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Original Articles

Neuroendocrine Disruption: More Than Hormones are Upset

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Pages 270-291 | Published online: 26 Jul 2011

REFERENCES

  • Basu , N. , Ta , C. A. , Waye , A. , Mao , J. , Hewitt , M. , Arnason , J. T. and Trudeau , V. L. 2009 . Pulp and paper mill effluents contain neuroactive substances that potentially disrupt neuroendocrine control of fish reproduction . Environ. Sci. Technol. , 43 : 1635 – 1641 .
  • Basu , N. , Scheuhammer , A. M. , Rouvinen-Watt , K. , Evans , R. D. , Trudeau , V. L. and Chan , L. H. M. 2010 . In vitro and whole animal evidence that methylmercury disrupts GABAergic systems in discrete brain regions in captive mink . Comp. Biochem. Physiol. Part C Toxicol. Pharmacol. , 151 : 379 – 385 .
  • Berg , C. , Gyllenhammar , I. and Kvarnryd , M. 2009 . Xenopus tropicalis as a test system for developmental and reproductive toxicity . J. Toxicol. Environ. Health A , 72 : 219 – 225 .
  • Bisenius , E. S. , Veeramachaneni , D. N. R. , Sammonds , G. E. and Tobet , S. 2006 . Sex differences and the development of the rabbit brain: Effects of vinclozolin . Biol. Reprod. , 75 : 469 – 476 .
  • Bourguignon , J. P. , Rasier , G. , Lebrethon , M. C. , Gérard , A. , Naveau , E. and Parent , A. S. 2010 . Neuroendocrine disruption of pubertal timing and interactions between homeostasis of reproduction and energy balance . Mol. Cell. Endocrinol. , 324 : 110 – 120 .
  • Campbell , J. K. Residues of prochloraz in milk and tissues of a lacting goat fed straw containing residues of radiactive prochloraz . FBC report METAB/83/8 submitted to FAO by FBC Ltd. Unpublished . 1983 .
  • Castoldi , A. F. , Coccini , T. , Ceccatelli , S. and Manzo , L. 2001 . Neurotoxicity and molecular effects of methylmercury . Brain. Res. Bull. , 55 : 197 – 203 .
  • Colborn , T. , vom Saal , F. S. and Soto , A. M. 1993 . Developmental effects of endocrine-disrupting chemicals in wildlife and humans . Environ. Health Perspect. , 101 : 378 – 384 .
  • Cooper , R. L. , Goldman , J. M. and Stoker , T. E. 1999 . Neuroendocrine and reproductive effects of contemporary-use pesticides . Toxicol. Ind. Health , 15 : 26 – 36 .
  • Crump , D. , Lean , D. and Trudeau , V. L. 2002 . Octylphenol and UV-B radiation alter larval development and hypothalamic gene expression in the leopard frog (Rana pipiens) . Environ. Health Perspect. , 110 : 277 – 284 .
  • Crump , K. L. and Trudeau , V. L. 2009 . Mercury-induced reproductive impairment in fish . Environ. Toxicol. Chem. , 28 : 895 – 907 .
  • Cummings , A. M. 1997 . Methoxychlor as a model for environmental estrogens . Crit. Rev. Toxicol. , 27 : 367 – 379 .
  • deFur , P. L. 2004 . Use and role of invertebrate models in endocrine disruptor research and testing . Inst. Lab. Anim. Res. J. , 45 : 484 – 493 .
  • Desbrow , C. , Routledge , E. J. , Brighty , G. C. , Sumpter , J. P. and Waldock , M. 1998 . Identification of estrogenic chemicals in STW effluent. 1. Chemical fractionation and in vitro biological screening . Environ. Sci. Technol. , 32 : 1549 – 1558 .
  • Devi , M. and Fingerman , M. 1995 . Inhibition of acetylcholinesterase activity in the central nervous system of the red swamp crayfish, Procambarus clarkii, by mercury, cadmium, and lead . Bull. Environ. Contam. Toxicol. , 55 : 746 – 750 .
  • Diotel , N. , Page , Y. L. , Mouriec , K. , Tong , S.-K. , Pellegrini , E. , Vaillant , C. , Anglade , I. , Brion , F. , Pakdel , F. , Chung , B. and Kah , O. 2010 . Aromatase in the brain of teleost fish: Expression, regulation and putative functions . Front. Neuroendocrinol. , 31 : 172 – 192 .
  • Dobson , H. , Ghuman , S. , Prabhakar , S. and Smith , R. 2003 . A conceptual model of the influence of stress on female reproduction . Reproduction , 125 : 151 – 163 .
  • Dufour , S. , Weltzien , F.-A. , Sebert , M.-E. , Le Belle , N. , Vidal , B. , Vernier , P. and Pasqualini , C. 2005 . Dopaminergic inhibition of reproduction in teleost fishes: Ecophysiological and evolutionary implications . Ann. NY Acad. Sci. , 1040 : 9 – 21 .
  • Duggan , R. E. , Corneliussen , P. E. , Duggan , M. G. , McMahon , B. M. and Martin , R. J. 1983 . Pesticide residue levels in foods in the United States from 1 July 1969 to 10 June 1976 , Washington, DC : Food and Drug Administration and Association of Official Analytical Chemistry .
  • Fingerman , M. , Jackson , N. C. and Nagabhushanam , R. 1998 . Hormonally-regulated functions in crustaceans as biomarkers of environmental pollution . Comp. Biochem. Physiol. C Pharmacol. Toxicol, Endocrinol. , 120 : 343 – 350 .
  • Fonnum , F. and Mariussen , E. 2009 . Mechanisms involved in the neurotoxic effects of environmental toxicants such as polychlorinated biphenyls and brominated flame retardants . J. Neurochem. , 111 : 1327 – 1347 .
  • Frazier , J. M. 1979 . Bioaccumulation of cadmium in marine organisms . Environ. Health Perspect. , 28 : 75 – 79 .
  • Gagné , F. and Blaise , C. 2003 . Effects of municipal effluents on serotonin and dopamine levels in the freshwater mussel Elliptio complanata . Comp. Biochem. Physiol. C Toxicol. Pharmacol. , 136 : 117 – 125 .
  • Gagné , F. , Blaise , C. , André , C. , Gagnon , C. and Salazar , M. 2007a . Neuroendocrine disruption and health effects in Elliptio complanata mussels exposed to aeration lagoons for wastewater treatment . Chemosphere , 68 : 731 – 743 .
  • Gagné , F. , Cejka , P. , André , C. , Hausler , R. and Blaise , C. 2007b . Neurotoxicological effects of a primary and ozonated treated wastewater on freshwater mussels exposed to an experimental flow-through system . Comp. Biochem. Physiol. C Toxicol. Pharmacol. , 146 : 460 – 470 .
  • Goldman , J. M. , Stoker , T. E. and Cooper , R. L. 1999 . Neuroendocrine and reproductive effects of contemporary-use pesticides . Toxicol. Ind. Health , 15 : 26 – 36 .
  • Gore , A. C. 2008 . Neuroendocrine systems as targets for environmental endocrine-disrupting chemicals . Fertil. Steril. , 89 : 101 – 102 .
  • Gore , A. C. 2010 . Neuroendocrine targets of endocrine disruptors . Hormones , 9 : 16 – 27 .
  • Gore , A. C. and Patisaul , H. B. 2010 . Neuroendocrine disruption: Historical roots, current progress, questions for the future . Front. Neuroendocrinol. , 31 : 395 – 399 .
  • Gyllenhammar , I. , Eriksson , H. , Söderqvist , A. , Lindberg , R. H. , Fick , J. and Berg , C. 2009 . Clotrimazole exposure modulates aromatase activity in gonads and brain during gonadal differentiation in Xenopus tropicalis frogs . Aquat. Toxicol. , 91 : 102 – 09 .
  • Hanumante , M. M. , Fingerman , S. W. and Fingerman , M. 1981 . Antagonism of the inhibitory effect of the polychlorinated biphenyl preparation, Aroclor 1242, on color changes of the fiddler crab, Uca pugilator, by norepinephrine and drugs affecting noradrenergic neurotransmission . Bull. Environ. Contamin. Toxicol. , 26 : 479 – 484 .
  • Hewitt , L. M. , Parrott , J. L. and McMaster , M. E. 2006 . A decade of research on the environmental impacts of pulp and paper mill effluents in Canada: Sources and characteristics of bioactive substances . J. Toxicol. Environ. Health B , 9 : 341 – 356 .
  • Hewitt , L. M. , Kovacs , T. G. , Dube , M. G. , MacLatchy , D. L. , Martel , P. H. , McMaster , M. E. , Paice , M. G. , Parrott , J. L. , van den Heuvel , M. R. and van der Kraak , G. J. 2008 . Altered reproduction in fish exposed to pulp and paper mill effluents: Roles of individual compounds and mill operating conditions . Environ. Toxicol. Chem. , 27 : 682 – 697 .
  • Hogan , N. S. , Crump , K. L. , Duarte , P. , Lean , D. R. S. and Trudeau , V. L. 2007 . Hormone cross-regulation in the tadpole brain: Developmental expression profiles and effect of T3 exposure on thyroid hormone- and estrogen-responsive genes in Rana pipiens . Gen. Comp. Endocrinol. , 154 : 5 – 15 .
  • Hotchkiss , A. K. , Rider , C. V. , Blystone , C. R. , Wilson , V. S. , Hartig , P. C. , Ankley , G. T. , Foster , P. M. , Gray , C. L. and Gray , L. E. 2008 . Fifteen years after “Wingspread”—Environmental endocrine disrupters and human and wildlife health: Where we are today and where we need to go . Toxicol. Sci. , 105 : 235 – 259 .
  • Johansson , C. , Castoldi , A. , Onishchenko , N. , Manzo , L. , Vahter , M. and Ceccatelli , S. 2007 . Neurobehavioural and molecular changes induced by methylmercury exposure during development . Neurotoxicol. Res. , 11 : 241 – 260 .
  • Khan , I. A. and Thomas , P. 2001 . Disruption of neuroendocrine control of luteinizing hormone secretion by Aroclor 1254 involves inhibition of hypothalamic tryptophan hydroxylase activity . Biol. Reprod. , 64 : 955 – 964 .
  • Kidd , K. A. , Blanchfield , P. J. , Mills , K. H. , Palace , V. P. , Evans , R. E. , Lazorchak , J. M. and Flick , R. W. 2007 . Collapse of a fish population after exposure to a synthetic estrogen . Proc. Natl. Acad. Sci. USA , 104 : 8897 – 8901 .
  • Kolpin , D. W. , Furlong , E. T. , Meyer , M. T. , Thurman , E. M. , Zaugg , S. D. , Barber , L. B. and Buxton , H. T. 2002 . Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999–2000: A national reconnaissance . Environ. Sci. Technol. , 36 : 1202 – 1211 .
  • Kovacs , T. G. , Martel , P. H. and Ricci , M. 2007 . A shortened adult fathead minnow reproduction test developed for investigation of cause and investigation of solution work involving pulp and paper mill effluents . Water Qual. Res. J. Can. , 42 : 91 – 100 .
  • Lafuente , A. , Márquez , N. , Pousada , Y. , Pazo , D. and Esquifino , A. I. 2000a . Possible estrogenic and/or antiandrogenic effects of methoxychlor on prolactin release in male rats . Arch. Toxicol. , 74 : 270 – 275 .
  • Lafuente , A. , Márquez , N. , Pazo , D. and Esquifino , A. 2000b . Effects of subchronic alternating cadmium exposure on dopamine turnover and plasma levels of prolactin, GH and ACTH . Biometals , 13 : 47 – 55 .
  • Lafuente , A. , Márquez , N. , Pérez-Lorenzo , M. , Pazo , D. and Esquifino , A. I. 2000c . Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat . Food Chem. Toxicol. , 38 : 913 – 923 .
  • Lafuente , A. , Marquez , N. , Perez-Lorenzo , M. , Pazo , D. and Esquifino , A. I. 2001a . Cadmium effects on hypothalamic-pituitary-testicular axis in male rats . Exp. Biol. Med. , 226 : 605 – 611 .
  • Lafuente , A. , Marquez , N. , Pazo , D. and Esquifino , A. I. 2001b . Cadmium effects on dopamine turnover and plasma levels of prolactin, GH and ACTH . J. Physiol. Biochem. , 57 : 231 – 236 .
  • Lafuente , A. , Cano , P. and Esquifino , A. I. 2003 . Are cadmium effects on plasma gonadotropins, prolactin, ACTH, GH and TSH levels, dose-dependent? . BioMetals , 16 : 243 – 250 .
  • Lafuente , A. , Cabaleiro , T. , Caride , A. and Esquifino , A. I. 2008 . Toxic effects of methoxychlor administered subcutaneously on the hypothalamic-pituitary-testicular axis in adult rats . Food Chem. Toxicol. , 46 : 1570 – 1575 .
  • Lagadic , L. , Coutellec , M.-A. and Caquet , T. 2007 . Endocrine disruption in aquatic pulmonate molluscs: Few evidences, many challenges . Ecotoxicology , 16 : 45 – 59 .
  • LeBlanc , G. 2007 . Crustacean endocrine toxicology: A review . Ecotoxicology , 16 : 61 – 81 .
  • Lorenzon , S. , Edomi , P. , Giulianini , P. G. , Mettulio , R. and Ferrero , E. A. 2004 . Variation of crustacean hyperglycemic hormone (cHH) level in the eyestalk and haemolymph of the shrimp Palaemon elegans following stress . J. Exp. Biol. , 207 : 4205 – 4213 .
  • Lorenzon , S. , Edomi , P. , Giulianini , P. G. , Mettulio , R. and Ferrero , E. A. 2005 . Role of biogenic amines and cHH in the crustacean hyperglycemic stress response . J. Exp. Biol. , 208 : 3341 – 3347 .
  • MacLatchy , D. L. and Van Der Kraak , G. J. 1995 . The phytoestrogen β-sitosterol alters the reproductive endocrine status of goldfish . Toxicol. Appl. Pharmacol. , 134 : 305 – 312 .
  • Martyniuk , C. J. , Xiong , H. , Crump , K. , Chiu , S. , Sardana , R. , Nadler , A. , Gerrie , E. R. , Xia , X. and Trudeau , V. L. 2006a . Gene expression profiling in the neuroendocrine brain of male goldfish (Carassius auratus) exposed to 17-ethinylestradiol . Physiol. Genom. , 27 : 328 – 336 .
  • Martyniuk , C. , Marlatt , V. , Gallant , N. , Wiens , S. , Woodhouse , M. and Trudeau , V. L. 2006b . “ Current perspectives on estrogen action and estrogen receptors in teleost fishes ” . In Fish endocrinology , Edited by: Reineke , M. , Zaccone , G. and Kapoor , B.G. 625 – 664 . Enfield, NH : Science Publishers .
  • Martyniuk , C. J. , Gerrie , E. R. , Popesku , J. T. , Ekker , M. and Trudeau , V. L. 2007 . Microarray analysis in the zebrafish (Danio rerio) liver and telencephalon after exposure to low concentration of 17alpha-ethinylestradiol . Aquat. Toxicol. , 84 : 38 – 49 .
  • Martyniuk , C. J. , Sanchez , B. C. , Szabo , N. J. , Denslow , N. D. and Sepúlveda , M. S. 2009 . Aquatic contaminants alter genes involved in neurotransmitter synthesis and gonadotropin release in largemouth bass . Aquat. Toxicol. , 95 : 1 – 9 .
  • Martyniuk , C. J. , Feswick , A. , Spade , D. J. , Kroll , K. J. , Barber , D. S. and Denslow , N.D. 2010a . Effects of acute dieldrin exposure on neurotransmitters and global gene transcription in largemouth bass (Micropterus salmoides) hypothalamus . Neurotoxicology , 31 : 356 – 366 .
  • Martyniuk , C. J. , Kroll , K. J. , Doperalski , N. J. , Barber , D. S. and Denslow , N. D. 2010b . Genomic and proteomic responses to environmentally relevant exposures to dieldrin: Indicators of neurodegeneration? . Toxicol. Sci. , 117 : 190 – 199 .
  • McGary , S. , Henry , P. F. P. and Ann Ottinger , M. 2001 . Impact of vinclozolin on reproductive behavior and endocrinology in Japanese quail (Coturnix coturnix japonica) . Environ. Toxicol. Chem. , 20 : 2487 – 2493 .
  • McMaster , M. E. , Hewitt , L. M. and Parrott , J. L. 2006 . A decade of research on the environmental impacts of pulp and paper mill effluents in Canada: field studies and mechanistic research . J. Toxicol. Environ. Health B , 9 : 319 – 339 .
  • Medesani , D. A. , Greco , L. S. L. and Rodríguez , E. M. 2004 . Interference of cadmium and copper with the endocrine control of ovarian growth, in the estuarine crab Chasmagnathus granulata . Aquat. Toxicol. , 69 : 165 – 174 .
  • Mennigen , J. A. , Martyniuk , C. J. , Crump , K. , Xiong , H. , Zhao , E. , Popesku , J. , Anisman , H. , Cossins , A. R. , Xia , X. and Trudeau , V. L. 2008 . Effects of fluoxetine on the reproductive axis of female goldfish (Carassius auratus) . Physiol. Genom. , 35 : 273 – 282 .
  • Mennigen , J. A. , Harris , E. A. , Chang , J. P. , Moon , T. W. and Trudeau , V. L. 2009 . Fluoxetine affects weight gain and expression of feeding peptides in the female goldfish brain . Regul. Peptides , 155 : 99 – 104 .
  • Mennigen , J. A. , Stroud , P. , Zamora , J. M. , Moon , T. W. and Trudeau , V. L. 2011 . Pharmaceuticals as neuroendocrine disruptors: Lessons learned from fish on Prozac . J. Environ. Toxicol. Health B. , 14 : 387 – 412 .
  • Metcalfe , C. D. , Tindale , K. , Li , H. , Rodayan , A. and Yargeau , V. 2010 . Illicit drugs in Canadian municipal wastewater and estimates of community drug use . Environ. Pollut. , 158 : 3179 – 3185 .
  • Molnár , G. , Salánki , J. and Kiss , T. 2004 . Cadmium inhibits GABA-activated ion currents by increasing intracellular calcium level in snail neurons . Brain Res. , 1008 : 205 – 211 .
  • Mordue , A. J. and Blackwell , A. 1993 . Azadirachtin: An update . J. Insect Physiol. , 39 : 903 – 24 .
  • Oakes , K. D. , Coors , A. , Escher , B. I. , Fenner , K. , Garric , J. , Gust , M. , Knacker , T. , Küster , A. , Kussatz , C. , Metcalfe , C. D. , Monteiro , S. , Moon , T. W. , Mennigen , J. A. , Parrott , J. , Péry , A. R. , Ramil , M. , Roennefahrt , I. , Tarazona , J. V. , Sánchez-Argüello , P. , Ternes , T. A. , Trudeau , V. L. , Boucard , T. , Van Der Kraak , G. J. and Servos , M. R. 2010 . Environmental risk assessment for the serotonin re-uptake inhibitor fluoxetine: Case study using the European risk assessment framework . Integr. Environ. Assess. Manage. , 6 : 524 – 539 .
  • Ottinger , M. A. , Wu , J. M. , Hazelton , J. L. , Abdelnabi , M. A. , Thompson , N. , Quinn , J. M. L. , Donoghue , D. , Schenck , F. , Ruscio , M. , Beavers , J. and Jaber , M. 2005 . Assessing the consequences of the pesticide methoxychlor: neuroendocrine and behavioral measures as indicators of biological impact of an estrogenic environmental chemical . Brain Res. Bull. , 65 : 199 – 209 .
  • Ottinger , M. A. , Lavoie , E. , Thompson , N. , Barton , A. , Whitehouse , K. , Barton , M. , Abdelnabi , M. , Quinn , M. J. Jr , Panzica , G. C. and Viglietti-Panzica , C. 2008 . Neuroendocrine and behavioral effects of embryonic exposure to endocrine disrupting chemicals in birds . Brain Res. Rev. , 57 : 376 – 385 .
  • Ottinger , M. A. , Lavoie , E. T. , Thompson , N. , Bohannon , M. , Dean , K. and Quinn , M. J. Jr. 2009 . Is the gonadotropin releasing hormone system vulnerable to endocrine disruption in birds? . Gen. Comp. Endocrinol. , 163 : 104 – 108 .
  • Palanza , P. , Morellini , F. , Parmigiani , S. and vom Saal , F. S. 1999 . Prenatal exposure to endocrine disrupting chemicals: Effects on behavioral development . Neurosci. Biobehav. Rev. , 23 : 1011 – 1027 .
  • Panzica , G. C. , Viglietti-Panzica , C. , Mura , E. , Quinn , M. J. Jr. , Lavoie , E. , Palanza , P. and Ottinger , M. A. 2007 . Effects of xenoextrogens on the differentiation of behaviorally-relevant neural circuits . Front. Neuroendocrinol. , 28 : 179 – 200 .
  • Parrott , J. L. , McMaster , M. E. and Hewitt , L. M. 2006 . A decade of research on the environmental impacts of pulp and paper mill effluents in Canada: Development and application of fish bioassays . J. Toxicol. Environ. Health B , 9 : 297 – 317 .
  • Perrot , V. , Moiseeva , E. B. , Gozes , Y. , Chan , S. J. , Ingleton , P. and Funkenstein , B. 1999 . Ontogeny of the insulin-like growth factor system (IGF-I, IGF-II, and IGF-1R) in gilthead seabream (Sparus aurata): Expression and cellular localization . Gen. Comp. Endocrinol. , 116 : 445 – 460 .
  • Pettersson , I. , Arukwe , A. , Lundstedt-Enkel , K. , Mortensen , A. S. and Berg , C. 2006 . Persistent sex-reversal and oviducal agenesis in adult Xenopus (Silurana) tropicalis frogs following larval exposure to the environmental pollutant ethynylestradiol . Aquat. Toxicol. , 79 : 356 – 365 .
  • Pillai , A. , Priya , L. and Gupta , S. 2003 . Effects of combined exposure to lead and cadmium on the hypothalamic-pituitary axis function in proestrous rats . Food Chem. Toxicol. , 41 : 379 – 384 .
  • Popesku , J. T. , Martyniuk , C. J. , Mennigen , J. , Xiong , H. , Zhang , D. , Xia , X. , Cossins , A. R. and Trudeau , V. L. 2008 . The goldfish (Carassius auratus) as a model for neuroendocrine signaling . Mol. Cell. Endocrinol. , 293 : 43 – 56 .
  • Popesku , J. T. , Tan , E. Y. Z. , Martel , P. H. , Kovacs , T. G. , Rowan-Carroll , A. , Williams , A. , Yauk , C. and Trudeau , V. L. 2010 . Gene expression profiling of the fathead minnow (Pimephales promelas) neuroendocrine brain in response to pulp and paper mill effluents . Aquat. Toxicol. , 99 : 379 – 388 .
  • Porte , C. , Janer , G. , Lorusso , L. C. , Ortiz-Zarragoitia , M. , Cajaraville , M. P. , Fossi , M. C. and Canesi , L. 2006 . Endocrine disruptors in marine organisms: Approaches and perspectives . Comp. Biochem. Physiol. C Toxicol. Pharmacol. , 143 : 303 – 315 .
  • Rao , K. V. , Ghouselazam , S. and Surendranath , P. 1991 . Inhibition and recovery of selected target enzyme activities in tissues of penaeid prawn, Metapenaeus monoceros (Fabricius), exposed to different insecticides . Indian J. Exp. Biol. , 29 : 489 – 491 .
  • Ratcliffe , H.E. , Swanson , G. M. and Fischer , L.J. 1996 . Human exposure to mercury: A critical assessment of the evidence of adverse effects . J. Toxicol. Environ. Health , 49 : 221 – 270 .
  • Reddy , M. S. , Jayaprada , P. and Rao , K. V. 1990 . Recovery of carbaryl inhibited AChE in penaeid prawn, Metapenaeus monoceros . Biochem. Int. , 22 : 189 – 198 .
  • Reddy , P. S. and Fingerman , M. 1995 . Effect of cadmium chloride on physiological color changes of the fiddler crab, Uca pugilator . Ecotoxicol. Environ. Saf. , 31 : 69 – 75 .
  • Reddy , P. S. , Nguyen , L. K. , Obih , P. and Fingerman , M. 1997a . Effect of cadmium chloride on the distal retinal pigment cells of the fiddler crab, Uca pugilator . Bull. Environ. Contam. Toxicol. , 58 : 504 – 510 .
  • Reddy , P. S. , Tuberty , S. R. and Fingerman , M. 1997b . Effects of cadmium and mercury on ovarian maturation in the red swamp crayfish, Procambarus clarkii . Ecotoxicol. Environ. Safety , 37 : 62 – 65 .
  • Repetto , G. , Sanz , P. and Repetto , M. 1988 . In vivo and in vitro effect of triclorfon on esterases of the red crayfish Procambarus clarkii . Bull. Environ. Contam. Toxicol. , 41 : 597 – 603 .
  • Rodríguez , E. M. , López Greco , L. S. and Fingerman , M. 2000 . Inhibition of ovarian growth by cadmium in the fiddler crab, Uca pugilator (Decapoda, Ocypodidae) . Ecotoxicol. Environ. Safety , 46 : 202 – 206 .
  • Sarojini , R. , Nagabhushanam , R. and Fingerman , M. 1994 . A possible neurotransmitter-neuroendocrine mechanism in naphthalene-induced atresia of the ovary of the red swamp crayfish, Procambarus clarkii . Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol. , 108 : 33 – 38 .
  • Sarojini , R. , Nagabhushanam , R. and Fingerman , M. 1995 . Mode of action of the neurotransmitter 5-hydroxytryptamine in stimulating ovarian maturation in the red swamp crayfish, Procambarus clarkii: An in vivo and in vitro study . J. Exp. Zool. , 271 : 395 – 400 .
  • Sayah , F. , Idaomar , M. , Soranzo , L. and Karlinsky , A. 1998 . Endocrine and neuroendocrine effects of Azadirachtin in adult females of the earwig Labidura riparia . Tissue Cell , 30 : 86 – 94 .
  • Shved , N. , Berishvili , G. , Baroiller , J.-F. , Segner , H. and Reinecke , M. 2008 . Environmentally relevant concentrations of 17β-ethinylestradiol (EE2) interfere with the growth hormone (GH)/insulin-like growth factor (IGF)-I system in developing bony fish . Toxicol. Sci. , 106 : 93 – 102 .
  • Shved , N. , Berishvili , G. , D'Cotta , H. , Baroiller , J.-F. , Segner , H. , Eppler , E. and Reinecke , M. 2007 . Ethinylestradiol differentially interferes with IGF-I in liver and extrahepatic sites during development of male and female bony fish . J. Endocrinol. , 195 : 513 – 523 .
  • Sickel , M. J. and McCarthy , M. M. 2000 . Calbindin-D28k immunoreactivity is a marker for a subdivision of the sexually dimorphic nucleus of the preoptic area of the rat: Developmental profile and gonadal steroid modulation . J. Neuroendocrinol. , 12 : 397 – 402 .
  • Singh , H. and Singh , T. P. 1980 . Short-term effect of two pesticides on the survival, ovarian 32P uptake and gonadotrophic potency in a freshwater catfish, Heteropneustes fossilis (Bloch) . J. Endocrinol. , 85 : 193 – 199 .
  • Smith , C. G. 1983 . Reproductive toxicity: hypothalamic-pituitary mechanisms . Am. J. Ind. Med. , 4 : 107 – 112 .
  • Staub , G. C. and Fingerman , M. 1984 . A mechanism of action for the inhibition of black pigment dispersion in the fiddler crab, Uca pugilator, by naphthalene . Comp. Biochem. Physiol. C Toxicol. Pharmacol. , 79 : 447 – 453 .
  • Surendranath , P. , Lazam , S. and Rao , V. R. 1990 . Monitoring insecticide biodegradation in penaeid prawn Penaeus indicus following subacute exposure to phosphamidon and DDT through reclamation studies . Environ. Ecol. , 8 : 397 – 400 .
  • Szücs , A. , Salánki , J. and S.-Rózsa , K. 1994 . Effects of chronic exposure to cadmium- or lead-enriched environments on ionic currents of identified neurons in Lymnaea stagnalis L . Cell. Mol. Neurobiol. , 14 : 769 – 780 .
  • Takeda , N. 1982 . Source of the tentacular hormone in terrestrial pulmonates . Cell. Mol. Life Sci. , 38 : 1058 – 1060 .
  • Ternes , T. A. , Stumpf , M. , Mueller , J. , Haberer , K. , Wilken , R. D. and Servos , M. 1999 . Behavior and occurrence of estrogens in municipal sewage treatment plants—I. Investigations in Germany, Canada and Brazil . Sci. Total Environ. , 225 : 81 – 90 .
  • Trudeau , V. L. 1997 . Neuroendocrine regulation of gonadotrophin II release and gonadal growth in the goldfish, Carassius auratus . Rev. Reprod. , 2 : 55 – 68 .
  • Trudeau , V. L. , Chiu , S. , Kennedy , S. W. and Brooks , R. J. 2002 . Octylphenol (OP) alters the expression of members of the amyloid protein family in the hypothalamus of the snapping turtle, Chelydra serpentina serpentina . Environ. Health Perspect. , 110 : 269 – 275 .
  • Trudeau , V. L. , Turque , N. , Le Mevel , S. , Alliot , C. , Gallant , N. , Coen , L. , Pakdel , F. and Demeneix , B. 2005 . Assessment of estrogenic endocrine-disrupting chemical actions in the brain using in vivo somatic gene transfer . Environ. Health Perspect. , 113 : 329 – 334 .
  • U.S. Environmental Protection Agency. 2000. Cadmium compounds (online). http://www.epa.gov/ttn/atw/hlthef/cadmium.html (http://www.epa.gov/ttn/atw/hlthef/cadmium.html) (Accessed: 30 June 2010 ).
  • U.S. Environmental Protection Agency. 2007. What are endocrine disruptors? http://www.epa.gov/endo/pubs/edspoverview/whatare.htm (http://www.epa.gov/endo/pubs/edspoverview/whatare.htm) (Accessed: 30 July 2010 ).
  • Van Der Kraak , G. J. , Munkittrick , K. R. , McMaster , M. E. , Portt , C. B. and Chang , J. P. 1992 . Exposure to bleached kraft pulp mill effluent disrupts the pituitary-gonadal axis of white sucker at multiple sites . Toxicol. Appl. Pharmacol. , 115 : 224 – 233 .
  • van der Ven , K. , Keil , D. , Moens , L. N. , Van Leemput , K. , van Remortel , P. and De Coen , W. M. 2006 . Neuropharmaceuticals in the environment: mianserin-induced neuroendocrine disruption in zebrafish (Danio rerio) using cDNA microarrays . Environ. Toxicol. Chem. , 25 : 2645 – 2652 .
  • Veeramachaneni , D. N. R. , Palmer , J. S. , Amann , R. P. , Kane , C. M. , Higuchi , T. T. and Pau , K.-Y. F. 2006 . Disruption of sexual function, FSH secretion, and spermiogenesis in rabbits following developmental exposure to vinclozolin, a fungicide . Reproduction , 131 : 805 – 816 .
  • Vos , J. G. , Dybing , E. , Greim , H. A. , Ladefoged , O. , Lambre , C. , Tarazona , J. V. , Brandt , I. and Vethaak , A. D. 2000 . Health effects of endocrine-disrupting chemicals on wildlife, with special reference to the European situation . Crit. Rev. Toxicol. , 30 : 71 – 133 .
  • Wijnhoven , S. , Leuven , R. S. , van der Velde , G. , Jungheim , G. , Koelemij , E. I. , de Vries , F. T. , Eijsackers , H. J. and Smits , A. J. 2007 . Heavy-metal concentrations in small mammals from a diffusely polluted floodplain: Importance of species- and location-specific characteristics . Arch. Environ. Contam. Toxicol. , 52 : 603 – 613 .
  • Zarubin , T. , Chang , E. and Mykles , D. 2009 . Expression of recombinant eyestalk crustacean hyperglycemic hormone from the tropical land crab, Gecarcinus lateralis, that inhibits Y-organ ecdysteroidogenesis in vitro . Mol. Biol. Rep. , 36 : 1231 – 1237 .
  • Zhang , D. and Trudeau , V. L. 2006 . Integration of membrane and nuclear estrogen receptor signalling . Comp. Biochem. Physiol. A Mol. Integr. Physiol. , 144 : 306 – 315 .
  • Zhang , D. , Popesku , J. T. , Martyniuk , C. J. , Xiong , H. , Duarte-Guterman , P. , Yao , L. , Xia , X. and Trudeau , V. L. 2009 . Profiling neuroendocrine gene expression changes following fadrozole-induced estrogen decline in the female goldfish . Physiol. Genom. , 38 : 351 – 361 .
  • Zhang , X. , Hecker , M. , Park , J.-W. , Tompsett , A. R. , Newsted , J. , Nakayama , K. , Jones , P. D. , Au , D. , Kong , R. , Wu , R. S. S. and Giesy , J. P. 2008a . Real-time PCR array to study effects of chemicals on the hypothalamic–pituitary–gonadal axis of the Japanese medaka . Aquat. Toxicol. , 88 : 173 – 182 .
  • Zhang , X. , Hecker , M. , Jones , P. D. , Newsted , J. , Au , D. , Kong , R. , Wu , R. S. S. and Giesy , J. P. 2008b . Responses of the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole . Environ. Sci. Technol. , 42 : 6762 – 6769 .
  • Zoeller , R. T. 2008 . Environmental neuroendocrine and thyroid disruption: relevance for reproductive medicine? . Fertil. Steril. , 89 : 99 – 100 .
  • Zuccato , E. and Castiglioni , S. 2009 . Illicit drugs in the environment . Philos. Trans. R. Soc. A , 367 : 3965 – 3978 .