468
Views
9
CrossRef citations to date
0
Altmetric
Research Articles

Engineering of siRNA loaded PLGA Nano-Particles for highly efficient silencing of GPR87 gene as a target for pancreatic cancer treatment

ORCID Icon, ORCID Icon & ORCID Icon
Pages 855-864 | Received 05 Aug 2019, Accepted 17 Mar 2020, Published online: 01 Apr 2020

References

  • Bahadori F, Büyük AŞ, Kozanoğlu AS, Eskandari Z, Ankarali H, Tekkeli ŞEK, Kaleli HN, Koçyiğit A. 2019. Preparation and evaluation of inflammation targeted nano-micellar formulation of celecoxib. Bezmialem Sci. 7(3):208–215.
  • Bannunah AM, Vllasaliu D, Lord J, Stolnik S. 2014. Mechanisms of nanoparticle internalization and transport across an intestinal epithelial cell model: effect of size and surface charge. Mol Pharm. 11(12):4363–4373.
  • Bhandari J, Mishra H, Mishra PK, Wimmer R, Ahmad FJ, Talegaonkar S. 2017. Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery. IJN. 12:2021–2031.
  • Chan JM, Zhang L, Yuet KP, Liao G, Rhee J-W, Langer R, Farokhzad OC. 2009. PLGA–lecithin–PEG core–shell nanoparticles for controlled drug delivery. Biomaterials. 30(8):1627–1634.
  • Chithrani BD, Ghazani AA, Chan WC. 2006. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett. 6(4):662–668.
  • Colombo S, Zeng X, Ragelle H, Foged C. 2014. Complexity in the therapeutic delivery of RNAi medicines: an analytical challenge. Expert Opin Drug Deliv. 11(9):1481–1495.
  • Cun D, Foged C, Yang M, Frøkjaer S, Nielsen HM. 2010. Preparation and characterization of poly(DL-lactide-co-glycolide) nanoparticles for siRNA delivery. Int J Pharm. 390(1):70–75.
  • Danhier F, Ansorena E, Silva JM, Coco R, Le Breton A, Préat V. 2012. PLGA-based nanoparticles: an overview of biomedical applications. J Control Release. 161(2):505–522.
  • Danhier F, Feron O, Préat V. 2010. To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J Control Release. 148(2):135–146.
  • Eskandari Z, Kazdal F, Bahadori F, Ebrahimi N. 2018. Quality-by-design model in optimization of PEG-PLGA nano micelles for targeted cancer therapy. J Drug Delivery Sci Technol. 48:393–402.
  • Furler M, Knobloch B, Sigel RK. 2009. Influence of decreased solvent permittivity on the structure and magnesium (II)-binding properties of the catalytic domain 5 of a group II intron ribozyme. Inorg Chim Acta. 362(3):771–776.
  • Garcia F, Petry KU, Muderspach L, Gold MA, Braly P, Crum CP, Magill M, Silverman M, Urban RG, Hedley ML. 2004. ZYC101a for treatment of high-grade cervical intraepithelial neoplasia: a randomized controlled trial. Obstet Gynecol. 103(2):317–326.
  • Gary DJ, Puri N, Won Y-Y. 2007. Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery. J Control Release. 121(1–2):64–73.
  • Glatt S, Halbauer D, Heindl S, Wernitznig A, Kozina D, Su KC, Puri C, Garin‐Chesa P, Sommergruber W. 2008. hGPR87 contributes to viability of human tumor cells. Int J Cancer. 122(9):2008–2016.
  • Hasan W, Chu K, Gullapalli A, Dunn SS, Enlow EM, Luft JC, Tian S, Napier ME, Pohlhaus PD, Rolland JP, et al. 2012. Delivery of multiple siRNAs using lipid-coated PLGA nanoparticles for treatment of prostate cancer. Nano Lett. 12(1):287–292.
  • Honary S, Zahir F. 2013. Effect of zeta potential on the properties of nano-drug delivery systems-a review (Part 2). Trop J Pharm Res. 12(2):265–273.
  • Howard KA. 2009. Delivery of RNA interference therapeutics using polycation-based nanoparticles. Adv Drug Delivery Rev. 61(9):710–720.
  • Klencke B, Matijevic M, Urban RG, Lathey JL, Hedley ML, Berry M, Thatcher J, Weinberg V, Wilson J, Darragh T, et al. 2002. Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: a Phase I study of ZYC101. Clin Cancer Res. 8(5):1028–1037.
  • Lee J-S, Green JJ, Love KT, Sunshine J, Langer R, Anderson DG. 2009. Gold, poly (β-amino ester) nanoparticles for small interfering RNA delivery. Nano Lett. 9(6):2402–2406.
  • Lee SH, Mok H, Lee Y, Park TG. 2011. Self-assembled siRNA-PLGA conjugate micelles for gene silencing. J Control Release. 152(1):152–158.
  • Liang GF, Zhu YL, Sun B, Hu FH, Tian T, Li SC, Xiao ZD. 2011. PLGA-based gene delivering nanoparticle enhance suppression effect of miRNA in HePG2 cells. Nanoscale Res Lett. 6(1):447.
  • Lindfors L, Skantze P, Skantze U, Westergren J, Olsson U. 2007. Amorphous drug nanosuspensions. 3. Particle dissolution and crystal growth. Langmuir. 23(19):9866–9874.
  • Luo G, Jin C, Long J, Fu D, Yang F, Xu J, Yu X, Chen W, Ni Q. 2009. RNA interference of MBD1 in BxPC-3 human pancreatic cancer cells delivered by PLGA-poloxamer nanoparticles. Cancer Biol Ther. 8(7):594–598.
  • Maeda H. 2012. Macromolecular therapeutics in cancer treatment: the EPR effect and beyond. J Control Release. 164(2):138–144.
  • Muro S, Garnacho C, Champion JA, Leferovich J, Gajewski C, Schuchman EH, Mitragotri S, Muzykantov VR. 2008. Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers. Mol Ther. 16(8):1450–1458.
  • Nakano S-I, Sugimoto N. 2016. The structural stability and catalytic activity of DNA and RNA oligonucleotides in the presence of organic solvents. Biophys Rev. 8(1):11–23.
  • Nakano S-I, Wu L, Oka H, Karimata HT, Kirihata T, Sato Y, Fujii S, Sakai H, Kuwahara M, Sawai H, et al. 2008. Conformation and the sodium ion condensation on DNA and RNA structures in the presence of a neutral cosolute as a mimic of the intracellular media. Mol Biosyst. 4(6):579–588.
  • Pantazis P, Dimas K, Wyche JH, Anant S, Houchen CW, Panyam J, Ramanujam RP. 2012. Preparation of siRNA-encapsulated PLGA nanoparticles for sustained release of siRNA and evaluation of encapsulation efficiency. Methods Mol Biol. 906:311–319.
  • Patil ML, Zhang M, Minko T. 2011. Multifunctional triblock nanocarrier (PAMAM-PEG-PLL) for the efficient intracellular siRNA delivery and gene silencing. ACS Nano. 5(3):1877–1887.
  • Patil Y, Panyam J. 2009. Polymeric nanoparticles for siRNA delivery and gene silencing. Int J Pharm. 367(1–2):195–203.
  • Pereira MC, Oliveira DA, Hill LE, Zambiazi RC, Borges CD, Vizzotto M, Mertens-Talcott S, Talcott S, Gomes CL. 2018. Effect of nanoencapsulation using PLGA on antioxidant and antimicrobial activities of guabiroba fruit phenolic extract. Food Chem. 240:396–404.
  • Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. 2014. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 74(11):2913–2921.
  • Shi J, Xiao Z, Votruba AR, Vilos C, Farokhzad OC. 2011. Differentially charged hollow core/shell lipid–polymer–lipid hybrid nanoparticles for small interfering RNA delivery. Angew Chem Int Ed Engl. 50(31):7027–7031.
  • Shu D, Shu Y, Haque F, Abdelmawla S, Guo P. 2011. Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics. Nat Nanotechnol. 6(10):658–667.
  • Türeli NG, Türeli AE, Schneider M. 2016. Optimization of ciprofloxacin complex loaded PLGA nanoparticles for pulmonary treatment of cystic fibrosis infections: design of experiments approach. Int J Pharm. 515(1–2):343–351.
  • Vichai V, Kirtikara K. 2006. Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat Protoc. 1(3):1112–1116.
  • Vijayanathan V, Thomas T, Thomas T. 2002. DNA nanoparticles and development of DNA delivery vehicles for gene therapy. Biochemistry. 41(48):14085–14094.
  • Wang J, Lu Z, Wientjes MG, Au J-S. 2010. Delivery of siRNA therapeutics: barriers and carriers. Aaps J. 12(4):492–503.
  • Wang L, Zhou W, Zhong Y, Huo Y, Fan P, Zhan S, Xiao J, Jin X, Gou S, Yin T, et al. 2017. Overexpression of G protein-coupled receptor GPR87 promotes pancreatic cancer aggressiveness and activates NF-κB signaling pathway. Mol Cancer. 16(1):61.
  • Wilson RC, Doudna JA. 2013. Molecular mechanisms of RNA interference. Annu Rev Biophys. 42(1):217–239.
  • Wise DL. 2000. Handbook of pharmaceutical controlled release technology. Boca Raton (FL): CRC Press.
  • Wittenberger T, Schaller HC, Hellebrand S. 2001. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. J Mol Biol. 307(3):799–813.
  • Yuan X, Shah BA, Kotadia NK, Li J, Gu H, Wu Z. 2010. The development and mechanism studies of cationic chitosan-modified biodegradable PLGA nanoparticles for efficient siRNA drug delivery. Pharm Res. 27(7):1285–1295.
  • Zhang Y, Qian Y, Lu W, Chen X. 2009. The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress. Cancer Res. 69(15):6049–6056.
  • Zhang Y, Scoumanne A, Chen X. 2010. G protein-coupled receptor 87: a promising opportunity for cancer drug discovery. Mol Cell Pharmacol. 2(3):111–116.
  • Zottel A, Videtič Paska A, Jovčevska I. 2019. Nanotechnology meets oncology: nanomaterials in brain cancer research, diagnosis and therapy. Materials (Basel). 12(10):1588. eng.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.