114
Views
0
CrossRef citations to date
0
Altmetric
Original Contributions

Does Single Dose Epinephrine Improve Outcomes for Patients with Out-of-Hospital Cardiac Arrest and Bystander CPR or a Shockable Rhythm?

ORCID Icon, ORCID Icon, ORCID Icon, , , , , ORCID Icon, ORCID Icon, ORCID Icon & show all
Received 29 Dec 2023, Accepted 11 Apr 2024, Published online: 21 May 2024

References

  • Sasson C, Rogers MAM, Dahl J, Kellermann AL. Predictors of survival from out-of-hospital cardiac arrest: a systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes. 2010;3(1):63–81. doi:10.1161/CIRCOUTCOMES.109.889576.
  • Virani SS, Alonso A, Aparicio HJ, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Cheng S, Delling FN, et al. Heart disease and stroke statistics-2021 update: a report From the American Heart Association. Circulation. 2021;143(8):e254–e743. doi:10.1161/CIR.0000000000000950.
  • Panchal AR, Berg KM, Hirsch KG, Kudenchuk PJ, Del Rios M, Cabañas JG, Link MS, Kurz MC, Chan PS, Morley PT, et al. 2019 American Heart Association focused update on advanced cardiovascular life support: use of advanced airways, vasopressors, and extracorporeal cardiopulmonary resuscitation during cardiac arrest: an update to the American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2019;140(24):e881–e894. doi:10.1161/CIR.0000000000000732.
  • Jacobs IG, Finn JC, Jelinek GA, Oxer HF, Thompson PL. Effect of adrenaline on survival in out-of-hospital cardiac arrest: a randomised double-blind placebo-controlled trial. Resuscitation. 2011;82(9):1138–43. doi:10.1016/j.resuscitation.2011.06.029.
  • Ng KT, Teoh WY. The effect of prehospital epinephrine in out-of-hospital cardiac arrest: a systematic review and meta-analysis. Prehosp Disaster Med. 2019;34(5):532–9. doi:10.1017/S1049023X19004758.
  • Perkins GD, Ji C, Deakin CD, Quinn T, Nolan JP, Scomparin C, Regan S, Long J, Slowther A, Pocock H, et al. A randomized trial of epinephrine in out-of-hospital cardiac arrest. N Engl J Med. 2018;379(8):711–21. doi:10.1056/NEJMoa1806842.
  • Overgaard CB, Dzavík V. Inotropes and vasopressors: review of physiology and clinical use in cardiovascular disease. Circulation. 2008;118(10):1047–56. doi:10.1161/CIRCULATIONAHA.107.728840.
  • Ristagno G, Tang W, Huang L, Fymat A, Chang Y-T, Sun S, Castillo C, Weil MH. Epinephrine reduces cerebral perfusion during cardiopulmonary resuscitation.* Crit Care Med. 2009;37(4):1408–15. doi:10.1097/CCM.0b013e31819cedc9.
  • Callaway CW. Epinephrine for cardiac arrest. Curr Opin Cardiol. 2013;28(1):36–42. doi:10.1097/HCO.0b013e32835b0979.
  • Ashburn NP, Beaver BP, Snavely AC, Nazir N, Winslow JT, Nelson RD, Mahler SA, Stopyra JP. One and done epinephrine in out-of-hospital cardiac arrest? Outcomes in a multiagency United States study. Prehosp Emerg Care. 2023;27(6):751–7. doi:10.1080/10903127.2022.2120135.
  • Pareek N, Kordis P, Beckley-Hoelscher N, Pimenta D, Kocjancic ST, Jazbec A, Nevett J, Fothergill R, Kalra S, Lockie T, et al. A practical risk score for early prediction of neurological outcome after out-of-hospital cardiac arrest: MIRACLE2. Eur Heart J. 2020;41(47):4508–17. doi:10.1093/eurheartj/ehaa570.
  • Gallagher EJ, Lombardi G, Gennis P. Effectiveness of bystander cardiopulmonary resuscitation and survival following out-of-hospital cardiac arrest. JAMA. 1995;274(24):1922–5. doi:10.1001/jama.1995.03530240032036.
  • Park GJ, Song KJ, Shin SD, Lee KW, Ahn KO, Lee EJ, Hong KJ, Ro YS. Timely bystander CPR improves outcomes despite longer EMS times. Am J Emerg Med. 2017;35(8):1049–55. doi:10.1016/j.ajem.2017.02.033.
  • Field N, Cohen T, Struelens MJ, Palm D, Cookson B, Glynn JR, Gallo V, Ramsay M, Sonnenberg P, Maccannell D, et al. Strengthening the reporting of molecular epidemiology for infectious diseases (STROME-ID): an extension of the STROBE statement. Lancet Infect Dis. 2014;14(4):341–52. doi:10.1016/S1473-3099(13)70324-4.
  • CARES Data Dictionary. 2021. Available from: https://mycares.net/ sitepages/uploads/2020/Data%20Dictionary%20(2021).pdf.
  • Chan PS, Girotra S, Tang Y, Al-Araji R, Nallamothu BK, McNally B. Outcomes for out-of-hospital cardiac arrest in the United States during the coronavirus disease 2019 pandemic. JAMA Cardiol. 2021;6(3):296–303. doi:10.1001/jamacardio.2020.6210.
  • Jennett B, Bond M. Assessment of outcome after severe brain damage: a practical scale. Lancet. 1975;1(7905):480–4. doi:10.1016/s0140-6736(75)92830-5.
  • Panchal AR, Bartos JA, Cabanas JG. Part 3: adult basic and advanced life support: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care [Internet]. [cited 2023 Feb 20]. Available from: https://www.ahajournals.org/doi/epub/10.1161/CIR.0000000000000916
  • Stoesser CE, Boutilier JJ, Sun CLF, Brooks SC, Cheskes S, Dainty KN, Feldman M, Ko DT, Lin S, Morrison LJ, et al. Moderating effects of out-of-hospital cardiac arrest characteristics on the association between EMS response time and survival. Resuscitation. 2021;169:31–8. doi:10.1016/j.resuscitation.2021.10.014.
  • Pearson DA, Darrell Nelson R, Monk L, Tyson C, Jollis JG, Granger CB, Corbett C, Garvey L, Runyon MS. Comparison of team-focused CPR vs standard CPR in resuscitation from out-of-hospital cardiac arrest: results from a statewide quality improvement initiative. Resuscitation. 2016;105:165–72. doi:10.1016/j.resuscitation.2016.04.008.
  • Valenzuela TD, Kern KB, Clark LL, Berg RA, Berg MD, Berg DD, Hilwig RW, Otto CW, Newburn D, Ewy GA, et al. Interruptions of chest compressions during emergency medical systems resuscitation. Circulation. 2005;112(9):1259–65. doi:10.1161/CIRCULATIONAHA.105.537282.
  • Cheskes S, Schmicker RH, Christenson J, Salcido DD, Rea T, Powell J, Edelson DP, Sell R, May S, Menegazzi JJ, et al. Perishock pause. Circulation. 2011;124(1):58–66. doi:10.1161/CIRCULATIONAHA.110.010736.
  • Stankovic N, Holmberg MJ, Høybye M, Granfeldt A, Andersen LW. Age and sex differences in outcomes after in-hospital cardiac arrest. Resuscitation. 2021;165:58–65. doi:10.1016/j.resuscitation.2021.05.017.
  • Song J, Guo W, Lu X, Kang X, Song Y, Gong D. The effect of bystander cardiopulmonary resuscitation on the survival of out-of-hospital cardiac arrests: a systematic review and meta-analysis. Scand J Trauma Resusc Emerg Med. 2018;26(1):86. doi:10.1186/s13049-018-0552-8.
  • Jentzer JC, Coons JC, Link CB, Schmidhofer M. Pharmacotherapy update on the use of vasopressors and inotropes in the intensive care unit. J Cardiovasc Pharmacol Ther. 2015;20(3):249–60. doi:10.1177/1074248414559838.
  • Fernando SM, Mathew R, Sadeghirad B, Rochwerg B, Hibbert B, Munshi L, Fan E, Brodie D, Di Santo P, Tran A, et al. Epinephrine in out-of-hospital cardiac arrest – a network meta-analysis and subgroup analyses of shockable and non-shockable rhythms. CHEST [Internet]. 2023. Jan 30 [cited 2023 Feb 3]. Available from: https://journal.chestnet.org/article/S0012-3692(23)00165-4/abstract.
  • Unity Health Toronto. CanROC Epinephrine Dose: optimal Versus Standard Evaluation Trial (CanROC EpiDOSE Trial) [Internet]. clinicaltrials.gov; 2023 Jun [cited 2022 Dec 31]. Report No.: NCT03826524. Available from: https://clinicaltrials.gov/study/NCT03826524.
  • Menegazzi JJ, Nichol G, Salcido DD. Caveat cum CARES. Prehosp Emerg Care. 2023;27(2):278. doi:10.1080/10903127.2022.2141932.
  • Ashburn NP, Snavely AC, Mahler SA, Stopyra JP. Response by Ashburn et al. to Letter “Caveat Cum CARES”. Prehosp Emerg Care. 2023;27(2):279. doi:10.1080/10903127.2022.2141933.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.