Long-term particulate matter exposure: Attributing health effects to individual PM components

References

• Amdur, M.O., J. Bayles, V. Ugro, and D.W. Underhill. 1978. Comparative irritant potency of sulfate salts. Environ. Res. 16:1–8. doi:10.1016/0013-9351(78)90135-4
   PubMed Web of Science ®Google Scholar
• Basu, R., M. Harris, L. Sie, B. Malig, R. Broadwin, and R. Green. 2014. Effects of fine particulate matter and its constituents on low birth weight among full-term infants in California. Environ. Res. 128:42–51. doi:10.1016/j.envres.2013.10.008
   PubMed Web of Science ®Google Scholar
• Beelen, R., O. Raaschou-Nielsen, M. Stafoggia, Z.J. Andersen, G. Weinmayr, B. Hoffman, et al. 2014. Effects of long-term exposure to air pollution on natural-cause mortality: An analysis of 22 European cohorts within the multicentre ESCAPE project. Lancet 383:785–95. doi:10.1016/S0140-6736(13)62158-3
   PubMed Web of Science ®Google Scholar
• Beelen, R., G. Hoek, P.A. van der Brandt, R.A. Goldbohm, P. Fischer, et al. 2008. Long term exposure to traffic-related air pollution and lung cancer risk. Epidemiology 19:702–10. doi:10.1097/EDE.0b013e318181b3ca
   PubMed Web of Science ®Google Scholar
• Bergen, S., L. Sheppard, P.D. Sampson, S.-Y. Kim, et al. 2013. A national prediction model for PM2.5 component exposures and measurement error-corrected health effect inference. Environ. Health Perspect. 121:1017–25. doi:10.1289/ehp.1206010
   PubMed Web of Science ®Google Scholar
• Brightwell, J., X. Fouillet, A.L. Cassano-Zoppi, D. Bernstein, F. Crawley, F. Duchosal, R. Gatz, S. Perczel, and H. Pfeifer. 1989. Tumors of the respiratory tract in rats and hamsters following chronic inhalation of engine exhaust emissions. J. Appl. Toxicol. 9:23–31. doi:10.1002/(ISSN)1099-1263
   PubMed Web of Science ®Google Scholar
• Busch, R.H., R.E. Filipy, M.T. Maragianes, and R.F. Palmer. 1981. Pathologic changes associated with experimental exposure of rats to coal dust. Environ. Res. 24:53–60. doi:10.1016/0013-9351(81)90131-6
   PubMed Web of Science ®Google Scholar
• Campen M.J., A.K. Lund, M. Doyle-Eisele, J.D. McDonald, T.L. Knuckles, A.C. Rohr, et al. 2010. A comparison of vascular effects from complex and individual air pollutants indicates a role for monoxide gases and volatile hydrocarbons. Environ. Health Perspect. 118:921–27. doi:10.1289/ehp.0901207
   PubMed Web of Science ®Google Scholar
• Castranova, V., L. Bowman, M.J. Reasor, T. Lewis, J. Tucker, and P.R. Miles. 1985. The response of rat alvolear macrophages to chronic inhalation of coal dust and/or diesel exhaust. Environ. Res. 36:405–19. doi:10.1016/0013-9351(85)90034-9
   PubMed Web of Science ®Google Scholar
• Cavender, F.L., B. Singh, and B.Y. Cockrell. 1978. Effects in rats and guinea pigs of six-month exposures to sulfuric acid mist, ozone, and their combination. J. Toxicol. Environ. Health 4:845–52. doi:10.1080/15287397809529705
   PubMed Web of Science ®Google Scholar
• Cesaroni, G., F. Forastiere, M. Stafoggia, Z.J. Andersen, C. Badaloni, et al. 2014. Long term exposure to ambient air pollution and incidence of acute coronary events: Prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project. Br. Med. J. 348:1–16. doi:10.1136/bmj.f7412
   Web of Science ®Google Scholar
• Chen, L.C., and J.-S. Hwang. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: IV. Characterization of acute and chronic effects of ambient air fine particulate matter exposures on heart rate variability. Inhal. Toxicol. 17:209–16. doi:10.1080/08958370590912789
   PubMed Web of Science ®Google Scholar
• Chen, L.C., and C. Nadziejko. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: V. CAPs exacerbate aortic plaque development in hyperlipidemic mice. Inhal. Toxicol. 17:217–24. doi:10.1080/08958370590912815
   PubMed Web of Science ®Google Scholar
• Chen, L.C., J.S. Hwang, R. Lall, G. Thurston, and M. Lippmann. 2010. Alteration of cardiac function in ApoE−/- mice by subchronic urban and regional exposure to concentrated ambient PM2.5. Inhal. Toxicol. 22: 580–92. doi:10.3109/08958371003596579
   PubMed Web of Science ®Google Scholar
• Dimakopoulou, K., E. Samoli, R. Beelen, M. Stqafoggie, Z.J. Anderen, et al. 2014. Air pollution and nonmalignant respiratory mortality in 16 cohorts within the ESCAPE project. Am. J. Respir. Crit. Care Med. 189:665–95. doi:10.1164/rccm.201310-1777OC
   Web of Science ®Google Scholar
• Dockery, D.W., C.A. Pope III, X. Xu, et al. 1993. An association between air pollution and mortality in six US cities. N. Engl. J. Med. 329: 1753–59. doi:10.1056/NEJM199312093292401
   Google Scholar
• Eeftens, M., M.-Y. Tsai, C. Ampe, B. Anwander, R. Beelen, T. Bellander, et al. 2012. Spatial variation of PM2.5, PM10, PM2.5 absorbance and PMcoarse concentrations between and within 20 European study areas and the relationship with NO2—Results of the ESCAPE project. Atmos. Environ. 62:303–17. doi:10.1016/j.atmosenv.2012.08.038
   Web of Science ®Google Scholar
• Eeftens, M., G. Hoek, O. Gruzieva, A. Molter, R. Agius, R. Beelen, et al. 2014. Elemental composition of particulate matter and the association with lung function. Epidemiology 25:648–57. doi:10.1097/EDE.0000000000000136
   PubMed Web of Science ®Google Scholar
• Fuertes, E., E. MacIntyre, R. Agius, R. Beelen, et al. 2014. Associations between particulate matter elements and early-life pneumonia in seven birth cohorts: Results from the ESCAPE and TRANSPHORM projects. Int. J. Hyg. Environ. Health 217(8):819–29. doi:10.1016/j.ijheh.2014.05.004
   Google Scholar
• Fuks, K.B., G. Weinmayr, M. Foraster, J. Dratva, R. Hampel, et al. 2014. Arterial blood pressure and long-term exposure to traffic-related air pollution: An analysis in the European Study of Cohorts for the Air Pollution Effects (ESCAPE). Environ. Health Perspect 122(9):896–905. doi:10.1289/ehp.1307725
   Google Scholar
• Gallagher, J., U. Heinrich, M. George, L. Hendee, D.H. Phillips, and J. Lewtas. 1994. Formation of DNA adducts in rat lung following chronic inhalation of diesel emissions, carbon black, and titanium dioxide particles. Carcinogenesis 15:1291–99. doi:10.1093/carcin/15.7.1291
   PubMed Web of Science ®Google Scholar
• Gan, W.Q., M. Koehoorn, H.W. Davies, P.A. Demers, O.L. Tamburis, and M. Brauer. 2010. Long term exposure to traffic-related air pollution and the risk of coronary heart disease hospitalization and mortality. Environ. Health Perspect. 119:501–7. doi:10.1289/ehp.1002511
   PubMed Web of Science ®Google Scholar
• Gan, W.Q., J.M. Fitzgerald, C. Carlsten, M. Sadatsafavi, and M. Brauer. 2013. Associations of ambient air pollution with chronic respiratory disease hospitalization and mortality. Am. J. Respir. Crit. Care Med. 187:721–27. doi:10.1164/rccm.201211-2004OC
   PubMed Web of Science ®Google Scholar
• Gearhart, J.M., and R.B. Schlesinger. 1988. Response of the tracheobronchial mucociliary clearance system to repeated irritant exposure: Effect of sulfuric acid mist on function and structure. Exp. Lung Res. 14:587–605. doi:10.3109/01902148809087831
   PubMed Web of Science ®Google Scholar
• Gehring, U., O. Gruzieva, R.M. Agius, R. Beelen, A. Custovic, et al. 2013. Air pollution exposure and lung function in children: The ESCAPE Project. Environ. Health Perspect. 121:1357–64. doi:10.1289/ehp.1306770
   PubMed Web of Science ®Google Scholar
• Grahame, T.J., R. Klemm, and R.B. Schlesinger. 2014. Public health and components of particulate matter: The changing assessment of black carbon. J. Air Waste Manage. Assoc. 64:620–60. doi:10.1080/10962247.2014.912692
   Web of Science ®Google Scholar
• Grahame, T.J., and R.B. Schlesinger. 2010. Cardiovascular health and particulate vehicular emissions: A critical evaluation of the evidence. Air Qual. Atmos. Health 3:3–27. doi:10.1007/s11869-009-0047-x
   PubMed Web of Science ®Google Scholar
• Griese, M., G., A. Schams, M. Josten, A. Ziesenis, and K. Maier. 1999. Health effects of sulfur-related environmental air pollution: The pulmonary surfactant system is not disturbed by exposure to acidic sulfate and neutral sulfite aerosols. J. Aerosol Med. 12:37–44. doi:10.1089/jam.1999.12.37
   PubMedGoogle Scholar
• Gruzieva, O., U. Gehring, R. Aalberse, R. Agius, R. Beelen, H. Behrendt, et al. 2014. Meta-analysis of air pollution exposure association with allergic sensitizartion in European birth cohorts. J. Allergy Clin. Immunol. 133:767–76. doi:10.1016/j.jaci.2013.07.048
   PubMed Web of Science ®Google Scholar
• Gunnison, A., and L.C. Chen. 2005. Effects of subchronic exposures to concentrated ambient particles in mice: VI. Gene expression in heart and lung tissue. Inhal. Toxicol. 17:225–33. doi:10.1080/08958370590912851
   PubMed Web of Science ®Google Scholar
• Guxens, M., R. Garcia-Esteban, L. Gioris-Allemand, J. Forns, C. Badaloni, F. Ballester, et al. 2014. Air pollution during pregnancy and childhood cognitive and psychomotor development: Six European birth cohorts. Epidemiology 25:636–47. doi:10.1097/EDE.0000000000000133
   PubMed Web of Science ®Google Scholar
• Hahon, N., J.A. Booth, F. Green, and T.R. Lewis. 1985. Influenza virus infection in mine after exposure to coal dust and diesel engine emissions. Environ. Res. 37:44–60. doi:10.1016/0013-9351(85)90048-9
   PubMed Web of Science ®Google Scholar
• Health Effects Institute. 2010. Traffic-Related Air Pollution: A Critical Review of the Literature on Emissions, Exposure, and Health Effects. Special Report 17. Boston, MA: HEI.
   Google Scholar
• Heyder, J., I. Beck-Speier, G.A. Ferron, P. Heilmann, E. Karg, W.G. Kreyling, A.-G. Lenz, K. Maier, H. Schulz, S. Takenaka, and T. Tuch. 1992. Early response of the canine respiratory tract following long-term exposure to a sulfur(IV) aerosol at low concentration: Rationale, design, methodology, and summary. Inhal. Toxicol. 4:159–74. doi:10.3109/08958379209145666
   Google Scholar
• Heyder, J., I. Beck-Speier, B. Busch, P. Dirscherl, P. Heilmann, G.A. Ferron, M. Josten, E. Karg, W.G. Kreyling, A.-G. Lenz, K.L. Maier, U. Miaskowski, S. Platz, P. Reitmeir, H. Schulz, S. Takenaka, and A. Ziesenis. 1999. Health effects of sulfur-related environmental air pollution. I. Executive summary. Inhal. Toxicol. 11:343–59.
   PubMed Web of Science ®Google Scholar
• Heyder, J., I. Beck-Speier, G.A. Ferron, M. Josten, E. Karg, W.G. Kreyling, A.-G. Lenz, K.L. Maier, P. Reitmeier, L. Ruprecht, S. Takenaka, T. Wohland, A. Ziesenis, and H. Schulz. 2009. Long-term responses of canine lungs to acidic particles. Inhal. Toxicol. 21:920–32. doi:10.1080/08958370802651994
   PubMed Web of Science ®Google Scholar
• Hwang, J.-S., C. Nadziejko, and L.C. Chen, 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: III. Acute and chronic effects of CAPs on heart rate, heart rate fluctuation, and body temperature. Inhal. Toxicol. 17:199–207. doi:10.1080/08958370590912761
   PubMed Web of Science ®Google Scholar
• Ishihara, Y., and J. Kagawa. 2003. Chronic diesel exhaust exposures of rats demonstrate concentration and time-dependent effects on pulmonary inflammation. Inhal. Toxicol. 15:473–92. doi:10.1080/08958370304464
   PubMed Web of Science ®Google Scholar
• Janssen, N.A., G. Hoek, M. Simic-Lawson, P. Fischer, L. van Bree, H. ten Brink, M. Keuken, R.W. Atkinson, H.R. Anderson, B. Brunekreef, and F.R. Cassee. 2011. Black carbon as an additional indicator of the adverse health effects of airborne particles compared with PM10 and PM2.5. Environ. Health Perspect. 119:1691–99. doi:10.1289/ehp.1003369
   PubMed Web of Science ®Google Scholar
• Jerrett, M., K.B. Newbold, R.T. Burnett, G. Thurston, et al. 2007. Geographies of uncertainty in the health benefits of air quality improvements. Stoch. Environ. Res. Risk. Assess. 21:511–22. doi:10.1007/s00477-007-0133-2
   Web of Science ®Google Scholar
• Kelly, F.J., and J.C. Fussell. 2012. Size, source and chemical composition as determinants of toxicity attributable to ambient particulate matter. Atmos. Environ. 60:504–26. doi:10.1016/j.atmosenv.2012.06.039
   Web of Science ®Google Scholar
• Krewski, D., R. Burnett, M. Jerrett, C.A. Pope, D. Rainham, et al. 2005. Mortality and the long-term exposure to ambient air pollution: ongoing analyses based on the American Cancer Society Cohort. J. Toxicol. Environ. Health A 68:1093–109. doi:10.1080/15287390590935941
   PubMed Web of Science ®Google Scholar
• Kreyling, W.G., G.A. Ferron, G. Furst, P. Heilmann, M. Neuner, L. Ruprecht, G. Schumann, S. Takenaka, and J. Heyder. 1992. Early response of the canine respiratory tract following long-term exposure to a sulfur(IV) aerosol at low concentration: III. Macrophage-mediated long-term particle clearance. Inhal. Toxicol. 4:197–233. doi:10.3109/08958379209145668
   Google Scholar
• Kreyling, W.G., P. Dirscherl, G.A. Ferron, P. Heilmann, M. Josten, U. Miaskowski, et al. 1999. Health effects of sulfur-related environmental air pollution. III. Nonspecific respiratory defense capacities. Inhal. Toxicol. 11:391–422.
   PubMed Web of Science ®Google Scholar
• Lenters, V., C.S. Uiterwaal, R. Beelen, M.L. Bots, P. Fischer, B.G. Brunekreef, and G. Hoek. 2010. Long-term exposure to air pollution and vascular damage in young adults. Epidemiology 21:512–20. doi:10.1097/EDE.0b013e3181dec3a7
   PubMed Web of Science ®Google Scholar
• Liang, C.K., N.Y. Quan, S.R. Cao, X.Z. He, and F. Ma. 1988. Natural inhalation exposure to coal smoke and wood smoke induces lung cancer in mice and rats. Biomed. Environ. Sci. 1:42–50.
   PubMedGoogle Scholar
• Lipfert, F.W., R.E. Wyzga, J.D. Baty, and J.P. Miller. 2009. Air pollution and survival within the Washington University-EPRI Veterans cohort: Risks based on modeled estimates of ambient levels of hazardous and criteria air pollutants. J. Air Waste Manage. Assoc. 59:473–89. doi:10.1080/10473289.2009.10465740
   Web of Science ®Google Scholar
• Lippmann, M. 2014. Toxicological and epidemiological studies of cardiovascular effects of ambient air fine particulate matter (PM2.5) and its chemical components: Coherence and public health implications. Crit. Rev. Toxicol. Epub ahead of print. doi:10.3109/10408444.2013.861796
   Google Scholar
• Lippmann, M., T. Gordon, and L.C. Chen. 2005a. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: I. Introduction, objectives and experimental plan. Inhal. Toxicol. 17:177–87. doi:10.1080/08958370590912716
   PubMed Web of Science ®Google Scholar
• Lippmann, M., T. Gordon, and L.C. Chen. 2005b. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: IX. Integral assessment and human health implications of subchronic exposures of mice to CAPs. Inhal. Toxicol. 17:255–61. doi:10.1080/08958370590912941
   PubMed Web of Science ®Google Scholar
• Lippmann, M., J.S. Hwang, P. Maciejczyk, and L.C. Chen. 2005c. PM source apportionment for short-term cardiac function changes in ApoE−/- mice. Environ. Health Perspect. 113:1575–79. doi:10.1289/ehp.8091
   PubMed Web of Science ®Google Scholar
• Lippmann, M., K. Ito, J.S. Hwang, et al. 2006. Cardiovascular effects of nickel in ambient air. Environ. Health Perspect. 114:1662–69. doi:10.1289/ehp.9150
   PubMed Web of Science ®Google Scholar
• Lippmann, M., and L.C. Chen. 2009. Health effects of concentrated ambient air particulate matter (CAPs) and its components. Crit. Rev. Toxicol. 39:895–913. doi:10.3109/10408440903300080
   Web of Science ®Google Scholar
• Lippmann, M., L.-C. Chen, T. Gordon, et al. 2013. National Particle Component Toxicity (NPACT) initiative: Integrated epidemiologic and toxicologic studies of the health effects of particulate matter components. Research report 177. Boston, MA: Health Effects Institute.
   Google Scholar
• Maciejczyk, P., and L.C. Chen. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: VIII. Source-related daily variations in in vitro responses to CAPs. Inhal. Toxicol. 17:243–53. doi:10.1080/08958370590912914
   PubMed Web of Science ®Google Scholar
• Maciejczyk, P., M. Zhong, Q. Li, J. Xiong, C. Nadziejko, and L.C. Chen. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: II. The design of a CAPs exposure system for biometric telemetry monitoring. Inhal. Toxicol. 17:189–97. doi:10.1080/08958370590912743
   PubMed Web of Science ®Google Scholar
• MacIntyre, E.A., U. Gehring, A. Molter, E. Fuertes, C. Klumper, U. Kramer, U. Quass, et al. 2014. Air pollution and respiratory infections during early childhood: An analysis of 10 European birth cohorts within the ESCAPE Project. Environ. Health Perspect. 122:107–13.
   Google Scholar
• Madrigano, J., A. Baccarelli, M. Mittleman, R.O. Wright, et al. 2011. Prolonged exposure to particulate pollution, genes associated with glutathione pathways, and DNA methylation in a cohort of older men. Environ. Health Perspect. 119:977–82. doi:10.1289/ehp.1002773
   PubMed Web of Science ®Google Scholar
• Maier, K., I. Beck-Speier, N. Dayal, P. Heilmann, H. Hinze, A.-G. Lenz, L. Leuschel, E. Matejkova, U. Miaskowski, J. Heyder, and L. Ruprecht. 1992. Early response of the canine respiratory tract following long-term exposure to a sulfur(IV) aerosol at low concentration: II. Biochemistry and cell biology of lung lavage fluid. Inhal. Toxicol. 4:175–96. doi:10.3109/08958379209145667
   Google Scholar
• Maier, K.L., I. Beck-Speier, N. Dayal, P. Dirscherl, M. Griese, P. Heilmann, M. Hinze, et al. 1999. Health effects of sulfur-related environmental air pollution. II. Cellular and molecular parameters of injury. Inhal. Toxicol. 11: 361–89.
   PubMed Web of Science ®Google Scholar
• Mauderly, J.L. 2014. National Environmental Respiratory Center (NERC) experiment in multipollutant air quality health research: I. Background, experimental strategy, and critique. Inhal. Toxicol. 26:643–50. doi:10.3109/08958378.2014.923546
   PubMed Web of Science ®Google Scholar
• Mauderly, J.L., and S.K. Seilkop. 2014. National Environmental Respiratory Center (NERC) experiment in multipollutant air quality health research: III. Components of diesel and gasoline engine exhausts, hardwood smoke, and simulated downwind coal emissions driving non-cancer biological responses in rodents. Inhal. Toxicol. 26:668–90. doi:10.3109/08958378.2014.920440
   PubMed Web of Science ®Google Scholar
• Mauderly, J.L., E.G. Barrett, K.C. Day, A.P. Gigliotti, J.D. McDonald, K.S. Harrod, A.K. Lund, M.D. Reed, J. Seagrave, M.J. Campen, and S.K. Seilkop. 2014a. National Environmental Respiratory Center (NERC) experiment in multipollutant air quality health research: II. Comparison of responses to diesel and gasoline engine exhausts, hardwood smoke, and simulated downwind coal emissions. Inhal. Toxicol. 26:651–67. doi:10.3109/08958378.2014.925523
   PubMed Web of Science ®Google Scholar
• Mauderly, J.L., D. Kracko, J. Brower, M. Doyle-Eisele, J.D. McDonald, A.K. Lund, and S.K. Seilkop. 2014b. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: IV. Vascular effects of repeated inhalation exposure to a mixture of five inorganic gases. Inhal. Toxicol. 26:691–96. doi:10.3109/08958378.2014.947448
   PubMed Web of Science ®Google Scholar
• Mauderly, J.L., E.G. Barrett, A.P. Gigliotti, J.D. McDonald, M.D. Reed, J.C. Seagrave, L.A. Mitchell, and S.K. Seilkop. 2011. Health effects of subchronic inhalation exposure to simulated downwind coal combustion emissions. Inhal. Toxicol. 23:349–62. doi:10.3109/08958378.2011.572932
   PubMed Web of Science ®Google Scholar
• Mauderly, J.L., M.B. Snipes, E.B. Barr, S.A. Belinsky, J.A. Bond, A.L. Brooks, I.Y. Chang, Y.S. Cheng, N.A. Gillett, W.C. Griffith, R.F. Henderson, C.E. Mitchell, K.J. Nikula, and D.G. Thomassen. 1994. Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats. Part I: Neoplastic and nonneoplastic lung lesions. Research report 68. Boston, MA: Health Effects Institute.
   Google Scholar
• McDonald, J.D., M. Doyle-Eisele, M.J. Campen, J.C. Seagrave, T. Holmes, A. Lund, et al. 2010. Cardiopulmonary response to inhalation of biogenic secondary organic aerosol. Inhal. Toxicol. 22:253–65. doi:10.3109/08958370903148114
   PubMed Web of Science ®Google Scholar
• McDonald, J.D., M. Doyle-Eisele, A. Gigliotti, R.A. Miller, S. Seilkop, J.L. Mauderly, et al. 2012. Part 1. Biologic responses in rats and mice to subchronic inhalation of diesel exhaust from U.S. 2007-compliant engines: Report on 1-, 3-, and 12-month exposures in the ACES bioassay. Research report 166. Boston, MA: Health Effects Institute.
   Google Scholar
• McDonald, J.D., M. Doyle-Eisele, J. Seagrave, A.P. Gigliotti, J. Chow, B. Zielinska, J.L. Mauderly, S.K. Seilkop, and R.A. Miller. 2015. Advanced Collaborative Emissions Study (ACES): Lifetime cancer and non-cancer assessment in rats exposed to new-technology diesel exhaust. Research Report 184. Boston, MA: Health Effects Institute.
   Google Scholar
• Naeher, L.P., M. Brauer, M. Lipsett, J.T. Zelikoff, C.D. Simpson, J.Q. Koenig, and K.R. Smith. 2007. Woodsmoke health effects: A review. Inhal. Toxicol. 19:67–106. doi:10.1080/08958370600985875
   PubMed Web of Science ®Google Scholar
• Nishimura, I., and T. Negishi. 1995. Chronic inhalation exposure and phospholipids in lung surfactant and tissue. Toxicol. Lett. 75:185–91. doi:10.1016/0378-4274(94)03184-9
   PubMed Web of Science ®Google Scholar
• National Academy of Sciences. 2004. Research Priorities for Airborne Particulate Matter, IV: Continuing Research Progress. Committee on Research Priorities for Airborne Particulate Matter, National Research Council of the National Academies. Washington, DC: National Academies Press.
   Google Scholar
• Ostro, B., M. Lipsett, P. Reynolds, D. Goldberg, et al. 2010. Long-term exposure to constituents of fine particle air pollution and mortality: Results from the California Teachers Study. Environ. Health Perspect. 118:363–69. doi:10.1289/ehp.0901181
   PubMed Web of Science ®Google Scholar
• Ostro, B., P. Reynolds, D. Goldberg, A. Hertz, et al. 2011. Erratum: assessing long-term exposure in the California Teachers Study. Environ. Health Perspect. 119:242–43.
   Web of Science ®Google Scholar
• Pedersen, M., L. Giorgis-Allemand, C. Bernard, I. Aguilera, A.-M. Andersen, F. Ballester, et al. 2013. Ambient air pollution and low birthweight: a European cohort study (ESCAPE). Lancet Respir. Med. 1:695–704. doi:10.1016/S2213-2600(13)70192-9
   PubMed Web of Science ®Google Scholar
• Pope, C.A. III, R.T. Burnett, M.J. Thun, et al. 2002. Lung cancer, cardiopulmonary mortality and long-term exposure to fine particulate air pollution. J. Am. Med. Assoc. 287:1132–41. doi:10.1001/jama.287.9.1132
   PubMed Web of Science ®Google Scholar
• Quan, C., Q. Sun, M. Lippmann, and L.-C. Chen. 2010. Comparative cardiovascular effects of diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction. Inhal. Toxicol. 22:738–53. doi:10.3109/08958371003728057
   PubMed Web of Science ®Google Scholar
• Raabe, O.G., W.S. Tyler, J.A. Last, L.W. Schwartz, L.O. Lollini, G.L. Risher, F.D. Wilson, and D.L. Dungworth. 1982. Studies of the chronic inhalation of coal fly ash by rats. Ann. Occup. Hyg. 26:189–211. doi:10.3109/08958371003728057
   PubMed Web of Science ®Google Scholar
• Raascshou-Nielson, O., Z.J. Andersen, R. Beelen, E. Samoli, M. Stafoggia, G. Weimayr, B. Hoffman, et al. 2013. Air pollution and lung cancer incidence in 17 European cohorts: Prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). Lancet Oncol. 14:813–22.
   PubMed Web of Science ®Google Scholar
• Reed, M.D., P. Gigliotti, J.D. McDonald, J.C. Seagrave, S.K. Seilkop, and J.L. Mauderly. 2004. Health effects of subchronic exposures to environmental levels of diesel exhaust. Inhal. Toxicol. 16:177–93. doi:10.1080/08958370490277146
   PubMed Web of Science ®Google Scholar
• Reed, M.D., M.J. Campen, A.P. Gigliotti, K.S. Harrod, J.D. McDonald, J.C. Seagrave, J.L. Mauderly, and S.K. Seilkop. 2006. Health effects of subchronic exposure to environmental levels of hardwood smoke. Inhal. Toxicol. 18:523–39. doi:10.1080/08958370600685707
   PubMed Web of Science ®Google Scholar
• Reed, M.D., E.G. Barrett, M.J. Campen, K.K. Divine, A.P. Gigliotti, J.D. McDonald, J.C. Seagrave, J.L. Mauderly, S.K. Seilkop, and J.A. Swenberg. 2008. Health effects of subchronic inhalation exposure to gasoline engine exhaust. Inhal. Toxicol. 20:1125–43. doi:10.1080/08958370802368722
   PubMed Web of Science ®Google Scholar
• Rohr, A.C., and R.E. Wyzga. 2012. Attributing health effects to individual particulate matter constituents. Atmos. Environ. 62:130–52. doi:10.1016/j.atmosenv.2012.07.036
   Web of Science ®Google Scholar
• Ross, H.F., E.J. King, M. Yoganathan, and G. Nagelschmidt. 1962. Inhalation experiments with coal dust containing 5 percent, 10 percent, 20 percent, and 40 percent quartz: Tissue reactions in the lungs of rats. Ann. Occup. Hyg. 5:149–61.
   Google Scholar
• Rumchev, K., J. Spickett, M. Bulsara, M. Phillips, and S. Stick. 2004. Association of domestic exposure to volatile organic compounds with asthma in young children. Thorax 59:746–51. doi:10.1136/thx.2003.013680
   PubMed Web of Science ®Google Scholar
• Schikowski, T., M. Adam, A. Marcon, Y. Cai, A. Vierkotter, A.E. Carsin, et al. 2014. Association of ambient air pollution with the prevalence and incidence of COPD. Eur. Respir. J 44(3):614–26. doi:10.1183/09031936.00132213
   Google Scholar
• Schlesinger, R.B., M. Halpern, R.E. Albert, and M. Lippmann. 1979. Effect of chronic inhalation of sulfuric acid mist upon mucociliary clearance from the lungs of donkeys. J. Environ. Pathol. Toxicol. 2:1351–67.
   PubMed Web of Science ®Google Scholar
• Schlesinger, R.B., J.E. Gorczynski, J. Dennison, L. Richards, P.L. Kinney, and M.C. Bosland. 1992. Long-term intermittent exposure to sulfuric acid aerosol, ozone, and their combination: Alterations in tracheobronchial mucociliary clearance and epithelial secretory cells. Exp. Lung Res. 18:505–34. doi:10.3109/01902149209064343
   PubMed Web of Science ®Google Scholar
• Schulz, H., G. Eder, P. Heilmann, E. Karg, T. Meyer, A. Schulz, A. Ziesenis, and J. Heyder. 1999. Health effects of sulfur-related environmental air pollution. IV. Respiratory lung function. Inhal. Toxicol. 11:423–38.
   PubMed Web of Science ®Google Scholar
• Stafoggia, M., G. Cesaroni, A. Peters, Z.J. Andersen, C. Badaloni, R. Beelen, et al. 2014. Long-term exposure to ambient air pollution and incidence of cerebrovascular events: Results from 11 European cohorts within the ESCAPE Project. Environ. Health Perspect 122(9):919–25. doi:10.1289/ehp.1307301
   Google Scholar
• Sun, M., J.D. Kaufman, S.-Y. Kim, T.V. Larson, et al. 2013. Particulate matter components and subclinical atherosclerosis: Common approaches to estimating exposure in a Multi-Ethnic Study of Atherosclerosis cross-sectional study. Environ. Health 12:39. doi:10.1186/1476-069X-12-39
   Web of Science ®Google Scholar
• Szpiro, A.A., C.J. Paciorek, and L. Sheppard. 2011. Does more accurate exposure prediction necessarily improve health effect estimates? Epidemiology 22:680–85. doi:10.1097/EDE.0b013e3182254cc6
   PubMed Web of Science ®Google Scholar
• Takenaka, S., G. Furst, P. Heilmann, A. Heini, U. Heinzmann, W.G. Kreyling, A.B. Murray, H. Schulz, and J. Heyder. 1992. Early response of the canine respiratory tract following long-term exposure to a sulfur(IV) aerosol at low concentrations: V. Morphology and morphometry. Inhal. Toxicol. 4:247–72. doi:10.3109/08958379209145670
   Google Scholar
• Takenaka, S., J.J. Godleski, A. Heini, E. Karg, W.G. Kreyling, B. Ritter, H. Schulz, et al. 1999. Health effects of sulfur-related environmental air pollution. V. Lung structure. Inhal. Toxicol. 11:439–54.
   PubMed Web of Science ®Google Scholar
• Thurston, G.D., K. Ito, R. Lall, R.T. Burnett, M.C. Turner, D. Krewski, Y. Shi, M. Jerrett, S.M. Gapstur, W.R. Diver, and C.A. Pope III. 2013. NPACT study 4. Mortality and long-term exposure to PM2.5 and its components in the American Cancer Society’s Cancer Prevention Study II Cohort. In National Particle Component Toxicity (NPACT) Initiative: Integrated Epidemiologic and Toxicologic Studies of the Health Effects of Particulate Matter Components. Research report 177. Boston, MA: Health Effects Institute.
   Google Scholar
• U.S. Environmental Protection Agency (EPA). 2002. Health assessment document for diesel engine exhaust. Prepared by the National Center for Environmental Assessment, Washington, DC, for the Office of Transportation and Air Quality; EPA/600/8-90/057F. Springfield, VA: National Technical Information Service. PB2002-107661. http://www.epa.gov/ncea
   Google Scholar
• U.S. Environmental Protection Agency (EPA). 2009. Integrated Science Assessment for Particulate Matter. EPA/600/R-08/139F, December. http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=216546#Download
   Google Scholar
• U.S. Environmental Protection Agency (EPA). 2011. Policy Assessment for the Review of the Particulate Matter National Ambient Air Quality Standards EPA 452/R-11-003. April. http://www.epa.gov/ttn/naaqs/standards/pm/data/20110419pmpafinal.pdf
   Google Scholar
• Vedal, S., S.-Y. Kim, K.A. Miller, J.R. Fox, S. Bergen, T. Gould, J.D. Kaufman, T.V. Larson, P.D. Sampson, L. Sheppard, C.D. Simpson, and A.A. Szpiro. 2013. Section 1. NPACT epidemiologic study of components of fine particulate matter and cardiovascular disease in the MESA and WHI-OS Cohorts. In National Particle Component Toxicity (NPACT) Initiative Report on Cardiovascular Effects. Research report 178. Boston, MA: Health Effects Institute.
   Google Scholar
• Veronesi, B., O. Makwana, M. Pooler, and L.C. Chen. 2005. Effects of subchronic exposure to concentrated ambient particles: VII. Degeneration of dopaminergic neurons in Apo E−/− mice. Inhal. Toxicol. 17:235–41. doi:10.1080/08958370590912888
   PubMed Web of Science ®Google Scholar
• Wang, M., R. Beelen, M. Stafoggia, O. Raaschou-Nielsen, Z.J. Andersen, et al. 2014. Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects. Environ. Int. 66:97–106. doi:10.1016/j.envint.2014.01.026
   PubMed Web of Science ®Google Scholar
• Wilhelm, M., J.K. Ghosh, J. Su, M. Cockburn, M. Jerrett, and B. Ritz. 2011. Traffic-based air toxics and preterm birth: A population-based case-control study in Los Angeles County, California. Environ. Health 10:89. doi:10.1186/1476-069X-10-89
   Web of Science ®Google Scholar
• Wolkoff, P., P.A. Clausen, K. Larsen, M. Hammer, S.T. Larsen, and G.D. Nielsen. 2008. Acute airway effects of ozone-initiated d-limonene chemistry: Importance of gaseous products. Toxicol. Lett. 181:171–76. doi:10.1016/j.toxlet.2008.07.018
   PubMed Web of Science ®Google Scholar
• Zou, Y., S. Li, W. Zou, G. Hu, Y. Zhou, G. Peng, F. He, B. Li, and P. Ran. 2014. Upregulation of gelatinases and epithelial-mesenchymal transition in small airway remodeling associated with chronic exposure to wood smoke. PLoS ONE 9(5):e96708. doi:10.1371/journal.pone.0096708
   PubMed Web of Science ®Google Scholar