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Original Articles

Pesticide Exposures and Developmental Outcomes: The Epidemiological Evidence

, &
Pages 41-80 | Published online: 10 Dec 2007

REFERENCES

  • Abu-Qare , A. W. , Abdel-Rahman , A. , Brownie , C. , Kishk , A. M. and Abou-Donia , M. B. 2001 . Inhibition of cholinesterase enzymes following a single dermal dose of chlorpyrifos and methyl parathion, alone and in combination, in pregnant rats . J. Toxicol. Environ. Health A , 63 : 173 – 189 .
  • Agriculture Canada . 1992 . Re-evaluation of heavy duty wood preservatives , Ottawa, Canada : Product Management Division, Pesticides Directorate . A92–02.
  • Al-Saleh , I. A. 1994 . Pesticides: A review . J. Environ. Pathol , 13 : 151 – 161 .
  • Amin-Zaki , L. , Elhassani , S. , Majeed , M. A. , Clarkson , T. W. , Doherty , R. A. and Greenwood , M. 1974 . Intrauterine methylmercury poisoning in Iraq . Pediatrics , 54 : 587 – 594 .
  • Andreyev , M. V. and Kvartovkina , L. K. 1993 . Impariment of reproductive health in women occupationally exposed to thiram . Reprod. Toxicol , 7 : 491
  • Arbuckle , T. E. and Sever , L. E. 1998 . Pesticide exposures and fetal death: A review of the epidemiologic literature . Crit. Rev. Toxicol , 28 : 229 – 270 .
  • Arbuckle , T. E. , Savitz , D. A. , Mery , L. S. and Curtis , K. M. 1999 . Exposure to phenoxy herbicides and the risk of spontaneous abortion . Epidemiology , 10 : 752 – 760 .
  • Arbuckle , T. E. , Lin , Z. and Mery , L. S. 2001 . An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population . Environ. Health Perspect , 109 : 851 – 857 .
  • Arbuckle , T. E. , Burnett , R. , Cole , D. , Teschke , K. , Dosemeci , M. , Bancej , C. and Zhang , J. 2002 . Predictors of herbicide exposure in farm applicators . Int. Arch. Occup. Environ. Health , 75 : 406 – 414 .
  • Arctic Monitoring Assessment Program . 1998 . AMAP assessment report: Arctic pollution issues , Oslo, , Norway : Artic Monitoring Assessment Program .
  • Banerjee , J. , Ghosh , P. , Mitra , S. , Ghosh , N. and Bhattacharya , S. 1991 . Inhibition of human fetal brain acetylcholinesterase: marker effect of neurotoxicity . J. Toxicol. Environ. Health , 33 : 283 – 290 .
  • Barker , D. , Eriksson , J. G. , Forsen , T. and Osmone , D. 2002 . Fetal origins of adult disease: Strength of effect and biological basis . Int. J. Epidemiol , 31 : 1235 – 1239 .
  • Beatty , R. G. 1973 . The DDT myth: Triumph of amateures , New York : John Day Co .
  • Bell , E. M. , Hertz-Picciotto , I. and Beaumont , J. J. 2001a . A case-control study of pesticides and fetal death due to congenital anomalies . Epidemiology , 12 : 148 – 156 .
  • Bell , E. M. , Hertz-Picciotto , I. and Beaumont , J. J. 2001b . Case-cohort analysis of agricultural pesticide applications near maternal residence and selected causes of fetal death . Am. J. Epidemiol , 154 : 702 – 710 .
  • Bercovici , B. , Wassermann , M. , Wassermann , D. , Cucos , S. and Ron , M. 1980 . Missed abortions and some organochlorine compounds: Organochlorine insecticides (OCI) and polychlorinated biphenyls (PCBs) . Acta Med. Leg. Soc (Liege) , 30 : 177 – 185 .
  • Bercovici , B. , Wassermann , M. , Cucos , S. , Ron , M. , Wassermann , D. and Pines , A. 1983 . Serum levels of polychlorinated biphenyls and some organochlorine insecticides in women with recent and former missed abortions . Environ. Res , 30 : 169 – 174 .
  • Berkowitz , G. S. , Wetmur , J. G. , Birman-Deych , E. , Obel , J. , Lapinski , R. H. , Godbold , J. H. , Holzman , I. R. and Wolff , M. S. 2004 . In utero pesticide exposure, maternal paraoxonase activity, and head circumference . Environ. Health Perspect , 112 : 388 – 391 .
  • Bhatia , R. , Shiau , R. , Petreas , M. , Weintraub , J. M. , Farhang , L. and Eskenazi , B. 2005 . Organochlorine pesticides and male genital anomalies in the child health and development studies . Environ. Health Perspect , 113 : 220 – 224 .
  • Bradlow , H. L. , Davis , L. D. , Lin , G. , Sepkovic , D. and Tiwari , R. 1995 . Effects of pesticides on the ratio of 16 alpha/2-hydroxyestrone: A biologic marker of breast cancer risk . Environ. Health Perspect , 103 : 147 – 150 .
  • Carlson , B. M. 1999 . Human embryology and developmental biology , St. Louis, MO : Mosby .
  • Casey , P. H. and Collie , W. R. 1984 . Severe mental retardation and multiple congenital anomalies of uncertain cause after extreme parental exposure to 2,4-D . J. Pediatr , 104 : 313 – 315 .
  • Chanda , S. M. and Pope , C. N. 1996 . Neurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats . Pharmacol. Biochem. Behav , 53 : 771 – 776 .
  • Chapin , R. E. , Robbins , W. A. , Schieve , L. A. , Sweeney , A. M. , Tabacova , S. A. and Tomashek , K. M. 2003 . Off to a good start: the influence of pre- and periconceptional exposures, parental fertility, and nutrition on children's health . Environ. Health Perspect , 112 : 69 – 78 .
  • Chia , S. E. and Shi , L. M. 2002 . Review of recent epidemiological studies on paternal occupations and birth defects . Occup. Environ. Med , 59 : 149 – 155 .
  • Chippaux , J. P. , Gardon-Wendel , N. , Gardon , J. and Ernould , J. C. 1993 . Absence of any adverse effect of inadvertent ivermectin treatment during pregnancy . Trans. R. Soc. Trop. Med. Hyg , 87 : 318
  • Clarke , R. 1990 . A summary of the draft recommendations of ICRP . J. Radiol. Prot , 10 : 143 – 145 .
  • Correa-villasenor , A. , Ferencz , C. , Boughman , J. A. and Neill , C. A. 1991 . Total anomalous pulmonary venous return: Familial and environmental factors . Teratology , 44 : 415 – 428 .
  • Czeizel , A. E. , Elek , C. , Gundy , S. , Metneki , J. , Nemes , E. , Reis , A. , Sperling , K. , Timar , L. , Tusnady , G. and Viragh , Z. 1993 . Environmental trichlorfon and cluster of congenital abnormalities . Lancet , 341 : 539 – 542 .
  • Dabrowski , S. , Hanke , W. , Polanska , K. , Makowiec-Dabrowska , T. and Sobala , W. 2003 . Pesticide exposure and birthweight: an epidemiological study in Central Poland . Int. J. Occup. Med. Environ. Health , 16 : 31 – 39 .
  • Dickson , D. 1979 . Herbicide claimed responsible for birth defects . Nature , 282 : 220
  • Dimich-Ward , H. , Hertzman , C. , Teschke , K. , Hershler , R. , Marion , S. A. , Ostry , A. and Kelly , S. 1996 . Reproductive effects of paternal exposure to chlorophenate wood preservatives in the sawmill industry . Scand. J. Work Environ. Health , 22 : 267 – 273 .
  • Economic Research Service, USDA. 2004. Pests and pest management. http://www.ers.usda.gov/publications/ah717/ah717b.pdf
  • Environment Canada . 1995 . Toxic substances managment policy , Ottawa, Ontario : Environment Canada . Cat. no. En40-499/1-1995.
  • Eskenazi , B. , Bradman , A. and Castorina , R. 1999 . Exposure of children to organophosphate pesticides and their potenital adverse health effects . Environ. Health Perspect , 107 : 409 – 419 .
  • Eskenazi , B. , Harley , K. , Bradman , A. , Weltzien , E. , Jewell , N. P. , Barr , D. B. , Furlong , C. E. and Holland , N. T. 2004 . Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population . Environ. Health Perspect , 112 : 1116 – 1124 .
  • Fed. Reg . 1997 . Raw and processed food schedule for pesticide tolerance reassessment . 62 ( 149 ) : 42019 – 42030 .
  • Food and Agriculture Organization of the United Nations . International code of conduct on the distribution and use of pesticides . (ammended to include prior informed consent in Article 9 as adopted by the 25th Session of the FAO Conference in November 1989) . Rome : FAO .
  • Fenton , S. E. , Condon , M. , Ettinger , A. S. , laKind , J. S. , Mason , A. , McDiarmid , M. , Xhengmin , Q. and Selevan , S. G. 2005 . Collection and use of exposure data from human milk biomonitoring in the United States . J. Toxicol. Environ. Health A , 68 : 1691 – 1712 .
  • Festing , M. F. 2001 . Experimental approaches to the determination of genetic variability . Toxicol. Lett , 120 : 293 – 300 .
  • Field , B. and Kerr , C. 1979 . Herbicide use and the incidence of neural tube defects . Lancet , 1 : 1341 – 1342 .
  • Flessel , P. , Quintana , P. J. and Hooper , K. 1993 . Genetic toxicity of malathion: A review . Environ. Mol. Mutagen , 22 : 7 – 17 .
  • Furlong , C. E. , Richter , R. J. , Seidel , S. L. and Motulsky , A. G. 1988 . Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon . Am. J. Hum. Genet , 43 : 230 – 238 .
  • Garcia , A. M. 1998 . Occupational exposure to pesticides and congenital malformations: A review of mechanisms, methods, and results . Am. J. Ind. Med , 33 : 232 – 240 .
  • Garcia , A. M. , Benavides , F. G. , Fletcher , T. and Orts , E. 1998 . Paternal exposure to pesticides and congenital malformations . Scand. J. Work Environ. Health , 24 : 473 – 480 .
  • Garcia , S. J. , Seidler , F. J. , Qiao , D. and Slotkin , T. A. 2002 . Chlorpyrifos targets developing glia: Effects on glial fibrillary acidic protein . Brain Res. Dev. Brain Res , 133 : 151 – 161 .
  • Garcia , S. J. , Seidler , F. J. and Slotkin , T. A. 2003 . Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: Effects on neurospecific proteins indicate changing vulnerabilities . Environ. Health Perspect , 111 : 297 – 304 .
  • Garry , V. F. , Schreinemachers , D. , Harkins , M. E. and Griffith , J. 1996 . Pesticide appliers, biocides, and birth defects in rural Minnesota . Environ. Health Perspect , 104 : 394 – 399 .
  • Garry , V. F. , Harkins , M. E. , Erickson , L. L. , Long-Simpson , L. K. , Holland , S. E. and Burroughs , B. L. 2002a . Birth defects, season of conception, and sex of children born to pesticide applicators living in the Red River Valley of Minnesota, USA . Environ. Health Perspect , 110 : 441 – 449 .
  • Garry , V. F. , Harkins , M. E. , Lyubimov , A. , Erickson , L. L. and Long , L. 2002b . Reproductive outcomes in the women of the Red River Valley of the North. I. The spouses of pesticide applicators: Pregnancy loss, age at menarche, and exposure to pesticides . J. Toxicol. Environ. Health A , 65 : 769 – 786 .
  • Gerhard , I. , Daniel , V. , Link , S. , Monga , B. and Runnebaum , B. 1998 . Chlorinated hydrocarbons in women with repeated miscarriages . Environ. Health Perspect , 106 : 675 – 681 .
  • Gianessi , L. P. and Sankula , S. 2003 . The value of herbicides in US crop production , Washington, DC : National Center for Food & Agricultural Policy .
  • Gladen , B. C. , Shkiryak-Nyzhnyk , Z. A. , Chyslovska , N. , Zadorozhnaja , T. D. and Little , R. E. 2003 . Persistent organochlorine compounds and birth weight . Ann. Epidemiol , 13 : 151 – 157 .
  • Gladen , B. C. , Klebanoff , M. A. , Hediger , M. L. , Katz , S. H. , Barr , D. B. , Davis , M. D. and Longnecker , MP. 2004 . Prenatal DDT exposure in relation to anthropometric and pubertal measures in adolescent males . Environ. Health Perspect , 112 : 1761 – 1767 .
  • Grether , J. K. , Harris , J. A. , Neutra , R. and Kizer , K. W. 1987 . Exposure to aerial malathion application and the occurrence of congenital anomalies and low birthweight . Am. J. Public Health , 77 : 1009 – 1010 .
  • Guillette , E. A. , Meza , M. M. , Aquilar , M. G. , Soto , A. D. and Garcia , I. E. 1998 . An anthropological approach to the evaluation of preschool children exposed to pesticides in Mexico . Environ. Health Perspect , 106 : 347 – 353 .
  • Hall , J. G. , McLaughlin , J. F. and Stamm , S. 1975 . Coarctation of the aorta in male cousins with similar maternal environmental exposure to insect repellent and insecticides . Pediatrics , 55 : 425 – 427 .
  • Hanify , J. A. , Metcalf , P. , Nobbs , C. L. and Worsley , K. 1981 . Aerial spraying of 2,4,5-T and human birth malformations: An epidemiolgical investigation . Science , 212 : 349 – 351 .
  • Hanke , W. , Romitti , P. , Fuortes , L. , Sobala , W. and Mikulski , M. 2003 . The use of pesticides in a Polish rural population and its effect on birth weight . Int. Arch. Occup. Environ. Health , 76 : 614 – 620 .
  • Health Canada . 1999 . The Pest Management Regulatory Agency's strategy for implementing the toxic substances management policy , Ottawa : Submission Management and Information Division, Pest Management Regulatory Agency . DIR99–03.
  • Health Canada . 2002 . Personal insect repellents containing DEET (N,N-diethyl-m-toluamide and related compounds) , Ottawa : Health Canada, Submission Coordination and Documentation Division, Pest Management Reglatory Agency .
  • Health Canada . 2005 . Re-evaluation of lawn and turf uses of (2,4-dichlorophenoxy)acetic acid [2,4-D] , Ottawa, Ontario : Alternative Strategies and Regulatory Affairs Division, Pest Management Regulatory Agency .
  • Heeren , G. A. , Tyler , J. and Mandeya , A. 2003 . Agricultural chemical exposures and birth defects in the Eastern Cape Province, South Africa: A case–control study . Environ. Health , 2 : 11
  • Heindel , J. , Mastin , J. and Kirshner , A. 2002 . Fetal basis of childhood and adult disease: role of the environment . Environ. Health Perspect , 110 : A353
  • Hjollund , N. H. , Bonde , J. P. , Ernst , E. , Lindenberg , S. , Andersen , A. N. and Olsen , J. 2004 . Pesticide exposure in male farmers and survival of in vitro fertilized pregnancies . Hum. Reprod , 19 : 1331 – 1337 .
  • Hooper , K. and Clark , G. C. 1995 . Workshop on perinatal exposure to dioxin-like compounds. VI. Role of biomarkers . Environ. Health Perspect , 103 : 161 – 167 .
  • Hosie , S. , Loff , S. , Witt , K. , Niessen , K. and Waag , K. 2000 . Is there a correlation between organochlorine compounds and undescended testes? . Eur. J. Pediatr. Surg , 10 : 304 – 309 .
  • Hunter , C. and McGee , B. 1999 . Survey of pesticide use in Ontario, 1998 , Toronto, Ontario : Policy Analysis Branch, Ontario Ministry of Agriculture Food and Rural Affairs .
  • Institute of Medicine . 2002 . Veterans and Agent Orange: Update 2002 , Washington, DC : National Academy Press .
  • International Agency for Research on Cancer. 1999. Preamble to the IARC Monographs. http://monographs.iarc.fr/monoenal/preamble.html
  • Jarrell , J. , Gocmen , A. , Foster , W. , Brant , R. , Chan , S. and Sevcik , M. 1998 . Evaluation of reproductive outcomes in women inadvertently exposed to hexachlorobenzene in southeastern Turkey in the 1950s . Reprod. Toxicol , 12 : 469 – 476 .
  • Karmaus , W. and Wolf , N. 1995 . Reduced birthweight and length in the offspring of females exposed to PCDFs, PCP, and lindane . Environ. Health Perspect , 103 : 1120 – 1125 .
  • Kharrazi , M. , Potashnik , G. and Goldsmith , J. R. 1980 . Reproductive effects of dibromochlorpropane . Isr. J. Med. Sci , 16 : 403 – 406 .
  • Kogevinas , M. 1998 . Pesticides and congenital malformations—How many studies will it take to reach a conclusion? . Scand. J. Work Environ. Health , 24 : 445 – 447 .
  • Korrick , S. A. , Chen , C. , Damokosh , A. I. , Ni , J. , Liu , X. , Cho , S. I. , Altshul , L. , Ryan , L. and Xu , X. 2001 . Association of DDT with spontaneous abortion: A case-control study . Ann. Epidemiol , 11 : 491 – 496 .
  • Kutz , F. W. , Wood , P. H. and Bottimore , D. P. 1991 . Organochlorine pesticides and polychlorinated biphenyls in human adipose tissue . Rev. Environ. Contam. Toxicol , 120 : 1 – 82 .
  • Landrigan , P. , Garg , A. and Droller , D. B. 2003 . Assessing the effects of endocrine disruptors in the National Children's Study . Environ. Health Perspect , 111 : 1678 – 1682 .
  • Le Marchand , L. , Kolonel , L. N. , Siegel , B. Z. and Dendle , W. H. III . 1986 . Trends in birth defects for a Hawaiian population exposed to heptachlor and for the United States . Arch. Environ. Health , 41 : 145 – 148 .
  • Lembrych , S. , Lorenz , K. , Guzikowski , W. and Plucinska , K. 1986 . [Evaluation of the presence of polychlorinated insecticides (pesticides) in trophoblasts from spontaneous and artificial abortions] . Ginekol. Pol , 57 : 353 – 356 .
  • Leoni , V. , Fabiani , L. , Marinelli , G. , Puccetti , G. , Tarsitani , G. F. , De Carolis , A. , Vescia , N. , Morini , A. , Aleandri , V. and Pozzi , V. 1989 . PCB and other organochlorine compounds in blood of women with or without miscarriage: A hypothesis of correlation . Ecotoxicol. Environ. Safety , 17 : 1 – 11 .
  • Levario-Carrillo , M. , Amato , D. , Ostroski , P. , Gonzalez-Horta , C. , Corona , Y. and Sanin , L. H. 2004 . Relation between pesticide exposure and intrauterine growth retardation . Chemosphere , 55 : 1421 – 1427 .
  • Li , D. K. , Zhou , Q. D. , Qin , X. B. , Sun , R. M. , Zhu , X. L. , Cheng , H. J. , Wang , C. S. , He , J. P. , Qian , C. X. and Xue , S. Z. 1986 . An epidemiological study on the effect of N, N′-methylene-bis-(2-amino-1,3,4-thiadiazole) (MATDA) on outcomes of pregnancy . Teratology , 33 : 289 – 297 .
  • Lin , S. , Marshall , E. G. and Davidson , G. K. 1994 . Potential parental exposure to pesticides and limb reduction defects . Scand. J. Work Environ. Health , 20 : 166 – 179 .
  • Lindhout , D. and Hageman , G. 1987 . Amyoplasia congenita-like condition and maternal malathion exposure . Teratology , 36 : 7 – 9 .
  • Loffredo , C. A. , Silbergeld , E. K. , Ferencz , C. and Zhang , J. 2001 . Association of transposition of the great arteries in infants with maternal exposures to herbicides and rodenticides . Am. J. Epidemiol , 153 : 529 – 536 .
  • Longnecker , M. P. , Klebanoff , M. A. , Zhou , H. and Brock , J. W. 2001 . Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-for-gestational-age babies at birth . Lancet , 358 : 110 – 114 .
  • Longnecker , M. P. , Klebanoff , M. A. , Brock , J. W. , Zhou , H. , Gray , K. A. , Needham , L. L. and Wilcox , A. J. 2002 . Maternal serum level of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and risk of cryptorchidism, hypospadias, and polythelia among male offspring . Am. J. Epidemiol , 155 : 313 – 322 .
  • Longnecker , M. P. , Bellinger , D. C. , Crews , D. , Eskenazi , B. , Silbergeld , E. K. , Woodruff , T. J. and Susser , E. S. 2003 . An approach to assessment of endocrine disruption in the National Children's Study . Environ. Health Perspect , 111 : 1691 – 1697 .
  • Longnecker , M. P. , Klebanoff , M. A. , Dunson , D. B. , Guo , X. , Chen , Z. , Zhou , H. and Brock , J. W. 2005 . Maternal serum level of the DDT metabolite DDE in relation to fetal loss in previous pregnancies . Environ. Res , 97 : 127 – 133 .
  • Makri , A. , Goveia , M. , Balbus , J. and Parkin , R. 2004 . Children's susceptibility to chemicals: A review by developmental stage . J. Toxicol. Environ. Health B , 7 : 417 – 435 .
  • Mazorchuk , B. F. , Zhukova , O. S. , Mazorchuk , S. G. and Fedorchenko , V. S. 1974 . [Content of certain chloroganic pesticides in the blood of pregnant women and embryos after miscarriage] . Pediatr. Akus. Ginekol , 6 : 59 – 61 .
  • McGready , R. , Simpson , J. A. , Htway , M. , White , N. J. , Nosten , F. and Lindsay , S. W. 2001 . A double-blind randomized therapeutic trial of insect repellents for the prevention of malaria in pregnancy . Trans. R. Soc. Trop. Med. Hyg , 95 : 137 – 138 .
  • Meyer , A. , Seidler , F. J. and Slotkin , T. A. 2004 . Developmental effects of chlorpyrifos extend beyond neurotoxicity: Critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling . Environ. Health Perspect , 112 : 170 – 178 .
  • Moses , M. , Lilis , R. , Crow , K. D. , Thornton , J. , Fischbein , A. , Anderson , H. A. and Selikoff , I. J. 1984 . Health status of workers with past exposure to 2,3,7,8-tetrachlrodibenzo-p-dixoin in the manufacture of 2,4,5-trichlorophenoxyacetic acid: Comparison of finding with and without chloracne . Am. J. Ind. Med , 5 : 161 – 182 .
  • Munger , R. , Isacson , P. , Kramer , M. , Hanson , J. , Burns , T. , Cherryholmes , K. and Hausler , W. Jr. 1992 . Birth defects and pesticide-contaminated water supplies in Iowa . Am. J. Epidemiol , 136 : 959
  • Munger , R. , Isacson , P. , Hu , S. , Burns , T. , Hanson , J. , Lynch , C. F. , Cherryholmes , K. , Van Dorpe , P. and Hausler , W. J. Jr. 1997 . Intrauterine growth retardation in Iowa communities with herbicide-contaminated drinking water supplies . Environ. Health Perspect , 105 : 308 – 314 .
  • National Research Council . 1993 . Pesticides in the diets of infants and children , Washington, DC : National Academy Press .
  • Needham , L. L. 2005 . Assessing exposure to organophosphorus pesticides by biomonitoring in epidemiologic studies of birth outcomes . Environ. Health Perspect , 113 : 494 – 498 .
  • Nelson , C. J. , Holson , J. F. , Green , H. G. and Gaylor , D. 1979 . Retrospective study of the relationship between agricultural use of 2,4,5‐T and cleft palate occurrence in Arkansas . Teratology , 19 : 377 – 383 .
  • Nikitina , E. 1974 . [Course of labor and puerperium in the vineyard workers and milkmaids in Crimea] . Gig. Tr. Prof. Zabol , 18 : 17 – 20 .
  • O'Leary , J. A. , Davies , J. E. and Feldman , M. 1970 . Spontaneous abortion and human pesticide residues of DDT and DDE . Am. J. Obstet. Gynecol , 108 : 1291 – 1292 .
  • Olsen , J. and Torsten , S. 1993 . Design options andmMethodological fallacies in the studies of reproductive failures . Environ. Health Perspect , 101 : 145 – 152 .
  • Pacque , M. , Munoz , B. , Poetschke , G. , Foose , J. , Greene , B. M. and Taylor , H. R. 1990 . Pregnancy outcome after inadvertent ivermectin treatment during community-based distribution . Lancet , 336 : 1486 – 1489 .
  • Padilla , S. , Sung , H. J. and Moser , V. C. 2004 . Further assessment of an in vitro screen that may help identify organophosphorus pesticides that are more acutely toxic to the young . J. Toxicol. Environ. Health A , 67 : 1477 – 1489 .
  • Palmiter , R. D. and Mulvihill , E. R. 1978 . Estrogenic activity of the insecticide kepone on the chicken oviduct . Science , 201 : 356 – 358 .
  • Pan American Health Organization . 2002 . Epidemiologic situation of acute pesticide poisoning in Central America, 1992–2000 . Epidemiol. Bull , 23 : 5 – 9 .
  • Pan , X. , Wang , J. , Wu , Z. , Liu , Y. and Liu , S. 1993 . A prospective study on the relationship between environmental exposure to pesticides and adverse pregnancy outcomes . China Environ. Sci , 4 : 91 – 96 .
  • Pastore , L. M. , Hertz-Picciotto , I. and Beaumont , J. J. 1997 . Risk of stillbirth from occupational and residential exposures . Occup. Environ. Med , 54 : 511 – 518 .
  • Perera , F. P. , Rauh , V. , Tsai , W. Y. , Kinney , P. , Camann , D. , Barr , D. , Bernert , T. , Garfinkel , R. , Tu , Y. H. , Diaz , D. , Dietrich , J. and Whyatt , R. M. 2003 . Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population . Environ. Health Perspect , 111 : 201 – 205 .
  • Pest Management Regulatory Agency. 1994. 2,4-D Re-evaluation update and label improvement program. www.pmra–arla.gc.ca/english/pdf/reg/reg-c9408–e.pdf
  • Pope , C. N. 1999 . Organophosphorus pesticides: do they all have the same mechanism of toxicity? . J. Toxicol. Environ. Health B , 2 : 161 – 181 .
  • Potashnik , G. and Yanai-Inbar , I. 1987 . Dibromochloropropane (DBCP): An 8-year reevaluation of testicular function and reproductive performance . Fertil. Steril , 47 : 317 – 323 .
  • Power , C. and Jefferis , B. J. 2002 . Fetal environment and subsequent obesity: a study of maternal smoking . Int. J. Epidemiol , 31 : 413 – 419 .
  • Procianoy , R. S. and Schvartsman , S. 1981 . Blood pesticide concentration in mothers and their newborn infants. Relation to prematurity . Acta Paediatr. Scand , 70 : 925 – 928 .
  • Qiao , D. , Seidler , F. J. , Padilla , S. and Slotkin , T. A. 2002 . Developmental neurotoxicity of chlorpyrifos: What is the vulnerable period? . Environ. Health Perspect , 110 : 1097 – 1103 .
  • Rawlings , N. C. , Cook , S. J. and Waldbillig , D. 1998 . Effects of the pesticides carbofuran, chlorpyrifos, dimethoate, lindane, triallate, trifluralin, 2,4-D, and pentachlorophenol on the metabolic endocrine and reproductive endocrine system in ewes . J. Toxicol. Environ. Health A , 54 : 21 – 36 .
  • Rhodes , M. C. , Seidler , F. J. , Qiao , D. , Tate , C. A. , Cousins , M. M. and Slotkin , T. A. 2004 . Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats . Toxicol. Appl. Pharmacol , 195 : 203 – 217 .
  • Ribas-Fito , N. , Sala , M. , Cardo , E. , Mazon , C. , De Muga , M. E. , Verdu , A. , Marco , E. , Grimalt , J. O. and Sunyer , J. 2002 . Association of hexachlorobenzene and other organochlorine compounds with anthropometric measures at birth . Pediatr. Res , 52 : 163 – 167 .
  • Richardson , J. and Chambers , J. 2003 . Effects of gestational exposure to chlorpyrifos on postnatal central and peripheral cholinergic neurochemistry . J. Toxicol. Environ. Health A , 66 : 275 – 289 .
  • Rita , P. , Reddy , P. P. and Reddy , S. V. 1987 . Monitoring of workers occupationally exposed to pesticides in grape gardens of Andhra Pradesh . Environ. Res , 44 : 1 – 5 .
  • Rivero-Rodriguez , L. , Borja-Aburto , V. H. , Santos-Burgoa , C. , Waliszewskiy , S. , Rios , C. and Cruz , V. 1997 . Exposure assessment for workers applying DDT to control malaria in Veracruz, Mexico . Environ. Health Perspect , 105 : 98 – 101 .
  • Roberts , D. R. , Laughlin , L. L. , Hsheih , P. and Legters , L. J. 1997 . DDT, global strategies, and a malaria control crisis in South America . Emerg. Infect. Dis , 3 : 295 – 302 .
  • Rogan , W. J. , Gladen , B. C. , McKinney , J. D. , Carreras , N. , Hardy , P. , Thullen , J. , Tinglestad , J. and Tully , M. 1986 . Neonatal effects of transplacental exposure to PCBs and DDE . J. Pediatr , 109 : 335 – 341 .
  • Rogan , W. J. , Gladen , B. C. , McKinney , J. D. , Carreras , N. , Hardy , P. , Thullen , J. , Tinglestad , J. and Tully , M. 1991 . PCBs, DDE, and child development at 18 and 24 months . Ann. Epidemiol , 1 : 407 – 413 .
  • Romero , P. , Barnett , P. G. and Midtling , J. E. 1989 . Congenital anomalies associated with maternal exposure to oxydemeton-methyl . Environ. Res , 50 : 256 – 261 .
  • Rosenstock , L. , Keifer , M. , Daniell , W. E. , Mcconnell , R. and Claypoole , K. 1991 . Chronic central nervous system effects of acute organophosphate pesticide intoxication. The Pesticide Health Effects Study Group . Lancet , 338 : 223 – 227 .
  • Rothman , K. J. and Greenland , S. 1998 . Modern epidemiology , Philadelphia, PA : Lippincott-Raven .
  • Rull , R. P. and Ritz , B. 2003 . Historical pesticide exposure in California using pesticide use reports and land-use surveys: An assessment of misclassification error and bias . Environ. Health Perspect , 111 : 1582 – 1589 .
  • Rupa , D. S. , Reddy , P. P. and Redd , O. 1991 . Reproductive performance in population exposed to pesticides in cotton fields in India . Environ. Res , 55 : 123 – 128 .
  • Salazar-Garcia , F. , Gallardo-Diaz , E. , Ceron-Mireles , P. , Loomis , D. and Borja-Aburto , V. H. 2004 . Reproductive effects of occupational DDT exposure among male malaria control workers . Environ. Health Perspect , 112 : 542 – 547 .
  • Savage , E. P. , Keefe , T. J. , Mounce , L. M. , Heaton , R. K. , Lewis , J. A. and Burcar , P. J. 1988 . Chronic neurological sequelae of acute organophosphate pesticide poisoning . Arch. Environ. Health , 43 : 38 – 45 .
  • Savitz , D. A. , Whelan , E. A. and Kleckner , R. C. 1989a . Effect of parents' occupational exposures on risk of stillbirth, preterm delivery, and small-for-gestational-age infants . Am. J. Epidemiol , 129 : 1201 – 1218 .
  • Savitz , D. A. , Whelan , E. A. and Kleckner , R. C. 1989b . Self-reported exposure to pesticides and radiation related to pregnancy outcome: Results from National Natlity and Fetal Mortality Surveys . Public Health Rep , 104 : 473 – 477 .
  • Savitz , D. A. , Sonnenfeld , N. L. and Olshan , A. F. 1994 . Review of epidemiologic studies of paternal occupational exposure and spontaneous abortion . Am. J. Ind. Med , 25 : 361 – 383 .
  • Savitz , D. A. , Arbuckle , T. E. , Kaczor , D. and Curtis , K. M. 1997 . Male pesticide exposure and pregnancy outcome . Am. J. Epidemiol , 146 : 1025 – 1036 .
  • Saxena , M. C. , Siddiqui , M. K. , Bhargava , A. K. , Seth , T. D. , Krishnamurti , C. R. and Kutty , D. 1980 . Role of chlorinated hydrocarbon pesticides in abortions and premature labour . Toxicology , 17 : 323 – 331 .
  • Saxena , M. C. , Siddiqui , M. K. , Seth , T. D. , Krishna Murti , C. R. , Bhargava , A. K. and Kutty , D. 1981 . Organochlorine pesticides in specimens from women undergoing spontaneous abortion, premature of full-term delivery . J. Anal. Toxicol , 5 : 6 – 9 .
  • Saxena , M. C. , Siddiqui , M. K. , Agarwal , V. and Kuuty , D. 1983 . A comparison of organochlorine insecticide contents in specimens of maternal blood, placenta, and umbilical-cord blood from stillborn and live-born cases . J. Toxicol. Environ. Health , 11 : 71 – 79 .
  • Schaefer , C. and Peters , P. W. 1992 . Intrauterine diethyltoluamide exposure and fetal outcome . Reprod. Toxicol , 6 : 175 – 176 .
  • Schreinemachers , D. M. 2003 . Birth malformations and other adverse perinatal outcomes in four U.S. Wheat-producing states . Environ. Health Perspect , 111 : 1259 – 1264 .
  • Sever , L. E. , Arbuckle , T. E. and Sweeney , A. 1997 . Reproductive and developmental effects of occupational pesticide exposure: The epidemiologic evidence . Occup. Med , 12 : 305 – 325 .
  • Shaw , G. M. , Velie , E. M. , Katz , E. A. , Morland , K. B. , Schaffer , D. M. and Nelson , V. 1999 . Maternal occupational and hobby chemical exposures as risk factors for neural tube defects . Epidemiology , 10 : 124 – 129 .
  • Shaw , G. M. , Nelson , V. , Iovannisci , D. M. , Finnell , R. H. and Lammer , E. J. 2001 . Maternal occupational chemical exposures and biotransformation genotypes as risk factors for selected congenital anomalies . Am. J. Epidemiol , 157 : 475 – 484 .
  • Sherman , J. D. 1997 . Dursban revisited: Birth defects, U.S. Environmental Protection Agency, and Centers for Disease Control . Arch. Environ. Health , 52 : 332 – 333 .
  • Siddiqui , M. K. , Srivastava , S. , Srivastava , S. P. , Mehrotra , P. K. , Mathur , N. and Tandon , I. 2003 . Persistent chlorinated pesticides and intra-uterine foetal growth retardation: A possible association . Int. Arch. Occup. Environ. Health , 76 : 75 – 80 .
  • Smith , A. H. , Matheson , D. P. , Fisher , D. O. and Chapman , C. J. 1981 . Preliminary report of reproductve outcomes among pesticide applicators using 2,4,5-T . N. Z. Med. J , 93 : 177 – 179 .
  • Smith , A. H. , Matheson , D. P. , Fisher , D. O. and Chapman , C. J. 1982 . Congenital defects and miscarriages among New Zealand 2,4,5‐T sprayers . Arch. Environ. Health , 37 : 197 – 200 .
  • Smith , R. J. 1982 . Hawaiian milk contamination creates alarm. A sour response by state regulators . Science , 217 : 137 – 140 .
  • Soto , A. M. , Chung , K. L. and Sonnenschein , C. 1994 . The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells . Environ. Health Perspect , 102 : 380 – 383 .
  • Stallones , L. and Beseler , C. 2002 . Pesticide illness, farm practices, and neurological symptoms among farm residents in Colorado . Environ. Res , 90 : 89 – 97 .
  • Steenland , K. 1996 . Chronic neurological effects of organophosphate pesticides . Br. Med. J , 312 : 1312 – 1313 .
  • Suskind , R. R. and Hertzberg , V. S. 1984 . Human health effects of 2,4,5-T and its toxic contaminants . J. Am. Med. Assoc , 251 : 2372 – 2380 .
  • Tenenbein , M. 1987 . Severe toxic reactions and death following the ingestion of diethyltoluamide-containing insect repellents . J. Am. Med. Assoc , 258 : 1509 – 1511 .
  • Thomas , D. C. , Petitti , D. B. , Goldhaber , M. , Swan , S. H. , Rappaport , E. B. and Hertz-Picciotto , I. 1992 . Reproductive outcomes in relation to malathion spraying in the San Francisco Bay Area, 1981–1982 . Epidemiology , 3 : 32 – 39 .
  • Thomas , H. F. 1980 . 2,4,5-T use and congenital malformation rates in Hungary . Lancet , 2 : 214 – 215 .
  • Torres-Arreola , L. , Berkowitz , G. , Torres-Sanchez , L. , Lopez-Cervantes , M. , Cebrian , M. E. , Uribe , M. and Lopez-Carrillo , L. 2003 . Preterm birth in relation to maternal organochlorine serum levels . Ann. Epidemiol , 13 : 158 – 162 .
  • United Nations Environmental Programme . 1996 . Operation of the prior informed consent procedure for banned or severely restricted chemicals in international trade: Decisional guidance documents 2,4,5-T , Rome : Joint FAO/UNEP Programme for the Operation of Prior Informed Consent .
  • U.S. Environmental Protection Agency . 1999 . Recognition and managment of pesticide poisonings , 5th , Washington, DC : Office of Prevention, Pesticides, and Toxic Substances, U.S. EPA . EPA 735-R-98-003.
  • U.S. Environmental Protection Agency. 2000. Chlorpyrifos revised risk assessment and agreement registrants. U.S. Environmental Protection Agency. http://www.epa.gov/pesticides/op/chloropyrifos/agreement.pdf
  • U.S. Environmental Protection Agency. 2003. Interim reregistration eligibility decision for carbaryl: List A, Case 0080. U.S. Environmental Protection Agency. http://www.epa.gov/REDS/carbaryl-ired.pdf
  • U.S. Environmental Protection Agency. 2004a. Consumer factsheet: Dibromochloropropane. U.S. Environmental Protection Agency. http://www.epa.gov./safewater/dwh/c-soc/dibromoc.html
  • U.S. Environmental Protection Agency. 2004b. EXTOXNET: Pesticide information profiles (PIPs). http://extonet.orst.edu/pips/ghindex.html
  • U.S. Environmental Protection Agency. 2005a. Organophosphate pesticide tolerance reassessment and reregistration. U.S. EPA. http://www.epa.gov/pesticides/op/
  • U.S. Environmental Protection Agency. 2005b. Notice of receipt of request to cancel registrations of certain pentachlorophenol preservative products and/or amend registrations to terminate certain uses of pentachlorophenol products. Fed. Regi. 70:1246–1248. http://www.epa.gov/EPA–PEST/2005/January/Day–06/p261.htm
  • Veltri , J. C. , Osimitz , T. G. , Bradford , D. C. and Page , B. C. 1994 . Retrospective analysis of calls to poison control centers resulting from exposure to the insect repellent N, N-diethyl-m-toluamide (DEET) from 1985–1989 . J. Toxicol. Clin. Toxicol , 32 : 1 – 16 .
  • Vial , T. , Nicolas , B. and Descotes , J. 1996 . Clinical immunotoxicity of pesticides . J. Toxicol. Environ. Health , 48 : 215 – 229 .
  • Villanueva , C. M. , Durand , G. , Coutte , M. B. , Chevrier , C. and Cordier , S. 2005 . Atrazine in municipal drinking water and risk of low birth weight, preterm delivery, and small-for-gestational-age status . Occup. Environ. Med , 62 : 400 – 405 .
  • Ware , G. W. 1975 . Pesticides: An auto-tutorial approach , San Francisco : W. H. Freeman .
  • Wassermann , M. , Ron , M. , Bercovici , B. , Wassermann , D. , Cucos , S. and Pines , A. 1982 . Premature delivery and organochlorine compounds: Polychlorinated biphenyls and some organochlorine insecticides . Environ. Res , 28 : 106 – 112 .
  • Weisskopf , M. G. , Anderson , H. A. , Hanrahan , L. P. , Kanarek , M. S. , Falk , C. M. , Steenport , D. M. and Draheim , L. A. 2005 . Maternal exposure to Great Lakes sport-caught fish and dichlorodiphenyl dichloroethylene, but not polychlorinated biphenyls, is associated with reduced birth weight . Environ. Res , 97 : 149 – 162 .
  • Wessels , D. , Barr , D. B. and Mendola , P. 2003 . Use of biomarkers to indicate exposure of children to organophosphate pesticides: Implications for a longitudinal study of children's environmental health . Environ. Health Perspect , 111 : 1939 – 1946 .
  • White , F. M. , Cohen , F. G. , Sherman , G. and McCurdy , R. 1988 . Chemicals, birth defects and stillbirths in New Brunswick: associations with agricultural activity . Can. Med. Assoc. J , 138 : 117 – 124 .
  • Whorton , M. D. , Wong , O. , Morgan , R. W. and Gordon , N. 1989 . An epidemiologic investigation of birth outcomes in relation to dibromochloropropane contamination in drinking water in Fresno County, California, USA . Int. Arch. Occup. Environ. Health , 61 : 403 – 407 .
  • Whyatt , R. M. , Rauh , V. , Barr , D. B. , Camann , D. E. , Andrews , H. F. , Garfinkel , R. , Hoepner , L. A. , Diaz , D. , Dietrich , J. , Reyes , A. , Tang , D. , Kinney , P. L. and Perera , F. P. 2004 . Prenatal insecticide exposures and birth weight and length among an urban minority cohort . Environ. Health Perspect , 112 : 1125 – 1132 .
  • Willis , W. O. , Depeyster , A. , Molgaard , C. A. , Walker , C. and Mackendrick , T. 1993 . Pregnancy outcome among women exposed to pesticides through work or residence in an agricultural area . J. Occup. Environ. Med , 35 : 943 – 949 .
  • Young , J. G. , Eskenazi , B. , Gladstone , E. A. , Bradman , A. , Pedersen , L. , Johnson , C. , Barr , D. B. , Furlong , C. E. and Holland , N. T. 2005 . Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates . Neurotoxicology , 26 : 199 – 209 .
  • Zahm , S. H. and Ward , M. H. 1998 . Pesticides and childhood cancer . Environ. Health Perspect , 106 ( suppl. 3 ) : 893 – 908 .
  • Zahm , S. H. , Ward , M. H. and Blair , A. 1997 . Pesticides and cancer . Occup. Med , 12 : 269 – 289 .

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