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Original Articles

The Influence of the Environment and Other Exogenous Agents on Spontaneous Abortion Risk

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Pages 221-241 | Published online: 26 Mar 2008

REFERENCES

  • Abdulrazzaq , Y. M. , Osman , N. and Ibrahim , A. 2002 . Fetal exposure to aflatoxins in the United Arab Emirates . Ann. Trop. Paediatr. , 22 : 3 – 9 .
  • Abel , E. L. 1997 . Maternal alcohol consumption and spontaneous abortion . Alcohol Alcohol , 32 : 211 – 219 .
  • Ahlbom , A. 1988 . A review of the epidemiologic literature on magnetic fields and cancer . Scand. J Work Environ. Health , 14 : 337 – 343 .
  • Ahlborg , G. Jr. 1995 . Physical work load and pregnancy outcome . J. Occup. Environ. Med. , 37 : 941 – 944 .
  • Ahmad , S. A. , Sayed , M. H. , Barua , S. , Khan , M. H. , Faruquee , M. H. , Jalil , A. , Hadi , S. A. and Talukder , H. K. 2001 . Arsenic in drinking water and pregnancy outcomes . Environ. Health Perspect. , 109 : 629 – 631 .
  • Aitken , R. J. , Gordon , E. , Harkiss , D. , Twigg , J. P. , Milne , P. , Jennings , Z. and Irvine , D. S. 1998 . Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa . Biol. Reprod. , 59 : 1037 – 1046 .
  • Al-Saleh , I. A. 1994 . Pesticides: A review . J. Environ. Pathol. Toxicol. Oncol. , 13 : 151 – 161 .
  • Alcser , K. H. , Brix , K. A. , Fine , L. J. , Kallenbach , L. R. and Wolfe , R. A. 1989 . Occupational mercury exposure and male reproductive health . Am. J. Ind. Med. , 15 : 517 – 529 .
  • Aldrich , T. E. and Easterly , C. E. 1987 . Electromagnetic fields and public health . Environ. Health Perspect. , 75 : 159 – 171 .
  • Aldridge , L. M. and Tunstall , M. E. 1986 . Nitrous oxide and the fetus. A review and the results of a retrospective study of 175 cases of anaesthesia for insertion of Shirodkar suture . Br. J. Anaesth. , 58 : 1348 – 1356 .
  • Aljicevic , M. , Beslagi , c. E , Zvizdic , S. , Hamzic , S. and Mahmutovic , S. 2005 . Listeria monocytogenes as the possible cause of the spontanous abortion in female of the fertile age . Bosn. J. Basic. Med. Sci. , 5 : 89 – 92 .
  • Altman , N. H. , New , A. E. , McConnell , E. E. and Ferrell , T. L. 1979 . A spontaneous outbreak of polychlorinated biphenyl (PCB) toxicity in rhesus monkeys (Macaca mulatta): Clinical observations . Lab. Anim. Sci. , 29 : 661 – 665 .
  • Andersen , A. M. , Vastrup , P. , Wohlfahrt , J. , Andersen , P. K. , Olsen , J. and Melbye , M. 2002 . Fever in pregnancy and risk of fetal death: A cohort study . Lancet , 360 : 1552 – 1556 .
  • Arbuckle , T. E. and Sever , L. E. 1998 . Pesticide exposures and fetal death: A review of the epidemiologic literature . Crit. Rev. Toxicol. , 28 : 229 – 270 .
  • Arbuckle , T. E. , Savitz , D. A. , Mery , L. S. and Curtis , K. M. 1999 . Exposure to phenoxy herbicides and the risk of spontaneous abortion . Epidemiology , 10 : 752 – 760 .
  • Arbuckle , T. E. , Lin , Z. and Mery , L. S. 2001 . An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population . Environ. Health Perspect. , 109 : 851 – 857 .
  • Arnon , J. , Meirow , D. , Lewis-Roness , H. and Ornoy , A. 2001 . Genetic and teratogenic effects of cancer treatments on gametes and embryos . Human Reprod. Update , 7 : 394 – 403 .
  • Aschengrau , A. , Zierler , S. and Cohen , A. 1989 . Quality of community drinking water and the occurrence of spontaneous abortion . Arch. Environ. Health , 44 : 283 – 290 .
  • Auvinen , A. , Vahteristo , M. , Arvela , H. , Suomela , M. , Rahola , T. , Hakama , M. and Rytomaa , T. 2001 . Chernobyl fallout and outcome of pregnancy in Finland . Environ. Health Perspect. , 109 : 179 – 185 .
  • Axelsson , G. , Ahlborg , G. Jr. and Bodin , L. 1996 . Shift work, nitrous oxide exposure, and spontaneous abortion among Swedish midwives . Occup. Environ. Med. , 53 : 374 – 378 .
  • Axmon , A. , Rylander , L. , Stromberg , U. and Hagmar , L. 2000 . Miscarriages and stillbirths in women with a high intake of fish contaminated with persistent organochlorine compounds . Int. Arch. Occup. Environ. Health , 73 : 204 – 208 .
  • Axmon , A. , Rylander , L. , Stromberg , U. and Hagmar , L. 2002 . Female fertility in relation to the consumption of fish contaminated with persistent organochlorine compounds . Scand. J. Work Environ. Health , 28 : 124 – 132 .
  • Barish , R. J. 2004 . In-flight radiation exposure during pregnancy . Obstet. Gynecol. , 103 : 1326 – 1330 .
  • Barsotti , D. A. , Marlar , R. J. and Allen , J. R. 1976 . Reproductive dysfunction in rhesus monkeys exposed to low levels of polychlorinated biphenyls (Aroclor 1248) . Food Cosmet. Toxicol. , 14 : 99 – 103 .
  • Belanger , K. , Leaderer , B. , Hellenbrand , K. , Holford , T. R. , McSharry , J. , Power , M. E. and Bracken , M. B. 1998 . Spontaneous abortion and exposure to electric blankets and heated water beds . Epidemiology , 9 : 36 – 42 .
  • Bellinger , D. C. 2005 . Teratogen update: Lead and pregnancy . Birth Defects Res. A Clin. Mol. Teratol. , 73 : 409 – 420 .
  • Bercovici , B. , Wassermann , M. , Cucos , S. , Ron , M. , Wassermann , D. and Pines , A. 1983 . Serum levels of polychlorinated biphenyls and some organochlorine insecticides in women with recent and former missed abortions . Environ. Res. , 30 : 169 – 174 .
  • Boivin , J. F. 1997 . Risk of spontaneous abortion in women occupationally exposed to anaesthetic gases: A meta-analysis . Occup. Environ. Med. , 54 : 541 – 548 .
  • Borja-Aburto , V. H. , Hertz-Picciotto , I. , Rojas , L. M. , Farias , P. , Rios , C. and Blanco , J. 1999 . Blood lead levels measured prospectively and risk of spontaneous abortion . Am. J. Epidemiol. , 150 : 590 – 597 .
  • Borzsonyi , M. , Bereczky , A. , Rudnai , P. , Csanady , M. and Horvath , A. 1992 . Epidemiological studies on human subjects exposed to arsenic in drinking water in southeast Hungary . Arch. Toxicol. , 66 : 77 – 78 .
  • Boue , J. , Bou , A. and Lazar , P. 1975 . Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions . Teratology , 12 : 11 – 26 .
  • Bove , F. , Shim , Y. and Zeitz , P. 2002 . Drinking water contaminants and adverse pregnancy outcomes: a review . Environ. Health Perspect. , 110 ( Suppl. 1 ) : 61 – 74 .
  • Branch , D. W. 1998 . Antiphospholipid antibodies and reproductive outcome: The current state of affairs . J. Reprod. Immunol. , 38 : 75 – 87 .
  • Briggs , G. G. , Freeman , R. K. and Yaffe , S. J. 2002 . Drugs in pregnancy and lactation , Philadelphia : Lippincott Williams & Wilkins .
  • Bulletti , C. , Flamigni , C. and Giacomucci , E. 1996 . Reproductive failure due to spontaneous abortion and recurrent miscarriage . Hum. Reprod. Update , 2 : 118 – 136 .
  • Buzhievskaya , T. I. , Tchaikovskaya , T. L. , Demidova , G. G. and Koblyanskaya , G. N. 1995 . Selective monitoring for a Chernobyl effect on pregnancy outcome in Kiev, 1969–1989 . Hum. Biol. , 67 : 657 – 672 .
  • Byrne , J. , Mulvihill , J. J. , Connelly , R. R. , Austin , D. A. , Holmes , G. E. , Holmes , F. F. , Latourette , H. B. , Meigs , J. W. , Strong , L. C. and Myers , M. H. 1988 . Reproductive problems and birth defects in survivors of Wilms’ tumor and their relatives . Med. Pediatr. Oncol. , 16 : 233 – 240 .
  • Caplan , D. M. 2001 . Involvement of Listeria monocytogenes in the abortive disease . Roum. Arch. Microbiol. Immunol. , 60 : 329 – 335 .
  • CDC . 1996 . Spontaneous abortions possibly related to ingestion of nitrate contaminated well water—LaGrange County, Indiana, 1991–1994 . Morb. Mortal. Weekly Rep. , 45 : 569 – 572 .
  • Chakraborti , D. , Mukherjee , S. C. , Pati , S. , Sengupta , M. K. , Rahman , M. M. , Chowdhury , U. K. , Lodh , D. , Chanda , C. R. , Chakraborti , A. K. and Basu , G. K. 2003 . Arsenic groundwater contamination in Middle Ganga Plain, Bihar, India: A future danger? . Environ. Health. Perspect. , 111 : 1194 – 1201 .
  • Chambers , C. D. 2006 . Risks of hyperthermia associated with hot tub or spa use by pregnant women . Birth. Defects. Res. A Clin. Mol. Teratol. , 76 : 569 – 573 .
  • Chao , W. Y , Hsu , C. C. and Guo , Y. L. 1997 . Middle-ear disease in children exposed prenatally to polychlorinated biphenyls and polychlorinated dibenzofurans . Arch. Environ. Health , 52 : 257 – 262 .
  • Chatenoud , L. , Parazzini , F. , Di Cintio , E. , Zanconato , G. , Benzi , G. , Bortolus , R. and La Vecchia , C. 1998 . Paternal and maternal smoking habits before conception and during the first trimester: Relation to spontaneous abortion . Ann. Epidemiol. , 8 : 520 – 526 .
  • Chia , S. E. and Shi , L. M. 2002 . Review of recent epidemiological studies on paternal occupations and birth defects . Occup. Environ. Med. , 59 : 149 – 155 .
  • Cho , S. I. , Li , Q. , Yang , J. , Chen , C. , Padungtod , C. , Ryan , L. , Christiani , D. C. and Xu , X. 1999 . Drinking water source and spontaneous abortion: A cross-sectional study in a rural Chinese population . Int. J. Occup. Environ. Health , 5 : 164 – 169 .
  • Choi , S. M. , Yoo , S. D. and Lee , B. M. 2004 . Toxicological characteristics of endocrine-disrupting chemical: Developmental toxicity, carcinogenicity and mutagenicity . J. Toxicol. Environ. Health B , 7 : 1 – 24 .
  • Chua , S. , Yeoh , S. C. , Ng , P. L. , Hagarty , A. , Rauff , M. and Ratnam , S. S. 1989 . Rapid karyotyping of spontaneous abortions with trophoblastic villi . Ann. Acad. Med. Singapore , 18 : 52 – 54 .
  • Clarke , R. 1990 . A summary of the draft recommendations of ICRP, 1990 . J. Radiol. Prot. , 10 : 143 – 145 .
  • Cocco , P. , Fadda , D. , Ibba , A. , Melis , M. , Tocco , M. G. , Atzeri , S. , Avataneo , G. , Meloni , M. , Monni , F. and Flore , C. 2005 . Reproductive outcomes in DDT applicators . Environ. Res. , 98 : 120 – 126 .
  • Coleman , M. and Beral , V. 1988 . A review of epidemiological studies of the health effects of living near or working with electricity generation and transmission equipment . Int. J. Epidemiol. , 17 : 1 – 13 .
  • Cordier , S. , Deplan , F. , Mandereau , L. and Hemon , D. 1991 . Paternal exposure to mercury and spontaneous abortions . Br. J. Ind. Med. , 48 : 375 – 381 .
  • Crisostomo , L. and Molina , V. V. 2002 . Pregnancy outcomes among farming households of Nueva Ecija with conventional pesticide use versus integrated pest management . Int. J. Occup. Environ. Health , 8 : 232 – 242 .
  • Critchley , H. O. 1999 . Factors of importance for implantation and problems after treatment for childhood cancer . Med. Pediatr. Oncol. , 33 : 9 – 14 .
  • Dar , E. , Kanarek , M. S. , Anderson , H. A. and Sonzogni , W. C. 1992 . Fish consumption and reproductive outcomes in Green Bay, Wisconsin . Environ. Res. , 59 : 189 – 201 .
  • De Vries , H. R. , Maxwell , S. M. and Hendrickse , R. G. 1989 . Fetal and neonatal exposure to aflatoxins . Acta Paediatr. Scand. , 78 : 373 – 378 .
  • De Felip , E. , di Domrnivo , A. , Minierom , R. and Silvestroni , L. 2004 . Polychlorobiphenyls and other organochlorine compounds in human follicular fluid . Chemosphere , 54 : 1445 – 1449 .
  • Deane , M. , Swan , S. H. , Harris , J. A. , Epstein , D. M. and Neutra , R. R. 1992 . Adverse pregnancy outcomes in relation to water consumption: A re-analysis of data from the original Santa Clara County Study, California, 1980–1981 . Epidemiology , 3 : 94 – 97 .
  • Dewailly , E. , Mulvad , G. , Pedersen , H. S. , Ayotte , P. , Demers , A. , Weber , J. P. and Hansen , J. C. 1999 . Concentration of organochlorines in human brain, liver, and adipose tissue autopsy samples from Greenland . Environ. Health Perspect. , 107 : 823 – 828 .
  • Dlugi , A. M. 1998 . Hyperprolactinemic recurrent spontaneous pregnancy loss: A true clinical entity or a spurious finding? . Fertil. Steril. , 70 : 253 – 255 .
  • Edwards , M. J. 1969 . Congenital defects in guinea pigs: Fetal resorptions, abortions, and malformations following induced hyperthermia during early gestation . Teratology , 2 : 313 – 328 .
  • Eggert , J. , Theobald , H. and Engfeldt , P. 2004 . Effects of alcohol consumption on female fertility during an 18-year period . Fertil. Steril. , 81 : 379 – 383 .
  • Eiben , B. , Bartels , I. , Bahr-Porsch , S. , Borgmann , S. , Gatz , G. , Gellert , G. , Goebel , R. , Hammans , W. , Hentemann , M. and Osmers , R. 1990 . Cytogenetic analysis of 750 spontaneous abortions with the direct-preparation method of chorionic villi and its implications for studying genetic causes of pregnancy wastage . Am. J. Hum. Genet. , 47 : 656 – 663 .
  • Ellish , N. J. , Saboda , K. , O'Connor , J. , Nasca , P. C. , Stanek , E. J and Boyle , C. 1996 . A prospective study of early pregnancy loss . Hum. Reprod. , 11 : 406 – 412 .
  • Empson , M. , Lassere , M. , Craig , J. C. and Scott , J. R. 2002 . Recurrent pregnancy loss with antiphospholipid antibody: A systematic review of therapeutic trials . Obstet. Gynecol. , 99 : 135 – 144 .
  • Engel , L. S. , Omeara , E. S. and Schwartz , S. M. 1995 . Maternal occupation in agriculture and risk of adverse birth outcomes in Washington State, 1980–1991 . Am. J. Epidemiol. , 141 : S73
  • Ericson , A. and Kallen , B. 1994 . Pregnancy outcome in Sweden after the Chernobyl accident . Environ. Res. , 67 : 149 – 159 .
  • Eskenazi , B. , Mocarelli , P. , Warner , M. , Chee , W. Y. , Gerthoux , P. M. , Samuels , S. , Needham , L. L. and Patterson , D. G. Jr. 2003 . Maternal serum dioxin levels and birth outcomes in women of Seveso, Italy . Environ. Health Perspect. , 111 : 947 – 953 .
  • Fara , G. M. and Del Corno , G. 1985 . Pregnancy outcome in the Seveso area after TCDD contamination . Prog. Clin. Biol. Res. , 163B : 279 – 285 .
  • Fedele , L. and Bianchi , S. 1995 . Habitual abortion: Endocrinological aspects . Curr. Opin. Obstet. Gynecol. , 7 : 351 – 356 .
  • Federal Aviation Administration Office of Aerospace Medicine, Civil Medical Institute. 2006. Galactic radiation received in flight [online] http://jag.cami.jccbi.gov./cariprofile.asp (Accessed: 26 November 2006 ).
  • Fenster , L. , Hubbard , A. E. , Windham , G. C. , Waller , K. O. and Swan , S. H. 1997 . A prospective study of work-related physical exertion and spontaneous abortion . Epidemiology , 8 : 66 – 74 .
  • Fenster , L. , Quale , C. , Hiatt , R. A. , Wilson , M. , Windham , G. C. and Benowitz , N. L. 1998 . Rate of caffeine metabolism and risk of spontaneous abortion . Am. J. Epidemiol. , 147 : 503 – 510 .
  • Fernandes , O. , Sabharwal , M. , Smiley , T. , Pastuszak , A. , Koren , G. and Einarson , T. 1998 . Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: A meta-analysis . Reprod. Toxicol. , 12 : 435 – 444 .
  • Fiore , B. J. , Anderson , H. A. , Hanrahan , L. P. , Olson , L. J. and Sonzogni , W. C. 1989 . Sport fish consumption and body burden levels of chlorinated hydrocarbons: A study of Wisconsin anglers . Arch. Environ. Health , 44 : 82 – 88 .
  • Fischer , G. , Bitschnau , M. , Peternell , A. , Eder , H. and Topitz , A. 1999 . Pregnancy and substance abuse . Arch. Woman's Mental Health , 2 : 57 – 65 .
  • Foster , W. , Chan , S. , Platt , L. and Hughes , C. 2000 . Detection of endocrine disrupting chemicals in samples of second trimester human amniotic fluid . J. Clin. Endocrinol. Metab. , 85 : 2954 – 2957 .
  • Friedler , G. 1996 . Paternal exposures: Impact on reproductive and developmental outcome. An overview . Pharmacol. Biochem. Behav. , 55 : 691 – 700 .
  • Fritz , M. A. 1988 . Inadequate luteal function and recurrent abortion: Diagnosis and treatment of luteal phase deficiency . Semin. Reprod. Med. , 6 : 143
  • Gabbe , S. G. , Niebyl , J. R. and Simpson , J. L. 2002 . Obstetrics: Normal and problem pregnancies , Churchill Livingstone .
  • Garaj-Vrhovac , V. and Zeljezic , D. 2002 . Assessment of genome damage in a population of Croatian workers employed in pesticide production by chromosomal aberration analysis, micronucleus assay and Comet assay . J. Appl. Toxicol. , 22 : 249 – 255 .
  • Garcia , A. M. 1998 . Occupational exposure to pesticides and congenital malformations: A review of mechanisms, methods, and results . Am. J. Ind. Med. , 33 : 232 – 240 .
  • Garcia-Enguidanos , A. , Calle , M. E. , Valero , J. , Luna , S. and Dominguez-Rojas , V. 2002 . Risk factors in miscarriage: A review . Eur. J. Obstet. Gynecol. Reprod. Biol. , 102 : 111 – 119 .
  • Gardella , J. R. and Hill , J. A. III . 2000 . Environmental toxins associated with recurrent pregnancy loss . Semin. Reprod. Med. , 18 : 407 – 424 .
  • Garry , V. F. , Danzl , T. J. , Tarone , R. , Griffith , J. , Cervenka , J. , Krueger , L. , Whorton , E. B. Jr. and Nelson , R. L. 1992 . Chromosome rearrangements in fumigant appliers: Possible relationship to non-Hodgkin's lymphoma risk . Cancer Epidemiol. Biomarkers Prev. , 1 : 287 – 291 .
  • Garry , V. F. , Griffith , J. , Danzl , T. J. , Nelson , R. L. , Whorton , E. B. , Krueger , L. A. and Cervenka , J. 1989 . Human genotoxicity: Pesticide applicators and phosphine . Science , 246 : 251 – 255 .
  • Garry , V. F. , Harkins , M. , Lyubimov , A. , Erickson , L. and Long , L. 2002 . Reproductive outcomes in the women of the Red River Valley of the north. I. The spouses of pesticide applicators: Pregnancy loss, age at menarche, and exposures to pesticides . J. Toxicol. Environ. Health A , 65 : 769 – 786 .
  • Gelperin , A. , Moses , V. K. and Bridger , C. 1975 . Relationship of high nitrate community water supply to infant and fetal mortality . Ill. Med. J. , 147 : 155 – 157 . 186
  • Gerhard , I. , Daniel , V. , Link , S. , Monga , B. and Runnebaum , B. 1998 . Chlorinated hydrocarbons in women with repeated miscarriages . Environ. Health Perspect. , 106 : 675 – 681 .
  • Giacomucci , E. , Bulletti , C. , Polli , V. and Flamigni , C. 1994a . Immunologically mediated abortion (IMA) . Ann. NY Acad. Sci. , 734 : 235 – 236 .
  • Giacomucci , E. , Bulletti , C. , Polli , V. , Prefetto , R. A. and Flamigni , C. 1994b . Immunologically mediated abortion (IMA) . J. Steroid Biochem. Mol. Biol. , 49 : 107 – 121 .
  • Goldhaber , M. K. 1990 . The risk of miscarriage and birth defects among women who use visual display terminals during pregnancy . Reprod. Toxicol. , 4 : 57 – 60 .
  • Golub , M. S. , Macintosh , M. S. and Baumrind , N. 1998 . Developmental and reproductive toxicity of inorganic arsenic: Animal studies and human concerns . J. Toxicol. Environ. Health B , 1 : 199 – 241 .
  • Green , D. M. , Fine , W. E. and Li , F. P. 1982 . Offspring of patients treated for unilateral Wilms’ tumor in childhood . Cancer , 49 : 2285 – 2288 .
  • Green , D. M. , Whitton , J. A. , Stovall , M. , Mertens , A. C. , Donaldson , S. S. , Ruymann , F. B. , Pendergrass , T. W. and Robison , L. L. 2002 . Pregnancy outcome of female survivors of childhood cancer: A report from the Childhood Cancer Survivor Study . Am. J. Obstet. Gynecol. , 187 : 1070 – 1080 .
  • Habash , R. W. , Brodsky , L. M. , Leiss , W. , Krewski , D. and Repacholi , M. 2003 . Health risks of electromagnetic fields. Part I: Evaluation and assessment of electric and magnetic fields . Crit. Rev. Biomed. Eng. , 31 : 141 – 195 .
  • Hasegawa , I. , Takakuwa , K. and Tanaka , K. 1996 . The roles of oligomenorrhoea and fetal chromosomal abnormalities in spontaneous abortions . Hum. Reprod. , 11 : 2304 – 2305 .
  • Hassold , T. , Abruzzo , M. , Adkins , K. , Griffin , D. , Merrill , M. , Millie , E. , Saker , D. , Shen , J. and Zaragoza , M. 1996 . Human aneuploidy: incidence, origin, and etiology . Environ. Mol. Mutagen. , 28 : 167 – 175 .
  • Hawkins , M. M. and Smith , R. A. 1989 . Pregnancy outcomes in childhood cancer survivors: Probable effects of abdominal irradiation . Int. J. Cancer , 43 : 399 – 402 .
  • Heidam , L. Z. 1984 . Spontaneous abortions among dental assistants, factory workers, painters, and gardening workers: A follow up study . J. Epidemiol. Commun. Health , 38 : 149 – 155 .
  • Hemminki , K. , Kyyronen , P. and Lindbohm , M. L. 1985 . Spontaneous abortions and malformations in the offspring of nurse exposed to anesthetic gases, cytostatic drugs, and other potential hazards in hosptials, based on registered information of outcome . J. Epidemiol. Commun. Health , 39 : 141 – 147 .
  • Hemminki , K. , Saloniemi , I. , Luoma , K. , Salonen , T. , Partenen , T. , Vainio , H. and Hemminki , E. 1980 . Transplacental carcinogens and mutagens: Childhood cancer, malformations, and abortions as risk indicators . J. Toxicol. Environ. Health , 20 : 370 – 378 .
  • Henriksen , T. B. , Hjollund , N. H. , Jensen , T. K. , Bonde , J. P. , Andersson , A. M. , Kolstad , H. , Ernst , E. , Giwercman , A. , Skakkebaek , N. E. and Olsen , J. 2004 . Alcohol consumption at the time of conception and spontaneous abortion . Am. J. Epidemiol. , 160 : 661 – 667 .
  • Herbst , A. L. , Hubby , M. M. , Azizi , F. and Makii , M. M. 1981 . Reproductive and gynecologic surgical experience in diethylstilbestrol-exposed daughters . Am. J. Obstet. Gynecol. , 141 : 1019 – 1028 .
  • Hertz-Picciotto , I. 2000 . The evidence that lead increases the risk for spontaneous abortion . Am. J. Ind. Med. , 38 : 300 – 309 .
  • Hertz-Picciotto , I. and Howards , P. P. 2003 . Hot tubs and miscarriage—Methodological and substantive reasons why the case is weak . Am. J. Epidemiol. , 158 : 938 – 940 .
  • Hertz-Picciotto , I. , Swan , S. H. , Neutra , R. R. and Samuels , S. J. 1989 . Spontaneous abortions in relation to consumption of tap water: An application of methods from survival analysis to a pregnancy follow-up study . Am. J. Epidemiol. , 130 : 79 – 93 .
  • High Background Radiation Research Group C . 1980 . Health survey in high background radiation areas in China . Science , 209 : 877 – 880 .
  • Hirahara , F. , Andoh , N. , Sawai , K. , Hirabuki , T. , Uemura , T. and Minaguchi , H. 1998 . Hyperprolactinemic recurrent miscarriage and results of randomized bromocriptine treatment trials . Fertil. Steril. , 70 : 246 – 252 .
  • Hjollund , N. H. , Bonde , J. P. , Ernst , E. , Lindenberg , S. , Andersen , A. N. and Olsen , J. 2004 . Pesticide exposure in male farmers and survival of in vitro fertilized pregnancies . Hum. Reprod. , 19 : 1331 – 1337 .
  • Homburg , R. , Armar , N. A. , Eshel , A. , Adams , J. and Jacobs , H. S. 1988 . Influence of serum luteinising hormone concentrations on ovulation, conception, and early pregnancy loss in polycystic ovary syndrome . Br. Med. J. , 297 : 1024 – 1026 .
  • Hooiveld , M. , Haveman , W. , Roskes , K. , Bretveld , R. , Burstyn , I. and Roeleveld , N. 2006 . Adverse reproductive outcomes among male painters with occupational exposure to organic solvents . Occup. Environ. Med. , 63 : 538 – 544 .
  • Ihrig , M. M. , Shalat , S. L. and Baynes , C. 1998 . A hospital-based case-control study of stillbirths and environmental exposure to arsenic using an atmospheric dispersion model linked to a geographical information system . Epidemiology , 9 : 290 – 294 .
  • International Agency for Research on Cancer . 2002 . Some drinking-water disinfectants and contaminants, including arsenic . IARC Monogr. Eval. Carcinogen. Risks Hum. , 84 : 15 – 22 .
  • International Agency for Research on Cancer . 1997 . Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans . IARC Monogr. Eval. Carcinogen. Risks Hum. , 69 : 33
  • International Commission on Radiological Protection . 1990 . Recommendations of the ICRP . Ann. ICRP , 21 : 42 – 46 .
  • International Program on Chemical Safety . 1981 . Arsenic: Environmental health criteria 18 , Geneva : World Health Organization .
  • Jarrell , J. , Gocmen , A. , Foster , W. , Brant , R. , Chan , S. and Sevcik , M. 1998 . Evaluation of reproductive outcomes in women inadvertently exposed to hexachlorobenzene in southeastern Turkey in the 1950s . Reprod. Toxicol. , 12 : 469 – 476 .
  • John , E. M. , Savitz , D. A. and Shy , C. M. 1994 . Spontaneous abortions among cosmetologists . Epidemiology , 5 : 147 – 155 .
  • Kacew , S. 1994 . Fetal consequences and risks attributed to the use of prescribed and over-the-counter (OTC) preparations during pregnancy . Int. J. Clin. Pharmacol. Ther. , 32 : 335 – 343 .
  • Kacew , S. 1995 . “ Neonatal toxicology ” . In General and applied toxicology , Edited by: Ballantyne , B. , Marrs , T. and Turner , P. 983 – 1004 . London : Macmillan Press .
  • Källén , B. 1988 . Epidemiology of human reproduction , Boca Raton, FL : CRC Press .
  • Kalousek , D. K. , Pantzar , T. , Tsai , M. and Paradice , B. 1993 . Early spontaneous abortion: Morpholic and karyotipic findings in 3912 cases . Birth Defects Orig. Artic Ser. , 29 : 53 – 61 .
  • Kerkvliet , N. I. 1995 . Immunological effects of chlorinated dibenzo-p-dioxins . Environ. Health Perspect. , 9 : 47 – 53 .
  • Kesmodel , U. 2001 . Binge drinking in pregnancy—Frequency and methodology . Am. J. Epidemiol. , 154 : 777 – 782 .
  • Kesmodel , U. , Wisborgm , K. , Olsenm , S. F. , Henriksenm , T. B. and Secher , N. J. 2002 . Moderate alcohol intake in pregnancy and the risk of spontaneous abortion . Alcohol Alcohol. , 37 : 87 – 92 .
  • Key , T. J. , Pike , M. C. , Brown , J. B. , Hermon , C. , Allen , D. S. and Wang , D. Y. 1996 . Cigarette smoking and urinary oestrogen excretion in premenopausal and post-menopausal women . Br. J. Cancer , 74 : 1313 – 1316 .
  • Khan , M. Y. , Mah , M. W. and Memish , Z. A. 2001 . Brucellosis in pregnant women . Clin. Infect. Dis. , 32 : 1172 – 1177 .
  • Khanjani , N. and Sim , M. R. 2006a . Maternal contamination with dichlorodiphenyltrichloroethane and reproductive outcomes in an Australian population . Environ. Res. , 101 : 373 – 379 .
  • Khanjani , N. and Sim , M. R. 2006b . Maternal contamination with PCBs and reproductive outcomes in an Australian population . J. Exp. Sci. Environ. Epidemiol. , 17 : 191 – 195 .
  • Khanjani , N. and Sim , M. R. 2006c . Reproductive outcomes of maternal contamination with cyclodiene insecticides, hexachlorobenzene and beta-benzene hexachloride . Sci. Total Environ. , 368 : 557 – 564 .
  • Kharrazi , M. , Potashnik , G. and Goldsmith , J. R. 1980 . Reproductive effects of dibromochlorpropane . Isr. J. Med. Sci. , 16 : 403 – 406 .
  • Klebanoff , M. A. , Levine , R. J. , DerSimonian , R. , Clemens , J. D. and Wilkins , D. G. 1999 . Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion . N. Engl. J. Med. , 341 : 1639 – 1644 .
  • Kline , J. , Stein , Z. , Susser , M. and Warburton , D. 1985 . Fever during pregnancy and spontaneous abortion . Am. J. Epidemiol. , 121 : 832 – 842 .
  • Knutti , R. , Rothweiler , H. and Schlatter , C. 1982 . The effect of pregnancy on the pharmacokinetics of caffeine . Arch. Toxicol. Suppl. , 5 : 187 – 192 .
  • Kojima , H. , Katsura , E. , Takeuchi , S. , Niiyama , K. and Kobayashi , K. 2004 . Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells . Environ. Health Perspect. , 112 : 524 – 531 .
  • Korrick , S. A. , Chen , C. , Damokosh , A. I. , Ni , J. , Liu , X. , Cho , S. I. , Altshul , L. , Ryan , L. and Xu , X. 2001 . Association of DDT with spontaneous abortion: A case-control study . Ann. Epidemiol. , 11 : 491 – 496 .
  • Kristensen , P. , Irgens , L. M. , Andersen , A. , Bye , A. S. and Sundheim , L. 1997 . Gestational age, birth weight, and perinatal death among births to Norwegian farmers, 1967–1991 . Am. J. Epidemiol. , 146 : 329 – 338 .
  • Kujovich , J. L. 2004 . Thrombophilia and pregancy complications . Am. J. Obstet. Gynecol. , 191 : 412 – 424 .
  • Kundiev , Y. I. 1994 . Actual medical and ergonomic problems in agriculture in the Ukraine . Int. J. Occup. Med. Environ. Health , 7 : 3 – 11 .
  • Lasley , B. L. and Overstreet , J. W. 1998 . Biomarkers for assessing human female reproductive health, an interdisciplinary approach . Environ. Health Perspect. , 4 : 955 – 960 .
  • Lazarus , J. H. and Kokandi , A. 2000 . Thyroid disease in relation to pregnancy: A decade of change . Clin. Endocrinol. (Oxf.) , 53 : 265 – 278 .
  • Lee , G. M. , Neutra , R. R. , Hristova , L. , Yost , M. and Hiatt , R. A. 2002 . A nested case-control study of residential and personal magnetic field measures and miscarriages . Epidemiology , 13 : 21 – 31 .
  • Lembrych , S. , Lorenz , K. , Guzikowski , W. and Plucinska , K. 1986 . Evaluation of the presence of polychlorinated insecticides (pesticides) in trophoblasts from spontaneous and artificial abortions . Ginekol. Pol. , 57 : 353 – 356 .
  • Leoni , V. , Fabiani , L. , Marinelli , G. , Morini , A. , Aleandri , V. , Pozzi , V. , Cappa , F. , Barbati , D. , Puccetti , G. and Tarsitani , G. F. 1986 . Spontaneous abortion in relation to the presence of hexachlorobenzene in the Italian environment . IARC Sci. Publ. , 14 : 3 – 146 .
  • Leviton , A. and Cowan , L. 2002 . A review of the literature relating caffeine consumption by women to their risk of reproductive hazards . Food Chem. Toxicol. , 40 : 1271 – 1310 .
  • Li , D. K. , Janevic , T. , Odouli , R. and Liu , L. 2003 . Hot tub use during pregnancy and the risk of miscarriage . Am. J. Epidemiol. , 158 : 931 – 937 .
  • Li , D. K. , Odouli , R. , Wi , S. , Janevic , T. , Golditch , I. , Bracken , T. D. , Senior , R. , Rankin , R. and Iriye , R. 2002 . A population-based prospective cohort study of personal exposure to magnetic fields during pregnancy and the risk of miscarriage . Epidemiology , 13 : 9 – 20 .
  • Li , D. K. , Zhou , Q. D. , Qin , X. B. , Sun , R. M. , Zhu , X. L. , Cheng , H. J. , Wang , C. S. , He , J. P. , Qian , C. X. and Xue , S. Z. 1986 . An epidemiological study on the effect of N, N’-methylene-bis-(2-amino-1,3,4-thiadiazole) (MATDA) on outcomes of pregnancy . Teratology , 33 : 289 – 297 .
  • Li , F. P. , Gimbrere , K. , Gelber , R. D. , Sallan , S. E. , Flamant , F. , Green , D. M. , Heyn , R. M. and Meadows , A. T. 1987 . Outcome of pregnancy in survivors of Wilms’ tumor . J. Am. Med. Assoc. , 257 : 216 – 219 .
  • Lindbohm , M. L. , Hemminki , K. and Kyyronen , P. 1984 . Parental occupational exposure and spontaneous abortions in Finland . Am. J. Epidemiol. , 120 : 370 – 378 .
  • Lindbohm , M. L. , Anttila , S. M. , Taskinen , H. and Hemminki , K. 1991 . Paternal occupational lead exposure and spontaneous abortion . Scand. J. Work Environ. Health , 17 : 95 – 103 .
  • Longnecker , M. P. , Klebanoff , M. A. , Dunson , D. B. , Guo , X. , Chen , Z. , Zhou , H. and Brock , J. W. 2005 . Maternal serum level of the DDT metabolite DDE in relation to fetal loss in previous pregnancies . Environ. Res. , 97 : 127 – 133 .
  • Lynberg , M. C. , Khoury , M. J. , Lu , X. and Cocian , T. 1994 . Maternal flu, fever, and the risk of neural tube defects: A population-based case-control study . Am. J. Epidemiol. , 140 : 244 – 255 .
  • Manassaram , D. M. , Backer , L. C. and Moll , D. M. 2006 . A review of nitrates in drinking water: Maternal exposure and adverse reproductive and developmental outcomes . Environ. Health Perspect. , 114 : 320 – 327 .
  • Mandell , G. L. , Bennet , J. E. and Dolin , R. 2000 . Mandell, Douglas and Bennett's principles and practice of infectious diseases , Philadelphia : Churchill Livingstone .
  • Martin , R. H. and Rademaker , A. 1995 . Reliability of aneuploidy estimates in human sperm: Results of fluorescence in situ hybridization studies using two different scoring criteria . Mol. Reprod. Dev. , 42 : 89 – 93 .
  • Matos , E. L. , Loria , D. I. , Albiano , N. , Sobel , N. and de Bujan , E. C. 1987 . Pesticides in intensive cultivation: Effects on working conditions and workers’ health . Bull. Pan Am. Health Organ. , 21 : 405 – 416 .
  • Mazorchuk , B. F. , Zhukova , O. S. , Mazorchuk , S. G. and Fedorchenko , V. S. 1974 . Content of certain chloroganic pesticides in the blood of pregnant women and embryos after miscarriage . Pediatr. Akus. Ginekol. , 5 : 9 – 61 .
  • McDonald , A. D. , Armstrong , B. , Cherry , N. M. , Delorme , C. , Diodati-Nolin , A. , McDonald , J. C. and Robert , D. 1986 . Spontaneous abortion and occupation . J. Occup. Med. , 28 : 1232 – 1238 .
  • McDonald , A. D. , McDonald , J. C. , Armstrong , B. , Cherry , N. M. , Cote , R. , Lavoie , J. , Nolin , A. D. and Robert , D. 1988 . Fetal death and work in pregnancy . Br. J. Ind. Med. , 45 : 148 – 157 .
  • McKinney , J. D. and Waller , C. L. 1998 . Molecular determinants of hormone mimicry: Halogenated aromatic hydrocarbon environmental agents . J. Toxicol. Environ. Health B , 1 : 27 – 58 .
  • McNulty , W. P. 1985 . Toxicity and fetotoxicity of TCDD, TCDF and PCB isomers in rhesus macaques (Macaca mulatta) . Environ. Health Perspect. , 60 : 77 – 88 .
  • Mendola , P. , Buck , G. M. , Vena , J. E. , Zielezny , M. and Sever , L. E. 1995 . Consumption of PCB-contaminated sport fish and risk of spontaneous fetal death . Environ. Health Perspect. , 103 : 498 – 502 .
  • Mestman , J. H. 2002 . Historical notes on diabetes and pregnancy . Endocrinologist , 12 : 224 – 242 .
  • Meyer , R. E. , Aldrich , T. E. and Easterly , C. E. 1989 . Effects of noise and electromagnetic fields on reproductive outcomes . Environ. Health Perspect. , 81 : 193 – 200 .
  • Miller , P. , Smith , D. W and Shepard , T. H. 1978 . Maternal hyperthermia as a possible cause of anencephaly . Lancet , 1 : 519 – 521 .
  • Milton , A. H. , Smith , W. , Rahman , B. , Hasan , Z. , Kulsum , U. , Dear , K. , Rakibuddin , M. and Ali , A. 2005 . Chronic arsenic exposure and adverse pregnancy outcomes in bangladesh . Epidemiology , 16 : 82 – 86 .
  • Milunsky , A. , Ulcickas , M. , Rothman , K. J. , Willett , W. , Jick , S. S. and Jick , H. 1992 . Maternal heat exposure and neural tube defects . J. Am. Med. Assoc. , 268 : 882 – 885 .
  • Mishra , G. D. , Dobson , A. J. and Schofield , M. J. 2000 . Cigarette smoking, menstrual symptoms and miscarriage among young women . Aust. N. Z. J. Public Health , 24 : 413 – 420 .
  • Muckle , G. , Ayotte , P. , Dewailly , E. , Jacobson , S. W. and Jacobson , J. L. 2001 . Determinants of polychlorinated biphenyls and methylmercury exposure in inuit women of childbearing age . Environ. Health Perspect. , 109 : 957 – 963 .
  • Murphy , H. H. , Sanusi , A. , Dilts , D. R. , Djajadisastra , M. , Hirschhorn , N. and Yuliantiningsih , S. 2000 . Health effects of pesticide use among Indonesian women farmers. II: Reproductive health outcomes . J. Agromed. , 6 : 27 – 43 .
  • National Institute for Occupational Safety and Health. 2006. Organic solvents [online]. http://www.cdc.gov/niosh/topics/organsolv/ (Accessed: 10 July 2007 ).
  • National Research Council . 1999 . Hormonally active agents in the environment , Washington, DC : National Academy of Sciences .
  • Nielsen , A. , Hannibal , C. G. , Lindekilde , B. E. , Tolstrup , J. , Frederiksen , K. , Munk , C. , Bergholt , T. , Buss , L. , Ottesen , B. , Gronbaek , M. and Kjaer , S. K. 2006 . Maternal smoking predicts the risk of spontaneous abortion . Acta Obstet. Gynecol. Scand. , 85 : 1057 – 1065 .
  • Niswender , G. D. , Juengel , J. L. , Silva , P. J. , Rollyson , M. K. and McIntush , E. W. 2000 . Mechanisms controlling the function and life span of the corpus luteum . Physiol. Rev. , 80 : 1 – 29 .
  • Nordstrom , S. , Birke , E. and Gustavsson , L. 1983 . Reproductive hazards among workers at high voltage substations . Bioelectromagnetics , 4 : 91 – 101 .
  • Nurminen , T. 1998 . Shift work and reproductive health . Scand. J. Work Environ. Health , 3 : 28 – 34 .
  • Nurminen , T. and Kurppa , K. 1989 . Occupational noise exposure and course of pregnancy . Scand. J. Work Environ. Health , 15 : 117 – 124 .
  • O'Leary , J. A. , Davies , J. E. and Feldman , M. 1970 . Spontaneous abortion and human pesticide residues of DDT and DDE . Am. J. Obstet. Gynecol. , 108 : 1291 – 1292 .
  • O'Rahilly , R. and Muller , F. 2001 . Human embryology and teratology , New York : Wiley-Liss .
  • Ohno , M. , Maeda , T. and Matsunobu , A. 1991 . A cytogenetic study of spontaneous abortions with direct analysis of chorionic villi . Obstet. Gynecol. , 77 : 394 – 398 .
  • Okon , M. A. , Laird , S. M. , Tuckerman , E. M. and Li , T. C. 1998 . Serum androgen levels in women who have recurrent miscarriages and their correlation with markers of endometrial function . Fertil. Steril. , 69 : 682 – 690 .
  • Olfert , S. M. 2006 . Reproductive outcomes among dental personnel: A review of selected exposures . J. Can. Dent. Assoc. , 72 : 821 – 825 .
  • Olsen , J. and Torsten , S. 1993 . Design options and methodological fallacies in the studies of reproductive failures . Environ. Health Perspect. , 101 : 145 – 152 .
  • Padungtod , C. , Hassold , T. J. , Millie , E. , Ryan , L. M. , Savitz , D. A. , Christiani , D. C. and Xu , X. 1999 . Sperm aneuploidy among Chinese pesticide factory workers: Scoring by the FISH method . Am. J. Ind. Med. , 36 : 230 – 238 .
  • Palmiter , R. and Mulvihill , E. R. 1978 . Estrogenic activity of the insecticide kepone on the chicken oviduct . Science , 201 : 356 – 358 .
  • Pan American Health Organization . 2002 . Epidemiologic situation of acute pesticide poisoning in Central America, 1992–2000 . Epidemiol. Bull. , 23 : 5 – 9 .
  • Parron , T. , Hernandez , A. F. , Pla , A. and Villanueva , E. 1996 . Clinical and biochemical changes in greenhouse sprayers chronically exposed to pesticides . Hum. Exp. Toxicol. , 15 : 957 – 963 .
  • Peraica , M. , Radic , B. , Lucic , A. and Pavlovic , M. 1999 . Toxic effects of mycotoxins in humans . Bull. WHO , 77 : 754 – 766 .
  • Peterka , M. , Peterkova , R. and Likovsky , Z. 1996 . Teratogenic and lethal effects of long-term hyperthermia and hypothermia in the chick embryo . Reprod. Toxicol. , 10 : 327 – 332 .
  • Petitti , D. B. 1992 . Opening Pandora's box . Epidemiology , 3 : 78 – 81 .
  • Petrelli , G. , Figa-Talamanca , I. , Tropeano , R. , Tangucci , M. , Cini , C. , Aquilani , S. , Gasperini , L. and Meli , P. 2000 . Reproductive male-mediated risk: Spontaneous abortion among wives of pesticide applicators . Eur. J. Epidemiol. , 16 : 391 – 393 .
  • Philipp , T. and Kalousek , D. K. 2002 . Generalized abnormal embryonic development in missed abortion: Embryoscopic and cytogenetic findings . Am. J. Med. Genet. , 111 : 43 – 47 .
  • Pirkle , J. L , Wolfe , W. H. , Patterson , D. G. , Needham , L. L. , Michalek , J. E. , Miner , J. C. , Peterson , M. R. and Phillips , D. L. 1989 . Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam Veterans of Operation Ranch Hand . J. Toxicol. Environ. Health , 27 : 165 – 171 .
  • Potashnik , G. and Yanai-Inbar , I. 1987 . Dibromochloropropane (DBCP): An 8-year reevaluation of testicular function and reproductive performance . Fertil. Steril. , 47 : 317 – 323 .
  • Rachootin , P. and Olsen , J. 1983 . The risk of infertility and delayed conception associated with exposures in the Danish workplace . J. Occup. Med. , 25 : 394 – 402 .
  • Rand , J. H. 1998 . Antiphospholipid antibody syndrome: New insights on thrombogenic mechanisms . Am. J. Med. Sci. , 316 : 142 – 151 .
  • Rasch , V. 2003 . Cigarette, alcohol, and caffeine consumption: Risk factors for spontaneous abortion . Acta Obstet. Gynecol. Scand. , 82 : 182 – 188 .
  • Recio , R. , Robbins , W. A. , Borja-Aburto , V. , Moran-Martinez , J. , Froines , J. R. , Hernandez , R. M. and Cebrian , M. E. 2001 . Organophosphorous pesticide exposure increases the frequency of sperm sex null aneuploidy . Environ. Health Perspect. , 109 : 1237 – 1240 .
  • Regan , L. , Owen , E. J. and Jacobs , H. S. 1990 . Hypersecretion of luteinising hormone, infertility, and miscarriage . Lancet , 336 : 1141 – 1144 .
  • Restrepo , M. , Munoz , N. , Day , N. , Parra , J. E. , Romero , L. and Nguyen-Dinh , X. 1990 . Prevalence of adverse reproductive outcomes in a population occupationally exposed to pesticides in Colombia . Scand. J. Work Environ. Health , 16 : 232 – 238 .
  • Revich , B. , Aksel , E. , Ushakova , T. , Ivanova , I. , Zhuchenko , N. , Klyuev , N. , Brodsky , B. and Sotskov , Y. 2001 . Dioxin exposure and public health in Chapaevsk, Russia . Chemosphere , 43 : 951 – 966 .
  • Rhainds , M. , Levallois , P. , Dewailly , E. and Ayotte , P. 1999 . Lead, mercury, and organochlorine compound levels in cord blood in Quebec, Canada . Arch. Environ. Health , 54 : 40 – 47 .
  • Rita , P. , Reddy , P. P. and Reddy , S. V. 1987 . Monitoring of workers occupationally exposed to pesticides in grape gardens of Andhra Pradesh . Environ. Res. , 44 : 1 – 5 .
  • Roan , C. C. , Matanoski , G. E. , McIlnay , C. Q. , Olds , K. L. , Pylant , F. , Trout , J. R. , Wheeler , P. and Morgan , D. P. 1984 . Spontaneous abortions, stillbirths, and birth defects in families of agricultural pilots . Arch. Environ. Health , 39 : 56 – 60 .
  • Rogan , W. J. , Gladen , B. C. and Wilcox , A. J. 1985 . Potential reproductive and postnatal morbidity from exposure to polychlorinated biphenyls: Epidemiologic considerations . Environ. Health Perspect. , 60 : 233 – 239 .
  • Ronis , M. J. , Badger , T. M. , Shema , S. J. , Roberson , P. K. , Templer , L. , Ringer , D. and Thomas , P. E. 1998a . Endocrine mechanisms underlying the growth effects of developmental lead exposure in the rat . J. Toxicol. Environ. Health A , 54 : 101 – 120 .
  • Ronis , M. J , Gandy , J. and Badger , T. 1998b . Endocrine mechanisms underlying reproductive toxicity in the developing rat chronically exposed to dietary lead . J. Toxicol. Environ. Health A , 54 : 77 – 99 .
  • Rowland , A. S. , Baird , D. D. , Shore , D. L. , Darden , B. and Wilcox , A. J. 1996 . Ethylene oxide exposure may increase the risk of spontaneous abortion, preterm birth, and postterm birth . Epidemiology , 7 : 363 – 368 .
  • Roy , D. , Palangat , M. , Chen , C.-W. , Thomas , R. D. , Colerangle , J. , Atkinson , A. and Yan , Z.-J. 1997 . Biochemical and molecular changes at the cellular level in response to exposure to environmental estrogen-like chemicals . J. Toxicol. Environ. Health , 50 : 1 – 29 .
  • Rupa , D. S. , Reddy , P. P. and Reddi , O. S. 1991 . Reproductive performance in population exposed to pesticides in cotton fields in India . Environ. Res. , 55 : 123 – 128 .
  • Saillenfait , A. M. and Robert , E. 2000 . Occupational exposure to organic solvents and pregnancy. Review of current epidemiologic knowledge . Rev. Epidemiol. Sante Publique , 48 : 374 – 388 .
  • Salazar-Garcia , F. , Gallardo-Diaz , E. , Ceron-Mireles , P. , Loomis , D. and Borja-Aburto , V. H. 2004 . Reproductive effects of occupational DDT exposure among male malaria control workers . Environ. Health Perspect. , 112 : 542 – 547 .
  • Savitz , D. A. and Ananth , C. V. 1994 . Residential magnetic fields, wire codes, and pregnancy outcome . Bioelectromagnetics , 15 : 271 – 273 .
  • Savitz , D. A. , Andrews , K. W. and Pastore , L. M. 1995 . Drinking water and pregnancy outcome in central North Carolina: Source, amount, and trihalomethane levels . Environ. Health Perspect. , 103 : 592 – 596 .
  • Savitz , D. A. , Arbuckle , T. , Kaczor , D. and Curtis , K. M. 1997 . Male pesticide exposure and pregnancy outcome . Am. J. Epidemiol. , 146 : 1025 – 1036 .
  • Savitz , D. A. , Singer , P. C. , Herring , A. H. , Hartmann , K. E. , Weinberg , H. S. and Makarushka , C. 2006 . Exposure to drinking water disinfection by-products and pregnancy loss . Am. J. Epidemiol. , 164 : 1043 – 1051 .
  • Savitz , D. A. , Sonnenfeld , N. L. and Olshan , A. F. 1994 . Review of epidemiologic studies of paternal occupational exposure and spontaneous abortion . Am. J. Ind. Med. , 25 : 361 – 383 .
  • Saxena , M. C. , Siddiqui , M. K. , Bhargava , A. K. , Seth , T. D. , Krishnamurti , C. R. and Kutty , D. 1980 . Role of chlorinated hydrocarbon pesticides in abortions and premature labour . Toxicology , 17 : 323 – 331 .
  • Saxena , M. C. , Siddiqui , M. K. , Seth , T. D. , Krishna Murti , C. R. , Bhargava , A. K. and Kutty , D. 1981 . Organochlorine pesticides in specimens from women undergoing spontaneous abortion, premature of full-term delivery . J. Anal. Toxicol. , 5 : 6 – 9 .
  • Schenker , M. B. , Samuels , S. J. , Green , R. S. and Wiggins , P. 1990 . Adverse reproductive outcomes among female veterinarians . Am. J. Epidemiol. , 132 : 96 – 106 .
  • Schmitz , J. T. 1961 . Methemoglobinemia—A cause of abortions? Preliminary report . Obstet. Gynecol. , 17 : 413 – 415 .
  • Schnorr , T. M. , Lawson , C. C. , Whelan , E. A. , Dankovic , D. A. , Deddens , J. A. , Piacitelli , L. A. , Reefhuis , J. , Sweeney , M. H. , Connally , L. B. and Fingerhut , M. A. 2001 . Spontaneous abortion, sex ratio, and paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin . Environ. Health Perspect. , 109 : 1127 – 1132 .
  • Schuurs , A. H. 1999 . Reproducive toxicity of occupational mercury. A review of the literature . J. Dent. , 27 : 249 – 256 .
  • Selevan , S. G. , Lindbohm , M. L. , Hornung , R. W. and Hemminki , K. 1985 . A study of occupational exposure to antineoplastic drugs and fetal loss in nurses . N. Engl. J. Med. , 313 : 1173 – 1178 .
  • Shaw , G. M. 2001 . “ Adverse human reproductive outcomes and electromagnetic fields: A brief summary of the epidemiologic literature ” . In Bioelectromagnetics , S5 – 18 . Suppl 5 .
  • Shaw , G. M. , Todoroff , K. , Velie , E. M. and Lammer , E. J. 1998 . Maternal illness, including fever and medication use as risk factors for neural tube defects . Teratology , 57 : 1 – 7 .
  • Shi , Q. and Martin , R. H. 2000 . Aneuploidy in human sperm: A review of the frequency and distribution of aneuploidy, effects of donor age and lifestyle factors . Cytogenet. Cell. Genet. , 90 : 219 – 226 .
  • Shiota , K. 1982 . Neural tube defects and maternal hyperthermia in early pregnancy: epidemiology in a human embryo population . Am. J. Med. Genet. , 12 : 281 – 288 .
  • Signorello , L. B. and McLaughlin , J. K. 2004 . Maternal caffeine consumption and spontaneous abortion: A review of the epidemiologic evidence . Epidemiology , 15 : 229 – 239 .
  • Skov , T. , Maarup , B. , Olsen , J. , Rorth , M. , Winthereik , H. and Lynge , E. 1992 . Leukaemia and reproductive outcome among nurses handling antineoplastic drugs . Br. J. Ind. Med. , 49 : 855 – 861 .
  • Skrivan , J. 1971 . Methemoglobinemia in pregnancy (clinical and experimental study) . Acta Univ. Carol. [Med.] (Praha) , 17 : 123 – 161 .
  • Slutsker , L. 1992 . Risks associated with cocaine use during pregnancy . Obstet. Gynecol. , 79 : 778 – 789 .
  • Smith , A. H. , Fisher , D. O. , Pearce , N. and Chapman , C. J. 1982 . Congenital defects and miscarriages among New Zealand 2,4,5-T sprayers . Arch. Environ. Health , 37 : 197 – 200 .
  • Sommer , K. R. , Hill , R. M. and Horning , M. G. 1975 . Identification and quantification of drugs in human amniotic fluid . Res. Commun. Chem. Pathol. Pharmacol. , 12 : 583 – 595 .
  • Sonnenschein , C. and Soto , A. M. 1998 . An updated review of environmental estrogen and androgen mimics and antagonists . J. Steroid. Biochem. Mol. Biol. , 65 : 143 – 150 .
  • Soto , A. M. , Chung , K. L. and Sonnenschein , C. 1994 . The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells . Environ. Health Perspect. , 102 : 380 – 383 .
  • Soyka , L. F. , Neese , A. L. , Main , D. and Main , E. 1981 . Studies of caffeine and theophylline in the neonate . Semin. Perinatol. , 5 : 332 – 336 .
  • Speroff , L. , Glass , R. H. and Kase , N. G. 1999 . Clinical gynecologic endocrinology and infertility , Philadelphia : Lippincott Williams & Wilkins .
  • Stachel , B. , Dougherty , R. C. , Lahl , U. , Schlosser , M. and Zeschmar , B. 1989 . Toxic environmental chemicals in human semen: Analytical method and case studies . Andrologia , 21 : 282 – 291 .
  • Statistics Canada. 2004. Vital statistics—Stillbirth database [online] http://www.statcan.ca/english/sdds/3234.htm (Accessed: 10 July 2007 ).
  • Steele , L. L. and Wilkins , J. R. III . 1996 . Occupational exposures and risks of spontaneous abortion among female veterinarians . Int. J. Occup. Environ. Health , 2 : 26 – 36 .
  • Stein , Z. and Susser , M. 1991 . Miscarriage, caffeine, and the epiphenomena of pregnancy: The causal model . Epidemiology , 2 : 163 – 167 .
  • Stenvenson , R. E. , Hall , J. G. and Goodman , R. M. 1993 . Human malformations and related anomalies , New York : Oxford University Press .
  • Strom , C. M. , Ginsberg , N. , Applebaum , M. , Bozorgi , N. , White , M. , Caffarelli , M. and Verlinsky , Y. 1992 . Analyses of 95 first-trimester spontaneous abortions by chorionic villus sampling and karyotype . J. Assist. Reprod. Genet. , 9 : 458 – 461 .
  • Stucker , I. , Caillard , J. F. , Collin , R. , Gout , M. , Poyen , D. and Hemon , D. 1990 . Risk of spontaneous abortion among nurses handling antineoplastic drugs . Scand. J. Work Environ. Health , 16 : 102 – 107 .
  • Sugiura-Ogasawara , M. , Ozaki , Y. , Sonta , S. , Makino , T. and Suzumori , K. 2003 . PCBs, hexachlorobenzene and DDE are not associated with recurrent miscarriage . Am. J. Reprod. Immunol. , 50 : 485 – 489 .
  • Suskind , R. R. and Hertzberg , V. S. 1984 . Human health effects of 2,4,5-T and its toxic contaminants . J. Am. Med. Assoc. , 251 : 2372 – 2380 .
  • Tannenbaum , T. N. and Goldberg , R. J. 1985 . Exposure to anesthetic gases and reproductive outcome. A review of the epidemiologic literature . J. Occup. Med. , 27 : 659 – 668 .
  • Thellin , O. , Coumans , B. , Zorzi , W. , Igout , A. and Heinen , E. 2000 . Tolerance to the foeto-placental ‘graft’: Ten ways to support a child for nine months . Curr. Opin. Immunol. , 12 : 731 – 737 .
  • Thellin , O. and Heinen , E. 2003 . Pregnancy and the immune system: Between tolerance and rejection . Toxicology , 185 : 179 – 184 .
  • Thomas , D. C. , Petitti , D. B. , Goldhaber , M. , Swan , S. H. , Rappaport , E. B. and Hertz-Picciotto , I. 1992 . Reproductive outcomes in relation to malathion spraying in the San Francisco Bay Area, 1981–1982 . Epidemiology , 3 : 32 – 39 .
  • Tikkanen , J. and Heinonen , O. P. 1991 . Maternal hyperthermia during pregnancy and cardiovascular malformations in the offspring . Eur. J. Epidemiol. , 7 : 628 – 635 .
  • Tolstrup , J. S. , Kjaer , S. K. , Munk , C. , Madsen , L. B. , Ottesen , B. , Bergholt , T. and Gronbaek , M. 2003 . Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion? . Hum. Reprod. , 18 : 2704 – 2710 .
  • Tryphonas , H. 1995 . Immunotoxicity of PCBs (Aroclors) in relation to Great Lakes . Environ. Health Perspect. , 9 : 35 – 46 .
  • Tulppala , M. , Stenman , U. H. , Cacciatore , B. and Ylikorkala , O. 1993 . Polycystic ovaries and levels of gonadotrophins and androgens in recurrent miscarriage: Prospective study in 50 women . Br. J. Obstet. Gynaecol. , 100 : 348 – 352 .
  • Ulstein , M. , Jensen , T. S. , Irgens , L. M. , Lie , R. T. and Sivertsen , E. 1990 . Outcome of pregnancy in one Norwegian county 3 years prior to and 3 years subsequent to the Chernobyl accident . Acta Obstet. Gynecol. Scand. , 69 : 277 – 280 .
  • UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation) . 1993 . The 1993 Report , New York : United Nations .
  • Valanis , B. , Vollmer , W.M. and Steele , P. 1999 . Occupational exposure to antineoplastic agents: Self-reported miscarriages and stillbirths among nurses and pharmacists . J. Occup. Environ. Med. , 41 : 632 – 638 .
  • Vaughan , T. L. , Daling , J. R. and Starzyk , P. M. 1984 . Fetal death and maternal occupation. An analysis of birth records in the State of Washington . J. Occup. Med. , 26 : 676 – 678 .
  • Vial , T. , Nicolas , B. and Descotes , J. 1996 . Clinical immunotoxicity of pesticides . J. Toxicol. Environ. Health , 48 : 215 – 229 .
  • Vinatier , D. , Dufour , P. , Cosson , M. and Houpeau , J. L. 2001 . Antiphospholipid syndrome and recurrent miscarriages . Eur. J. Obstet. Gynecol. Reprod. Biol. , 93 : 37 – 50 .
  • von Ehrenstein , O. S. , Guha Mazumder , D. N. , Hira-Smith , M. , Ghosh , N. , Yuan , Y. , Windham , G. , Ghosh , A. , Haque , R. , Lahiri , S. , Kalman , D. , Das , S. and Smith , A. H. 2006 . Pregnancy outcomes, infant mortality, and arsenic in drinking water in West Bengal, India . Am. J. Epidemiol. , 163 : 662 – 669 .
  • Waller , K. , Swan , S. H. , DeLorenze , G. and Hopkins , B. 1998 . Trihalomethanes in drinking water and spontaneous abortion . Epidemiology , 9 : 134 – 140 .
  • Werler , M. M. 1997 . Teratogen update: smoking and reproductive outcomes . Teratology , 55 : 382 – 388 .
  • Wertheimer , N. and Leeper , E. 1989 . Fetal loss associated with two seasonal sources of electromagnetic field exposure . Am. J. Epidemiol. , 129 : 220 – 224 .
  • Wilcox , A. J. , Weinberg , C. R. , O'Connor , J. F. , Baird , D. D. , Schlatterer , J. P. , Canfield , R. E. , Armstrong , E. G. and Nisula , B. C. 1988 . Incidence of early loss of pregnancy . N. Engl. J. Med. , 319 : 189 – 194 .
  • Wilson , J. G. and Fraser , F. C. 1977 . Handbook of teratology , New York : Plenum Press .
  • Windham , G. C. , Swan , S. H. and Fenster , L. 1992 . Parental cigarette smoking and the risk of spontaneous abortion . Am. J. Epidemiol. , 135 : 1394 – 1403 .
  • Windham , G. C. , Von Behren , J. , Fenster , L. , Schaefer , C. and Swan , S. H. 1997 . Moderate maternal alcohol consumption and risk of spontaneous abortion . Epidemiology , 8 : 509 – 514 .
  • Wisborg , K. , Kesmodel , U. , Henriksen , T. B. , Hedegaard , M. and Secher , N. J. 2003 . A prospective study of maternal smoking and spontaneous abortion . Acta Obstet. Gynecol. Scand. , 82 : 936 – 941 .
  • Wolfe , W. H. , Michalek , J. E. , Miner , J. C. , Rahe , A. J. , Moore , C. A. , Needham , L. L. and Patterson , D. G. Jr. 1995 . Paternal serum dioxin and reproductive outcomes among veterans of Operation Ranch Hand . Epidemiology , 6 : 17 – 22 .
  • World Health Organization . 1977 . Recommended defintions, terminology and format for statistical tables related to the perinatal period and use of new certificate for cause of perinatal deaths (modifications recommended by FIGO as amended October 14, 1976) . Acta Obstet. Gynecol. Scand. , 56 : 247 – 253 .
  • World Health Organization . 2002 . Global assessment of the state-of-the-science of endocrine disruptors , Geneva : World Health Organization .
  • Wrensch , M. , Swan , S. H. , Lipscomb , J. , Epstein , D. M. , Neutra , R. R. and Fenster , L. 1992 . Spontaneous abortions and birth defects related to tap and bottled water use, San Jose, California, 1980–1985 . Epidemiology , 3 : 98 – 103 .
  • Wulff , M. , Hogberg , U. and Stenlund , H. 2002 . Occupational and environmental risks of spontaneous abortions around a smelter . Am. J. Ind. Med. , 41 : 131 – 138 .
  • Xu , X. , Cho , S. I. , Sammel , M. , You , L. , Cui , S. , Huang , Y. , Ma , G. , Padungtod , C. , Pothier , L. , Niu , T. , Christiani , D. , Smith , T. , Ryan , L. and Wang , L. 1998 . Association of petrochemical exposure with spontaneous abortion . Occup. Environ. Med. , 55 : 31 – 36 .
  • Zahm , S. H. , Ward , M. H. and Blair , A. 1997 . Pesticides and cancer . Occup. Med. State Art Rev. , 12 : 269 – 289 .
  • Zeljezic , D. and Garaj-Vrhovac , V. 2002 . Sister chromatid exchange and proliferative rate index in the longitudinal risk assessment of occupational exposure to pesticides . Chemosphere , 46 : 295 – 303 .
  • Zhou , C. R. 1990 . Cytogenetic studies of spontaneous abortions in humans . Zhonghua Fu Chan Ke Za Zhi , 25 : 89 – 91 . 124
  • Zinaman , M. J. , Clegg , E. D. , Brown , C. C. , O'Connor , J. and Selevan , S. G. 1996 . Estimates of human fertility and pregnancy loss . Fertil. Steril. , 65 : 503 – 509 .

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