Comorbid anxiety and depression: illumination of a controversy

References

• Angst J. Depression and anxiety: implications for nosology, course, and treatment. J Clin Psychiatry 1997; 58(Suppl 8)3–5
   PubMed Web of Science ®Google Scholar
• Zajecka JM, Ross JS. Management of comorbid anxiety and depression. J Clin Psychiatry 1995; 56(Suppl 2)10–13
   PubMedGoogle Scholar
• Boulenger J-P, Lavallee Y-J. Mixed anxiety and depression: diagnostic issues. J Clin Psychiatry 1993; 54(Suppl 1)3–8
   PubMedGoogle Scholar
• Wittchen H-U, Essau CA. Comorbidity and mixed anxiety–depressive disorders: is there epidemiologic evidence?. J Clin Psychiatry 1993; 54(Suppl 1)9–15
   PubMedGoogle Scholar
• Tyrer P. General neurotic syndrome and mixed anxiety–depressive disorders. Classification of neurosis, P Tyrer. Wiley, New York 1989; 132–64
   Google Scholar
• Shorter E, Tyrer P. Separation of anxiety and depressive disorders: blind alley in psychopharmacology and classification of disease. Br Med J 2003;327(7407):158–160. Comment Br Med J 2003; 327(7419)869–70
   Google Scholar
• Tyrer P. The case for cothymia: mixed anxiety and depression as a single diagnosis (Editorial). Br J Psychiatry 2001; 179: 191–3
   PubMed Web of Science ®Google Scholar
• Zinbarg RE, Barlow DH, Liebowitz M, et al. The DSM-IV field trial for mixed anxiety–depression. Am J Psychiatry 1994; 151: 1153–62
   PubMed Web of Science ®Google Scholar
• Hoehn-Saric R, McLeod DR, Zimmerli WD. Differential effects of alprazolam amd imipramine in generalized anxiety disorder: somatic versus psychic symptoms. J Clin Psychiatry 1988; 49: 293–301
   PubMed Web of Science ®Google Scholar
• Fava GA, Grandi S, Zielezny M, Canestrari R, Morphy MA. Cognitive behavioral treatment of residual symptoms in primary major depressive disorder. Am J Psychiatry 1994; 151: 1295–9
   PubMed Web of Science ®Google Scholar
• Katon W, Roy-Byrne PP. Mixed anxiety and depression. J Abnorm Psychol 1991; 100: 337–45
   PubMed Web of Science ®Google Scholar
• Cloninger CR. Comorbidity of anxiety and depression. J Clin Psychopharmacol 1990; 10(Suppl 3)43–6C
   Google Scholar
• Fowles DC, Gersh FS. Neurotic depression: the endogenous-neurotic distinction. The psychobiology of the depressive disorders: implications for the effects of stress, RA Depue. Academic Press, New York 1979
   Google Scholar
• Frances A, Manning D, Marin D, et al. Relationship of anxiety and depression. Psychopharmacology (Berlin) 1992; 106(Suppl): S82–6
   Google Scholar
• Gersh FS, Fowles DC. Neurotic depression: the concept of anxious depression. The psychobiology of the depressive disorders: implications for the effects of stress, RA Depue. Academic Press, New York 1979
   Google Scholar
• Katon W, Von Korff M, Lin E, et al. Population-based care of depression: effective disease management strategies to decrease prevalence. Gen Hosp Psychiatry 1997; 19: 169–78
   PubMed Web of Science ®Google Scholar
• Rouillon F. Anxiety with depression: a treatment need. Eur Neuropsychopharm 1999; 9(Suppl 3)S87–92
   Google Scholar
• Simon G, Ormel J, Von Korff, Barlow W. Health care costs associated with depressive and anxiety disorders in primary care. Am J Psychiatry 1995; 152: 352–7
   PubMed Web of Science ®Google Scholar
• Stavrakaki C, Vargo B. The relationship of anxiety and depression: a review of the literature. Br J Psychiatry 1986; 149: 7–16
   PubMed Web of Science ®Google Scholar
• Tollefson GD, Holman SL, Sayler ME, Potvin JH. Fluoxetine, placebo, and tricyclic antidepressants in major depression with and without anxious features. J Clin Psychiatry 1994; 55: 50–9
   PubMed Web of Science ®Google Scholar
• Tollefson GD, Souetre E, Thomander L, Potvin JH. Comorbid anxious signs and symptoms in major depression: impact on functional work capacity and comparative treatment outcomes. Int Clin Psychopharmacol 1993; 8: 281–93
   PubMedGoogle Scholar
• Breier A, Charney DS, Heninger GR. Major depression in patients with agoraphobia and panic disorder. Arch Gen Psychiatry 1984; 41: 1129–35
   PubMed Web of Science ®Google Scholar
• Kendler KS, Eaves LJ. Models for the joint effect of genotype and environment on liability to psychiatric illness. Am J Psychiatry 1986; 143: 279–89
   PubMed Web of Science ®Google Scholar
• Leckman JF, Merikangas KR, Pauls DL, Prusoff BA, Weissman MM. Anxiety disorders and depression: contradictions between family study data and DSM-III conventions. Am J Psychiatry 1983; 140: 880–2
   PubMedGoogle Scholar
• Breier A, Charney DS, Heninger GR. The diagnostic validity of anxiety disorders and their relationship to depressive illness. Am J Psychiatry 1985; 142: 787–97
   PubMed Web of Science ®Google Scholar
• Coryell W, Endicott J, Winokur G. Anxiety syndromes as epiphenomena of primary major depression: outcome and familial psychopathology. Am J Psychiatry 1992; 149: 100–7
   PubMed Web of Science ®Google Scholar
• Van Praag HM. Depression, anxiety, aggression: attempts to unravel the Gordian knot. Medicographia 1998; 20: 107–14
   Google Scholar
• Brown TA, Chorpita BF, Barlow DH. Structural relationships among dimensions of DSM-IV anxiety and mood disorders and dimensions of negative affect, positive affect and autonomic arousal. J Abnorm Psychol 1998; 107: 179–92
   PubMed Web of Science ®Google Scholar
• Barlow DH, Campbell LA. Mixed anxiety–depression and its implications for models of mood and anxiety disorders. Compr Psychiatry 2000; 41(Suppl 1)55–60
   PubMedGoogle Scholar
• Bystritsky A, Waikar SV, Vapnik T. Four-dimensional anxiety and depression scale: a preliminary psychometric report. Anxiety 1996; 2: 47–50
   PubMedGoogle Scholar
• Mullaney JA. The relationship between anxiety and depression – a review of some principal component analytic studies. J Affect Disord 1984; 7: 139–48
   PubMed Web of Science ®Google Scholar
• Widlocher D, Lecrubier Y, LeGoc Y. The place of anxiety in depressive symptomatology. Br J Clin Pharmacol 1983; 15(Suppl 2)172–9
   Google Scholar
• Clark LA, Watson D. Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. J Abnorm Psychol 1991; 100: 316–36
   PubMed Web of Science ®Google Scholar
• Liebowitz MR, Hollander E, Schneier F, et al. Anxiety and depression: discrete diagnostic entities?. J Clin Psychopharmacol 1990; 10(Suppl 3)61–6
   Google Scholar
• Schoevers RA, Deeg JDH, van Tilburg W, Beekman ATF. Depression and generalized anxiety disorder. Co-occurrence and longitudinal patterns in elderly patients. Am J Geriatr Psychiatry 2005; 13: 31–9
   PubMed Web of Science ®Google Scholar
• Berk M. Selective serotonin reuptake inhibitors in mixed anxiety–depression. Int J Clin Pharmacol 2000; 15(Suppl 2)S41–S45
   Google Scholar
• Linden M. The clinical interrelation between anxiety and mood disorder. Presented at the 11th ECNP Congress, 31 October–4 November 1998. ParisFrance
   Google Scholar
• Bienvenu OJ, Brown C, Samuels JF, et al. Normal personality traits and comorbidity among phobic, panic and major depressive disorders. Psychiatry Res 2001; 102: 73–85
   PubMed Web of Science ®Google Scholar
• Khan AA, Jacobson KC, Gardner CO, Prescott CA, Kendler KS. Personality and comorbidity of common psychiatric disorders. Br J Psychiatry 2005; 186: 190–6
   PubMed Web of Science ®Google Scholar
• Beekman ATF, De Beurs E, Van Balkom AJLM, et al. Anxiety and depression in later life: co-occurrence and communality of risk factors. Am J Psychiatry 2000; 157: 89–95
   PubMed Web of Science ®Google Scholar
• Wittchen H-U, Kessler RC, Pfister H, Lieb M. Why do people with anxiety disorders become depressed? A prospective-longitudinal community study. Acta Psychiatr Scand 2000; 102(Suppl 406)14–23
   Google Scholar
• Clayton PJ, Grove WM, Coryell W, et al. Follow-up and family study of anxious depression. Am J Psychiatry 1991; 148: 1512–7
   PubMed Web of Science ®Google Scholar
• Joyce PR, Romans SE, Ellis PM, Silverstone TS. Affective disorders. Christchurch: Christchurch School of Medicine; 1995
   Google Scholar
• Piccinelli M. Comorbidity of depression and generalized anxiety: is there any distinct boundary?. Curr Opin Psychiarty 1998; 11: 57–60
   PubMed Web of Science ®Google Scholar
• Merikangas KR. Comorbidity for anxiety and depression: review of family and genetic studies. Comorbidity of mood and anxiety disorders, JD Maser, CR Cloninger. American Psychiatric Press, Washington, DC 1990; 331–48
   Google Scholar
• Merikangas K, Gelernter CS. Comorbidity of alcoholism and depression. Psychiatr Clin N Am 1990; 13: 613–33
   PubMed Web of Science ®Google Scholar
• Prescott CA, Kendler KS. Do anxious and depressive states share common genetic factors?. Presented at the 11th ECNP Congress, 31 October–4 November 1998. ParisFrance
   Google Scholar
• Torgersen S. A twin-study perspective of the comorbidity of anxiety and depression. Comorbidity of mood and anxiety disorders, JD Maser, CR Cloninger. American Psychiatric Press, Washington, DC 1990; 367–78
   Google Scholar
• Weissman MM, Gershon ES, Kidd KK, et al. Psychiatric disorders in the relatives of probands with affective disorders: the Yale University – NIMH Collaborative Study. Arch Gen Psychiatry 1984; 41: 13–21
   PubMed Web of Science ®Google Scholar
• Angst J, Vollrath M, Merikangas K, . Comorbidity of anxiety and depression in the Zurich Cohort Study of Young Adults. Comorbidity of mood and anxiety disorders, JD Maser, CR Cloninger, et al. American Psychiatric Press, Washington, DC 1990; 123–37
   Google Scholar
• Wittchen H-U. Common risk factors in anxiety and depressive disorders. Presented at the 11th ECNP Congress, 31 October–4 November 1998. ParisFrance
   Google Scholar
• Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. Major depression and GAD. Same genes, (partly) different environments – revisited. Arch Gen Psychiatry 1992; 49: 716–22
   PubMed Web of Science ®Google Scholar
• Kendler KS. Major depression and GAD. Same genes, (partly) different environments – revisited?. Br J Psychiatry 1996; 168(Suppl 30)68–75
   PubMedGoogle Scholar
• Mombereau C, Kaupmann K, Gassmann M, Bettler B, van der Putten H, Cryan JF. Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits. NeuroReport 2005; 16: 307–10
   PubMedGoogle Scholar
• Rickels K. A new concept in the treatment of anxiety. Presented at the XXth CINP Congress, 23–27 June 1996. MelbourneAustralia
   Google Scholar
• Deakin JFW. 5HT receptor subtypes in depression. Behavioral pharmacology of 5HT, P Bevan, AR Cools, T Archer. Lawrence Erlbaum Associates, Hillsdale, NJ 1989; 179–204
   Google Scholar
• Deakin JFW, Strickland PL, Dixon J, et al. Social stress, steroid levels, 5HT and depression. J Psychopharmacology 1997; 11(Suppl 3)A93
   PubMedGoogle Scholar
• Eison MS. Serotonin: a common neurobiologic substrate in anxiety and depression. J Clin Psychopharmacol 1990; 10: 26–30S
   Google Scholar
• Johnson J, Weissman MM, Klerman GL. Panic disorder, comorbidity and suicide attempts. Arch Gen Psychiatry 1990; 47: 805–8
   PubMed Web of Science ®Google Scholar
• Nutt D, Argyropoulos S, Forshall S. Generalized anxiety disorder: diagnosis, treatment and its relationship to other anxiety disorders. Martin Dunitz Ltd, London 1998
   Google Scholar
• Schulberg HC, Katon WJ, Shear MK. Management of mood and anxiety disorders in primary care. Mood and anxiety disorders, AJ Rush. Current Science Inc, Philadelphia, PA 1998
   Google Scholar
• Deakin JFW. Roles of serotonergic systems in escape, avoidance and other behaviors. Theory in psychopharmacology, SJ Cooper. Academic Press, New York 1983; 2: 149–93
   Google Scholar
• Fibiger HC. Neuropathology of depression: focus on dopamine. Depression and mania: from neurobiology to treatment, G Gessa, W Fratta, L Pani, et al. Raven Press, New York 1995; 1–17
   Google Scholar
• Aoki T, Suetsugi M, Mizuki Y, , et al Differential effects of noradrenergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety. Presented at the XXIst CINP Congress, 12–16 July 1998. GlasgowUK
   Google Scholar
• Suetsugi M, Mizuki Y, Aoki T, , et al Differential effects of dopaminergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety. Presented at the XXIst CINP Congress, 12–16 July 1998. GlasgowUK
   Google Scholar
• Nutt DJ. Depression and generalized anxiety disorder: separation evidence. Presented at the 12th ECNP Congress, 21–25 September 1999. LondonUK
   Google Scholar
• Walf AA, Frye CA. Antianxiety and antidepressive behavior produced by physiological estradiol regimen may be modulated by hypothalamic-pituitary-adrenal axis activity. Neuropsychopharmacology 2005; 30: 1–14
   PubMedGoogle Scholar
• Boyer P. Do anxiety and depression have a common pathophysiological mechanism?. Acta Psychiatr Scand 2000; 102(Suppl 406)24–9
   Google Scholar
• Roy-Byrne PP, Uhde TW, Post RM, Gallucci W, Chrousos GP, Gold PW. The corticotropin-releasing hormone stimulation test in patients with panic disorder. Am J Psychiatry 1986; 143: 896–9
   PubMed Web of Science ®Google Scholar
• Rajkowska J. Depression: what we can learn from post-mortem studies. Neuroscientist 2003; 9: 273–84
   PubMed Web of Science ®Google Scholar
• Westenberg H. Understanding the links across the spectrum of depression and anxiety disorders: a common neurobiology? Presented at the 13th ECNP Congress, 9–13 September 2000, MunichGermany.
   Google Scholar
• Nutt D. Neurobiology of depression and anxiety – is there a common thread? Presented at the XXIInd CINP Congress, 9–13 July 2000, BrusselsBelgium
   Google Scholar
• Feinstein AR. The pretherapeutic classification of comorbidity in chronic disease. J Chron Dis 1970; 23: 455–68
   PubMedGoogle Scholar
• Burke JD, Wittchen H-U, Regier DA, . Extracting information from diagnostic interviews on co-occurrence of symptoms of anxiety and depression. Co-morbidity and anxiety disorders, JD Maser, CR Colinger, et al. APA, Washington, DC 1990; 649–67
   Google Scholar
• Kessler RC, McGonagle KA, Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: results of the National Comorbidity Survey. Arch Gen Psychiatry 1994; 51: 8–19
   PubMed Web of Science ®Google Scholar
• Angst J, Dobler-Mikola A. The Zurich Study VI: a continuum from depression to anxiety disorders?. Eur Arch Psychiatr Clin Neurosci 1985; 235: 179–86
   Google Scholar
• Derogatis LR, Lipman RS, Covi L, Rickels K. Factorial invariance of symptom dimensions in anxious and depressive neuroses. Arch Gen Psychiatry 1972; 27: 659–65
   PubMedGoogle Scholar
• Goldberg D. A dimensional model for common mental disorders. Br J Psychiatry 1996; 168(Suppl 30)44–9
   Web of Science ®Google Scholar
• Judd LL, Kessler RC, Paulus MP, et al. Comorbidity as a fundamental feature of generalized anxiety disorders: results from the National Comorbidity Study (NCS). Acta Psychiatr Scand 1998; 98(Suppl 393)6–11
   Google Scholar
• Prusoff B, Klerman GL. Differentiating depressed from anxious neurotic outpatients: use of discriminant function analysis for separation of neurotic affective states. Arch Gen Psychiatry 1974; 30: 302–9
   PubMed Web of Science ®Google Scholar
• Hirschfeld RMA. The comorbidity of major depression and anxiety disorders: recognition and management in primary care. Primary Care Companion. J Clin Psychiatry 2001; 2: 244–54
   Google Scholar
• Wittchen H-U. The burden and patterns of comorbidity of generalized anxiety disorder. Presented at the 12th ECNP Congress, 21–25 September 1999. LondonUK
   Google Scholar
• Hiller W, Zaudig M, van Bose M. The overlap between depression and anxiety on different levels of psychopathology. J Affect Disord 1989; 16: 223–31
   PubMed Web of Science ®Google Scholar
• Kendell RE. The stability of psychiatric diagnoses. Br J Psychiatry 1974; 124: 352–6
   PubMed Web of Science ®Google Scholar
• Shapira K, Roth M, Kerr T, et al. The prognosis of affective disorders: the differentiation of anxiety states and depressive illness. Br J Psychiatry 1972; 121: 175–81
   PubMedGoogle Scholar
• Tyrer P, Alexander J, Remington M, Riley P. Relationship between neurotic symptoms and neurotic diagnosis: a longitudinal study. J Affect Disord 1987; 13: 13–21
   PubMedGoogle Scholar
• Kraan H, Meertens H, Peters F. Positive affectivity or energy arousal: a dimension discriminating between depression and anxiety. Presented at the 2nd International Conference on New Directions in Affective Disorders, 3–8 September 1995. JerusalemIsrael
   Google Scholar
• Claghorn J. The anxiety–depression syndrome. Psychosomatics 1970; 11: 438–41
   PubMedGoogle Scholar
• Downing RW, Rickels K. Mixed anxiety–depression: fact or myth?. Arch Gen Psychiatry 1974; 30: 312–7
   PubMed Web of Science ®Google Scholar
• Fawcett J, Kravitz HM. Anxiety syndromes and their relationship to depressive illness. J Clin Psychiatry 1983; 44: 8–11
   PubMed Web of Science ®Google Scholar
• Fleiss JL, Lawlor W, Platman S, et al. Of the use of inverted factor analysis for generating typologies. J Abnorm Psychol 1971; 77: 127–32
   Google Scholar
• Kolvin I, Berney TR, Bhate SR. Classification and diagnosis of depression in school phobia. Br J Psychiatry 1984; 145: 347–57
   PubMed Web of Science ®Google Scholar
• Roth M, Gurney C, Garsdide RF, Kerr TA. Studies in the classification of affective disorders: the relationship between anxiety states and depressive illnesses, I and II. Br J Psychiatry 1972; 121: 147–66
   PubMedGoogle Scholar
• VanValkenburg C, Winokur G, Lowry M, Behar D, VanValkenburg D. Depression occurring in chronically anxious persons. Compr Psychiatry 1983; 24: 285–9
   PubMedGoogle Scholar
• Bowen RC, Kohout J. The relationship between agoraphobia and primary affective disorders. Can J Psychiatry 1979; 24: 317–22
   Web of Science ®Google Scholar
• Rouillon F, Chignon JM. Psychiatric comorbidity of anxiety disorders. Anxiety disorders in the year 2000: controversies and perspectives, E Costa, JA Silva. Adis Int'l Ltd, Chester 1992; 26–33
   Google Scholar
• Schoevers RA, Beekman ATF, Deeg JDH, Jonker C, van Tilburg W. Comorbidity and risk patterns of depression, generalised anxiety disorder and mixed anxiety–depression in later life: results from the AMSTEL study. Int J Geriatr Psychiatry 2003; 18: 994–1001
   PubMed Web of Science ®Google Scholar
• Starcevic V, Bogojevic G. The symptom structure of generalized anxiety disorder revisited. Presented at the 9th AEP Congress, 20–24 September 1998. CopenhagenDenmark
   Google Scholar
• Goldberg DP, Babigian HM, Locke BA, Rosen BM. Role of non-psychiatrist physicians in the delivery of mental health services: implications from three studies. Pub Health Rep 1978; 92: 240–5
   Google Scholar
• Jameson J, Schuman LJ, Young WW. The effects of outpatient psychiatric utilization on the cost of providing third party coverage. Med Care 1978; 16: 383–99
   PubMed Web of Science ®Google Scholar
• Haug TT, Mykletun A, Dahl AA. The association between anxiety, depression, and somatic symptoms in a large population: the HUNT-II study. Psychosom Med 2004; 66: 845–51
   PubMed Web of Science ®Google Scholar
• Stewart A, Sherbourne C, Wells K, et al. Do depressed patients in different treatment settings have different levels of well-being and functioning?. J Consult Clin Psychol 1993; 61: 849–57
   PubMed Web of Science ®Google Scholar
• Wells K, Rogers W, Burnam A, Greenfield S, Ware JE, Jr. How the medical comorbidity of depressed patients differs across health care settings: results from the Medical Outcomes Study. Am J Psychiatry 1991; 148: 1688–96
   PubMed Web of Science ®Google Scholar
• Bebbington P, Marsden L, Brewin CR. The need for psychiatric treatment in the general population: the Camberwell Needs for Care Survey. Psychol Med 1997; 27: 821–34
   PubMed Web of Science ®Google Scholar
• Jones RL, Badger LW, Ficken RP, Leeper JD, Anderson RL. Inside the hidden mental health network. Gen Hosp Psychiatry 1987; 9: 287–93
   PubMed Web of Science ®Google Scholar
• McCombs JS, Nichol MB, Stimmel GL, et al. The cost of antidepressant drug therapy failure: a study of antidepressant use patterns in a medicaid population. J Clin Psychiatry 1990; 51(Suppl 6)60–9
   PubMedGoogle Scholar
• Zajecka JM, Ross JS. A systematized approach to the management of the depressed and anxious patient. Int J Clin Pract 1998; 2: 27–30
   Google Scholar
• Shapiro S, Skinner EA, Kessler LG, et al. Utilization of health and mental health services: three Epidemiologic Catchment Area sites. Arch Gen Psychiatry 1984; 41: 971–8
   PubMed Web of Science ®Google Scholar
• Stokes PE. A primary care perspective on management of acute and long-term depression. J Clin Psychiatry 1993; 54(Suppl 8)74–84
   PubMedGoogle Scholar
• Goldberg D. The management of anxious depression in primary care. J Clin Psychiatry 1999; 60(Suppl 7)39–42
   PubMedGoogle Scholar
• Goldberg DP, Huxley PJ. Common mental disorders: a biosocial model. Routledge, London 1992
   Google Scholar
• Blazer D, Swartz M, Woodbury M, et al. Depressive symptoms and depressive diagnoses in a community population: use of a new procedure for analysis of psychiatric comorbidity. Arch Gen Psychiatry 1988; 45: 1078–84
   PubMed Web of Science ®Google Scholar
• Johnson MR, Lydiard RB, Ballenger JC. Panic disorder: pathophysiology and drug treatment. Drugs 1995; 49: 328–44
   PubMedGoogle Scholar
• Lepine JP, Wittchen H-U, Essau CA, et al. Lifetime and current comorbidity of anxiety and depressive disorders: results from the international WHO/ADAMHA CIDI field trials. Int J Methods Psychiatr Res 1993; 3: 67–77
   Web of Science ®Google Scholar
• Agoston G, Szadoczky E. The prevalence of mixed anxiety–depression in a sample of the Hungarian population. Presented at the 12th ECNP Congress, 21–25 September 1999. LondonUK
   Google Scholar
• Ronnes A, Mykletun A, Dahl AA. Help-seeking behaviour in patients with anxiety disorder and depression. Acta Psychiatr Scand 2005; 111: 51–8
   PubMedGoogle Scholar
• Murphy JM, Sobol AM, Olivier DC, et al. Prodromes of depression and anxiety: the Stirling county study. Br J Psychiatry 1989; 155: 490–5
   PubMed Web of Science ®Google Scholar
• Strauss CC, Last CG, Hersen M, Kazdin AE. Association between anxiety and depression in children and adolescents with anxiety disorders. J Abnorm Child Psychol 1988; 16: 57–68
   PubMed Web of Science ®Google Scholar
• Kovacs M, Gatsonis C, Paulauskas SL, Richards C. Depressive disorders in childhood. Arch Gen Psychiatry 1989; 46: 776–82
   PubMed Web of Science ®Google Scholar
• Brady EU, Kendall PC. Comorbidity of anxiety and depression in children and adolescents. Psychol Bull 1992; 111: 244–55
   PubMed Web of Science ®Google Scholar
• Zahn-Waxler C, Klimes-Dougan B, Slattery MJ. Internalizing problems of childhood and adolescence: prospects, pitfalls, and progress in understanding the development of anxiety and depression. Dev Psychopathol 2000; 12: 443–66
   PubMed Web of Science ®Google Scholar
• Smalbrugge M, Jongenelis L, Pot AM, et al. Comorbidity of depression and anxiety in nursing home patients. Int J Geriatr Psychiatry 2005; 20: 218–26
   PubMed Web of Science ®Google Scholar
• Medvedev A, Belova M, Kolesnitshenko A, , et al Cross-sectional comorbid mental pathology in the late life major depression. Presented at the 12th ECNP Congress, 21–25 September 1999. LondonUK
   Google Scholar
• O'Hara M, Swain A. Rates and risk of postpartum depression – a meta-analysis. Int Rev Psychiatry 1996; 8: 37–54
   Web of Science ®Google Scholar
• Sutter-Dallay AL, Giaconne-Marcesche V, Glatigny-Dallay E, Verdoux H. Women with anxiety disorders during pregnancy are at increased risk of intense postnatal depressive symptoms: a prospective survey of the MATQUID cohort. Eur Psychiatry 2004; 19: 459–63
   PubMed Web of Science ®Google Scholar
• Sartorius N, Ustun TB, Lecrubier Y, Wittchen HU. Depression comorbid with anxiety: results from the WHO study on psychological disorders in primary health care. Br J Psychiatry 1996; 168(Suppl 30)38–43
   PubMedGoogle Scholar
• Boulenger J-P, Fournier M, Rosales D, Lavallee YJ. Mixed anxiety and depression: from theory to practice. J Clin Psychiatry 1997; 58(Suppl 8)27–34
   PubMedGoogle Scholar
• Gaudiano BA, Miller IW. Anxiety disorder comorbidity in bipolar I disorder: relationship to depression severity and treatment outcome. Depress Anxiety 2005; 21: 71–7
   PubMed Web of Science ®Google Scholar
• Wittchen H-U, Lieb R, Wunderlich U, Schuster P. Comorbidity in primary care: presentation and consequences. J Clin Psychiatry 1999;60((Suppl 7)):29–36. [Discussion 87–8; Review.]
   PubMedGoogle Scholar
• Clancy J, Noyes R, Jr, Hoenk PR, Slymen DJ. Secondary depression in anxiety neurosis. J Nerv Ment Dis 1978; 166: 846–50
   PubMed Web of Science ®Google Scholar
• Stein MB, Kirk P, Prabhu V, Grott M, Terepa M. Mixed anxiety–depression in a primary care clinic. J Affect Disord 1995; 34: 79–84
   PubMed Web of Science ®Google Scholar
• Rosenblatt RA, Cherkin DC, Schneeweiss R, Hart LG. The content of ambulatory care medicine in the United States: an interspeciality comparison. New Engl J Med 1983; 309: 892–97
   PubMedGoogle Scholar
• Robins LN, Regier DA. Psychiatric disorders in America. The Epidemiologic Catchment Area Study. New York: The Free Press; 1991
   Google Scholar
• Barrett JE, Barrett JA, Oxman TE, Gerber PD. The prevalence of psychiatric disorders in a primary care practice. Arch Gen Psychiatry 1988; 45: 1100–6
   PubMed Web of Science ®Google Scholar
• Kessler RC, Wittchen H-U. Anxiety, mood, and substance abuse disorders: patterns and correlates of comorbidity. Presented at the 12th ECNP Congress, 21–25 September 1999. LondonUK
   Google Scholar
• Paykel ES, Henderson AJ. Application of cluster analysis in the classification of depression: a replication study. Neuropsychobiology 1977; 3: 111–9
   PubMed Web of Science ®Google Scholar
• Stahl SM. Mixed anxiety and depression: clinical implications. J Clin Psychiatry 1993; 54(Suppl 1)33–8
   PubMedGoogle Scholar
• Fava M. Depression-anxiety comorbidity. Presented at the 11th ECNP Congress, 31 October–3 November 1998. ParisFrance
   Google Scholar
• Hamilton M. Distinguishing between anxiety and depressive disorders. Handbook of anxiety disorders, CA Last, M Hersen. Pergamon Press, New York 1988; 143–55
   Google Scholar
• Salzman C. Practical considerations in the pharmacological treatment of depression and anxiety in the elderly. J Clin Psychiatry 1990; 51(Suppl 1)40–3
   PubMedGoogle Scholar
• Lenze EJ, Mulsant BH, Shear MK, et al. Comorbid anxiety disorders in depressed elderly patients. Am J Psychiatry 2000; 157: 722–8
   PubMed Web of Science ®Google Scholar
• Steffens DC, McQuoid DR. Impact of symptoms of generalized anxiety disorder on the course of late-life depression. Am J Geriatr Psychiatry 2005; 13: 40–7
   PubMed Web of Science ®Google Scholar
• Keller MB, Lavori PW, Mueller TI, et al. Time to recovery, chronicity, and levels of psychopathology in major depression. A 5-year prospective follow-up of 431 subjects. Arch Gen Psychiatry 1992; 49: 809–16
   PubMed Web of Science ®Google Scholar
• Mueller TI, Keller MB, Leon AC, et al. Recovery after 5 years of unremitting major depressive disorder. Arch Gen Psychiatry 1996; 53: 794–9
   PubMed Web of Science ®Google Scholar
• Alnaes R, Torgersen S. DSM-III personality disorders among patients with major depression, anxiety disorders, and mixed conditions. J Nerv Ment Dis 1990; 178: 693–8
   PubMed Web of Science ®Google Scholar
• Bakish D. The patient with comorbid depression and anxiety: the unmet need. J Clin Psychiatry 1999; 60(Suppl 6)20–4
   PubMed Web of Science ®Google Scholar
• Bijl RV, Ravelli A. Current and residual functional disability associated with psychopathology: findings from The Netherlands Mental Health Survey and Incidence Study (NEMESIS). Psychol Med 2000; 30: 657–68
   PubMed Web of Science ®Google Scholar
• De Beurs E, Beekman ATF, Van Balkom AJLM, et al. Consequences of anxiety in older persons: its effect on disability, well-being and use of health services. Psychol Med 1999; 29: 583–93
   PubMed Web of Science ®Google Scholar
• Emmanuel J, Simmonds S, Tyrer P. Systematic review of the outcome of anxiety and depressive disorders. Br J Psychiatry 1998; 173: 35–41
   Google Scholar
• Fawcett J. Predictors of early suicide: identification and appropriate intervention. J Clin Psychiatry 1988; 49(Suppl 10)7–8
   PubMedGoogle Scholar
• Feske U, Frank E, Kupfer DJ, Shear MK, Weaver E. Anxiety as a predictor of response to interpersonal psychotherapy for recurrent major depression. Depress Anxiety 1998; 8: 135–41
   PubMedGoogle Scholar
• Judd L. Comorbidity and health costs. Int Med News 1994; 92: 4–5
   Google Scholar
• Lenze EJ, Mulsant BH, Mohlman J, et al. Generalized anxiety disorder in late life. Lifetime course and comorbidity with major depressive disorder. Am J Geriatr Psychiatry 2005; 13: 77–80
   PubMed Web of Science ®Google Scholar
• Liebowitz MR. Depression with anxiety and atypical depression. J Clin Psychiatry 1993; 54(Suppl 2)10–14
   PubMedGoogle Scholar
• Liebowitz MR. Mixed anxiety and depression: should it be included in DSM-IV?. J Clin Psychiatry 1993; 54(Suppl 5)4–7
   PubMedGoogle Scholar
• Murphy JM. Depression in the community: findings from the Stirling county study. Can J Psychiatry 1990; 35: 390–6
   PubMedGoogle Scholar
• Rovner BW. Depression and increased risk of mortality in the nursing home patient. Am J Med 1993; 94: 19S–22S
   Google Scholar
• Rush AJ, Zimmerman M, Wisniewski SR, et al. Comorbid psychiatric disorders in depressed outpatients: demographic and clinical features. J Affect Disord 2005; 87(1)43–55
   PubMed Web of Science ®Google Scholar
• Schatzberg AF. Fluoxetine in the treatment of comorbid anxiety and depression. J Clin Psychiatry Monogr 1995; 13: 2–12
   Google Scholar
• Schoevers RA, Beekman ATF, Deeg JDH, et al. The natural history of late-life depression: results from the Amsterdam Study of the Elderly (AMSTEL). J Affect Disord 2002; 76: 5–14
   Google Scholar
• Stordal E, Bjelland I, Dahl AA, Mykletun A. Anxiety and depression in individuals with somatic health problems. The Nord-Trøndelag Health Study (HUNT). Scand J Prim Health Care 2003; 21: 136–41
   PubMed Web of Science ®Google Scholar
• VanValkenburg C, Akiskal HS, Puzantian V, Rosenthal T. Anxious depressions: clinical, family history, and naturalistic outcome – comparisons with panic and major depressive disorders. J Affect Disord 1984; 6: 67–82
   PubMedGoogle Scholar
• Gaynes BN, Magruder KM, Burns BJ, et al. Does a coexisting anxiety disorder predict persistence of depressive illness in primary care patients with major depression?. Gen Hosp Psychiatry 1999; 21: 158–67
   PubMed Web of Science ®Google Scholar
• Loebel AD, Hyde TS, Dunner DL. Early placebo response in anxious and depressed patients. J Clin Psychiatry 1986; 47: 230–3
   PubMedGoogle Scholar
• Bruce SE, Yonkers KA, Otto MW, et al. Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study. Am J Psychiatry 2005; 162: 1179–87
   PubMed Web of Science ®Google Scholar
• Trivedi MH. Managing residual anxiety in patients with depression. Presented at the XXVth Collegium Internationale Neuro-Psychopharmacorum (CINP) Congress, 9–13 July 2006. Chicago, ILUSA
   Google Scholar
• Wittchen H-U, Zhao S, Kessler RC, Eaton WW. DSM-III-R generalized anxiety disorder in the National Comorbidity Survey. Arch Gen Psychiatry 1994; 51: 355–64
   PubMed Web of Science ®Google Scholar
• Wittchen H-U, Essau CA, Krieg JC. Anxiety disorders: similarities and differences in comorbidity in treated and untreated groups. Br J Psychiatry 1991; 159(Suppl 12)23–33
   Google Scholar
• Ormel J, Kempen GI, Deeg DJ, et al. Functioning, well-being and health perception in late middle-aged and older people: comparing the effects of depressive symptoms and chronic medical conditions. J Am Geriatr Soc 1998; 46: 39–48
   PubMed Web of Science ®Google Scholar
• Ormel J, Kempen GI, Penninx BW, et al. Chronic mental conditions and mental health in older people: disability and psychosocial resources mediate specific mental health effects. Psychol Med 1997; 27: 1065–77
   PubMed Web of Science ®Google Scholar
• Bronisch T, Hecht H. Major depression with and without a coexisting anxiety disorder: social dysfunction, social integration, and personality features. J Affect Disord 1990; 20: 151–7
   PubMedGoogle Scholar
• Brown CW, Bifulco A, Harris TO, Bridge L. Life stress, chronic subclinical symptoms and vulnerability to clinical depression. J Affect Disord 1986; 11: 1–19
   PubMed Web of Science ®Google Scholar
• Clayton PJ. The comorbidity factor: establishing the primary diagnosis in patients with mixed symptoms of anxiety and depression. J Clin Psychiatry 1990; 51(Suppl 11)35–9
   PubMedGoogle Scholar
• Ormel J, Oldehinkel T, Brilman E, vanden Brink W. Outcome of depression and anxiety in primary care. Arch Gen Psychiatry 1993; 50: 759–66
   PubMed Web of Science ®Google Scholar
• Preisig M, Merikangas KR, Angst J. The impact of comorbidity on the course of depression and anxiety. Presented at the 9th AEP Congress, 20–24 September 1998. CopenhagenDenmark
   Google Scholar
• Wetzler S, Katz MM. Problems with the differentiation of anxiety and depression. J Psychiatr Res 1989; 23: 1–12
   PubMed Web of Science ®Google Scholar
• Kessler RC, Berglund P, Demler O, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). J Am Med Assoc 2003; 289: 3095–101
   PubMed Web of Science ®Google Scholar
• Hranov LG. Panic disorder. A comprehensive study of a clinical sample. Sofia, Medical University (in Bulgarian). 1995
   Google Scholar
• Lesses S. The relationship of anxiety to depression. Am J Psychother 1982; 36: 332–48
   PubMedGoogle Scholar
• Merikangas KR, Zhang H, Avenevoli S, et al. Zurich Cohort Study. Longitudinal trajectories of depression and anxiety in a prospective community study. Arch Gen Psychiatry 2003; 60: 993–1000
   PubMed Web of Science ®Google Scholar
• Angst J, Vollrath M. The natural history of anxiety disorders. Acta Psychiatr Scand 1991; 84: 446–52
   PubMed Web of Science ®Google Scholar
• Coryell W, Endicott J, Andreasen NC, et al. Depression and panic attacks: the significance of overlap as reflected in follow-up and family study data. Am J Psychiatry 1988; 145: 293–300
   PubMed Web of Science ®Google Scholar
• Grunhaus L, Rabin D, Greden JF. Simultaneous panic and depressive disorder: response to antidepressant treatments. J Clin Psychiatry 1986; 47: 4–7
   PubMedGoogle Scholar
• Schweizer E, Rickels K. The long-term management of generalized anxiety in primary care settings: practical concepts of classification and management. J Clin Psychiatry 1996; 58(Suppl 11)4–10
   Google Scholar
• Yonkers KA, Warshaw MG, Massion AO, Keller MB. Phenomenology and course of generalized anxiety disorder. Br J Psychiatry 1996; 168: 308–13
   PubMed Web of Science ®Google Scholar
• Fawcett J. The detection and consequences of anxiety in clinical depression. J Clin Psychiatry 1997; 58(Suppl 8)35–40
   PubMedGoogle Scholar
• Fawcett J, Scheftner WA, Fogg L, et al. Time-related predictors of suicide in major affective disorder. Am J Psychiatry 1990; 147: 1189–94
   PubMed Web of Science ®Google Scholar
• Wunderlich U, Bronisch T, Wittchen H-U. Comorbidity patterns in adolescents and young adults with suicide attempts. Eur Arch Psychiatry Clin Neurosci 1998; 248: 87–95
   PubMed Web of Science ®Google Scholar
• McGlynn TJ, Metcalf HL. Diagnosis and treatment of anxiety disorders: a physician's handbook. Washington, DC: American Psychiatric Press. 1989; p 8–11, 49.
   Google Scholar
• Lepine J-P. The challenge and impact of comorbid anxiety in patients with major depressive disorders Presented at the CINP XXVth Congress, 9–13 July 2006, Chicago, ILUSA
   Google Scholar
• Pollack MH. The problem of concomitant depression in patients with anxiety disorders. Presented at the CINP XXVth Biennal Congress, 9–13 July 2006, Chicago, ILUSA
   Google Scholar
• Schweizer E. Generalized anxiety disorder: longitudinal course and pharmacologic treatment. Psychiatr Clin North Am 1995; 18: 843–57
   PubMedGoogle Scholar
• Zung WWK, Magruder-Habib K, Velez R, Alling W. The comorbidity of anxiety and depression in general medical patients: a longitudinal study. J Clin Psychiatry 1990;51((Suppl 6)):77–80. [Discussion 91.]
   PubMedGoogle Scholar
• Rickels K, Downing R, Schweizer E, Hassman H. Antidepressants for the treatment of generalized anxiety disorder. A placebo-controlled comparison of imipramine, trazodone, and diazepam. Arch Gen Psychiatry 1993; 50: 884–95
   PubMed Web of Science ®Google Scholar
• Catalan J, Gath D, Edmonds G, Ennis J. The effects of non-prescribing of anxiolytics in general practice. I. Controlled evaluation of psychiatric and social outcome. Br J Psychiatry 1984; 144: 593–602
   PubMed Web of Science ®Google Scholar
• Smith BD, Salzman C. Do benzodiazepines cause depression?. Hosp Community Psychiatry 1991; 42: 1101–2
   PubMedGoogle Scholar
• van Meter SA, Doraiswamy PM. Anxiety disorders. Conns Current Therapy 2001, RE Rakel, ET Bope. WB Saunders Co, Philadelphia, PA 2001; 1137–42
   Google Scholar
• Zamorski MA, Albucher RC. What to do when SSRIs fail: eight strategies for optimizing treatment of panic disorder. Fam Physician 2002; 66: 1477–84
   PubMedGoogle Scholar
• Judd FK, Burrows GD. Anxiety disorders and their relationship to depression. Handbook of affective disorders, ES Paykel. Guilford Press, New York 1992; 77–87
   Google Scholar
• Paykel ES. Remission and residual symptomatology in major depression. Psychopathology 1998; 31: 5–14
   PubMedGoogle Scholar
• Nelson JC, Portera L, Leon AC. Residual symptoms in depressed patients after treatment with fluoxetine or reboxetine. J Clin Psychiatry 2005; 66: 1409–14
   PubMed Web of Science ®Google Scholar
• Menza M, Marin H, Opper RS. Residual symptoms in depression: can treatment be symptom-specific?. J Clin Psychiatry 2003; 64: 516–23
   PubMed Web of Science ®Google Scholar
• Lecrubier Y, Weiller E, Andersen H. Qualitative changes in symptomatology before and after treatment to remission in GAD and major depression Presented at the CINP XXVth Congress, 9–13 July 2006, Chicago, ILUSA
   Google Scholar
• Silverstone PH, Salinas E. Efficacy of venlafaxine extended release in patients with major depressive disorder and comorbid generalized anxiety disorder. J Clin Psychiatry 2001; 62: 523–9
   PubMed Web of Science ®Google Scholar
• Tyrer P, Seivewright N, Murphy S, et al. The Nottingham study of neurotic disorder: comparison of drug and psychological treatments. Lancet 1988; 39: 235–40
   Google Scholar
• Lipman RD, Covi L, Rickels K, et al. Imipramine and chlordiazepoxide in depressive and anxiety disorders. I. Efficacy in depressed outpatients. Arch Gen Psychiatry 1986; 43: 68–77
   PubMedGoogle Scholar
• Rickels K, Schweizer E. The treatment of generalized anxiety disorder in patients with depressive symptomatology. J Clin Psychiatry 1993; 54(Suppl 1)20–3
   PubMedGoogle Scholar
• Fava M, Rosenbaum J, Hoog SL, et al. Fluoxetine versus sertraline and paroxetine in major depression: tolerability and efficacy in anxious depression. J Affect Disord 2000; 59: 119–26
   PubMed Web of Science ®Google Scholar
• Kasper S. Neurobiology and new psychopharmacological strategies for treatment of anxiety disorders. Current therapeutical approaches on panic and other anxiety disorders, G Racagni, N Brunelli. Karger, Basel 1995
   Google Scholar
• Dunbar GC, Fuell DL. The anti-anxiety and anti-agitation effects of paroxetine in depressed patients. Int Clin Psychopharmacol 1992; 6(Suppl 4)81–90
   PubMedGoogle Scholar
• Montgomery S, Porto L, Plewes T, et al. Does comorbid anxiety predict antidepressant success or failure? A meta-analysis of 3800 clinical trial patients. Eur Neuropsychopharmacol 1998; 8(Suppl 2)S153
   PubMedGoogle Scholar
• Lydiard RB. Effects of escitalopram on anxiety symptoms in depression. Poster presented at the 154th APA Annual Meeting, 5–10 May. New Orleans, LA, USA. 2001
   Google Scholar
• Galinowski A, Tonnoir B, Florea I, Olie J-P. The efficacy of escitalopram in depressed patients with comorbid anxiety. Presented at the 158th annual meeting of the APA, 21–26 May 2005, Atlanta, GAUSA
   Google Scholar
• Boulenger J-PP, Huusom AKT, Florea I, Baekdal T, Sarchiapone M. A comparative study of the efficacy of long-term treatment with escitalopram and paroxetine in severely depressed patients. Curr Med Res Opin 2006; 22: 1331–41
   PubMed Web of Science ®Google Scholar
• Laws D, Ashford JJ, Anstee JA. A multicentre double-blind comparative trial of fluvoxamine versus lorazepam in mixed anxiety and depression treated in general practice. Acta Psychiatr Scand 1990; 81: 185–9
   PubMed Web of Science ®Google Scholar
• Rausch JL, Hobby H, Shendarkar N, Johnson ME, Li J. Fluvoxamine treatment of mixed anxiety and depression: evidence for serotonergically mediated anxiolysis. J Clin Psychopharmacol 2001; 21: 139–142
   PubMed Web of Science ®Google Scholar
• Rapaport MH, Jonas J, Bose A, , et al Escitalopram improves somatic symptoms of depression Presented at the XXIVth Collegium Internationale Neuro-Psychopharmacorum (CINP) Congress, 20–24 June 2004. ParisFrance
   Google Scholar
• Sheline YI, Barch DM, Donnelly JM, et al. Increased amygdale response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biol Psychiatry 2001; 50: 651–8
   PubMed Web of Science ®Google Scholar
• Rausch JL. A hypothesis of initial conditions: receptor-effector systems as determinants of psychopharmacologic drug response. Int J Neuropsychopharmacol 1998; 1: 137–51
   PubMedGoogle Scholar
• Fontaine R, Ontiveros A, Elie R, et al. A double-blind comparison of nefazodone, imipramine, and placebo in major depression. J Clin Psychiatry 1994; 55: 234–41
   PubMed Web of Science ®Google Scholar
• Fawcett J, Marcus RN, Anton SF, O'Brien K, Schwiderski U. Response of anxiety and agitation symptoms during nefazodone treatment of major depression. J Clin Psychiatry 1995; 56(Suppl 6)37–42
   PubMedGoogle Scholar
• Bremmer JD. A double-blind comparison of Org 3770, amitriptyline, and placebo in major depression. J Clin Psychiatry 1995; 56: 519–26
   PubMedGoogle Scholar
• Feighner JP, Entsuah AR, McPherson MK. Efficacy of once-daily venlafaxine extended release (XR) for symptoms of anxiety in depressed outpatients. J Affect Disord 1998; 47: 55–62
   PubMed Web of Science ®Google Scholar
• Trivedi MH, Rush AJ, Carmody TJ, Donahue RM, Bolden-Watson C, et al. Do bupropion SR and sertraline differ in their effects on anxiety in depressed patients?. J Clin Psychiatry 2001; 62: 776–81
   PubMedGoogle Scholar
• Pini S, Amador XF, Dell'Osso L, et al. Treatment of depression with comorbid anxiety disorders: differential efficacy of paroxetine versus moclobemide. Int Clin Psychopharmacol 2003; 18: 15–21
   PubMedGoogle Scholar
• Cameron OG, Abelson JL, Young EA. Anxious and depressive disorders and their comorbidity: effect on central nervous system noradrenergic function. Biol Psychiatry 2004; 56: 875–83
   PubMed Web of Science ®Google Scholar
• Pariante CM, Miller AH. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry 2001; 49: 391–404
   PubMed Web of Science ®Google Scholar
• Ninan PT, Feigon SA, Knight B. Neurobiology and mechanisms of antidepressant treatment response in anxiety. Psychopharm Bull 2002; 36(Suppl 3)67–78
   PubMedGoogle Scholar
• Hen R. Genetic modules of depression and anxiety Presented at the 158th Annual Meeting of the APA, 21–26 May 2005, Atlanta, GAUSA
   Google Scholar
• Nibuya M, Morinobu S, Duman RS. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive and antidepressant drug treatments. J Neurosci 1995; 15: 7539–47
   PubMed Web of Science ®Google Scholar
• Duman RS. The neurochemistry of mood disorders: preclinical studies. The neurobiology of mental illness, DS Charney. Oxford University Press, New York 1999; 333–64
   Google Scholar
• Chambless DL, Sanderson WC, Shoham V, et al. An update on empirically validated therapies. Clin Psychol 1996; 49: 5–18
   Google Scholar
• Freeston MH, Ladoceur R, Gagnon F, et al. Cognitive-behavioral treatment of obsessive thoughts: a controlled study. J Consult Clin Psychology 1997; 65: 405–13
   PubMed Web of Science ®Google Scholar
• Tsao JC, Lewin MR, Craske MG. The effects of cognitive-behavior therapy for panic disorder on comorbid conditions. J Anxiety Disord 1998; 12: 357–71
   PubMed Web of Science ®Google Scholar
• Woody S, McLean PD, Taylor S, Koch WJ. Treatment of major depression in the context of panic disorder. J Affect Disord 1999; 53: 163–74
   PubMed Web of Science ®Google Scholar
• Paykel ES, Scott J, Teasdale JD, et al. Prevention of relapse in residual depression by cognitive therapy. Arch Gen Psychiatry 1999; 56: 829–35
   PubMed Web of Science ®Google Scholar
• Fava GA, Rafanelli C, Grandi S, Canestrari R, Morphy A. Six-year outcome for cognitive behavioral treatment of residual symptoms in major depression. Am J Psychiatry 1998; 155: 1443–5
   PubMed Web of Science ®Google Scholar
• Durham RC, Allan T. Psychological treatment of generalized anxiety disorder: a review of the clinical significance of results in outcome studies since 1980. Br J Psychiatry 1993; 163: 19–26
   PubMedGoogle Scholar