://doi.org/10.1007/s00520-023-07881-6
  • McHugh, M. L. (2012). Interrater reliability: The kappa statistic. Biochemia Medica, 22(3), 276–282. https://www.biochemia-medica.com/assets/images/upload/xml_tif/McHugh_ML_Interrater_reliability.pdf
  • McLaren, J., Swift, W., Dillon, P., & Allsop, S. (2008). Cannabis potency and contamination: A review of the literature. Addiction, 103(7), 1100–1109. https://doi.org/10.1111/j.1360-0443.2008.02230.x
  • Mittleman, M. A., Lewis, R. A., Maclure, M., Sherwood, J. B., & Muller, J. E. (2001). Triggering myocardial infarction by marijuana. Circulation, 103(23), 2805–2809. https://doi.org/10.1161/01.cir.103.23.2805
  • Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLOS Medicine, 6(7), e1000097. https://doi.org/10.1371/journal.pmed.1000097
  • Murdock, K. (2023). The most significant federal marijuana reform in modern history. Third Way. https://www.thirdway.org/memo/the-most-significant-federal-marijuana-reform-in-modern-history
  • National Conference of State Legislatures (2023). State medical cannabis laws. Retrieved January 27, 2023, from https://www.ncsl.org/health/state-medical-cannabis-laws
  • National Institute of Drug Abuse (2019). Marijuana. Retrieved February 11, 2019, from https://www.drugabuse.gov/publications/research-reports/marijuana
  • Newmeyer, M. N., Swortwood, M. J., Abulseoud, O. A., & Huestis, M. A. (2017). Subjective and physiological effects, and expired carbon monoxide concentrations in frequent and occasional cannabis smokers following smoked, vaporized, and oral cannabis administration. Drug and Alcohol Dependence, 175, 67–76. https://doi.org/10.1016/j.drugalcdep.2017.02.003
  • Obafemi, A. I., Kleinschmidt, K., Goto, C., & Fout, D. (2015). Cluster of acute toxicity from ingestion of synthetic cannabinoid-laced brownies. Journal of Medical Toxicology, 11(4), 426–429. https://doi.org/10.1007/s13181-015-0482-z
  • Page, R. L., Allen, L. A., Kloner, R. A., Carriker, C. R., Martel, C., Morris, A. A., Piano, M. R., Rana, J. S., Saucedo, J. F., & Null, N. (2020). Medical marijuana, recreational cannabis, and cardiovascular health: A scientific statement from the American Heart Association. Circulation, 142(10), e131–e152. https://doi.org/10.1161/CIR.0000000000000883
  • Parikh, K., Patel, M., Bansal, T., Raco, J., Gupta, S., Jain, R., & Jain, R. (2022). Cannabis and the heart: Unchartered territory. Future Cardiology, 18(11), 883–890. https://doi.org/10.2217/fca-2022-0018
  • Pasha, A. K., Clements, C. Y., Reynolds, C. A., Lopez, M. K., Lugo, C. A., Gonzalez, Y., Shirazi, F. M., & Abidov, A. (2021). Cardiovascular effects of medical marijuana: A systematic review. The American Journal of Medicine, 134(2), 182–193. https://doi.org/10.1016/j.amjmed.2020.09.015
  • Pepin, L. C., Simon, M. W., Banerji, S., Leonard, J., Hoyte, C. O., & Wang, G. S. (2023). Toxic tetrahydrocannabinol (THC) dose in pediatric cannabis edible ingestions. Pediatrics, 152(3), e2023061374. https://doi.org/10.1542/peds.2023-061374
  • Peshkovsky, A. (2017). Ways to consume cannabis: How water-compatible nanoemulsions can help. https://blog.sonomechanics.com/blog/ways-to-consume-cannabis-how-nanoemulsions-can-help
  • Peters, J., & Chien, J. (2018). Contemporary routes of cannabis consumption: A primer for clinicians. The Journal of the American Osteopathic Association, 118(2), 67–70. https://doi.org/10.7556/jaoa.2018.020
  • Pletcher, M. J., Vittinghoff, E., Kalhan, R., Richman, J., Safford, M., Sidney, S., Lin, F., & Kertesz, S. (2012). Association between marijuana exposure and pulmonary function over 20 years. JAMA, 307(2), 173–181. https://doi.org/10.1001/jama.2011.1961
  • Polit, D. F., & Beck, C. T. (2017). Nursing research: Generating and assessing evidence for nursing practice (10th ed.). Wolters Kluwer.
  • Preteroti, M., Wilson, E. T., Eidelman, D. H., & Baglole, C. J. (2023). Modulation of pulmonary immune function by inhaled cannabis products and consequences for lung disease. Respiratory Research, 24(1), 95. https://doi.org/10.1186/s12931-023-02399-1
  • Prota, C., Ravera, A., Caleo, O., & Campanile, A. (2022). Marijuana-induced toxic myocarditis: A case report and a review of the literature. Journal of Cardiovascular Medicine, 23(12), 814–818. https://doi.org/10.2459/jcm.0000000000001374
  • Rabgay, K., Waranuch, N., Chaiyakunapruk, N., Sawangjit, R., Ingkaninan, K., & Dilokthornsakul, P. (2019). The effects of cannabis, cannabinoids, and their administration routes on pain control efficacy and safety: A systematic review and network meta-analysis. Journal of the American Pharmacists Association, 60(1), 225–234.e6. https://doi.org/10.1016/j.japh.2019.07.015
  • Rajanahally, S., Raheem, O., Rogers, M., Brisbane, W., Ostrowski, K., Lendvay, T., & Walsh, T. (2019). The relationship between cannabis and male infertility, sexual health, and neoplasm: A systematic review. Andrology, 7(2), 139–147. https://doi.org/10.1111/andr.12585
  • Rezkalla, S., & Kloner, R. A. (2019). Cardiovascular effects of marijuana. Trends in Cardiovascular Medicine, 29(7), 403–407. https://doi.org/10.1016/j.tcm.2018.11.004
  • Richards, J. R., Bing, M. L., Moulin, A. K., Elder, J. W., Rominski, R. T., Summers, P. J., & Laurin, E. G. (2019). Cannabis use and acute coronary syndrome. Clinical Toxicology, 57(10), 831–841. https://doi.org/10.1080/15563650.2019.1601735
  • Richards, J. R., Blohm, E., Toles, K. A., Jarman, A. F., Ely, D. F., & Elder, J. W. (2020). The association of cannabis use and cardiac dysrhythmias: A systematic review. Clinical Toxicology, 58(9), 861–869. https://doi.org/10.1080/15563650.2020.1743847
  • Rickner, S. S., Cao, D., Kleinschmidt, K., & Fleming, S. (2017). A little “dab” will do ya’ in: A case report of neuro-and cardiotoxicity following use of cannabis concentrates. Clinical Toxicology, 55(9), 1011–1013. https://doi.org/10.1080/15563650.2017.1334914
  • Russell, C., Rueda, S., Room, R., Tyndall, M., & Fischer, B. (2017). Routes of administration for cannabis use – Basic prevalence and related health outcomes: A scoping review and synthesis. The International Journal on Drug Policy, 52(2018), 87–96. https://doi.org/10.1016/j.drugpo.2017.11.008
  • Shiplo, S., Asbridge, M., Leatherdale, S. T., & Hammond, D. (2016). Medical cannabis use in Canada: Vapourization and modes of delivery. Harm Reduction Journal, 13(1), 30. https://doi.org/10.1186/s12954-016-0119-9
  • Slawek, D., & Arnsten, J. H. (2023). Medical use of cannabis and cannabinoids in adults. Wolters Kluwer. Retrieved January 30, 2023, from https://www.uptodate.com/contents/medical-use-of-cannabis-and-cannabinoids-in-adults#:∼:text=%2DFor%20patients%20using%20cannabis%20to,and%20lack%20respiratory%20side%20effects
  • Solem, R. C. (2015). Limitation of a cross-sectional study. American Journal of Orthodontics and Dentofacial Orthopedics, 148(2), 205. https://doi.org/10.1016/j.ajodo.2015.05.006
  • Spindle, T. R., Bonn-Miller, M. O., & Vandrey, R. (2019). Changing landscape of cannabis: Novel products, formulations, and methods of administration. Current Opinion in Psychology, 30, 98–102. https://doi.org/10.1016/j.copsyc.2019.04.002
  • Steigerwald, S., Wong, P. O., Cohen, B. E., Ishida, J. H., Vali, M., Madden, E., & Keyhani, S. (2018). Smoking, vaping, and use of edibles and other forms of marijuana among U.S. adults. Annals of Internal Medicine, 169(12), 890–892. https://doi.org/10.7326/m18-1681
  • Stuyt, E. (2018). The problem with the current high potency THC marijuana from the perspective of an addiction psychiatrist. Missouri Medicine, 115(6), 482–486. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312155/pdf/ms115_p0482.pdf
  • Subramaniam, V. N., Menezes, A. R., DeSchutter, A., & Lavie, C. J. (2019). The cardiovascular effects of marijuana: Are the potential adverse effects worth the high? Missouri Medicine, 116(2), 146–153. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461323/pdf/ms116_p0146.pdf
  • Svrakic, D. M., Lustman, P. J., Mallya, A., Lynn, T. A., Finney, R., & Svrakic, N. M. (2012). Legalization, decriminalization & medicinal use of cannabis: A scientific and public health perspective. Missouri Medicine, 109(2), 90–98. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181739/pdf/ms109_p0090.pdf
  • Tait, R. J., Caldicott, D., Mountain, D., Hill, S. L., & Lenton, S. (2016). A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatment. Clinical Toxicology, 54(1), 1–13. https://doi.org/10.3109/15563650.2015.1110590
  • Tan, W. C., Lo, C., Jong, A., Xing, L., Fitzgerald, M. J., Vollmer, W. M., Buist, S. A., & Sin, D. D. (2009). Marijuana and chronic obstructive lung disease: A population-based study. Canadian Medical Association Journal, 180(8), 814–820. https://doi.org/10.1503/cmaj.081040
  • Tashkin, D. P. (2013). Effects of marijuana smoking on the lung. Annals of the American Thoracic Society, 10(3), 239–247. https://doi.org/10.1513/AnnalsATS.201212-127FR
  • Tashkin, D. P. (2015). How beneficial is vaping cannabis to respiratory health compared to smoking? Addiction, 110(11), 1706–1707. https://doi.org/10.1111/add.13075
  • Tashkin, D. P., Simmons, M. S., & Tseng, C.-H. (2012). Impact of changes in regular use of marijuana and/or tobacco on chronic bronchitis. COPD: Journal of Chronic Obstructive Pulmonary Disease, 9(4), 367–374. https://doi.org/10.3109/15412555.2012.671868
  • Thomas, G., Kloner, R. A., & Rezkalla, S. (2014). Adverse cardiovascular, cerebrovascular, and peripheral vascular effects of marijuana inhalation: What cardiologists need to know. The American Journal of Cardiology, 113(1), 187–190. https://doi.org/10.1016/j.amjcard.2013.09.042
  • U.S. Department of Health and Human Services (2014). The health consequences of smoking—50 Years of progress: A report of the surgeon general. Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health. https://stacks.cdc.gov/view/cdc/21569/cdc_21569_DS1.pdf
  • United Nations Office on Drugs and Crimes (2023). World drug report 2023: Special reports of interest. UNODC. Research. https://www.unodc.org/res/WDR-2023/Special_Points_WDR2023_web_DP.pdf
  • Van Dam, N. T., & Earleywine, M. (2010). Pulmonary function in cannabis users: Support for a clinical trial of the vaporizer. The International Journal on Drug Policy, 21(6), 511–513. https://doi.org/10.1016/j.drugpo.2010.04.001
  • Vernich, F., Stefani, L., Fiorelli, D., Mineo, F., Pallocci, M., Treglia, M., Marsella, L. T., & Tittarelli, R. (2023). Trends in illicit cannabis potency based on the analysis of law enforcement seizures in the southern area of Rome. Toxics, 11(8), 648. https://doi.org/10.3390/toxics11080648
  • Volkow, N. D., Baler, R. D., Compton, W. M., & Weiss, S. R. B. (2014). Adverse health effects of marijuana use. The New England Journal of Medicine, 370(23), 2219–2227. https://doi.org/10.1056/NEJMra1402309
  • Weresa, J., Pędzińska-Betiuk, A., Mińczuk, K., Malinowska, B., & Schlicker, E. (2022). Why do marijuana and synthetic cannabimimetics induce acute myocardial infarction in healthy young people? Cells, 11(7), 1142. https://doi.org/10.3390/cells11071142
  • Wilkinson, S. T., Yarnell, S., Radhakrishnan, R., Ball, S. A., & D’Souza, D. C. (2016). Marijuana legalization: Impact on physicians and public health. Annual Review of Medicine, 67(1), 453–466. https://doi.org/10.1146/annurev-med-050214-013454

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