Potential Input From Metabolomics for Exploring and Understanding the Links Between Environment and Health

REFERENCES

• Aliferis , K. A. and Chrysayi-Tokousbalides , M. 2011 . Metabolomics in pesticide research and development: review and future perspectives . Metabolomics , 7 : 35 – 53 .
   Web of Science ®Google Scholar
• Alvarez-Sanchez , B. , Priego-Capote , F. and Luque de Castro , M. 2010a . Metabolomics analysis II. Preparation of biological samples prior to detection . Trends Anal. Chem , 29 : 120 – 127 .
   Web of Science ®Google Scholar
• Alvarez-Sanchez , B. , Priego-Capote , F. and Luque de Castro , M. 2010b . Metabolomics analysis I. Selection of biological samples and practical aspects preceding sample preparation . Trends Anal. Chem , 29 : 111 – 119 .
   Web of Science ®Google Scholar
• Athersuch , T. J. 2012 . The role of metabolomics in characterizing the human exposome . Bioanalysis , 4 : 2207 – 2212 .
   PubMed Web of Science ®Google Scholar
• Bair , E. , Hastie , T. , Paul , D. and Tibshirani , R. 2006 . Prediction by supervised principal components . J. Am. Stat. Assoc , 101 : 119 – 137 .
   Web of Science ®Google Scholar
• Bedair , M. and Sumner , L. W. 2008 . Current and emerging mass-spectrometry technologies for metabolomics . Trends Anal. Chem , 27 : 238 – 250 .
   Web of Science ®Google Scholar
• Beger , R. D. , Sun , J. and Schnackenberg , L. K. 2010 . Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity . Toxicol. Appl. Pharmacol , 243 : 154 – 166 .
   PubMed Web of Science ®Google Scholar
• Bertram , H. C. , Duus , J. O. , Petersen , B. O. , Hoppe , C. , Larnkjaer , A. , Schack-Nielsen , L. , Molgaard , C. and Michaelsen , K. 2009 . Nuclear magnetic resonance-based metabonomics reveals strong sex effect on plasma metabolism in 17-year-old Scandinavians and correlation to retrospective infant plasma parameters . Metabolism , 58 : 1039 – 1045 .
   PubMed Web of Science ®Google Scholar
• Bessonneau , V. , Bojko , B. and Pawliszyn , J. 2013 . Analysis of human saliva metabolome by direct immersion solid-phase microextraction LC and benchtop orbitrap MS . Bioanalysis , 5 : 783 – 792 .
   PubMed Web of Science ®Google Scholar
• Bictash , M. , Ebbels , T. M. , Chan , Q. , Loo , R. L. , Yap , I. K. S. , Brown , I. J. , de Iorio , M. , Daviglus , M. L. , Holmes , E. , Stamler , J. , Nicholson , J. K. and Elliott , P. 2010 . Opening up the “black box”: Metabolic phenotyping and metabolome-wide association studies in epidemiology . J. Clin. Epidemiol , 63 : 970 – 979 .
   PubMed Web of Science ®Google Scholar
• Bonvallot , N. , Tremblay-Franco , M. , Chevrier , C. , Canlet , C. , Warembourg , C. , Cravedi , J.-P. and Cordier , S. 2013 . Metabolomics tools for describing complex pesticide exposure in pregnant women in Brittany (France) . PLoS One , 8 ( 5 ) : e64433
   PubMedGoogle Scholar
• Booth , S. C. , Weljie , A. M. and Turner , R. J. 2013 . Computational tools for the secondary analysis of metabolomics experiments . Comput. Struct. Biol. J , 4 : e201301003
   Google Scholar
• Bothwell , J. H. F. and Griffin , J. L. 2011 . An introduction to biological nuclear magnetic resonance spectroscopy . Biol. Rev , 86 : 493 – 510 .
   PubMed Web of Science ®Google Scholar
• Bouhifd , M. , Hartung , T. , Hogberg , H. T. , Kleensang , A. and Zhao , L. 2013 . Review: Toxicometabolomics . J. Appl. Toxicol , doi: 10.1002/jat.2874
   PubMed Web of Science ®Google Scholar
• Bradman , A. , Castorina , R. , Boyd Barr , D. , Chevrier , J. , Harnly , M. E. , Eisen , E. A. , McKone , T. E. , Harley , K. , Holland , N. and Eskenazi , B. 2011 . Determinants of organophosphorus pesticide urinary metabolite levels in young children living in an agricultural community . Int. J. Environ. Res. Public Health , 8 : 1061 – 1083 .
   PubMed Web of Science ®Google Scholar
• Broadhurst , D. and Kell , D. B. 2006 . Statistical strategies for avoiding false discoveries in metabolomics and related experiments . Metabolomics , 2 : 171 – 196 .
   Web of Science ®Google Scholar
• Cabaton , N. , Canlet , C. , Wadia , P. R. , Tremblay-Franco , M. , Gautier , R. , Molina , J. , Sonnenschein , C. , Cravedi , J.-P. , Rubin , B. S. , Soto , A. M. and Zalko , D. 2013 . “ Effects of low doses of bisphenol A on the metabolome of perinatally exposed CD-1 mice ” . In Environ. Health Perspect doi: 10.1289/ehp.1205588
   Google Scholar
• Canlet C., M. Tremblay-Franco, R. Gautier, J. Molina, B. Métais, F. Blas-Y-EstradaL. Gamet-Payrastre. 2013. Specific metabolic fingerprint of a dietary exposure to very low dose of endosulfan. J. Toxicol. 2013: 545802 http://dx.doi.org/10.1155/2013/545802 (http://dx.doi.org/10.1155/2013/545802)
   Google Scholar
• Chen , M. , Xu , B. , Ji , W. , Qiao , S. , Hu , N. , Hu , Y. , Wu , W. , Qiu , L. , Zhang , R. , Wang , S. , Zhou , Z. , Xia , Y. and Wang , X. 2012 . Bisphenol A alters n-6 fatty acid composition and decreases antioxidant enzyme levels in rat testes: A LC-QTOF-based metabolomics study . PLoS One , 7 : e44754
   PubMed Web of Science ®Google Scholar
• Cubbon , S. , Antonio , C. , Watson , J. and Thomas-Oates , J. 2010 . Metabolomic applications of HILIC-LC-MS . Mass Spectrom. Rev , 29 : 671 – 684 .
   PubMed Web of Science ®Google Scholar
• D'Adamo , P. , Ulivi , S. , Beneduci , A. , Pontoni , G. , Capasso , G. , Lanzara , C. , Andrighetto , G. , Hladnik , U. , Nunes , V. , Palacin , M. and Gasparini , P. 2010 . Metabonomics and population studies: age-related amino acids excretion and inferring networks through the study of urine samples in two Italian isolated populations . Amino Acids , 38 : 65 – 73 .
   PubMed Web of Science ®Google Scholar
• Demur , C. , Métais , B. , Canlet , C. , Tremblay-Franco , M. , Gautier , R. , Blas-Y-Estradas , F. , Sommer , C. and Gamet-Payrastre , L. 2013 . Dietary exposure to a low dose of pesticides alone or as a mixture: The biological metabolic fingerprint and impact on hematopoiesis . Toxicology , 308 : 74 – 87 .
   PubMed Web of Science ®Google Scholar
• Deprez , S. , Sweatman , B. C. , Connor , S. C. , Haselden , J. N. and Waterfield , C. J. 2002 . Optimisation of collection, storage and preparation of rat plasma for 1H NMR spectroscopic analysis in toxicology studies to determine inherent variation in biochemical profiles . J. Pharm. Biomed. Anal , 30 : 1297 – 1310 .
   PubMed Web of Science ®Google Scholar
• Dettmer , K. , Aronov , P. A. and Hammock , B. D. 2007 . Mass spectrometry-based metabolomics . Mass Spectrom. Rev , 26 : 51 – 78 .
   PubMed Web of Science ®Google Scholar
• Diaz , S. O. , Pinto , J. , Graça , G. , Duarte , I. F. , Barros , A. S. , Galhano , E. , Pita , C. , Almeida , M. , Goodfellow , B. J. , Carreira , I. M. and Gil , A. M. 2011 . Metabolic biomarkers of prenatal disorders: An exploratory NMR metabonomics study of 2nd trimester maternal urine and blood plasma . J. Proteome Res , 10 : 3732 – 3742 .
   PubMed Web of Science ®Google Scholar
• Du , L. , Wang , H. , Xu , W. , Zeng , Y. , Hou , Y. , Zhang , Y. , Zhao , X. and Sun , C. 2013 . “ Application of ultraperformance liquid chromatography/mass spectrometry-based metabonomic techniques to analyze the joint toxic action of long-term low-level exposure to a mixture of organophosphate pesticides on rat urine profile ” . In Toxicol. Sci doi: 10.1093/toxsci/kft091
   Google Scholar
• Duarte , N. C. , Becker , S. A. , Jamshidi , N. , Thiele , I. , Mo , M. L. , Vo , T. D. , Srivas , R. and Palsson , B. O. 2007 . Global reconstruction of the human metabolic network based on genomic and bibliomic data . Proc. Natl. Acad. Sci. USA , 104 : 1777 – 1782 .
   PubMed Web of Science ®Google Scholar
• Dumas , M. E. , Maibaum , E. C. , Teague , C. , Ueshima , H. , Zhou , B. , Lindon , J. C. , Nicholson , J. K. , Stamler , J. , Elliott , P. , Chan , Q. and Holmes , E. 2006 . Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: The INTERMAP Study . Anal. Chem , 78 : 2199 – 2208 .
   PubMed Web of Science ®Google Scholar
• Dunn , W. B. , Bailey , N. J. C. and Johnson , H. E. 2005 . Measuring the metabolome: current analytical technologies . Analyst , 130 : 606 – 625 .
   PubMed Web of Science ®Google Scholar
• Dunn , W. B. , Broadhurst , D. , Ellis , D. I. , Brown , M. , Halsall , A. , O'Hagan , S. , Spasic , I. , Tseng , A. and Kell , D. B. 2008 . A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols . Int. J. Epidemiol , 37 : i23 – i30 . (suppl. 1)
   Web of Science ®Google Scholar
• Ellis , J. , Athersuch , T. , Thomas , L. , Teichert , F. , Perez-Trujillo , M. , Svendsen , C. , Spurgeon , D. , Singh , R. , Jarup , L. , Bundy , J. and Keun , H. 2012 . Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population . BMC Med , 10 : 61
   PubMed Web of Science ®Google Scholar
• Eveillard , A. , Lasserre , F. , de Tayrac , M. , Polizzi , A. , Claus , S. , Canlet , C. , Mselli-Lakhal , L. , Gotardi , G. , Paris , A. , Guillou , H. , Martin , P. G. P. and Pineau , T. 2009 . Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach . Toxicol. Appl. Pharmacol , 236 : 282 – 292 .
   PubMed Web of Science ®Google Scholar
• Feng , Z. , Sun , X. , Yang , J. , Hao , D. , Du , L. , Wang , H. , Xu , W. , Zhao , X. and Sun , C. 2012 . Metabonomics analysis of urine and plasma from rats given long-term and low-dose dimethoate by ultra-performance liquid chromatography-mass spectrometry . Chem. Biol. Interact , 199 : 143 – 153 .
   PubMed Web of Science ®Google Scholar
• Fiehn , O. 2002 . Metabolomics—The link between genotypes and phenotypes . Plant Mol. Biol , 48 : 151 – 171 .
   Google Scholar
• Fukushima , A. and Kusano , M. 2013 . Recent progress in the development of metabolome databases for plant systems biology . Front. Plant Sci , 4 : 73
   Google Scholar
• Gu , H. , Pan , Z. , Xi , B. , Hainline , B. E. , Shanaiah , N. , Asiago , V. , Gowda , G. A. N. and Raftery , D. 2009 . 1H NMR metabolomics study of age profiling in children . NMR Biomed , 22 : 826 – 833 .
   PubMed Web of Science ®Google Scholar
• Gunier , R. B. , Ward , M. H. , Airola , M. , Bell , E. M. , Colt , J. , Nishioka , M. , Buffler , P. A. , Reynolds , P. , Rull , R. P. , Hertz , A. , Metayer , C. and Nuckols , J. R. 2011 . Determinants of agricultural pesticide concentrations in carpet dust . Environ. Health Perspect , 119 : 970 – 976 .
   PubMed Web of Science ®Google Scholar
• Hao , D. F. , Xu , W. , Wang , H. , Du , L. F. , Yang , J. D. , Zhao , X. J. and Sun , C. H. 2012 . Metabolomic analysis of the toxic effect of chronic low-dose exposure to acephate on rats using ultra-performance liquid chromatography/mass spectrometry . Ecotoxicol. Environ. Safety , 83 : 25 – 33 .
   PubMed Web of Science ®Google Scholar
• Hebels , D. G. , Georgiadis , P. , Keun , H. C. , Athersuch , T. J. , Vineis , P. , Vermeulen , R. , Portengen , L. , Bergdahl , I. A. , Hallmans , G. , Palli , D. , Bendinelli , B. , Krogh , V. , Tumino , R. , Sacerdote , C. , Panico , S. , Kleinjans , J. C. S. , De Kok , T. M. C. M. , Smith , M. T. and Kyrtopoulos , S. A. 2013 . Performance in omics analyses of blood samples in long-term storage: Opportunities for the exploitation of existing biobanks in environmental health research . Environ. Health Perspect , 121 : 480 – 487 .
   PubMed Web of Science ®Google Scholar
• Holmes , E. , Loo , R. L. , Stamler , J. , Bictash , M. , Yap , I. K. , Chan , Q. , Ebbels , T. , de Iorio , M. , Brown , I. J. , Veselkov , K. A. , Daviglus , M. L. , Kesteloot , H. , Ueshima , H. , Zhao , L. , Nicholson , J. K. and Elliott , P. 2008 . Human metabolic phenotype diversity and its association with diet and blood pressure . Nature , 453 : 396 – 400 .
   PubMed Web of Science ®Google Scholar
• Idborg , H. , Zamani , L. , Edlund , P. O. , Schuppe-Koistinen , I. and Jacobsson , S. P. 2005 . Metabolic fingerprinting of rat urine by LC/MS Part 1. Analysis by hydrophilic interaction liquid chromatography-electrospray ionization mass spectrometry . J. Chromatogr. B , 828 : 9 – 13 .
   PubMed Web of Science ®Google Scholar
• Jamin , E. , Bonvallot , N. , Tremblay-Franco , M. , Cravedi , J.-P. , Chevrier , C. , Cordier , S. and Debrauwer , L. 2013 . Untargeted profiling of pesticide metabolites by LC–HRMS: An exposomics tool for human exposure evaluation . Anal. Bioanal. Chem , doi: 10.1007/s00216-013-7136-2
   PubMedGoogle Scholar
• Jourdan , F. , Cottret , L. , Huc , L. , Wildridge , D. , Scheltema , R. , Hillenweck , H. , Barrett , M. P. , Zalko , D. , Watson , D. G. and Debrauwer , L. 2010 . Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining . Metabolomics , 6 : 312 – 321 .
   PubMed Web of Science ®Google Scholar
• Kanehisa , M. and Goto , S. 2000 . KEGG: Kyoto encyclopedia of genes and genomes . Nucleic Acids Res , 28 : 27 – 30 .
   PubMed Web of Science ®Google Scholar
• Kenny , L. C. , Broadhurst , D. , Brown , M. , Dunn , W. B. , Redman , C. W. G. , Kell , D. B. and Baker , P. N. 2008 . Detection and identification of novel metabolomic biomarkers in preeclampsia . Reprod. Sci , 15 : 591 – 597 .
   PubMed Web of Science ®Google Scholar
• Kholodenko , B. , Yaffe , M.B. and Kolch , W. 2012 . Computational approaches for analyzing information flow in biological networks . Sci. Signal , 5 : 1 – 14 .
   PubMedGoogle Scholar
• Kim , K. B. , Kim , S. H. , Um , S. Y. , Chung , M. W. , Oh , J. S. , Jung , S. C. , Kim , T. S. , Moon , H. J. , Han , S. Y. , Oh , H. Y. , Lee , B. M. and Choi , K. H. 2009 . Metabolomics approach to risk assessment: methoxyclor exposure in rats . J. Toxicol. Environ. Health A , 72 : 1352 – 1368 .
   PubMed Web of Science ®Google Scholar
• Kim , K. B. , Yang , J. Y. , Kwack , S. J. , Park , K. L. , Kim , H. S. , Ryu , D. H. , Kim , Y. J. , Hwang , G. S. and Lee , B. M. 2010 . Toxicometabolomics of urinary biomarkers for human gastric cancer in a mouse model . J. Toxicol. Environ. Health A , 73 : 1420 – 1430 .
   PubMed Web of Science ®Google Scholar
• Kochhar , S. , Jacobs , D. M. , Ramadan , Z. , Berruex , F. , Fuerholz , A. and Fay , L. B. 2006 . Probing gender-specific metabolism differences in humans by nuclear magnetic resonance-based metabonomics . Anal. Biochem , 352 : 274 – 281 .
   PubMed Web of Science ®Google Scholar
• Koek , M. , Jellema , R. H. , van der Greef , J. , Tas , A. C. and Hankemeier , T. 2011 . Quantitative metabolomics based on gas chromatography mass spectrometry: Status and perspectives . Metabolomics , 7 : 307 – 328 .
   PubMed Web of Science ®Google Scholar
• Kuo , C. H. , Wang , K. C. , Tian , T. F. , Tsai , M. H. , Chiung , Y. M. , Hsiech , C. M. , Tsai , S. J. , Wang , S. Y. , Tsai , D. M. , Huang , C. C. and Tseng , Y. J. 2012 . Metabolomic characterization of laborers exposed to welding fumes . Chem. Res. Toxicol , 25 : 676 – 686 .
   PubMed Web of Science ®Google Scholar
• Lacroix , M. Z. , Puel , S. , Collet , S. H. , Corbel , T. , Picard-Hagen , N. , Toutain , P. L. , Viguié , C. and Gayrard , V. 2011 . Simultaneous quantification of bisphenol A and its glucuronide metabolite (BPA-G) in plasma and urine: Applicability to toxicokinetic investigations . Talanta , 85 : 2053 – 2059 .
   PubMed Web of Science ®Google Scholar
• Lenz , E. M. , Bright , J. , Wilson , I. D. , Hughes , A. , Morrisson , J. , Lindberg , H. and Lockton , A. 2004 . Metabonomics, dietary influences and cultural differences: A 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects . J. Pharm. Biomed. Anal , 36 : 841 – 849 .
   PubMed Web of Science ®Google Scholar
• Li , L. , Li , R. , Zhou , J. , Zuniga , A. , Stanislaus , A. E. , Wu , Y. , Huan , T. , Zhang , J. , Shi , Y. , Wishart , D. S. and Lin , G. 2013 . My compound ID: Using evidence-based metabolome library for metabolite identification . Anal. Chem , 85 : 3401 – 3408 .
   PubMed Web of Science ®Google Scholar
• Liang , Y.J. , Wang , H. P. , Yang , L. , Li , W. and Wu , Y. J. 2012a . Metabonomic responses in rat urine following subacute exposure to propoxur . Int. J. Toxicol , 31 : 287 – 293 .
   PubMed Web of Science ®Google Scholar
• Liang , Y. J. , Wang , H. P. , Long , D. X. and Wu , Y. J. 2012b . (1)H NMR-based metabonomic profiling of rat serum and urine to characterize the subacute effects of carbamate insecticide propoxur . Biomarkers , 17 : 566 – 574 .
   PubMed Web of Science ®Google Scholar
• Liang , Y. J. , Wang , H. P. , Long , D. X. and Wu , Y. J. 2012c . Applying biofluid metabonomic techniques to analyze the combined subchronic toxicity of propoxur and permethrin in rats . Bioanalysis , 4 : 2897 – 2907 .
   PubMed Web of Science ®Google Scholar
• Lindon , J. C. , Holmes , E. , Bollard , M. E. , Stanley , E. G. and Nicholson , J. K. 2004 . Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis . Biomarkers , 9 : 1 – 31 .
   PubMed Web of Science ®Google Scholar
• Lindon , J. C. and Nicholson , J. K. 2008 . Analytical techniques for metabonomics and metabolomics, and multi-omic information recovery . Trends Anal. Chem , 27 : 194 – 204 .
   Web of Science ®Google Scholar
• Lioy , P. J. and Rappaport , S. M. 2011 . Exposure science and the exposome: An opportunity for coherence in the environmental health sciences . Environ. Health Perspect , 109 : A466 – A467 .
   Google Scholar
• Madsen , R. , Lundstedt , T. and Trygg , J. 2010 . Chemometrics in metabolomics—A review in human disease diagnosis . Anal. Chim. Acta , 659 : 23 – 33 .
   PubMed Web of Science ®Google Scholar
• Maher , A. D. , Zirah , S. F. , Holmes , E. and Nicholson , J. K. 2007 . Experimental and analytical variation in human urine in 1H NMR spectroscopy-based metabolic phenotyping studies . Anal. Chem , 79 : 5204 – 5211 .
   PubMed Web of Science ®Google Scholar
• Mamas , M. , Dunn , W. , Neyses , L. and Goodacre , R. 2011 . The role of metabolites and metabolomics in clinically applicable biomarkers of disease . Arch. Toxicol , 85 : 5 – 17 .
   PubMed Web of Science ®Google Scholar
• Merhi , M. , Demur , C. , Racaud-Sultan , C. , Bertrand , J. , Canlet , C. , Estrada , F. B. and Gamet-Payrastre , L. 2010 . Gender-linked haematopoietic and metabolic disturbances induced by a pesticide mixture administered at low dose to mice . Toxicology , 267 : 80 – 90 .
   PubMed Web of Science ®Google Scholar
• Miller , M. G. 2007 . Environmental metabolomics: A SWOT analysis (strengths, weaknesses, opportunities, and threats) . J. Proteome Res , 6 : 540 – 545 .
   PubMed Web of Science ®Google Scholar
• Molinska , A. , Blanchet , L. , Buydens , L. M. C. and Wijmenga , S. S. 2012 . NMR and pattern recognition methods in metabolomics: From data acquisition to biomarker discovery: A review . Anal. Chim. Acta , 750 : 82 – 97 .
   PubMed Web of Science ®Google Scholar
• Munoz-Quezada , M. T. , Iglesias , V. , Lucero , B. , Steenland , K. , Barr , D. B. , Levy , K. , Ryan , P. B. , Alvarado , S. and Concha , C. 2012 . Predictors of exposure to organophosphate pesticides in schoolchildren in the Province of Talca, Chile . Environ. Int , 47 : 28 – 36 .
   PubMed Web of Science ®Google Scholar
• Neyraud , E. , Tremblay-Francon , M. , Gregoire , S. , Berdeaux , O. and Canlet , C. 2013 . Relationships between the metabolome and the fatty acid composition of human saliva; effects of stimulation . Metabolomics , 9 : 213 – 222 .
   Web of Science ®Google Scholar
• Peakman , T. C. and Elliott , P. 2008 . The UK Biobank sample handling and storage validation studies . Int. J. Epidemiol , 37 : i2 – i6 . (suppl. 1)
   PubMed Web of Science ®Google Scholar
• Putri, S. P., S. Yamamoto, H. TsugawaE. Fukusaki. 2013. Current metabolomics: Technological advances. J. Biosci. Bioeng http://dx.doi.org/10.1016/j.jbiosc.2013.01.004 (http://dx.doi.org/10.1016/j.jbiosc.2013.01.004)
   Google Scholar
• Ramautar , R. , Somsen , G. W. and de Jong , G. J. 2013 . CE-MS for metabolomics: developments and applications in the period 2010–2012 . Electrophoresis , 34 : 86 – 98 .
   PubMed Web of Science ®Google Scholar
• Rappaport , S. M. 2011 . Implication of the exposome for exposure science . J. Expos. Sci. Environ. Epidemiol , 21 : 5 – 9 .
   PubMed Web of Science ®Google Scholar
• Robertson , D. G. , Watkins , P. B. and Reily , M. D. 2011 . Metabolomics in toxicology: Preclinical and clinical applications . Toxicol. Sci , 120 : S146 – S170 .
   PubMed Web of Science ®Google Scholar
• Robertson , D. 2005 . Metabonomics in toxicology: A review . Toxicol. Sci , 85 : 806 – 822 .
   Google Scholar
• Ross , A. , Schlotterbeck , G. , Dieterle , F. and Senn , H. 2007 . “ NMR spectroscopy techniques for application to metabonomics ” . In The handbook of metabonomics and metabolomics Edited by: Lindon , J. C. , Nicholson , J. K. and Holmes , H. 55 – 112 . Elsevier , The Netherlands
   Google Scholar
• Shintu , L. , Baudoin , R. , Navratil , V. , Prot , J-M. , Pointoizeau , C. , Defernez , M. , Blaise , B. , Domange , C. , Péry , A. R. , Toulhoat , P. , Legallais , C. , Brochot , C. , Leclerc , E. and Dumas , M.-E. 2012 . Metabolomics-on-a-chip and predictive systems toxicology in microfluidic bioartificial organs . Anal. Chem , 84 : 1840 – 1848 .
   PubMed Web of Science ®Google Scholar
• Sumner , S. , Snyder , R. , Burgess , J. , Myers , C. , Tyl , R. , Sloan , C. and Fennell , T. 2009 . Metabolomics in the assessment of chemical-induced reproductive and developmental outcomes using non-invasive biological fluids: Application to the study of butylbenzyl phthalate . J. Appl. Toxicol , 29 : 703 – 714 .
   PubMed Web of Science ®Google Scholar
• Sun , X. , Xu , W. , Zeng , Y. , Hou , Y. , Guo , L. , Zhao , X. and Sun , C. 2012a . Metabonomics evaluation of urine from rats administered with phorate under long-term and low-level exposure by ultra-performance liquid chromatography-mass spectrometry . J. Appl. Toxicol , doi: 10.1002/jat.2848
   Web of Science ®Google Scholar
• Sun , R. , Zhang , J. , Xiong , M. , Chen , Y. , Yin , L. and Pu , Y. 2012b . Metabolomics biomarkers for subacute toxicity screening for benzene exposure in mice . J. Toxicol. Environ. Health A , 75 : 1163 – 1173 .
   PubMed Web of Science ®Google Scholar
• Sun , J. , Schnackenberg , L. , Pence , L. , Bhattacharyya , S. , Doerge , D. , Bowyer , J. and Beger , R. 2010 . Metabolomic analysis of urine from rats chronically dosed with acrylamide using NMR and LC/MS . Metabolomics , 6 : 550 – 563 .
   Web of Science ®Google Scholar
• Theodoridis , G. A. , Gika , H. G. , Want , E. J. and Wilson , I. D. 2012 . Liquid chromatography–mass spectrometry based global metabolite profiling: A review . Anal. Chim. Acta , 711 : 7 – 16 .
   PubMed Web of Science ®Google Scholar
• Trygg , J. and Wold , S. 2002 . Orthogonal projections to latent structures . J. Chemometrics , 16 : 119 – 128 .
   Web of Science ®Google Scholar
• Tuplan , D. , Léger , S. , Belliveau , L. , Culf , A. and Čuperlović-Culf , M. 2011 . MetaboHunter: An automatic approach for identification of metabolites from 1H-NMR spectra of complex mixtures . BMC Bioinfo , 12 : 400
   PubMedGoogle Scholar
• van den Berg , R. , Hoefsloot , H. , Westerhuis , J. , Smilde , A. and van der Werf , M. 2006 . Centering, scaling, and transformations: Improving the biological information content of metabolomics data . BMC Genomics , 7 : 142
   PubMed Web of Science ®Google Scholar
• van Ravenzwaay , B. , Coelho-Palermo Cunha , G. , Strauss , V. , Wiemer , J. , Leibold , E. , Kamp , H. , Walk , T. , Mellert , W. , Looser , R. , Prokoudine , A. , Fabian , E. , Krenrish , G. and Herold , M. 2010 . The individual and combined metabolite profiles (metabolomics) of dibutylphthalate and di(2-ethylhexyl)phthalate following a 28-day dietary exposure in rats . Toxicol. Lett , 198 : 159 – 170 .
   PubMed Web of Science ®Google Scholar
• van Vliet , E. , Morath , S. , Eskes , C. , Linge , J. , Rappsilber , J. , Honegger , P. , Hartung , T. and Coecke , S. 2008 . A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methylmercury, mercury chloride and caffeine . Neurotoxicology , 29 : 1 – 12 .
   PubMed Web of Science ®Google Scholar
• Vineis , P. , van Veldhoven , K. , Chadeau-Hyam , M. and Atersuch , T. J. 2013 . Advancing the application of omics-based biomarkers in environmental epidemiology . Environ. Mol. Mutagen , doi: 10.1002/em.21764
   Web of Science ®Google Scholar
• Vlaanderen , J. , Moore , L. E. , Smith , M. T. , Lan , Q. , Zhang , L. , Skibola , C. F. , Rothman , N. and Vermeulen , R. 2010 . Application of OMICS technologies in occupational and environmental health research; current status and projections . Occup. Environ. Med , 67 : 136 – 143 .
   PubMed Web of Science ®Google Scholar
• Vulimiri , S. V. , Misra , M. , Hamm , J. T. , Mitchell , M. and Berger , A. 2009 . Effects of mainstream cigarette smoke on the global metabolome of human lung epithelial cells . Chem. Res. Toxicol , 22 : 492 – 503 .
   PubMed Web of Science ®Google Scholar
• Wang , H. P. , Liang , Y. J. , Long , D. X. , Chen , J. X. , Hou , W. Y. and Wu , Y. J. 2009 . Metabolic profiles of serum from rats after subchronic exposutre to chlorpyrifos and carbaryl . Chem. Res. Toxicol , 22 : 1026 – 1033 .
   PubMed Web of Science ®Google Scholar
• Wang , H. P. , Liang , Y. J. , Zhang , Q. , Long , D. X. , Li , W. , Li , L. , Yang , L. , Yan , X. Z. and Wu , Y. J. 2011 . Changes in metabolic profiles of urine from rats following chronic exposure to anticholinesterase pesticides . Pestic. Biochem. Physiol , 101 : 232 – 239 .
   Web of Science ®Google Scholar
• Wang , H. P. , Liang , Y. J. , Sun , Y. J. , Chen , J. X. , Hou , W. Y. , Long , D. X. and Wu , Y. J. 2013 . 1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides . Chem. Biol. Interact , 203 : 588 – 596 .
   PubMed Web of Science ®Google Scholar
• Waterman , D. S. , Bonner , F. W. and Lindon , J. C. 2009 . Spectroscopic and statistical methods in metabonomics . Bioanalysis , 1 : 1559 – 1578 .
   PubMed Web of Science ®Google Scholar
• Werner , E. , Heilier , J. F. , Ducruix , C. , Ezan , E. , Junot , C. and Tabet , J. C. 2008 . Mass spectrometry for the identification of the discriminating signals from metabolomics: Current status and future trends . J. Chromatogr. B , 871 : 143 – 163 .
   PubMed Web of Science ®Google Scholar
• Wild , C. P. 2005 . Complementing the genome with an “exposome”: The outstanding challenge of environmental exposure measurement in molecular epidemiology . Cancer Epidemiol. Biomarker Prev. BP , 14 : 1847 – 1850 .
   PubMed Web of Science ®Google Scholar
• Wishart , D. S. , Tzur , D. , Knox , C. , Eisner , R. , Guo , A. C. , Young , N. , Cheng , D. , Jewell , K. , Arndt , D. , Sawhney , S. , Fung , C. , Nikolai , L. , Lewis , M. , Coutouly , M.-A. , Forsythe , I. , Tang , P. , Shrivastava , S. , Jeroncic , K. , Stothard , P. , Amegbey , G. , Block , D. , Hau , D. D. , Wagner , J. , Miniaci , J. , Clements , M. , Gebremedhin , M. , Guo , N. , Zhang , Y. , Duggan , G. E. , MacInnis , G. D. , Weljie , A. M. , Dowlatabadi , R. , Bamforth , F. , Clive , D. , Greiner , R. , Li , L. , Marrie , T. , Sykes , B. D. , Vogel , H. J. and Querengesser , L. 2007 . HMDB: The human metabolome database . Nucleic Acids Res , 35 : D521 – D526 .
   PubMed Web of Science ®Google Scholar
• Wishart , D. S. , Jewison , T. , Guo , A. C. , Wilson , M. , Knox , C. , Liu , Y. , Djoumbou , Y. , Mandal , R. , Aziat , F. , Bouatra , E. S. , Sinelnikov , I. , Arndt , D. , Xia , J. , Liu , P. , Yallou , F. , Bjorndahl , T. , Perez-Pineiro , R. , Eisner , R. , Allen , F. , Neveu , V. , Greiner , R. and Scalbert , A. 2013 . HMDB 3.0—The Human Metabolome Database in 2013 . Nucleic Acids Res , 41 : D801 – D807 . doi: 10.1093/nar/gks1065
   PubMed Web of Science ®Google Scholar
• Wishart , D. S. , Knox , C. , Guo , A. C. , Eisner , R. , Young , N. , Gautam , B. , Hau , D. D. , Psychogios , N. , Dong , E. , Bouatra , S. , Mandal , R. , Sinelnikov , I. , Xia , J. , Jia , L. , Cruz , J. A. , Lim , E. , Sobsey , C. A. , Shrivastava , S. , Huang , P. , Liu , P. , Fang , L. , Peng , J. , Fradette , R. , Cheng , D. , Tzur , D. , Clements , M. , Lewis , A. , De Souza , A. , Zuniga , A. , Dawe , M. , Xiong , Y. , Clive , D. , Greiner , R. , Nazyrova , A. , Shaykhutdinov , R. , Li , L. , Vogel , H. J. and Forsythe , I. 2009 . HMDB: A knowledge base for the human metabolome . Nucleic Acids Res , 37 : D603 – D610 . doi: 10.1093/nar/gkn810
   PubMed Web of Science ®Google Scholar
• Wold , S. , Sjostrom , M. and Eriksson , L. 2001 . PLS-regression: A basic tool of chemometrics . Chem. Intel. Lab. Syst , 58 : 109 – 130 .
   Web of Science ®Google Scholar
• Xia , H. F. , Chi , Y. , Qi , X. , Su , M. M. , Cao , Y. , Song , P. P. , Li , X. , Chen , T. L. , Zhao , A. H. , Zhang , Y. N. , Cao , Y. , Ma , X. and Jia , W. 2011 . Metabolomic evaluation of di-n-butyl phthalate-induced teratogenesis in mice . Metabolomics , 7 : 559 – 571 .
   Web of Science ®Google Scholar
• Xu , Y. , Agrawal , S. , Cook , T. J. and Knipp , G. T. 2007 . Di-(2-ethylhexyl)-phthalate affects lipid profiling in fetal rat brain upon maternal exposure . Arch. Toxicol , 81 : 57 – 62 .
   PubMed Web of Science ®Google Scholar
• Yang , J. , Sun , X. , Feng , Z. , Hao , D. , Wang , M. , Zhao , X. and Sun , C. 2011 . Metabolomic analysis of the toxic effects of chronic exposure to low-level dichlorvos on rats using ultra-performance liquid chromatography-mass spectrometry . Toxicol. Lett , 206 : 306 – 313 .
   PubMed Web of Science ®Google Scholar
• Yang , J. , Wang , H. , Xu , W. , Hao , D. , Du , L. , Zhao , X. and Sun , C. 2013 . Metabolomic analysis of rat plasma following chronic low-dose exposure to dichlorvos . Hum. Exp. Toxicol , 32 : 196 – 205 .
   PubMed Web of Science ®Google Scholar
• Zhang , H. , Ding , L. , Fang , X. , Shi , Z. , Zhang , Y. , Chen , H. , Yan , X. and Dai , J. 2011a . Biological responses to perfluorododecanoic acid exposure in rat kidneys as determined by integrated proteomic and metabonomic studies . PLoS One , e20862-1-11
   Web of Science ®Google Scholar
• Zhang , Y. , Wu , B. , Zhang , Z. Y. and Cheng , S. P. 2011b . A metabonomic analysis on health effects of drinking water on male mice (Mus musculus) . J. Hazard Mater , 190 : 515 – 519 .
   PubMed Web of Science ®Google Scholar
• Zhang , J. , Yan , L. , Tian , M. , Huang , Q. , Peng , S. , Dong , S. and Shen , H. 2012a . The metabonomics of combined dietary exposure to phthalates and polychlorinated biphenyls in mice . J. Pharm. Biomed. Anal , 66 : 287 – 297 .
   PubMed Web of Science ®Google Scholar
• Zhang , A. , Sun , H. and Wang , X. 2012b . Saliva metabolomics opens door to biomarker discovery, disease diagnosis, and treatment . Appl. Biochem. Biotechnol , 168 : 1718 – 1727 .
   PubMed Web of Science ®Google Scholar
• Zhou , B , Wang , J. and Ressom , H. W. 2012 . MetaboSearch: Tool for mass-based metabolite identification using multiple databases . PLoS One , 7 : e40096
   PubMedGoogle Scholar
• Zivkovic , A. , Wiest , M. , Nguyen , U. , Davis , R. , Watkins , S. and German , J. 2009 . Effects of sample handling and storage on quantitative lipid analysis in human serum . Metabolomics , 5 : 507 – 516 .
   PubMed Web of Science ®Google Scholar