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Review Article

Chronic kidney disease (CKD) in the elderly – a geriatrician's perspective

Pages 113-137 | Received 06 Mar 2007, Accepted 30 Mar 2007, Published online: 06 Jul 2009

References

  • Schoolwerth A C, Engelgau M M, Hostetter T H, Rufo K H, Chianchiano D, McClellan W M, et al. Chronic kidney disease: a public health problem that needs a public health action plan. Prev Chronic Dis 2006; 3: A57
  • US Renal Data System. USRDS 2004 annual data report. Atlas of end-stage renal disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, http://www.usrds.org/atlas_2004.htm. Accessed 20.7.2006
  • Coresh J, Astor B C, Greene T, Eknoyan G, Levey A S. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003; 41: 1–12
  • US Renal Data System: USRDS 2003 annual data report: atlas of end stage renal disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney diseases, Bethesda, MD 2003
  • Xue J L, Ma J Z, Louis T A, Collins A J. Forecast of the number of patients with end-stage renal disease in the United States to the year 2010. J Am Soc Nephrol 2001; 12: 2753–2758
  • Hansberry M R, Whittier W L, Krause M W. The elderly patient with chronic kidney disease. Adv Chronic Kidney Dis 2005; 12: 71–77
  • Lamb E J, O'Riordan S E, Delaney M P. Kidney function in older people: pathology, assessment and management. Clin Chim Acta 2003; 334: 25–40
  • John R, Webb M, Young A, Stevens P E. Unreferred chronic kidney disease: a longitudinal study. Am J Kidney Dis 2004; 43: 825–835
  • Chapter 1. Chronic kidney disease. US Renal Data System: USRDS 2006 Annual Data Report: atlas of end stage renal disease in the United States. National Institute of Health, National Institute of Diabetes & Digestive Kidney Diseases, Bathesda, MD 2006; 47–64, Accessed at: http://www.usrds.org/2006/pdf/01_ckd_06.pdf. Accessed 24.12.2006
  • Taal M W, Brenner B M. Predicting initiation and progression of chronic kidney disease: developing renal risk scores. Kidney Int 2006; 70: 1694–1705
  • Iseki K, Iseki C, Ikemiya Y, Fukiyama K. Risk of developing end-stage renal disease in a cohort of mass screening. Kidney Int 1996; 49: 800–805
  • Weller J M, Wu S C, Ferguson C W, Hawthorne V M. End-stage renal disease in Michigan. Incidence, underlying causes, prevalence, and modalities of treatment. Am J Nephrol 1985; 5: 84–95
  • Haroun M K, Jaar B G, Hoffman S C, Comstock G W, Klag M J, Coresh J. Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, Maryland. J Am Soc Nephrol. 2003; 14: 2934–2941
  • Silbiger S R, Neugarten J. The role of gender in the progression of renal disease. Adv Ren Replace Ther 2003; 10: 3–14
  • Gandolfo M T, Verzola D, Salvatore F, Gianiorio G, Procopio V, Romagnoli A, et al. Gender and the progression of chronic renal diseases: does apoptosis make the difference?. Minerva Urol Nefrol 2004; 56: 1–14
  • Seliger S L, Davis C, Stehman-Breen C. Gender and the progression of renal disease. Curr Opin Nephrol Hypertens 2001; 10: 219–225
  • Morley J E, Haren M T, Rolland Y, Kim M J. Frailty. Med Clin North Am 2006; 90: 837–847
  • Fried L P, Tangen C M, Walston J, Newman A B, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56: M146–M156
  • Fried L P, Ferrucci L, Darer J, Williamson J D, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 2004; 59: 255–263
  • Walston J, Fried L P. Frailty and the older man. Med Clin North Am 1999; 83: 1173–1194
  • Fried L P, Newman A, Walston J, et al. Frailty and mortality in the cardiovascular health study. Report presented at 51st Annual Scientific Meeting of the Gerontological Society of America, Philadelphia, November, 1998
  • Newman A, Walston J, Hirsch C, et al. Physiologic correlates of frailty in the cardiovascular health study cohort. Report presented at 51st Annual Scientific Meeting of the Gerontological Society of America, Philadelphia, November, 1998
  • Morley J E, Kaiser F E, Sih R, Hajjar R, Perry H M, III. Testosterone and frailty. Clin Geriatr Med 1997; 13: 685–695
  • Phillips S K, Rook K M, Siddle N C, Bruce S A, Woledge R C. Muscle weakness in women occurs at an earlier age than in men, but strength is preserved by hormone replacement therapy. Clin Sci (Lond) 1993; 84: 95–98
  • Morley J E, Perry H M, III, Kaiser F E, Kraenzle D, Jensen J, Houston K, et al. Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J Am Geriatr Soc 1993; 41: 149–152
  • Reid I R, Wattie D J, Evans M C, Stapleton J P. Testosterone therapy in glucocorticoid-treated men. Arch Intern Med 1996; 156: 1173–1177
  • Sih R, Morley J E, Kaiser F E, Perry H M, III, Patrick P, Ross C. Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab 1997; 82: 1661–1667
  • Tenover J S. Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab 1992; 75: 1092–1098
  • Urban R J, Bodenburg Y H, Gilkison C, Foxworth J, Coggan A R, Wolfe R R, et al. Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am J Physiol 1995; 269: E820–E826
  • Morley J E. An overview of diabetes mellitus in older persons. Clin Geriatr Med 1999; 15: 211–224
  • Rodriguez-Saldana J, Morley J E, Reynoso M T, Medina C A, Salazar P, Cruz E, et al. Diabetes mellitus in a subgroup of older Mexicans: prevalence, association with cardiovascular risk factors, functional and cognitive impairment, and mortality. J Am Geriatr Soc 2002; 50: 111–116
  • Miller D K, Lui L Y, Perry H M, III, Kaiser F E, Morley J E. Reported and measured physical functioning in older inner-city diabetic African Americans. J Gerontol A Biol Sci Med Sci 1999; 54: M230–M236
  • Shlipak M G, Stehman-Breen C, Fried L F, Song X, Siscovick D, Fried L P, et al. The presence of frailty in elderly persons with chronic renal insufficiency. Am J Kidney Dis 2004; 43: 861–867
  • McIntyre C W, Selby N M, Sigrist M, Pearce L E, Mercer T H, Naish P F. Patients receiving maintenance dialysis have more severe functionally significant skeletal muscle wasting than patients with dialysis-independent chronic kidney disease. Nephrol Dial Transplant 2006; 21: 2210–2216
  • Kovesdy C P, Trivedi B K, Anderson J E. Association of kidney function with mortality in patients with chronic kidney disease not yet on dialysis: a historical prospective cohort study. Adv Chronic Kidney Dis 2006; 13: 183–188
  • Tonelli M, Wiebe N, Culleton B, House A, Rabbat C, Fok M, et al. Chronic kidney disease and mortality risk: a systematic review. J Am Soc Nephrol 2006; 17: 2034–2047
  • K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002; 39: S1–S266
  • Besarab A, Ross R P, Nasca T J. The use of recombinant human erythropoietin in predialysis patients. Curr Opin Nephrol Hypertens 1995; 4: 155–161
  • Obrador G T, Ruthazer R, Arora P, Kausz A T, Pereira B J. Prevalence of and factors associated with suboptimal care before initiation of dialysis in the United States. J Am Soc Nephrol 1999; 10: 1793–1800
  • Ismail N. Hemodialysis in the elderly. UpToDate 2006, Accessed at: http://www.utdol.com/utd/content/topic.do?topicKey=dialysis/19941&type=A&selectedTitle=25∼289. Accessed 20.7.2006
  • Loos C, Briancon S, Frimat L, Hanesse B, Kessler M. Effect of end-stage renal disease on the quality of life of older patients. J Am Geriatr Soc 2003; 51: 229–233
  • Abrass C K. Renal disease in the elderly. Best Practice of Medicine 1999, Accessed at: http://merck2.micromedex.com/index.asp?page=bpm_cited&article_id=CPM01NP277. Accessed 31.1.2006
  • Huisman R M. The deadly risk of late referral. Nephrol Dial Transplant 2004; 19: 2175–2180
  • O'Riordan S. Chronic kidney disease and older people – implications of the publication of the Part 2 of the National Service Framework for Renal Services. Age Ageing 2005; 34: 546–548
  • Epstein M. Aging and the kidney. J Am Soc Nephrol 1996; 7: 1106–1122
  • Choudhury D, Raj D SC, Levi M. Effect of aging on renal function and disease. The kidney7th ed, Brenner, Rector's. PA Saunders, Philadelphia 2004; 2305–2321
  • Takazakura E, Sawabu N, Handa A, Takada A, Shinoda A, Takeuchi J. Intrarenal vascular changes with age and disease. Kidney Int 1972; 2: 224–230
  • Davison A M. Renal disease in the elderly. Nephron 1998; 80: 6–16
  • Lindeman R D, Tobin J, Shock N W. Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 1985; 33: 278–285
  • Godin M, Moulin B, Etienne I, Fillastre J P. [Renal aging in man]. Presse Med 1992; 21: 1246–1248
  • Macias Nunez J F, Garcia I C, Bondia R A, Rodriguez Commes J L, Corbacho B L, Tabernero Romo J M, et al. Renal handling of sodium in old people: a functional study. Age Ageing 1978; 7: 178–181
  • Luft F C, Fineberg N S, Miller J Z, Rankin L I, Grim C E, Weinberger M H. The effects of age, race and heredity on glomerular filtration rate following volume expansion and contraction in normal man. Am J Med Sci 1980; 279: 15–24
  • Fliser D, Zeier M, Nowack R, Ritz E. Renal functional reserve in healthy elderly subjects. J Am Soc Nephrol 1993; 3: 1371–1377
  • MacGregor M S, Boag D E, Innes A. Chronic kidney disease: evolving strategies for detection and management of impaired renal function. QJM 2006; 99: 365–375
  • NKF-K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification. 2002, 2006, Accessed at: http://www.kidney.org/professionals/KDOQI/guidelines_ckd/toc.htm
  • Hall P M. Proteinuria, The Cleveland Clinic. Center for Continuing Education.Accessed at: http://www.clevelandclinicmeded.com/diseasemanagement/nephrology/proteinuria/proteinuria.htm. Accessed 20.8.2006
  • K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification. Part 4. Definition and Classification of Stages of Chronic Kidney Disease, Accessed at: http://www.kidney.org/professionals/KDOQI/guidelines_ckd/p4_class_g1.htm. Accessed 11.3.2006
  • Stevens L A, Levey A S. Clinical implications of estimating equations for glomerular filtration rate. Ann Intern Med 2004; 141: 959–961
  • Kelleher C L, Lindeman R D. Kidney Diseases and Disorders (chapter 50). Geriatrics review syllabus: a core curriculum in geriatric medicinesixth edition, P Pompei, J B Murphy. American Geriatrics Society, New York, NY 2006
  • Stevens L, Perrone D R. Assessment of kidney function: serum creatinine; BUN; and GFR. UpToDate 2006, Version 14.3.Accessed at: http://www.utdol.com/utd/content/topic.do?topicKey=fldlytes/32110&type=A&selectedTitle=1∼30. Accessed 10.12.2006
  • O'Riordan S E, Webb M C, Stowe H J, Simpson D E, Kandarpa M, Coakley A J, et al. Cystatin C improves the detection of mild renal dysfunction in older patients. Ann Clin Biochem 2003; 40: 648–655
  • Swedko P J, Clark H D, Paramsothy K, Akbari A. Serum creatinine is an inadequate screening test for renal failure in elderly patients. Arch Intern Med 2003; 163: 356–360
  • Fraser C G. Test result variation and the quality of evidence-based clinical guidelines. Clin Chim Acta 2004; 346: 19–24
  • Mussap M, Plebani M. Biochemistry and clinical role of human cystatin C. Crit Rev Clin Lab Sci 2004; 41: 467–550
  • Stevens L A, Levey A S. Chronic kidney disease in the elderly – how to assess risk. N Engl J Med 2005; 352: 2122–2124
  • Shlipak M G, Katz R, Sarnak M J, Fried L F, Newman A B, Stehman-Breen C, et al. Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann Intern Med 2006; 145: 237–246
  • Hoek F J, Kemperman F A, Krediet R T. A comparison between cystatin C, plasma creatinine and the Cockcroft and Gault formula for the estimation of glomerular filtration rate. Nephrol Dial Transplant 2003; 18: 2024–2031
  • Newman D J, Thakkar H, Edwards R G, Wilkie M, White T, Grubb A O, et al. Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine. Kidney Int 1995; 47: 312–318
  • Shlipak M G, Sarnak M J, Katz R, Fried L F, Seliger S L, Newman A B, et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med 2005; 352: 2049–2060
  • Fricker M, Wiesli P, Brandle M, Schwegler B, Schmid C. Impact of thyroid dysfunction on serum cystatin C. Kidney Int 2003; 63: 1944–1947
  • Jayagopal V, Keevil B G, Atkin S L, Jennings P E, Kilpatrick E S. Paradoxical changes in cystatin C and serum creatinine in patients with hypo- and hyperthyroidism. Clin Chem 2003; 49: 680–681
  • Wiesli P, Schwegler B, Spinas G A, Schmid C. Serum cystatin C is sensitive to small changes in thyroid function. Clin Chim Acta 2003; 338: 87–90
  • Wasen E, Isoaho R, Mattila K, Vahlberg T, Kivela S L, Irjala K. Serum cystatin C in the aged: relationships with health status. Am J Kidney Dis 2003; 42: 36–43
  • Knight E L, Verhave J C, Spiegelman D, Hillege H L, de Z D, Curhan G C, et al. Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement. Kidney Int 2004; 65: 1416–1421
  • Macdonald J, Marcora S, Jibani M, Roberts G, Kumwenda M, Glover R, et al. GFR estimation using cystatin C is not independent of body composition. Am J Kidney Dis 2006; 48: 712–719
  • Coresh J, Astor B. Decreased kidney function in the elderly: clinical and preclinical, neither benign. Ann Intern Med 2006; 145: 299–301
  • Macisaac R J, Tsalamandris C, Thomas M C, Premaratne E, Panagiotopoulos S, Smith T J, et al. Estimating glomerular filtration rate in diabetes: a comparison of cystatin-C- and creatinine-based methods. Diabetologia 2006; 49: 1686–1689
  • Pedone C, Corsonello A, Incalzi R A. Estimating renal function in older people: a comparison of three formulas. Age Ageing 2006; 35: 121–126
  • Levey A S, Bosch J P, Lewis J B, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130: 461–470
  • Levey A S, Bosch J P, Lewis J B, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130: 461–470
  • Levin A. The advantage of a uniform terminology and staging system for chronic kidney disease (CKD). Nephrol Dial Transplant 2003; 18: 1446–1451
  • Kidney Health Australia. National Chronic Kidney Disease Strategy, Accessed at: http://www.kidney.org.au/?section=86&subsection=544. Accessed 28.8.2006
  • Bertolatus J A, Goddard L. Evaluation of renal function in potential living kidney donors. Transplantation 2001; 71: 256–260
  • Bostom A G, Kronenberg F, Ritz E. Predictive performance of renal function equations for patients with chronic kidney disease and normal serum creatinine levels. J Am Soc Nephrol 2002; 13: 2140–2144
  • Kuan Y, Hossain M, Surman J, El Nahas A M, Haylor J. GFR prediction using the MDRD and Cockcroft and Gault equations in patients with end-stage renal disease. Nephrol Dial Transplant 2005; 20: 2394–2401
  • Lin J, Knight E L, Hogan M L, Singh A K. A comparison of prediction equations for estimating glomerular filtration rate in adults without kidney disease. J Am Soc Nephrol 2003; 14: 2573–2580
  • Pierrat A, Gravier E, Saunders C, Caira M V, it-Djafer Z, Legras B, et al. Predicting GFR in children and adults: a comparison of the Cockcroft-Gault, Schwartz, and modification of diet in renal disease formulas. Kidney Int 2003; 64: 1425–1436
  • Poggio E D, Wang X, Greene T, Van L F, Hall P M. Performance of the modification of diet in renal disease and Cockcroft-Gault equations in the estimation of GFR in health and in chronic kidney disease. J Am Soc Nephrol 2005; 16: 459–466
  • Rule A D, Larson T S, Bergstralh E J, Slezak J M, Jacobsen S J, Cosio F G. Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease. Ann Intern Med 2004; 141: 929–937
  • Rule A D, Gussak H M, Pond G R, Bergstralh E J, Stegall M D, Cosio F G, Larson T S. Measured and estimated GFR in healthy potential kidney donors. Am J Kidney Dis 2004; 43: 112–119
  • Stoves J, Lindley E J, Barnfield M C, Burniston M T, Newstead C G. MDRD equation estimates of glomerular filtration rate in potential living kidney donors and renal transplant recipients with impaired graft function. Nephrol Dial Transplant 2002; 17: 2036–2037
  • Vervoort G, Willems H L, Wetzels J F. Assessment of glomerular filtration rate in healthy subjects and normoalbuminuric diabetic patients: validity of a new (MDRD) prediction equation. Nephrol Dial Transplant 2002; 17: 1909–1913
  • Van Den Noortgate N J, Janssens W H, Delanghe J R, Afschrift M B, Lameire N H. Serum cystatin C concentration compared with other markers of glomerular filtration rate in the old old. J Am Geriatr Soc 2002; 50: 1278–1282
  • Lamb E J, Webb M C, Simpson D E, Coakley A J, Newman D J, O'Riordan S E. Estimation of glomerular filtration rate in older patients with chronic renal insufficiency: is the modification of diet in renal disease formula an improvement?. J Am Geriatr Soc 2003; 51: 1012–1017
  • Fehrman-Ekholm I, Skeppholm L. Renal function in the elderly (>70 years old) measured by means of iohexol clearance, serum creatinine, serum urea and estimated clearance. Scand J Urol Nephrol 2004; 38: 73–77
  • Clase C M, Garg A X, Kiberd B A. Classifying kidney problems: can we avoid framing risks as diseases?. BMJ 2004; 329: 912–915
  • Haas M, Spargo B H, Wit E J, Meehan S M. Etiologies and outcome of acute renal insufficiency in older adults: a renal biopsy study of 259 cases. Am J Kidney Dis 2000; 35: 433–447
  • Modesto-Segonds A, Ah-Soune M F, Durand D, Suc J M. Renal biopsy in the elderly. Am J Nephrol 1993; 13: 27–34
  • Preston R A, Stemmer C L, Materson B J, Perez-Stable E, Pardo V. Renal biopsy in patients 65 years of age or older. An analysis of the results of 334 biopsies. J Am Geriatr Soc 1990; 38: 669–674
  • Pharmacological therapy: use of antihypertensives in CKD. K/DOQI Clinical Practice Guidelines on Hypertension and Antihypertensive Agents in Chronic Kidney Disease, Accessed at: http://www.kidney.org/professionals/KDOQI/guidelines_bp/guide_7.htm. Accessed 10.12.2006
  • Use of diuretics in CKD. K/DOQI Clinical Practice Guidelines on Hypertension and Antihypertensive Agents in Chronic Kidney Disease, Accessed at: http://www.kidney.org/professionals/KDOQI/guidelines_bp/guide_12.htm. Accessed 10.12.2006
  • Use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in CKD. K/DOQI Clinical Practice Guidelines on Hypertension and Antihypertensive Agents in Chronic Kidney Disease, Accessed at: http://www.kidney.org/professionals/KDOQI/guidelines_bp/guide_11.htm. Accessed 9.12.2006
  • Bakris G L. Effects of diltiazem or lisinopril on massive proteinuria associated with diabetes mellitus. Ann Intern Med 1990; 112: 707–708
  • Bakris G L, Barnhill B W, Sadler R. Treatment of arterial hypertension in diabetic humans: importance of therapeutic selection. Kidney Int 1992; 41: 912–919
  • Bakris G L, Copley J B, Vicknair N, Sadler R, Leurgans S. Calcium channel blockers versus other antihypertensive therapies on progression of NIDDM associated nephropathy. Kidney Int 1996; 50: 1641–1650
  • Bohlen L, de Court Weidmann P. Comparative study of the effect of ACE-inhibitors and other antihypertensive agents on proteinuria in diabetic patients. Am J Hypertens 1994; 7: 84S–92S
  • Bakris G L, Weir M R, DeQuattro V, McMahon F G. Effects of an ACE inhibitor/calcium antagonist combination on proteinuria in diabetic nephropathy. Kidney Int 1998; 54: 1283–1289
  • Ritz E, Koch M. Morbidity and mortality due to hypertension in patients with renal failure. Am J Kidney Dis 1993; 21: 113–1118
  • Pharmacological therapy: diabetic kidney disease. K/DOQI Clinical Practice Guidelines on Hypertension and Antihypertensive Agents in Chronic Kidney Disease, Accessed at: http://www.kidney.org/professionals/KDOQI/guidelines_bp/guide_8.htm. Accessed 9.12.2006
  • Pharmacological therapy: nondiabetic kidney disease. K/DOQI Clinical Practice Guidelines on Hypertension and Antihypertensive Agents in Chronic Kidney Disease, Accessed at: http://www.kidney.org/professionals/KDOQI/guidelines_bp/guide_9.htm. Accessed 9.12.2006
  • Association of chronic kidney disease with diabetic complications. K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification, Accessed at: http://www.kidney.org/professionals/KDOQI/guidelines_ckd/p7_risk_g14.htm. Accessed 9.12.2006
  • Deckert T, Kofoed-Enevoldsen A, Norgaard K, Borch-Johnsen K, Feldt-Rasmussen B, Jensen T. Microalbuminuria. Implications for micro- and macrovascular disease. Diabetes Care 1992; 15: 1181–1191
  • Perna A, Remuzzi G. Abnormal permeability to proteins and glomerular lesions: a meta-analysis of experimental and human studies. Am J Kidney Dis 1996; 27: 34–41
  • Diabetes. K/DOQI Clinical Practice Guidelines for Cardiovascular Disease in Dialysis Patients, Accessed at: http://www.kidney.org/professionals/KDOQI/guidelines_cvd/guide11.htm. Accessed 9.12.2006
  • Borch-Johnsen K, Andersen P K, Deckert T. The effect of proteinuria on relative mortality in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1985; 28: 590–596
  • Nelson R G, Pettitt D J, Carraher M J, Baird H R, Knowler W C. Effect of proteinuria on mortality in NIDDM. Diabetes 1988; 37: 1499–1504
  • Joy M S, Cefalu W T, Hogan S L, Nachman P H. Long-term glycemic control measurements in diabetic patients receiving hemodialysis. Am J Kidney Dis 2002; 39: 297–307
  • Oyibo S O, Pritchard G M, McLay L, James E, Laing I, Gokal R, et al. Blood glucose overestimation in diabetic patients on continuous ambulatory peritoneal dialysis for end-stage renal disease. Diabet Med 2002; 19: 693–696
  • Tzamaloukas A H. Interpreting glycosylated hemoglobin in diabetic patients on peritoneal dialysis. Adv Perit Dial. 1996; 12: 171–175
  • Association of chronic kidney disease with cardiovascular disease. K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification, Accessed at: http://www.kidney.org/professionals/KDOQI/guidelines_ckd/p7_risk_g15.htm. Accessed 9.12.2006
  • Sarnak M J, Levey A S. Cardiovascular disease and chronic renal disease: a new paradigm. Am J Kidney Dis 2000; 35: S117–S131
  • Foley R N, Parfrey P S, Sarnak M J. Epidemiology of cardiovascular disease in chronic renal disease. J Am Soc Nephrol 1998; 9: S16–S23
  • Zager P G, Nikolic J, Brown R H, Campbell M A, Hunt W C, Peterson D, et al. ‘U’ curve association of blood pressure and mortality in hemodialysis patients. Medical Directors of Dialysis Clinic, Inc. Kidney Int. 1998; 54: 561–569
  • Salahudeen A K. Obesity and survival on dialysis. Am J Kidney Dis 2003; 41: 925–932
  • Nishizawa Y, Shoji T, Ishimura E, Inaba M, Morii H. Paradox of risk factors for cardiovascular mortality in uremia: is a higher cholesterol level better for atherosclerosis in uremia?. Am J Kidney Dis 2001; 38: S4–S7
  • Kalantar-Zadeh K, Block G, Humphreys M H, Kopple J D. Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int 2003; 63: 793–808
  • Stevens J, Cai J, Pamuk E R, Williamson D F, Thun M J, Wood J L. The effect of age on the association between body-mass index and mortality. N Engl J Med 1998; 338: 1–7
  • Yeh S, Wu S Y, Levine D M, Parker T S, Olson J S, Stevens M R, et al. Quality of life and stimulation of weight gain after treatment with megestrol acetate: correlation between cytokine levels and nutritional status, appetite in geriatric patients with wasting syndrome. J Nutr Health Aging 2000; 4: 246–251
  • Liu Y, Coresh J, Eustace J A, Longenecker J C, Jaar B, Fink N E, et al. Association between cholesterol level and mortality in dialysis patients: role of inflammation and malnutrition. JAMA 2004; 291: 451–459
  • Kalantar-Zadeh K. Recent advances in understanding the malnutrition-inflammation-cachexia syndrome in chronic kidney disease patients: what is next?. Semin Dial 2005; 18: 365–369
  • Kalantar-Zadeh K, Block G, McAllister C J, Humphreys M H, Kopple J D. Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr 2004; 80: 299–307
  • Stenvinkel P, Heimburger O, Lindholm B. Wasting, but not malnutrition, predicts cardiovascular mortality in end-stage renal disease. Nephrol Dial Transplant 2004; 19: 2181–2183
  • Stenvinkel P, Pecoits-Filho R, Lindholm B. Coronary artery disease in end-stage renal disease: no longer a simple plumbing problem. J Am Soc Nephrol 2003; 14: 1927–1939
  • Blood pressure. K/DOQI Clinical Practice Guidelines for Cardiovascular Disease in Dialysis Patients, Accessed at: http://www.kidney.org/professionals/KDOQI/guidelines_cvd/guide12.htm. Accessed 9.12.2006
  • Hsu C Y, McCulloch C E, Curhan G C. Epidemiology of anemia associated with chronic renal insufficiency among adults in the United States: results from the Third National Health and Nutrition Examination Survey. J Am Soc Nephrol 2002; 13: 504–510
  • Braumann K M, Nonnast-Daniel B, Boning D, Bocker A, Frei U. Improved physical performance after treatment of renal anemia with recombinant human erythropoietin. Nephron 1991; 58: 129–134
  • Cannella G, La C G, Sandrini M, Gaggiotti M, Nordio G, Movilli E, et al. Renormalization of high cardiac output and of left ventricular size following long-term recombinant human erythropoietin treatment of anemic dialyzed uremic patients. Clin Nephrol 1990; 34: 272–278
  • Gafter U, Kalechman Y, Orlin J B, Levi J, Sredni B. Anemia of uremia is associated with reduced in vitro cytokine secretion: immunopotentiating activity of red blood cells. Kidney Int 1994; 45: 224–231
  • Harnett J D, Foley R N, Kent G M, Barre P E, Murray D, Parfrey P S. Congestive heart failure in dialysis patients: prevalence, incidence, prognosis and risk factors. Kidney Int 1995; 47: 884–890
  • Horina J H, Schwaberger G, Brussee H, Sauseng-Fellegger G, Holzer H, Krejs G J. Increased red cell 2,3-diphosphoglycerate levels in haemodialysis patients treated with erythropoietin. Nephrol Dial Transplant 1993; 8: 1219–1222
  • Macdougall I C, Lewis N P, Saunders M J, Cochlin D L, Davies M E, Hutton R D, et al. Long-term cardiorespiratory effects of amelioration of renal anaemia by erythropoietin. Lancet 1990; 335: 489–493
  • Mayer G, Thum J, Cada E M, Stummvoll H K, Graf H. Working capacity is increased following recombinant human erythropoietin treatment. Kidney Int 1988; 34: 525–528
  • Pascual J, Teruel J L, Moya J L, Liano F, Jimenez-Mena M, Ortuno J. Regression of left ventricular hypertrophy after partial correction of anemia with erythropoietin in patients on hemodialysis: a prospective study. Clin Nephrol 1991; 35: 280–287
  • Robertson H T, Haley N R, Guthrie M, Cardenas D, Eschbach J W, Adamson J W. Recombinant erythropoietin improves exercise capacity in anemic hemodialysis patients. Am J Kidney Dis 1990; 15: 325–332
  • Sobh M A, Abd eH I, Atta M G, Refaie A F. Effect of erythropoietin on sexual potency in chronic haemodialysis patients. A preliminary study. Scand J Urol Nephrol 1992; 26: 181–185
  • Teehan B, Sigler M H, Brown J M, Benz R L, Gilgore G S, Schleifer C R, et al. Hematologic and physiologic studies during correction of anemia with recombinant human erythropoietin in predialysis patients. Transplant Proc 1989; 212: 63–69
  • Vanholder R, Van B W, Ringoir S. Contributing factors to the inhibition of phagocytosis in hemodialyzed patients. Kidney Int 1993; 44: 208–214
  • Wizemann V, Kaufmann J, Kramer W. Effect of erythropoietin on ischemia tolerance in anemic hemodialysis patients with confirmed coronary artery disease. Nephron 1992; 62: 161–165
  • Wizemann V, Schafer R, Kramer W. Follow-up of cardiac changes induced by anemia compensation in normotensive hemodialysis patients with left-ventricular hypertrophy. Nephron 1993; 64: 202–206
  • Wolcott D L, Marsh J T, La R A, Carr C, Nissenson A R. Recombinant human erythropoietin treatment may improve quality of life and cognitive function in chronic hemodialysis patients. Am J Kidney Dis 1989; 14: 478–485
  • Factors associated with loss of kidney function in chronic kidney disease. K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification, Accessed at: http://www.kidney.org/professionals/kdoqi/guidelines_ckd/p7_risk_g13.htm. Accessed 9.12.2006
  • Morbidity and mortality of renal dialysis: an NIH consensus conference statement. Consensus Development Conference Panel. Ann Intern Med 1994; 121: 62–70
  • NKF-K/DOQI Clinical practice guidelines for anemia of chronic kidney disease: update 2000. Am J Kidney Dis 2001; 37: S182–S238
  • Evans R W, Rader B, Manninen D L. The quality of life of hemodialysis recipients treated with recombinant human erythropoietin. Cooperative Multicenter EPO Clinical Trial Group. JAMA 1990; 263: 825–830
  • Grutzmacher P, Scheuermann E, Low I, Bergmann M, Rauber K, Baum R, et al. Correction of renal anaemia by recombinant human erythropoietin: effects on myocardial function. Contrib Nephrol 1988; 66: 176–184
  • Lowrie E G, Ling J, Lew N L, Yiu Y. The relative contribution of measured variables to death risk among hemodialysis patients. Death on hemodialysis: preventable or inevitable?, E A Friedman. Kluwer Academic Publishers, Boston, MA 1994; 121–141
  • Mocks J, Frank W, Ehmer B, Scigalla P, Quarder O. Analysis of safety database for long-term epoetin-beta treatment. A meta-analysis covering 3697 patients. Pathogenetic and therapeutic aspects of chronic renal failure, K M Koch, G Stein. Marcel Dekker, New York 1997; 163–179
  • Renal Physicians Association: Appropriate Preparation of the Patient for Renal Replacement Therapy: Clinical Practice Guideline No. 3. RPA, Rockville, MD 2002
  • Collins A J, Li S, Ebben J, Ma J Z, Manning W. Hematocrit levels and associated Medicare expenditures. Am J Kidney Dis 2000; 36: 282–293
  • Collins A J, Li S, St P W, Ebben J, Roberts T, Ma J Z, et al. Death, hospitalization, and economic associations among incident hemodialysis patients with hematocrit values of 36 to 39%. J Am Soc Nephrol 2001; 12: 2465–2473
  • Fink J, Blahut S, Reddy M, Light P. Use of erythropoietin before the initiation of dialysis and its impact on mortality. Am J Kidney Dis 2001; 37: 348–355
  • Ma J Z, Ebben J, Xia H, Collins A J. Hematocrit level and associated mortality in hemodialysis patients. J Am Soc Nephrol 1999; 10: 610–619
  • Owen W F, Jr. Patterns of care for patients with chronic kidney disease in the United States: dying for improvement. J Am Soc Nephrol 2003; 14: S76–S80
  • US Renal Data System. USRDS 2002 Annual report: atlas of end-stage renal disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 2002
  • Owen W F, Jr., Szczech L, Johnson C, Frankenfield D. National perspective on iron therapy as a clinical performance measure for maintenance hemodialysis patients. Am J Kidney Dis 1999; 34: S5–S11
  • Nurko S. Anemia in chronic kidney disease: causes, diagnosis, treatment. Cleve Clin J Med 2006; 73: 289–297
  • Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003; 102: 783–788
  • Moreno F, Sanz-Guajardo D, Lopez-Gomez J M, Jofre R, Valderrabano F. Increasing the hematocrit has a beneficial effect on quality of life and is safe in selected hemodialysis patients. Spanish Cooperative Renal Patients Quality of Life Study Group of the Spanish Society of Nephrology. J Am Soc Nephrol 2000; 11: 335–342
  • KDOQI. Clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease. Am J Kidney Dis 2006; 47: S11–S145
  • Locatelli F, Aljama P, Barany P, Canaud B, Carrera F, Eckardt K U, et al. Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure. Nephrol Dial Transplant 2004; 19(Suppl 2)ii1–47
  • NKF-K/DOQI guidelines: anemia of chronic kidney disease: iron support. UpToDate 2006, Version 14.3. Accessed at: http://uptodateonline.com/utd/content/topic.do?topicKey=nkf_doqi/14137&type=A&selectedTitle=165∼333. Accessed 7.12.2006
  • NKF-K/DOQI Clinical practice guidelines for anemia of chronic kidney disease: iron support: Update. 2000, Accessed at: http://www.kidney.org/professionals/kdoqi/guidelines/doqi_uptoc.html#an. Accessed 7.12.2006
  • Drueke T B, Locatelli F, Clyne N, Eckardt K U, Macdougall I C, Tsakiris D, et al. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 2006; 355: 2071–2084
  • Remuzzi G, Ingelfinger J R. Correction of anemia – payoffs and problems. N Engl J Med 2006; 355: 2144–2146
  • Singh A K, Szczech L, Tang K L, Barnhart H, Sapp S, Wolfson M, et al. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 2006; 355: 2085–2098
  • Berns J S, Cronin R E, Henrich W L. Erythropoietin for the anemia of chronic kidney disease. UpToDate 2006, Version 14.3. Accessed at: http://www.utdol.com/utd/content/topic.do?topicKey=dialysis/9597&type=A&selectedTitle=18∼333. Accessed 9.1.2007
  • Nissenson A R, Anand S. Darbepoetin alfa for the management of anemia in chronic kidney disease. UpToDate 2006, Version 14.3. Accessed at: http://uptodateonline.com/utd/content/topic.do?topicKey=dialysis/39273&type=A&selectedTitle=1∼17. Accessed 7.12.2006
  • VHA/DoD Clinical practice guideline for management of chronic kidney disease and pre-ESRD in primary care setting, Accessed at: http://www.oqp.med.va.gov/cpg/ESRD/ESRD_cpg/algoframe.htm. Accessed 9.12.2006
  • Muhlberg W, Platt D. Age-dependent changes of the kidneys: pharmacological implications. Gerontology 1999; 45: 243–253
  • Cantu T G, Ellerbeck E F, Yun S W, Castine S D, Kornhauser D M. Drug prescribing for patients with changing renal function. Am J Hosp Pharm 1992; 49: 2944–2948
  • Canadian Institute for Health Information. Report, Volume 1: Dialysis and renal transplantation. Canadian organ replacement register. Canadian Institute for Health Information, Ottawa 2000
  • Davison S N. Quality end-of-life care in dialysis units. Semin Dial 2002; 15: 41–44
  • Deoreo P B. Hemodialysis patient-assessed functional health status predicts continued survival, hospitalization, and dialysis-attendance compliance. Am J Kidney Dis 1997; 30: 204–212
  • Kimmel P L, Weihs K, Peterson R A. Survival in hemodialysis patients: the role of depression. J Am Soc Nephrol 1993; 4: 12–27
  • McClellan W M, Anson C, Birkeli K, Tuttle E. Functional status and quality of life: predictors of early mortality among patients entering treatment for end stage renal disease. J Clin Epidemiol 1991; 44: 83–89
  • McClellan W M, Stanwyck D J, Anson C A. Social support and subsequent mortality among patients with end-stage renal disease. J Am Soc Nephrol 1993; 4: 1028–1034
  • Parkerson G R, Jr, Broadhead W E, Tse C K. Health status and severity of illness as predictors of outcomes in primary care. Med Care 1995; 33: 53–66
  • Smith C, Da Silva-Gane M, Chandna S, Warwicker P, Greenwood R, Farrington K. Choosing not to dialyse: evaluation of planned non-dialytic management in a cohort of patients with end-stage renal failure. Nephron Clin Pract 2003; 95: c40–c46
  • Braveman C, Cohen L M. Discontinuation of dialysis: the role of hospice and palliative care. AAHPM Bull 2003; 3: 16–17
  • Holley J L. A single-center review of the death notification form: discontinuing dialysis before death is not a surrogate for withdrawal from dialysis. Am J Kidney Dis 2002; 40: 525–530
  • Holley J L. Palliative care in end-stage renal disease: focus on advance care planning, hospice referral, and bereavement. Semin Dial 2005; 18: 154–156
  • Moss A H, Holley J L, Davison S N, Dart R A, Germain M J, Cohen L, et al. Palliative care. Am J Kidney Dis 2004; 43: 172–173
  • Fazekas G, Fazekas F, Schmidt R, Kapeller P, Offenbacher H, Krejs G J. Brain MRI findings and cognitive impairment in patients undergoing chronic hemodialysis treatment. J Neurol Sci 1995; 134: 83–88
  • Madan P, Kalra O P, Agarwal S, Tandon O P. Cognitive impairment in chronic kidney disease. Nephrol Dial Transplant 2006; 22: 440–444
  • Sehgal A R, Grey S F, Deoreo P B, Whitehouse P J. Prevalence, recognition, and implications of mental impairment among hemodialysis patients. Am J Kidney Dis 1997; 30: 41–49
  • Kurella M, Chertow G M, Luan J, Yaffe K. Cognitive impairment in chronic kidney disease. J Am Geriatr Soc 2004; 52: 1863–1869
  • Kurella M, Bennett W M, Chertow G M. Analgesia in patients with ESRD: a review of available evidence. Am J Kidney Dis 2003; 42: 217–228
  • Griffin M R, Ray W A, Schaffner W. Nonsteroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons. Ann Intern Med 1988; 109: 359–363
  • Griffin M R, Piper J M, Daugherty J R, Snowden M, Ray W A. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 1991; 114: 257–263
  • Greenberger N J. Update in gastroenterology. Ann Intern Med 1997; 126: 221–225
  • Hawkey C J, Karrasch J A, Szczepanski L, Walker D G, Barkun A, Swannell A J. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus misoprostol for NSAID-induced ulcer management (OMNIUM) study group. N Engl J Med 1998; 338: 727–734
  • Yeomans N D, Tulassay Z, Juhasz L, Racz I, Howard J M, van Rensburg C J. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid suppression trial: ranitidine versus omeprazole for NSAID-associated ulcer treatment (ASTRONAUT) study group. N Engl J Med7 1998; 338: 719–726

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