Phenolic profile, antioxidant and cytotoxic properties of polar extracts from leaves and flowers of Isatis tinctoria L. (Brassicaceae) growing in Sicily

References

• Akeroid JR. 2002. Isatis Linnaeus. In: Cullen J, Alexander JCM, Brady A, Brickell CD, Green PS, Heywood VH, Jørgensen PM, Jury SL, Knees SG, Leslie AC, et al., editors. The European garden flora, Vol. IV. Cambridge: Cambridge University Press. p. 135.
   Google Scholar
• Alam MN, Bristi NJ, Rafiquzzaman M. 2013. Review on in vivo and in vitro methods evaluation of antioxidant activity. Saudi Pharm J. 21: 143–152.10.1016/j.jsps.2012.05.002
   PubMed Web of Science ®Google Scholar
• Ball PW. 1964. Isatis L. In: Tutin TG, Heywood VH, Burges NA, Valentine DH, Walters SM, Webb D, editors. Flora Europaea, Vol. I. Cambridge: Cambridge University Press. pp. 268–269.
   Google Scholar
• Bulotta S, Celano M, Costante G, Russo D. 2016. Emerging strategies for managing differentiated thyroid cancers refractory to radioiodine. Endocrine 52: 214–221.10.1007/s12020-015-0830-4
   PubMed Web of Science ®Google Scholar
• Chahar MK, Sharma N, Dobhal MP, Joshi YC. 2011. Flavonoids: A versatile source of anticancer drugs. Pharmacogn Rev 5(9): 1–12.
   PubMedGoogle Scholar
• Condurso C, Verzera A, Romeo V, Ziino M, Trozzi A, Ragusa S. 2006. The leaf volatile constituents of Isatis tinctoria by solid-phase microextraction and gas chromatography/mass spectrometry. Planta Med 72: 1–5.
   Web of Science ®Google Scholar
• D’Agostino M, Voce P, Celano M, Sponziello M, Moretti S, Maggisano V, Verrienti A, Durante C, Filetti S, Puxeddu E, et al. 2012. Sunitinib exerts only limited effects on the proliferation and differentiation of anaplastic thyroid cancer cells. Thyroid 22: 138–144.10.1089/thy.2011.0060
   PubMed Web of Science ®Google Scholar
• Dahpour AA, Rahdari P, Sobati Z. 2012. Chemical composition of essential oil, antibacterial activity and brine shrimp lethality of ethanol extracts from Sedum pallidum. J Med Plants Res. 6(16): 3105–3109.
   Google Scholar
• deGraft-Johnson J, Kolodziejczyk K, Krol M, Nowak P, Krol B, Nowak D. 2007. Ferric-reducing ability power of selected plant polyphenols and their metabolites: implications for clinical studies on the antioxidant effects of fruits and vegetable consumption. Basic Clin Pharmacol Toxicol. 100: 345–352.10.1111/pto.2007.100.issue-5
   PubMed Web of Science ®Google Scholar
• Denaro N, Lo Nigro C, Russi EG, Merlano MC. 2013. The role of chemotherapy and latest emerging target therapies in anaplastic thyroid cancer. Onco Targets Ther. 9: 1231–1241.10.2147/OTT
   PubMedGoogle Scholar
• Eisenbrand G, Hippe F, Jakobs S, Muehlbeyer S. 2004. Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine. J Cancer Res Clin Oncol. 130: 627–635.10.1007/s00432-004-0579-2
   PubMed Web of Science ®Google Scholar
• Fantini M, Benvenuto M, Masuelli L, Frajese GV, Tresoldi I, Modesti A, Bei R. 2015. In vitro and in vivo antitumoral effects of combinations of polyphenols, or polyphenols and anticancer drugs: perspectives on cancer treatment. Int J Mol Sci. 16: 9236–9282.10.3390/ijms16059236
   PubMed Web of Science ®Google Scholar
• Fialova S, Valigura R, Tekelova D, Grancai D. 2009. Isatis tinctoria L. (dyer’s woad) from the standpoint of phenolic compound content and scavenging activity. Farm Obz. 78: 54–58.
   Google Scholar
• Firuzi O, Lacanna A, Petrucci R, Marrosu G, Saso L. 2004. Evaluation of the antioxidant activity of flavonoids by “ferric reducing antioxidant power” assay and cyclic voltammetry. Biochim Biophys Acta 1721(1–3): 174–184.
   PubMed Web of Science ®Google Scholar
• Galletti S, Righetti L, Bagatta M. 2008. Glucosinolate content and antioxidant activity of woad (Isatis tinctoria L.) flower buds consumed by rural people living in Sicily around Mount Etna. First European Food Congress; Nov 3–9; Ljubljana.
   Google Scholar
• Guarino C, Casoria P, Menale B. 2000. Cultivation and use of Isatis tinctoria L. (Brassicaceae) in Southern Italy. Econ Bot 54: 395–400.10.1007/BF02864789
   Web of Science ®Google Scholar
• Gülçin I. 2006. Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid). Toxicology 217(2–3): 213–220.
   PubMed Web of Science ®Google Scholar
• Hamburger M. 2002. Isatis tinctoria – From the rediscovery of an ancient medicinal plant towards a novel anti-inflammatory phytopharmaceutical. Phytochem Rev 1(3): 333–344.10.1023/A:1026095608691
   Google Scholar
• Hartleb I, Seifert K. 1994. A novel anthranilic acid derivative from Isatis tinctoria. Planta Med. 60(6): 578–579.10.1055/s-2006-959577
   PubMed Web of Science ®Google Scholar
• Hassan EM, Hassan RA, El-Toumy SA, Mohamed SM, Omer EA. 2014. Phenolic metabolites and antioxidant activity of Codiaeum variegatum CV. spirale. J Pharm Res. 8(5): 619–623.
   Google Scholar
• Jalaludeen AM, Pari L. 2011. Studies on the antioxidant and free radical-scavenging effect of sinapic acid: An in vivo and in vitro model. J Pharm Sci Res. 3(9): 1447–1455.
   Google Scholar
• Li H-B, Wong C-C, Cheng K-W, Chen F. 2008. Antioxidant properties in vitro and total phenolic contents in methanol extracts from medicinal plants. LWT – Food Sci Technol. 41(3): 385–390.10.1016/j.lwt.2007.03.011
   Web of Science ®Google Scholar
• Maggisano V, Puppin C, Celano M, D’Agostino M, Sponziello M, Micali S, Navarra M, Damante G, Filetti S, Russo D. 2014. Cooperation of histone deacetylase inhibitors SAHA and valproic acid in promoting sodium/iodide symporter expression and function in rat Leydig testicular carcinoma cells. Endocrine 45(1): 148–152.10.1007/s12020-013-9972-4
   PubMed Web of Science ®Google Scholar
• Marina AM, Man YB, Nazimah SAH, Amin I. 2009. Antioxidant capacity and phenolic acids of virgin coconut oil. Int J Food Sci Nutr. 60(Suppl 2): 114–123.10.1080/09637480802549127
   PubMed Web of Science ®Google Scholar
• Melchini A, Costa C, Traka M, Miceli N, Mithen R, De Pasquale R, Trovato A. 2009. Erucin, a new promising cancer chemopreventive agent from rocket salads, shows anti-proliferative activity on human lung carcinoma A549 cells. Food Chem Toxicol 47: 1430–1436.10.1016/j.fct.2009.03.024
   PubMed Web of Science ®Google Scholar
• Mohn T, Suter K, Hamburger M. 2008. Seasonal changes and effect of harvest on glucosinolates in Isatis leaves. Planta Med. 74(5): 582–587.10.1055/s-2008-1074504
   PubMed Web of Science ®Google Scholar
• Mohn T, Plitzko I, Hamburger M. 2009. A comprehensive metabolite profiling of Isatis tinctoria leaf extracts. Phytochemistry 70: 924–934.10.1016/j.phytochem.2009.04.019
   PubMed Web of Science ®Google Scholar
• Nićiforović N, Abramovič H. 2014. Sinapic acid and its derivatives: Natural sources and bioactivity. Compr Rev Food Sci Food Saf. 13: 34–51.
   PubMed Web of Science ®Google Scholar
• Pham-Huy LA, He H, Pham-Huy C. 2008. Free radicals, antioxidants in disease and health. Int J Biomed Sci. 4(2): 89–96.
   PubMedGoogle Scholar
• Pignatti S. 1982. Isatis tinctoria L. In: Anzalone B, Becherer A, Ehrendorfer F, Merxmüller H, Metlesics H, Montelucci G, Rasetti F, Reichstein T, Segelberg I, editors. Flora D’Italia, Vol. I. Bologna: Edagricole. p. 381.
   Google Scholar
• Recio MC, Cerdá-Nicolás M, Potterat Olivier, Hamburger Matthias, Ríos JL. 2006a. Anti-inflammatory and antiallergic activity in vivo of lipophilic Isatis tinctoria extracts and tryptanthrin. Planta Med. 72: 539–546.10.1055/s-2006-931562
   PubMed Web of Science ®Google Scholar
• Recio MC, Cerdá-Nicolás M, Hamburger M, Ríos JL. 2006b. Anti-arthritic activity of a lipophilic woad (Isatis tinctoria) extract. Planta Med. 72: 715–720.10.1055/s-2006-941507
   PubMed Web of Science ®Google Scholar
• Roleira FMF, Tavares-da-Silva EJ, Varela CL, Costa SC, Silva T, Garrido J, Borges F. 2015. Plant derived and dietary phenolic antioxidants: Anticancer properties. Food Chem 183: 235–258.10.1016/j.foodchem.2015.03.039
   PubMed Web of Science ®Google Scholar
• Salazar R, Pozos ME, Cordero P, Perez J, Salinas MC, Waksman N. 2008. Determination of the antioxidant activity of plants from Northeast Mexico. Pharm Biol. 46: 166–170.10.1080/13880200701498952
   Web of Science ®Google Scholar
• Sheh Hong L, Ibrahim D, Kassim J. 2011. Assessment of in vivo and in vitro cytotoxic activity of hydrolysable tannin extracted from Rhizophora apiculata barks. World J Microb Biot. 27: 2737–2740.10.1007/s11274-011-0727-1
   Web of Science ®Google Scholar
• Sini KR, Sinha BN, Karpagavalli M. 2010. Determining the antioxidant activity of certain medicinal plants of Attapady, (Palakkad), India using DPPH assay. Curr Bot. 1(1): 13–16.
   Google Scholar
• Steriti R. 2002. Nutritional support for chronic myelogenous and other leukemias: a review of the scientific literature. Altern Med Rev. 7: 404–409.
   PubMedGoogle Scholar
• Sultana B, Anwar F, Przybylski R. 2007. Antioxidant activity of phenolic components present in barks of Azadirachta indica, Terminalia arjuna, Acacia nilotica, and Eugenia jambolana Lam Trees. Food Chem. 104: 1106–1114.10.1016/j.foodchem.2007.01.019
   Web of Science ®Google Scholar
• Taviano MF, Marino A, Trovato A, Bellinghieri V, La Barbera TM, Güvenç A, Hürkul MM, De Pasquale R, Miceli N. 2011. Antioxidant and antimicrobial activities of branches extracts of five Juniperus species from Turkey. Pharm Biol. 49(10): 1014–1022.10.3109/13880209.2011.560161
   PubMed Web of Science ®Google Scholar
• Taviano MF, Marino A, Trovato A, Bellinghieri V, Melchini A, Dugo P, Cacciola F, Donato P, Mondello L, Güvenç A, et al. 2013. Juniperus oxycedrus L. subsp. oxycedrus and Juniperus oxycedrus L. subsp. macrocarpa (Sibth. & Sm.) Ball. “berries” from Turkey: comparative evaluation of phenolic profile, antioxidant, cytotoxic and antimicrobial activities. Food Chem Toxicol. 58: 22–29.10.1016/j.fct.2013.03.049
   PubMed Web of Science ®Google Scholar
• Teixeira J, Gaspar A, Garrido EM, Garrido J, Borges F. 2013. Hydroxycinnamic acid antioxidants: An electrochemical overview. BioMed Res Int. 2013: 1–11.
   Web of Science ®Google Scholar
• Veeru P, Kishor MP, Meenakshi M. 2009. Screening of medicinal plant extracts for antioxidant activity. J Med Plants Res. 3(8): 608–612.
   Google Scholar
• Vitali F, Pennisi C, Tomaino A, Bonina F, De Pasquale A, Saija A, Tita B. 2006. Effect of a standardized extract of red orange juice on proliferation of human prostate cells in vitro. Fitoterapia 77: 151–155.10.1016/j.fitote.2005.10.001
   PubMed Web of Science ®Google Scholar
• Yang C-H, Chang H-W, Lin H-Y, Chuang L-Y. 2013. Evaluation of antioxidant and antimicrobial activities from 28 Chinese Herbal Medicines. J Pharmacogn Phytochem. 2(1): 294–305.
   Google Scholar
• Yin F, Giuliano AE, Van Herle AJ. 1999. Growth inhibitory effects of flavonoids in human thyroid cancer cell lines. Thyroid 9(4): 369–376.10.1089/thy.1999.9.369
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zheng J, Li Y, Xu D-P, Li S, Chen Y-M, Li H-B. 2016. Natural polyphenols for prevention and treatment of cancer. Nutrients 8(8): 515.10.3390/nu8080515
   PubMed Web of Science ®Google Scholar