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Research Article

Lipid-Gelucire based rectal delivery of ramipril prodrug exhibits significant lowering of intra-ocular pressure in normotensive rabbit: sustained structural relaxation release kinetics and IVIVC

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Received 27 Feb 2024, Accepted 17 Apr 2024, Published online: 02 May 2024

References

  • Adel S, ElKasabgy NA. 2014. Design of innovated lipid-based floating beads loaded with an antispasmodic drug: in-vitro and in-vivo evaluation. J Liposome Res. 24(2):136–149. doi: 10.3109/08982104.2013.857355.
  • Aksu B, Paradkar A, de Matas M, Özer Ö, Güneri T, York P. 2013. A quality by design approach using artificial intelligence techniques to control the critical quality attributes of ramipril tablets manufactured by wet granulation. Pharm Dev Technol. 18(1):236–245. doi: 10.3109/10837450.2012.705294.
  • Al-Qaysi ZK, Beadham IG, Schwikkard SL, Bear JC, Al-Kinani AA, Alany RG. 2023. Sustained release ocular drug delivery systems for glaucoma therapy. Expert Opin Drug Deliv. 20(7):905–919. (just-accepted). doi: 10.1080/17425247.2023.2219053.
  • Bae HW, Lee N, Lee HS, Hong S, Seong GJ, Kim CY. 2014. Systemic hypertension as a risk factor for open-angle glaucoma: a meta-analysis of population-based studies. PLoS One. 9(9):e108226. doi: 10.1371/journal.pone.0108226.
  • Bakhrushina EO, Anurova MN, Aleshkin AV, Kiseleva IA, Bochkareva SS, Vorobev AM, Bagandova KM, Demina NB. 2020. Development of the composition and pharmacokinetic studies of suppositories with combined substance of bacteriophages. J Drug Deliv Sci Technol. 59:101841. doi: 10.1016/j.jddst.2020.101841.
  • Bao G, Gohlke P, Qadri F, Unger T. 1992. Chronic kinin receptor blockade attenuates the antihypertensive effect of ramipril. Hypertension. 20(1):74–79. doi: 10.1161/01.HYP.20.1.74.
  • Beaumont K, Webster R, Gardner I, Dack K. 2003. Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist. Curr Drug Metab. 4(6):461–485. doi: 10.2174/1389200033489253.
  • Chakraborty S, Shukla D, Mishra B, Singh S. 2009. Lipid–an emerging platform for oral delivery of drugs with poor bioavailability. Eur J Pharm Biopharm. 73(1):1–15. doi: 10.1016/j.ejpb.2009.06.001.
  • Chalhoub G, Kolleritsch S, Maresch LK, Taschler U, Pajed L, Tilp A, Eisner H, Rosina P, Kien B, Radner FPW, et al. 2021. Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease. J Lipid Res. 62:100075. doi: 10.1016/j.jlr.2021.100075.
  • Choi H, Lee M, Kim M, Kim C. 1999. Effect of additives on the physicochemical properties of liquid suppository bases. Int J Pharm. 190(1):13–19. doi: 10.1016/S0378-5173(99)00225-2.
  • Choi H-G, Jung J-H, Ryu J-M, Yoon S-J, Oh Y-K, Kim C-K. 1998. Development of in situ-gelling and mucoadhesive acetaminophen liquid suppository. Int J Pharm. 165(1):33–44. doi: 10.1016/S0378-5173(97)00386-4.
  • Dash R, Sahoo RN, Nandi S, Swain R, Mallick S. 2019. Sustained release bioadhesive suppository formulation for systemic delivery of ornidazole: in-silico docking study. IJPER. 53(4s):s580–s586. doi: 10.5530/ijper.53.4s.153.
  • El-Sonbaty MM, Ismail HR, Kassem AA, Samy AM, Akl MA. 2020. Mucoadhesive thermoreversible formulation of metoclopramide for rectal administration: a promising strategy for potential management of chemotherapy-induced nausea and vomiting. Pharm Dev Technol. 25(5):535–546. doi: 10.1080/10837450.2020.1712419.
  • Gan C, Wang J, Martínez-Chávez A, Hillebrand M, de Vries N, Beukers J, Wagenaar E, Wang Y, Lebre MC, Rosing H, et al. 2023. Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism. Acta Pharm Sin B. 13(2):618–631. doi: 10.1016/j.apsb.2022.10.017.
  • Guichard S, Terret C, Hennebelle I, Lochon I, Chevreau P, Frétigny E, Selves J, Chatelut E, Bugat R, Canal P, et al. 1999. CPT-11 converting carboxylesterase and topoisomerase I activities in tumour and normal colon and liver tissues. Br J Cancer. 80(3-4):364–370. doi: 10.1038/sj.bjc.6690364.
  • Hori S, Kawada T, Kogure S, Yabu S, Mori K, Akimoto M. 2017. Comparative release studies on suppositories using the basket, paddle, dialysis tubing and flow-through cell methods I. Acetaminophen in a lipophilic base suppository. Pharm Dev Technol. 22(1):130–135. doi: 10.1080/10837450.2016.1230132.
  • Imai T. 2006. Human carboxylesterase isozymes: catalytic properties and rational drug design. Drug Metab Pharmacokinet. 21(3):173–185. doi: 10.2133/dmpk.21.173.
  • Jain SK, Gupta A. 2009. Development of Gelucire 43/01 beads of metformin hydrochloride for floating delivery. AAPS PharmSciTech. 10(4):1128–1136. doi: 10.1208/s12249-009-9302-6.
  • Jansen WJM, Zwart B, Hulscher STM, Giaccone G, Pinedo HM, Boven E. 1997. CPT‐11 in human colon‐cancer cell lines and xenografts: characterization of cellular sensitivity determinants. Int. J. Cancer. 70(3):335–340. doi: 10.1002/(SICI)1097-0215(19970127)70:3<335::AID-IJC15>3.0.CO;2-E.
  • Jayaramudu T, Raghavendra GM, Varaprasad K, Reddy GVS, Reddy AB, Sudhakar K, Sadiku ER. 2016. Preparation and characterization of poly (ethylene glycol) stabilized nano silver particles by a mechanochemical assisted ball mill process. J of Applied Polymer Sci. 133(7) doi: 10.1002/app.43027(7).
  • Jin Q, Wu J, Wu Y, Li H, Finel M, Wang D, Ge G. 2022. Optical substrates for drug-metabolizing enzymes: recent advances and future perspectives. Acta Pharm Sin B. 12(3):1068–1099. doi: 10.1016/j.apsb.2022.01.009.
  • Kaneria NS, Tuleu C, Ernest T. 2022. Opportunities for enteral drug delivery for neonates, infants, and toddlers: a critical exploration. Expert Opin Drug Deliv. 19(5):475–519. doi: 10.1080/17425247.2022.2064449.
  • Kelly JG, O'Malley K. 1990. Clinical pharmacokinetics of the newer ACE inhibitors. Clin Pharmacokinet. 19(3):177–196. doi: 10.2165/00003088-199019030-00003.
  • Koirala S, Nepal P, Ghimire G, Basnet R, Rawat I, Dahal A, Pandey J, Parajuli-Baral K. 2021. Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac. Heliyon. 7(3):e06439. doi: 10.1016/j.heliyon.2021.e06439.
  • Leeman M, Kestelyn P. 2019. Glaucoma and blood pressure. Hypertension. 73(5):944–950. doi: 10.1161/HYPERTENSIONAHA.118.11507.
  • Levitt DG, Schoemaker RC. 2006. Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat. BMC Clin Pharmacol. 6(1):1–27. doi: 10.1186/1472-6904-6-1.
  • Lima IBC, Moreno LCGAI, Peres AV, Santana ACG, Carvalho A, Chaves MH, Lima L, Sousa RW, Dittz D, Rolim HML, et al. 2022. Nanoparticles obtained from zein for encapsulation of mesalazine. Pharmaceutics. 14(12):2830. doi: 10.3390/pharmaceutics14122830.
  • Mehta A, Iyer L, Parmar S, Shah G, Goyal R. 2010. Oculohypotensive effect of perindopril in acute and chronic models of glaucoma in rabbits. Can J Physiol Pharmacol. 88(5):595–600. doi: 10.1139/Y10-026.
  • Meisel S, Shamiss A, Rosenthal T. 1994. Clinical pharmacokinetics of ramipril. Clin Pharmacokinet. 26(1):7–15. doi: 10.2165/00003088-199426010-00002.
  • Meyer MR, Schütz A, Maurer HH. 2015. Contribution of human esterases to the metabolism of selected drugs of abuse. Toxicol Lett. 232(1):159–166. doi: 10.1016/j.toxlet.2014.10.026.
  • Nandi S, Nanda A, Sahoo RN, Swain R, Mallick S. 2022. Formulation and administration of ramipril prodrug for improving bioactivity significantly: in vitro and in vivo correlation. J Drug Delivery Sci Technol. 74:103597. doi: 10.1016/j.jddst.2022.103597.
  • Nandi S, Nanda A, Sahoo RN, Swain R, Mallick S. 2022. Formulation and administration of ramipril prodrug for improving bioactivity significantly: In vitro and in vivo correlation. J Drug Deliv Sci Technol. 74:103597. doi: 10.1016/j.jddst.2022.103597.
  • Panda B, Subhadarsini R, Mallick S. 2016. Biointerfacial phenomena of amlodipine buccomucosal tablets of HPMC matrix system containing polyacrylate polymer/β-cyclodextrin: correlation of swelling and drug delivery performance. Expert Opin Drug Deliv. 13(5):633–643. doi: 10.1517/17425247.2016.1154038.
  • Panigrahi KC, Patra CN, Jena GK, Ghose D, Jena J, Panda SK, Sahu M. 2018. Gelucire: a versatile polymer for modified release drug delivery system. Future J Pharm Sci. 4(1):102–108. doi: 10.1016/j.fjps.2017.11.001.
  • Purohit TJ, Hanning SM, Wu Z. 2018. Advances in rectal drug delivery systems. Pharm Dev Technol. 23(10):942–952. doi: 10.1080/10837450.2018.1484766.
  • Rawooth M, Habibullah SK, Qureshi D, Bharti D, Pal A, Mohanty B, Jarzębski M, Smułek W, Pal K. 2022. Effect of tamarind gum on the properties of phase-separated poly (vinyl alcohol) films. Polymers (Basel). 14(14):2793. doi: 10.3390/polym14142793.
  • Roy SK, Das P, Mondal A, Mandal A, Kuotsu K. 2021. Design, formulation and evaluation of multiparticulate time programmed system of ramipril for pulsed release: an approach in the management of early morning surge in blood pressure. J Drug Delivery Sci Technol. 62:102344. doi: 10.1016/j.jddst.2021.102344.
  • Roy SK, Das P, Mondal A, Mandal A, Kuotsu K. 2021. Design, formulation and evaluation of multiparticulate time programmed system of ramipril for pulsed release: an approach in the management of early morning surge in blood pressure. J Drug Deliv Sci Technol. 62:102344. doi: 10.1016/j.jddst.2021.102344.
  • Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M. 2007. Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharm Biopharm. 66(2):227–243. doi: 10.1016/j.ejpb.2006.10.014.
  • Shi J-H, Pan D-Q, Jiang M, Liu T-T, Wang Q. 2016. Binding interaction of ramipril with bovine serum albumin (BSA): insights from multi-spectroscopy and molecular docking methods. J Photochem Photobiol B. 164:103–111. doi: 10.1016/j.jphotobiol.2016.09.025.
  • Swain R, Nandi S, Bardhan P, Swain SS, Mohapatra S, Mallick S, JCE. 2023. Aerosil in solid-state buccal film for improved and sustained delivery of valsartan: molecular docking studies. Chem Biochem Eng Q. 37(1):33–43. doi: 10.15255/CABEQ.2022.2108.
  • Swain R, Nandi S, Sahoo RN, Swain SS, Mohapatra S, Mallick S. 2022. Bentonite clay incorporated topical film formulation for delivery of trimetazidine: control of ocular pressure and in vitro-in vivo correlation. J Drug Delivery Sci Technol. 67:102956. doi: 10.1016/j.jddst.2021.102956.
  • Thomsen R, Rasmussen HB, Linnet K. 2014. In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors. Drug Metab Dispos. 42(1):126–133. doi: 10.1124/dmd.113.053512.
  • Tsuji T, Kaneda N, Kado K, Yokokura T, Yoshimoto T, Tsuru D. 1991. CPT-11 converting enzyme from rat serum: purification and some properties. J Pharmacobiodyn. 14(6):341–349. doi: 10.1248/bpb1978.14.341.
  • Unagolla JM, Jayasuriya AC. 2018. Drug transport mechanisms and in vitro release kinetics of vancomycin encapsulated chitosan-alginate polyelectrolyte microparticles as a controlled drug delivery system. Eur J Pharm Sci. 114:199–209. doi: 10.1016/j.ejps.2017.12.012.
  • Uresin Y, Taylor AA, Kilo C, Tschöpe D, Santonastaso M, Ibram G, Fang H, Satlin A. 2007. Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension. J Renin Angiotensin Aldosterone Syst. 8(4):190–198. doi: 10.3317/jraas.2007.02.
  • van Griensven JM, Schoemaker RC, Cohen AF, Luus HG, Seibert-Grafe M, Röthig HJ. 1995. Pharmacokinetics, pharmacodynamics and bioavailability of the ACE inhibitor ramipril. Eur J Clin Pharmacol. 47(6):513–518. doi: 10.1007/BF00193704.
  • Voronova A, Pagneux Q, Decoin R, Woitrain E, Butruille L, Barras A, Foulon C, Lecoeur M, Jaramillo D, Rumipamba J, et al. 2022. Heat-based transdermal delivery of a ramipril loaded cream for treating hypertension. Nanoscale. 14(34):12247–12256. doi: 10.1039/D2NR02295H.

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