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Diagnosis of acute intoxications in critically ill patients: focus on biomarkers – part 2: markers for specific intoxications

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Pages 112-125 | Received 02 Apr 2019, Accepted 26 Jan 2020, Published online: 10 Feb 2020

References

  • Abdullat, I.M., Battah, A.H., and Hadidi, K.A., 2006. The use of serial measurement of plasma cholinesterase in the management of acute poisoning with organophosphates and carbamates. Forensic science international, 162 (1-3), 126–130.
  • Adla, M.R., Gonzalez-Paoli, J.A., and Rifkin, S.I., 2009. Isopropyl alcohol ingestion presenting as pseudorenal failure due to acetone interference. Southern medical journal, 102 (8), 867–869.
  • Akdemir, H.U., et al., 2014. The role of S100B protein, neuron-specific enolase, and glial fibrillary acidic protein in the evaluation of hypoxic brain injury in acute carbon monoxide poisoning. Human and experimental toxicology, 33 (11), 1113–1120.
  • Alahakoon, C., et al., 2018. Can we predict intermediate syndrome? A review. NeuroToxicology, 69, 209–216.
  • Anantharam, P., et al., 2016. Improved tissue-based analytical test methods for orellanine, a biomarker of cortinarius mushroom intoxication. Toxins (toxins), 8 (5), 158.
  • Andresen-Streichert, H., et al., 2018. Alcohol biomarkers in clinical and forensic contexts. Deutsches arzteblatt international, 115 (18), 309–315.
  • Annane, D., et al., 2001. Prognostic factors in unintentional mild carbon monoxide poisoning. Intensive care medicine, 27 (11), 1776–1781.
  • Anseeuw, K., et al., 2013. Cyanide poisoning by fire smoke inhalation: a European expert consensus. European journal of emergency medicine, 20 (1), 2–9.
  • Antoine, D.J., et al., 2009. High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo. Toxicological sciences, 112 (2), 521–531.
  • Aslan, S., et al., 2006. The evaluation of myocardial damage in 83 young adults with carbon monoxide poisoning in the East Anatolia region in Turkey. Human and experimental toxicology, 25 (8), 439–446.
  • Audi, J., et al., 2005. Ricin poisoning: a comprehensive review. JAMA, 294 (18), 2342–2351.
  • Avsarogullari, L., et al., 2012. Characteristics of acute adult poisonings in a university hospital emergency department in central Turkey: a three-year analysis. Journal of Pakistan medical association, 62 (2), 129–133.
  • Aygun, D., et al., 2002. Serum acetylcholinesterase and prognosis of acute organophosphate poisoning. Journal of toxicology: clinical toxicology, 40 (7), 903–910.
  • Bailey, B., Amre, D.K., and Gaudreault, P., 2003. Fulminant hepatic failure secondary to acetaminophen poisoning: a systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation. Critical care medicine, 31 (1), 299–305.
  • Bartoli, M., et al., 2012. Recommendations for the prescription, implementation and interpretation of medical examinations in biology in the context of severe poisoning. Annales de biologie clinique, 70, 431–450. [].
  • Baud, F.J., 2007. Cyanide: critical issues in diagnosis and treatment. Human and experimental toxicology, 26 (3), 191–201.
  • Baud, F.J., et al., 1991. Elevated blood cyanide concentrations in victims of smoke inhalation. New England journal of medicine, 325 (25), 1761–1766.
  • Baud, F.J., et al., 2002. Value of lactic acidosis in the assessment of the severity of acute cyanide poisoning. Critical care medicine, 30 (9), 2044–2050.
  • Benaissa, M.L., et al., 2003. Is elevated plasma lactate a useful marker in the evaluation of pure carbon monoxide poisoning? Intensive care medicine, 29 (8), 1372–1375.
  • Binder, C., et al., 2016. Does acute alcohol intoxication cause transaminase elevations in children and adolescents?. Alcohol, 51, 57–62.
  • Bortolotti, F., et al., 2018. Analytical and diagnostic aspects of carbohydrate deficient transferrin (CDT): A critical review over years 2007-2017. Journal of pharmaceutical and biomedical analysis, 147, 2–12.
  • Botanischer Sondergarten Wandsbek. 2018. Rizinus Giftpflanze des Jahres 2018 [Online]. Available: https://www.hamburg.de/wandsbek/gdj-2018-rizinus/ [Accessed March 20, 2019].
  • Brahmi, N., et al., 2006. Prognostic value of human erythrocyte acetyl cholinesterase in acute organophosphate poisoning. The American journal of emergency medicine, 24 (7), 822–827.
  • Brandenburg, W.E., and Ward, K.J., 2018. Mushroom poisoning epidemiology in the United States. Mycologia, 110 (4), 637–641.
  • Brent, J., et al., 1999. Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. New England journal of medicine, 340 (11), 832–838.
  • Brooks, D.E., et al., 2011. Toxicology in the ICU: Part 2: specific toxins. Chest, 140 (4), 1072–1085.
  • Brvar, M., et al., 2003. The potential value of the protein S-100B level as a criterion for hyperbaric oxygen treatment and prognostic marker in carbon monoxide poisoned patients. Resuscitation, 56 (1), 105–109.
  • Bundgens, L., et al., 2016. Consciousness disorders from toxicological view. Deutsche medizinische wochenschrift, 141 (19), 1376–1383.
  • Caglar, A., et al., 2015. Predictive factors for determining the clinical severity of pediatric scorpion envenomation cases in southeastern Turkey. Wilderness environmental medicine, 26, 451–458.
  • Carrieri, M., et al., 2007. Acute, nonfatal intoxication with trichloroethylene. Archives of toxicology, 81 (7), 529–532.
  • Cervellin, G., et al., 2014. Initial blood lactate correlates with carboxyhemoglobin and clinical severity in carbon monoxide poisoned patients. Clinical biochemistry, 47 (18), 298–301.
  • Cervellin, G., et al., 2018. Epidemiology and clinics of mushroom poisoning in Northern Italy: A 21-year retrospective analysis. Human and experimental toxicology, 37 (7), 697–703.
  • Cha, Y.S., et al., 2014. Features and predictors of myocardial injury in carbon monoxide poisoned patients. Emergency medicine journal, 31 (3), 210–215.
  • Chakroun-Walha, O., et al., 2018. Value of troponin levels in the diagnosis of cardiac dysfunction in moderate scorpion envenomation. Human and experimental toxicology, 37 (6), 580–586.
  • Clemessy, J.L., et al., 1995. Hypokalaemia related to acute chloroquine ingestion. The lancet, 346 (8979), 877–880.
  • Colak, S., et al., 2014. Epidemiology of organophosphate intoxication and predictors of intermediate syndrome. Turkish journal of medical science, 44, 279–282.
  • Coopman, V., et al., 2009. Suicidal death after injection of a castor bean extract (Ricinus communis L.). Forensic science international, 189 (1-3), e13–20.
  • Cupo, P., DE Azevedo-Marques, M.M., and Hering, S.E., 2003. Absence of myocardial involvement in children victims of Crotalus durissus terrificus envenoming. Toxicon, 42 (7), 741–745.
  • D’Souza EL-Guindy, N. B., et al., 2007. Acute alcohol intake impairs lung inflammation by changing pro- and anti-inflammatory mediator balance. Alcohol, 41, 335–345.
  • Damian, L.O., et al., 2016. Anticytoplasm neutrophil antibodies-positive vasculitis with diffuse alveolar hemorrhage related to a spider bite. American journal of emergency medicine, 34, 339 e3–4.
  • Damlapinar, R., et al., 2016. Lactate level is more significant than carboxihemoglobin level in determining prognosis of carbon monoxide intoxication of childhood. Pediatric emergency care, 32 (6), 377–383.
  • Dandapani, M., et al., 2003. Oxidative damage in intermediate syndrome of acute organophosphorous poisoning. The Indian journal of medical research, 117, 253–259.
  • Darby, S.M., Miller, M.L., and Allen, R.O., 2001. Forensic determination of ricin and the alkaloid marker ricinine from castor bean extracts. Journal of forensic science, 46 (5), 1033–1042.
  • Davutoglu, V., et al., 2006. Serum levels of NT-ProBNP as an early cardiac marker of carbon monoxide poisoning. Inhalation toxicology, 18 (2), 155–158.
  • DE Paepe, P., et al., 2016. Disulfiram inhibition of cyanide formation after acetonitrile poisoning. Clinical toxicology, 54 (1), 56–60.
  • Dillinger, J.G., et al., 2011. Prognostic value of plasma B-type natriuretic peptide in patients with severe cardiotoxic drug poisoning. Acute cardiac care, 13 (3), 174–180.
  • Dogan, N., 2016. The role of lactic acid in carbon monoxide poisoning and the difficulty of defining the worse outcome. Humand and experimental toxicology, 35, 795–796.
  • Dogan, N.O., et al., 2015. Can initial lactate levels predict the severity of unintentional carbon monoxide poisoning? Human and experimental toxicology, 34, 324–329.
  • Eddleston, M., 2000. Patterns and problems of deliberate self-poisoning in the developing world. Qjm : monthly journal of the association of physicians, 93 (11), 715–731.
  • Eddleston, M., et al., 2008. Management of acute organophosphorus pesticide poisoning. The lancet, 371 (9612), 597–607.
  • EL-Naggar Ael, R., et al., 2009. Clinical findings and cholinesterase levels in children of organophosphates and carbamates poisoning. European journal of pediatrics, 168, 951–956.
  • Erdmann, A., et al., 2015. Focused use of drug screening in overdose patients increases impact on management. Swiss medical weekly, 145, w14242
  • Eren, S.H., et al., 2010. Mushroom poisoning: retrospective analysis of 294 cases. Clinics, 65 (5), 491–496.
  • EUROPEAN ASSOCIATION FOR THE STUDY OF THE LIVER. ELECTRONIC ADDRESS, E. E. E., CLINICAL PRACTICE GUIDELINES, P., Wendon, J., et al., 2017. EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure. Journal of hepatology, 66 (5), 1047–1081.
  • Eyer, F., et al., 2010. Free and total digoxin in serum during treatment of acute digoxin poisoning with Fab fragments: case study. American journal of critical care, 19 (4), 391–387.
  • Fukuhara, Y.D., et al., 2003. Increased plasma levels of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha in patients moderately or severely envenomed by Tityus serrulatus scorpion sting. Toxicon: official journal of the international society on toxinology, 41 (1), 49–55.
  • Garrabou, G., et al., 2011. Mitochondrial injury in human acute carbon monoxide poisoning: the effect of oxygen treatment. Journal of environmental science and health part C: environmental carcinogenesis ecotoxicology reviews, 29 (1), 32–51.
  • Gaskell, H., Ge, X., and Nieto, N., 2018. High-mobility group box-1 and liver disease. Hepatology communications, 2 (9), 1005–1020.
  • Gawarammana, I.B., and Buckley, N.A., 2011. Medical management of paraquat ingestion. British journal of clinical pharmacology, 72 (5), 745–757.
  • Giannini, L., et al., 2007. Amatoxin poisoning: a 15-year retrospective analysis and follow-up evaluation of 105 patients. Clinical toxicology, 45 (5), 539–542.
  • Gil, H.W., et al., 2009. Clinical implication of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in patients with acute paraquat intoxication. Clinical toxicology, 47 (9), 870–875.
  • Gokay, S.S., et al., 2018. Myocarditis and early markers of cardiac response associated with scorpion stings in children. Wilderness environ med, 29, 471–478.
  • Goral, J., Choudhry, M.A., and Kovacs, E.J., 2004. Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK. Journal of leukocyte biology, 75 (3), 553–559.
  • Grabowska, T., et al., 2012. Prevalence of hydrogen cyanide and carboxyhaemoglobin in victims of smoke inhalation during enclosed-space fires: a combined toxicological risk. Clinical toxicology, 50 (8), 759–763.
  • Grieb, G., et al., 2011. Glasgow Coma Scale and laboratory markers are superior to COHb in predicting CO intoxication severity. Burns, 37 (4), 610–615.
  • Gummin, D.D., et al., 2018. 2017 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 35th Annual Report. Clinical toxicology, 56 (12), 1213–1415.
  • Hadem, J., ACUTE LIVER FAILURE STUDY GROUP, G., et al., 2012. Etiologies and outcomes of acute liver failure in Germany. Clinical gastroenterology and hepatology, 10 (6), 664–669 e2.
  • Hampson, N.B., 2005. Trends in the incidence of carbon monoxide poisoning in the United States. The American journal of emergency medicine, 23 (7), 838–841.
  • Hampson, N.B., and Hauff, N.M., 2008. Carboxyhemoglobin levels in carbon monoxide poisoning: do they correlate with the clinical picture?. The American journal of emergency medicine, 26 (6), 665–669.
  • Hampson, N.B., et al., 2012. Practice recommendations in the diagnosis, management, and prevention of carbon monoxide poisoning. American journal of respiratory and critical care medicine, 186 (11), 1095–1101.
  • Hantson, P., Bernard, A., and Hermans, C., 2008a. Kinetics and determinants of the changes of CC16, a lung secretory protein in a rat model of toxic lung injury. Clinical toxicology, 46 (3), 230–238.
  • Hantson, P., et al., 2008b. Pneumoproteins as markers of paraquat lung injury: a clinical case. Journal of forensic and legal medicine, 15 (1), 48–52.
  • Hart, T.B., Nevitt, A., and Whitehead, A., 1984. A new statistical approach to the prognostic significance of plasma paraquat concentrations. The lancet, 2, 1222–1223.
  • Hassanian-Moghaddam, H., et al., 2014. Methanol mass poisoning in Iran: role of case finding in outbreak management. Journal of public health, 37 (2), 354–359.
  • Heard, K., et al., 2018. Serum paracetamol-protein adducts in ambulatory subjects: Relationship to recent reported paracetamol use. Biomarkers, 23 (3), 288–292.
  • Henry, C.R., et al., 2006. Myocardial injury and long-term mortality following moderate to severe carbon monoxide poisoning. JAMA, 295 (4), 398–402.
  • Herres, J., Ryan, D., and Salzman, M., 2009. Delayed salicylate toxicity with undetectable initial levels after large-dose aspirin ingestion. American journal of emergency medicine, 27, 1173 e1–3.
  • Hifumi, T., et al., 2015. Potentially fatal coagulopathy secondary to yamakagashi (Rhabdophis tigrinus) bites that completely recovered with antivenom treatment. Acute medicine and surgery, 2 (2), 123–126.
  • Hifumi, T., et al., 2014. Clinical characteristics of yamakagashi (Rhabdophis tigrinus) bites: a national survey in Japan, 2000-2013. Journal of intensive care, 2 (1), 19.
  • Hong, S.Y., et al., 2014. Prediction of patient survival in cases of acute paraquat poisoning. PLoS One, 9 (11), e111674.
  • Hovda, K.E., et al., 2010. Renal toxicity of ethylene glycol results from internalization of calcium oxalate crystals by proximal tubule cells. Toxicology letters, 192 (3), 365–372.
  • Hovda, K.E., et al., 2005. Methanol outbreak in Norway 2002-2004: epidemiology, clinical features and prognostic signs. Journal of internal medicine, 258 (2), 181–190.
  • Ide, T., and Kamijo, Y., 2009. The early elevation of interleukin 6 concentration in cerebrospinal fluid and delayed encephalopathy of carbon monoxide poisoning. The American journal of emergency medicine, 27 (8), 992–996.
  • Inoue, S., et al., 2008. Lactate as a prognostic factor in carbon monoxide poisoning: a case report. American journal of emergency medicine, 26, 966 e1–3.
  • Jacobsen, D., et al., 1988. Ethylene glycol intoxication: evaluation of kinetics and crystalluria. The American journal of medicine, 84 (1), 145–152.
  • Jang, D.H., et al., 2017a. Measurement of Mitochondrial Respiration and Motility in Acute Care: Sepsis, Trauma, and Poisoning. Journal of intensive care medicine, 32 (1), 86–94.
  • Jang, D.H., et al., 2017b. A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells. Clinical toxicology, 55 (6), 579–584.
  • Jang, D.H., et al., 2018. Translational Application of Measuring Mitochondrial Functions in Blood Cells Obtained from Patients with Acute Poisoning. Journal of medical toxicology, 14 (2), 144–151.
  • Jang, D.H., et al., 2016. Impairment of mitochondrial respiration following ex vivo cyanide exposure in peripheral blood mononuclear cells. Clinical toxicology, 54 (4), 303–307.
  • Johnson, R.C., et al., 2005. Quantification of ricinine in rat and human urine: a biomarker for ricin exposure. Journal of analytical toxicology, 29 (3), 149–155.
  • Jones, A.L., Elton, R., and Flanagan, R., 1999. Multiple logistic regression analysis of plasma paraquat concentrations as a predictor of outcome in 375 cases of paraquat poisoning. QJM, 92 (10), 573–578.
  • Juurlink, D.N., et al., 2015. Extracorporeal Treatment for Salicylate Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup. Annals of emergency medicine, 66 (2), 165–181.
  • Kaland, M.E., Klein-Schwartz, W., and Anderson, B.D., 2015. Toxalbumin exposures: 12 years’ experience of U.S. poison centers. Toxicon, 99, 125–129.
  • Kaldirim, U., et al., 2014. The relationship between blood lactate, carboxy-hemoglobin and clinical status in CO poisoning. European review for medical and pharmacological sciences, 18 (19), 2777.
  • Kamijo, Y., et al., 2011. Severe carbon monoxide poisoning complicated by hypothermia: a case report. American journal of emergency medicine, 29 (357), e5–7.
  • Kamijo, Y., Soma, K., and Ide, T., 2007. Recurrent myelin basic protein elevation in cerebrospinal fluid as a predictive marker of delayed encephalopathy after carbon monoxide poisoning. The American journal of emergency medicine, 25 (4), 483–485.
  • Kang, E.J., et al., 2009. Factors for determining survival in acute organophosphate poisoning. The korean journal of internal medicine, 24 (4), 362–367.
  • Kao, H.K., et al., 2009. Assessment of myocardial injury in the emergency department independently predicts the short-term poor outcome in patients with severe carbon monoxide poisoning receiving mechanical ventilation and hyperbaric oxygen therapy. Pulmonary pharmacology and therapeutics, 22 (6), 473–477.
  • Kara, H., A.K., A., Bayir, A., and Avci, A., 2013. Reversible myocarditis after spider bite. BMJ case report. doi:10.1136/bcr-2013-008957
  • Kechagias, S., et al., 2015. Phosphatidylethanol compared with other blood tests as a biomarker of moderate alcohol consumption in healthy volunteers: a prospective randomized study. Alcohol alcohol, 50 (4), 399–406.
  • Keller, S.A., et al., 2018. Mushroom Poisoning-A 17 Year Retrospective Study at a Level I University Emergency Department in Switzerland. International journal of environmental research and public health, 15 (12). doi:10.3390/ijerph15122855
  • Khan, R., and Koppe, S., 2018. Modern management of acute liver failure. Gastroenterology clinics of North America, 47 (2), 313–326.
  • Kim, T., et al., 2017. Predictors of poor outcomes in patients with wild mushroom-induced acute liver injury. World journal of gastroenterology, 23 (7), 1262–1267.
  • King, A.M., and Aaron, C.K., 2015. Organophosphate and carbamate poisoning. Emergency medicine clinics of North America, 33 (1), 133–151.
  • Kitterer, D., et al., 2015. Drug-induced acid-base disorders. Pediatric nephrology, 30 (9), 1407–1423.
  • Kothe, L., and Radke, J., 2010. Carboxyhemoglobin concentration in carbon monoxide poisoning. Critical appraisal of the predictive value. Anaesthesist, 59, 529–534.
  • Kotwica, M., and Czerczak, S., 2007. Acute poisonings registered since 1970: trends and characteristics. Analysis of the files collected in the National Poison Information Centre, Łódź, Poland. International journal of occupational medicine and environmental health, 20 (1), 38–43.
  • Kraut, J.A., and Mullins, M.E., 2018. Toxic Alcohols. The new England journal of medicine, 378 (3), 270–280.
  • Kuroda, H., et al., 2015. Novel clinical grading of delayed neurologic sequelae after carbon monoxide poisoning and factors associated with outcome. NeuroToxicology, 48, 35–43.
  • Lam, S.M., Lau, A.C., and Yan, W.W., 2010. Over 8 years experience on severe acute poisoning requiring intensive care in Hong Kong, China. Human and experimental toxicology, 29 (9), 757–765.
  • Larson, A.M., ACUTE LIVER FAILURE STUDY, G., et al., 2005. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology, 42 (6), 1364–1372.
  • Lee, H.L., et al., 2000. Clinical presentations and prognostic factors of a glyphosate-surfactant herbicide intoxication: a review of 131 cases. Academic emergency medicine, 7 (8), 906–910.
  • Lee, P., and Tai, D.Y., 2001. Clinical features of patients with acute organophosphate poisoning requiring intensive care. Intensive care medicine, 27 (4), 694–699.
  • Lee, S.H., et al., 2016. The anion gap is a predictive clinical marker for death in patients with acute pesticide intoxication. Journal of Korean medical science, 31 (7), 1150–1159.
  • Levine, M., et al., 2007. Assessment of hyperglycemia after calcium channel blocker overdoses involving diltiazem or verapamil. Critical care medicine, 35 (9), 2071–2075.
  • Ley, E.J., et al., 2012. Support for blood alcohol screening in pediatric trauma. The American journal of surgery, 204 (6), 939–943; discussion 943.
  • Lillsunde, P., 2008. Analytical techniques for drug detection in oral fluid. Therapeutic drug monitoring, 30 (2), 181–187.
  • Lin, C.L., et al., 2004. Most common intoxication in nephrology ward organophosphate poisoning. Renal failure, 26 (4), 349–354.
  • Liu, J.H., et al., 2008. Acid-base interpretation can be the predictor of outcome among patients with acute organophosphate poisoning before hospitalization. The American journal of emergency medicine, 26 (1), 24–30.
  • Mahdyoon, H., et al., 1990. The evolving pattern of digoxin intoxication: observations at a large urban hospital from 1980 to 1988. American heart journal, 120 (5), 1189–1194.
  • Mallet, M., et al., 2017. Elevated procalcitonin is associated with bacterial infection during acute liver failure only when unrelated to acetaminophen intoxication. European journal of gastroenterology and hepatology, 29 (7), 811–816.
  • Mandrekar, P., et al., 2004. Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production. The journal of immunology, 173 (5), 3398–3407.
  • Manini, A.F., et al., 2010. Utility of serum lactate to predict drug-overdose fatality. Clinical toxicology, 48 (7), 730–736.
  • Mao, Y.C., et al., 2011. Hyperammonemia following glufosinate-containing herbicide poisoning: a potential marker of severe neurotoxicity. Clinical toxicology, 49 (1), 48–52.
  • Mcmahon, A., et al., 2014. Characteristics of patients admitted to the intensive care unit following self-poisoning and their impact on resource utilisation. Irish journal of medical science, 183 (3), 391–395.
  • Megarbane, B., et al., 2010a. Blood concentrations are better predictors of chioroquine poisoning severity than plasma concentrations: a prospective study with modeling of the concentration/effect relationships. Clinical toxicology (Phila), 48, 904–915.
  • Megarbane, B., et al., 2010b. Usefulness of the serum lactate concentration for predicting mortality in acute beta-blocker poisoning. Clinical toxicology (Phila), 48, 974–978.
  • Meki, A.R., EL-Deen, Z.M., and EL-Deen, H.M., 2002. Myocardial injury in scorpion envenomed children: significance of assessment of serum troponin I and interleukin-8. Neuro endocrinology letters, 23 (2), 133–140.
  • Meki, A.R., Mohamed, Z.M., and Mohey EL-Deen, H.M., 2003. Significance of assessment of serum cardiac troponin I and interleukin-8 in scorpion envenomed children. Toxicon, 41 (2), 129–137.
  • Meki, A.R., and Mohey EL-Dean, Z.M., 1998. Serum interleukin-1beta, interleukin-6, nitric oxide and alpha1-antitrypsin in scorpion envenomed children. Toxicon, 36 (12), 1851–1859.
  • Moon, J.M., and Chun, B.J., 2010. Predicting acute complicated glyphosate intoxication in the emergency department. Clinical toxicology, 48 (7), 718–724.
  • Moon, J.M., Shin, M.H., and Chun, B.J., 2011. The value of initial lactate in patients with carbon monoxide intoxication: in the emergency department. Human and experimental toxicology, 30 (8), 836–843.
  • Musshoff, F., and Madea, B., 2008. Modern analytical procedures for the determination of taxus alkaloids in biological material. International journal of legal medicine, 122 (4), 357–358.
  • Nakstad, E.R., et al., 2017. Bronchial wheezing predicts inflammation and respiratory failure in fire smoke victims. Acta anaesthesiologica scandinavica, 61 (9), 1142–1154.
  • Neufeld, M., and Rehm, J., 2018. Effectiveness of policy changes to reduce harm from unrecorded alcohol in Russia between 2005 and now. The international journal on drug policy, 51, 1–9.
  • Ohtake, T., et al., 2001. Decreased plasma and cerebrospinal fluid glutamine concentrations in a patient with bialaphos poisoning. Human and experimental toxicology, 20 (8), 429–434.
  • Paasma, R., et al., 2012. Risk factors related to poor outcome after methanol poisoning and the relation between outcome and antidotes–a multicenter study. Clinical toxicology, 50 (9), 823–831.
  • Paasma, R., et al., 2007. Methanol mass poisoning in Estonia: outbreak in 154 patients. Clinical toxicology (Philadelphia, PA.), 45 (2), 152–157.
  • Pepe, G., et al., 2011. Delayed neuropsychological sequelae after carbon monoxide poisoning: predictive risk factors in the Emergency Department. A retrospective study. Scandinavian journal of trauma, resuscitation and emergency medicine, 19 (1), 16.
  • Pizon, A.F., and Brooks, D.E., 2006. Hyperosmolality: another indication for hemodialysis following acute ethylene glycol poisoning. Clinical toxicology, 44 (2), 181–183.
  • Porter, W.H., 2012. Ethylene glycol poisoning: quintessential clinical toxicology; analytical conundrum. Clinica chimica acta, 413 (3-4), 365–377.
  • Proudfoot, A.T., et al., 1979. Paraquat poisoning: significance of plasma-paraquat concentrations. The lancet, 2, 330–332.
  • Pruett, S.B., et al., 2004. Acute exposure to ethanol affects Toll-like receptor signaling and subsequent responses: an overview of recent studies. Alcohol, 33 (3), 235–239.
  • Pruett, S.B., et al., 2004. Ethanol suppresses cytokine responses induced through Toll-like receptors as well as innate resistance to Escherichia coli in a mouse model for binge drinking. Alcohol, 33 (2), 147–155.
  • Reijnen, G., et al., 2017. Post-mortem findings in 22 fatal Taxus baccata intoxications and a possible solution to its detection. Journal of forensic and legal medicine, 52, 56–61.
  • Roberts, D.M., and Aaron, C.K., 2007. Management of acute organophosphorus pesticide poisoning. BMJ, 334 (7594), 629–634.
  • Roberts, D.M., et al., 2011. Changes in the concentrations of creatinine, cystatin C and NGAL in patients with acute paraquat self-poisoning. Toxicology letters, 202 (1), 69–74.
  • Roberts, D.M., et al., 2015. Recommendations for the role of extracorporeal treatments in the management of acute methanol poisoning: a systematic review and consensus statement. Critical care medicine, 43 (2), 461–472.
  • Rose, J.J., et al., 2017. Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy. American journal of respiratory and critical care medicine, 195 (5), 596–606.
  • Sagarad, S.V., et al., 2012. Elevated cardiac troponin (cTnI) levels correlate with the clinical and echocardiographic evidences of severe myocarditis in scorpion sting envenomation. Journal of clinical and diagnostic research: JCDR, 6 (8), 1369–1371.
  • Sagarad, S.V., et al., 2013. NT-proBNP in Myocarditis after a Scorpion Sting Envenomation. Journal of clinical and diagnostic research: JCDR, 7 (1), 118–121.
  • Satran, D., et al., 2005. Cardiovascular manifestations of moderate to severe carbon monoxide poisoning. Journal of the American college of cardiology, 45 (9), 1513–1516.
  • Schep, L.J., et al., 2009. Diethylene glycol poisoning. Clinical toxicology (Philadelphia, PA.), 47 (6), 525–535.
  • Scherrmann, J.M., et al., 1987. Prognostic value of plasma and urine paraquat concentration. Human toxicology, 6 (1), 91–93.
  • Schiodt, F.V., et al., 1997. Acetaminophen toxicity in an urban county hospital. New England journal of medicine, 337, 1112–1117.
  • Schnittger, V., et al., 2004. Effects of carbon monoxide poisoning on neutrophil responses in patients treated with hyperbaric oxygen. Journal of investigative medicine, 52, 523–530.
  • Shadnia, S., et al., 2009. Prognostic value of long QT interval in acute and severe organophosphate poisoning. Journal of medical toxicology, 5 (4), 196–199.
  • Shen, C.H., et al., 2015. Predicting duration of mechanical ventilation in patients with carbon monoxide poisoning: a retrospective study. Journal of critical care, 30 (1), 19–24.
  • Shively, R.M., Hoffman, R.S., and Manini, A.F., 2017. Acute salicylate poisoning: risk factors for severe outcome. Clinical toxicology, 55 (3), 175–180.
  • Sircar, K., et al., 2015. Carbon monoxide poisoning deaths in the United States, 1999 to 2012. The American journal of emergency medicine, 33 (9), 1140–1145.
  • Soltaninejad, K., 2018. Outbreak of Mushroom Poisoning in Iran: April-May, 2018. The international journal of occupational and environmental medicine, 9 (3), 152–156.
  • Soltaninejad, K., et al., 2007. Blood beta-glucuronidase as a suitable biomarker at acute exposure of severe organophosphorus poisoning in human. Human and experimental toxicology, 26 (12), 963–966.
  • Sorge, M., et al., 2015. Self-poisoning in the acute care medicine 2005-2012. Der anaesthesist, 64 (6), 456–462.
  • Sorodoc, L., et al., 2010. Is MARS system enough for A. phalloides-induced liver failure treatment?. Human and experimental toxicology, 29 (10), 823–832.
  • Spies, C.D., et al., 1998. Elevated carbohydrate-deficient transferrin predicts prolonged intensive care unit stay in traumatized men. Alcohol and alcoholism, 33 (6), 661–669.
  • Staufer, K., et al., 2011. Urinary ethyl glucuronide as a novel screening tool in patients pre- and post-liver transplantation improves detection of alcohol consumption. Hepatology, 54 (5), 1640–1649.
  • Tang, W., et al., 2016. Independent prognostic factors for acute organophosphorus pesticide poisoning. Respiratory care, 61 (7), 965–970.
  • Thomas, S.H., et al., 1996. Presentation of poisoned patients to accident and emergency departments in the north of England. Human and experimental toxicology, 15 (6), 466–470.
  • Thornton, S.L., et al., 2014. Castor bean seed ingestions: a state-wide poison control system’s experience. Clinical toxicology, 52 (4), 265–268.
  • Thulin, P., et al., 2017. A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat. Biomarkers, 22 (5), 461–469.
  • Tsai, J.R., et al., 2007. Organophosphate poisoning: 10 years of experience in southern Taiwan. The Kaohsiung journal of medical sciences, 23 (3), 112–119.
  • Tuero, G., et al., 2018. Value of glycolic acid analysis in ethylene glycol poisoning: A clinical case report and systematic review of the literature. Forensic science international, 290, e9–e14.
  • Tufekci, I.B., Curgunlu, A., and Sirin, F., 2004. Characteristics of acute adult poisoning cases admitted to a university hospital in Istanbul. Human and experimental toxicology, 23, 347–351.
  • USDA 1938. ELIXIR SULFANILAMIDE-MASSENGILL: Report of the United States Secretary of Agriculture. Cal west med, 48, 68–70.
  • Verougstraete, N., et al., 2018. Lethal injection of a castor bean extract: ricinine quantification as a marker for ricin exposure using a validated LC-MS/MS method. Journal of analytical toxicology, 43 (3), e1–e5. doi: 10.1093/jat/bky100
  • Von Haefen, C., et al., 2011. Ethanol changes gene expression of transcription factors and cytokine production of CD4+ T-cell subsets in PBMCs stimulated with LPS. Alcoholism: Clinical and experimental research, 35 (4), 621–631.
  • Waring, W.S., 2006. Management of lithium toxicity. Toxicological reviews, 25 (4), 221–230.
  • Waring, W.S., 2007. Delayed cardiotoxicity in chronic lithium poisoning: discrepancy between serum lithium concentrations and clinical status. Basic and clinical pharmacology and toxicology, 100 (5), 353–355.
  • Weaver, L.K., 2009. Clinical practice. Carbon monoxide poisoning. New England journal of medicine, 360 (12), 1217–1225.
  • Whitcomb, D.C., and Block, G.D., 1994. Association of acetaminophen hepatotoxicity with fasting and ethanol use. Jama: the journal of the American medical association, 272 (23), 1845–1850.
  • Willaert, W., et al., 2002. Intoxication with taxus baccata: cardiac arrhythmias following yew leaves ingestion. Pacing and clinical electrophysiology, 25 (4), 511–512.
  • Woo, J.H., and Lim, Y.S., 2015. Severe human poisoning with a flufenoxuron-containing insecticide: Report of a case with transient myocardial dysfunction and review of the literature. Clinical toxicology, 53 (6), 569–572.
  • Worek, F., et al., 2005. Diagnostic aspects of organophosphate poisoning. Toxicology, 214 (3), 182–189.
  • Wu, A.H.B., 2019. On vivo and wearable clinical laboratory testing devices for emergency and critical care laboratory testing. The journal of applied laboratory medicine, 4 (2), 254–263.
  • Wunnapuk, K., et al., 2013. Renal biomarkers predict nephrotoxicity after paraquat. Toxicology letters, 222 (3), 280–288.
  • Zakharov, S., et al., 2015. Is the measurement of serum formate concentration useful in the diagnostics of acute methanol poisoning? A prospective study of 38 patients. Basic and clinical pharmacology and toxicology, 116 (5), 445–451.
  • Zakharov, S., et al., 2017. Positive serum ethanol concentration on admission to hospital as the factor predictive of treatment outcome in acute methanol poisoning. Monatshefte für chemie – chemical monthly, 148 (3), 409–419.
  • Zakharov, S., et al., 2014. Czech mass methanol outbreak 2012: epidemiology, challenges and clinical features. Clinical toxicology, 52 (10), 1013–1024.
  • Zhao, P., et al., 2013. Causes and outcomes of acute liver failure in China. PLoS One, 8 (11), e80991
  • Zimmerman, H.J., and Maddrey, W.C., 1995. Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure. Hepatology, 22 (3), 767–773.

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