1,137
Views
43
CrossRef citations to date
0
Altmetric
Original Article

Effect of testosterone therapy on lumbar spine and hip mineral density in elderly men

, , , , &
Pages 140-145 | Received 17 May 2007, Accepted 14 Jun 2008, Published online: 06 Jul 2009

References

  • Kaufman M, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 2005; 26: 833–876
  • Gennari L, Merlotti D, Martini G, Gonneli S, Franci B, Campagna S, Lucani B, Dal Canto N, Valenti R, Gennari C, Nuti R. Longitudinal association between sex hormone levels, bone loss, and bone turnover in elderly men. J Clin Endocrinol Metab 2003; 88: 5327–5333
  • Rochira V, Balestrieri A, Madeo B, Zirilli L, Granata A RM, Carani C. Osteoporosis and male age-related hypogonadism: Role of sex steroids on bone (patho)physiology. Eur J Endocrinol 2006; 154: 175–185
  • Vanderschueren D, Vandenput L, Boonen S, Lindberg M K, Bouillon R, Ohlsson C. Androgens and bone. Endocr Rev 2004; 25: 389–425
  • Falahati-Nini A, Riggs L, Atkinson E J, O'Fallon W M, Eastell R, Khosla S. Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. J Clin Invest 2000; 106: 1553–1560
  • Tenover J S. Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab 1992; 75: 1092–1098
  • Snyder P J, Peachey H, Berlin J A, Hannoush P, Haddad G, Dlewati A, Santanna J, Loh L, Lenrow D A, Holmes J H, Kapoor S C, Atkinson L E, Strom B L. Effects of testosterone replacement in hypogonadal men. J Clin Endocrinol Metab 2000; 85: 2670–2677
  • Kenny A M, Prestwood K M, Gruman C A, Marcello K M, Raisz L G. Effect of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels. J Gerontol A Biol Sci Med Sci 2001; 56: M266–272
  • Amory J K, Watts N B, Easley K A, Sutton P R, Anawalt B D, Matsumoto A M, Bremner W J, Tenover J L. Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone. J Clin Endocrinol Metab 2004; 89: 503–510
  • Snyder H PJ, Peachey H, Hannoush P, Berlin J A, Loh L, Holmes J H, Dlewati A, Staley J, Santanna H, Kapoor S C, Attie M F, Haddad J G, Strom B L. Effect of testosterone treatment on bone mineral density in men over 65 years of age. J Clin Endocrinol Metab 1999; 84: 1966–1972
  • Saucedo R, Fonseca M E, Basurto L, Ochoa R, Sánchez M, Zárate A. Decremento en los andrógenos circulantes en el hombre durante la senescencia. Gac Med Mex 2000; 136: 335–339
  • Ruiz-Argüelles G J, Sanchez-Medal L, Loria A, Piedras J, Cordova M S. Red cell indices in normal adultsresiding at altitudes from sea level to 2670 m. Am J Hematol 1980; 8: 265–267
  • Bhasin S, Cunningham G R, Hayes F J, Matsumoto A M, Snyder P J, Swerdloff R S, Montori V M. Testosterone therapy in adult men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2006; 91: 1995–2010
  • Szulc P, Munoz F, Claustrat B, Garnero P, Marchand F. Bioavailable estradiol may be an important determinant of osteoporosis in men: The MINOS study. J Clin Endocrinol Metab 2001; 86: 192–199
  • Mellstrom D, Johnell O, Ljunggren O, Eriksson A L, Lorentzon M, Mallmin H, Holmberg A, Redlund-Johnell I, Orwoll E, Ohlsson C. Free testosterone is an independent predictor of BMD and prevalent fractures in elderly men: MrOS Sweden. J Bone Miner Res 2006; 21: 529–535
  • Behre H M, Kliesch S, Leifke E, Link T M, Nieschlag E. Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. J Clin Endocrinol Metab 1997; 82: 2386–2390
  • Benito M, Gomberg B, Wehrli F W, Weening R H, Zemel B, Wright A C, Song H K, Cucchiara C, Snyder P J. Deterioration of trabecular architecture in hypogonadal men. J Clin Endocrinol Metab 2003; 88: 1497–1502
  • Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto A M, Snyder P J, Weber T, Berman N, Hull L, Swerdloff R S. Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab 2004; 89: 2085–2098
  • Katznelson L, Finkelstein J S, Schoenfeld D A, Rosenthal D J, Anderson E J, Klinbanski A. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab 1996; 81: 4358–4365
  • Duan Y, Tabensky A, DeLuca V, Seeman E. The benefit of hormone replacement therapy on bone mass is greater at the vertebral body than posterior processes or proximal femur. Bone 1997; 21: 447–451
  • Emmelot-Vonk M H, Verhaar H JJ, Pour H RN, Aleman A, Lock T MT, Bosch J LH, Grobbee D E, van der Schouw I T. Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men. A randomized controlled trial. JAMA 2008; 299: 39–52
  • Tracz M J, Sideras K, Boloña E R, Haddad R M, Kennedy C C, Uraga M V, Caples S M, Edwin P J, Montori V M. Testosterone use in men and its effects on bone health. A systematic review and meta-analysis of randomized placebo-controlled. J Clin Endocrinol Metab 2006; 91: 2011–2016
  • Khosla S, Melton L J, III, Riggs B L. Estrogen and the male skeleton. J Clin Endocrinol Metab 2002; 87: 1443–1450
  • Compston J. Local biosynthesis of sex steroids in bone. J Clin Endocrinol Metab 2002; 87: 5398–5400
  • Meier C, Liu P Y, Handelsman D J, Seibel M J. Endocrine regulation of bone turnover in men. Clin Endocrinol (Oxf) 2005; 63: 603–613
  • Proctor D N, Melton L J, Khosla S, Crowson C S, O'Connor M K, Riggs B L. Relative influence of physical activity, muscle mass and strength on bone density. Osteoporosis Int 2000; 11: 944–952
  • Allan C A, McLachlan R I. Age-related changes in testosterone and the role of replacement therapy in older men. Clin Endocrinol (Oxf) 2004; 60: 653–670
  • Kelleher S, Conway A J, Handelsman D J. Blood testosterone threshold for androgen deficiency symptoms. J Clin Endocrinol Metab 2004; 89: 3813–3817
  • Liu P Y, Swerdloff R S, Veldhuis J D. The rationale, efficacy and safety of androgen therapy in older men: Future research and current practice recommendations. J Clin Endocrinol Metab 2004; 89: 4789–4796

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.