References
- Agha, A., et al., 2005. Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults. The journal of clinical endocrinology and metabolism, 90 (12), 6355–6360.
- Appelman-Dijkstra, N.M., et al., 2011. Pituitary dysfunction in adult patients after cranial radiotherapy: Systematic review and meta-analysis. The journal of clinical endocrinology and metabolism, 96 (8), 2330–2340.
- Araujo, I.K., Muñoz-Guglielmetti, D., and Mollà, M., 2020. Radiation-induced damage in the lower gastrointestinal tract: Clinical presentation, diagnostic tests and treatment options. Best practice and research: Clinical gastroenterology, 48–49, 1–9.
- Bentzen, S.M., 2006. Preventing or reducing late side effects of radiation therapy: Radiobiology meets molecular pathology. Nature reviews. Cancer, 6 (9), 702–713.
- Boersma, L.J., et al., 1996. Regional variation in functional subunit density in the lung: Regarding Liao et al. IJROBP 32(5):1359-1370; 1995 [2]. International journal of radiation oncology*biology*physics, 34 (5), 1187–1188.
- Chen, G., et al., 2021. Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms. Frontiers in oncology, 11 (November), 757973–18.
- Cui, L., et al., 2010. Sublethal total body ırradiation leads to early cerebellar damage and oxidative stress. Current neurovascular research, 7 (2), 125–135.
- Çınar, S., et al., 2021. Can dexmedetomidine be effective in the protection of radiotherapy-ınduced brain damage in the rat? Neurotoxicity research, 39 (4), 1338–1351.
- Darzy, K.H., 2009. Radiation-induced hypopituitarism after cancer therapy: who, how and when to test. Nature clinical practice. Endocrinology & metabolism, 5 (2), 88–99.
- Darzy, K.H., 2013. Radiation-induced hypopituitarism. Current opinion in endocrinology, diabetes, and obesity, 20 (4), 342–353.
- Darzy, K.H., et al., 2003. The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time interval. The journal of clinical endocrinology and metabolism, 88 (1), 95–102.
- Datta, R., et al., 1997. Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. The journal of biological chemistry, 272 (3), 1965–1969.
- Defraene, G., et al., 2017. Regional variability in radiation-induced lung damage can be predicted by baseline CT numbers. Radiotherapy and oncology: journal of the european society for therapeutic radiology and oncology, 122 (2), 300–306.
- El-Maraghi, E.F., et al., 2018. Taurine provides a time-dependent amelioration of the brain damage induced by Γ-irradiation in rats. Journal of hazardous materials, 359, 40–46.
- Ghita, M., et al., 2020. Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart. Radiotherapy and oncology: journal of the european society for therapeutic radiology and oncology, 152, 216–221.
- Kamiryo, T., et al., 1996. Histological changes in the normal rat brain after gamma irradiation. Acta neurochirurgica, 138 (4), 451–459.
- Kataoka, T., et al., 1998. FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation. Journal of immunology (baltimore, Md.: 1950), 161 (8), 3936–3942.
- Landolt, A.M., et al., 2000. Octreotide may act as a radioprotective agent in acromegaly. The journal of clinical endocrinology and metabolism, 85 (3), 1287–1289.
- Lebaron-Jacobs, L., Wysocki, J., and Griffiths, N.M., 2004. Differential qualitative and temporal changes in the response of the hypothalamus-pituitary-adrenal axis in rats after localized or total-body irradiation. Radiation research, 161 (6), 712–722.
- Lıttley, M.D., et al., 1989. Radiation-ınduced hypopituitarism ıs dose-dependent. Clinical endocrinology, 31 (3), 363–373.
- Minniti, G., Gilbert, D.C., and Brada, M., 2009. Modern techniques for pituitary radiotherapy. Reviews in endocrine & metabolic disorders, 10 (2), 135–144.
- Murphy, E.S., et al., 2015. Review of cranial radiotherapy-induced vasculopathy. Journal of neuro-oncology, 122 (3), 421–429.
- Nagayama, K., et al., 2005. Radiation-induced apoptosis of oligodendrocytes in the adult rat optic chiasm. Neurological research, 27 (4), 346–350.
- Onal, C., et al., 2011. Protective effects of melatonin and octreotide against radiation-induced intestinal injury. Digestive diseases and sciences, 56 (2), 359–367.
- Pekic, S., and Popovic, V., 2014. Alternative causes of hypopituitarism: Traumatic brain injury, cranial irradiation, and infections. In: J.M. Aminoff, F. Boller and D.F. Swaab, eds. Handbook of clinical neurology. 1st ed. Amsterdam, Netherlands: Elsevier B.V., 271–290.
- Qiu, R., et al., 2018. Dexmedetomidine restores septic renal function via promoting inflammation resolution in a rat sepsis model. Life sciences, 204 (2017), 1–8.
- Qiu, Z., et al., 2020. Dexmedetomidine ınhibits neuroinflammation by altering microglial M1/M2 polarization through MAPK/ERK pathway. Neurochemical research, 45 (2), 345–353.
- Rahmanian, N., Hosseinimehr, S.J., and Khalaj, A., 2016. The paradox role of caspase cascade in ionizing radiation therapy. Journal of biomedical science, 23 (1), 1–13.
- Reinhold, H.S., et al., 1990. Development of blood vessel-related radiation damage in the fimbria of the central nervous system. International journal of radiation oncology, biology, physics, 18 (1), 37–42.
- Samaan, N.A., et al., 1982. Hypothalamic, pituitary and thyroid dysfunction after radiotherapy to the head and neck. International journal of radiation oncology*biology*physics, 8 (11), 1857–1867.
- Sathyapalan, T., and Dixit, S., 2012. Radiotherapy-induced hypopituitarism: a review. Expert review of anticancer therapy, 12 (5), 669–683.
- Schlaak, R.A., et al., 2020. Advances in preclinical research models of radiation-induced cardiac toxicity. Cancers, 12 (2), 415.
- Sham, J., et al., 1994. Radiotherapy for nasopharyngeal carcinoma: shielding the pituitary may ımprove therapeutic ratio. International journal of radiation oncology*biology*physics, 29 (4), 699–704. Vol.,
- Shi, L., et al., 2019. Dexmedetomidine attenuates lung ınjury in obstructive jaundice rats through PI3K/Akt/HIF-1α signaling pathway. Archives of medical research, 50 (5), 233–240.
- Stam, B., et al., 2017. Dose to heart substructures is associated with non-cancer death after SBRT in stage I–II NSCLC patients. Radiotherapy and oncology: journal of the european society for therapeutic radiology and oncology, 123 (3), 370–375.
- Stam, B., et al., 2019. Subgroup survival analysis in stage I-II NSCLC patients with a central tumor partly treated with risk-adapted SBRT. International journal of radiation oncology, biology, physics, 103 (1), 132–141.
- Su, X., et al., 2016. Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. The lancet, 388 (10054), 1893–1902.
- Sun, R., et al., 2016. Long-term outcome of changes in cognitive function of young rats after various/different doses of whole brain irradiation. Neurological research, 38 (7), 647–654.
- Tan, F., et al., 2018. Intraoperative dexmedetomidine attenuates postoperative systemic inflammatory response syndrome in patients who underwent percutaneous nephrolithotomy: A retrospective cohort study. Therapeutics and clinical risk management, 14, 287–293.
- Tan, Y.F., et al., 2011. Depletion of new neurons by image guided irradiation. Frontiers in neuroscience, 5, 59–8.
- Tian, H., et al., 2021. Dexmedetomidine upregulates microRNA-185 to suppress ovarian cancer growth via inhibiting the SOX9/Wnt/β-catenin signaling pathway. Cell cycle (georgetown, tex.), 20 (8), 765–780.
- Tomlinson, J.W., et al., 2001. Association between premature mortality and hypopituitarism. Lancet (london, England), 357 (9254), 425–431.
- Torino, F., et al., 2013. MAbs and pituitary dysfunction: clinical evidence and pathogenic hypotheses. European journal of endocrinology, 169 (6), R153–R164.
- Verheij, M., and Bartelink, H., 2000. Radiation-induced apoptosis. Cell and tissue research, 301 (1), 133–142.
- Wang, T., et al., 2022. Targeting p65 to inhibit Cas3 transcription by Onjisaponin B for radiation damage therapy in p65+/- mice. Phytomedicine: international journal of phytotherapy and phytopharmacology, 104, 154317.
- Wen, G., and Xin, N., 2021. Dexmetomidine promotes the activity of breast cancer cells through miR-199a/HIF-1α axis. Translational cancer research, 10 (11), 4817–4828.
- Xu, Y., et al., 2020. Cranial irradiation alters neuroinflammation and neural proliferation in the pituitary gland and induces late-onset hormone deficiency. Journal of cellular and molecular medicine, 24 (24), 14571–14582.
- Yamanaka, D., et al., 2017. Preventive effects of dexmedetomidine on the development of cognitive dysfunction following systemic inflammation in aged rats. Journal of anesthesia, 31 (1), 25–35.4.
- Yi, X., et al., 2018. Cardiocerebral protective effects of dexmedetomidine and reduce expression levels of cytokines associa- ted with a brain injury like S100β, European review for medical and pharmacological sciences, 22 (11), 3570–3576.
- Zhang, P., et al., 2020. Dexmedetomidine suppresses the progression of esophageal cancer via miR-143-3p/epidermal growth factor receptor pathway substrate 8 axis. Anti-cancer drugs, 31 (7), 693–701.
- Zhang, X., et al., 2018. Dexmedetomidine inhibits inflammatory reaction in the hippocampus of septic rats by suppressing NF-κB pathway. PLoS one, 13 (5), e0196897.