Analysis of cardiovascular risk factors associated with serum testosterone levels according to the US 2011–2012 National Health and Nutrition Examination Survey

References

• Dandona P, Rosenberg MT. A practical guide to male hypogonadism in the primary care setting. Int J Clin Pract. 2010;64:682–696.
   PubMed Web of Science ®Google Scholar
• Miner MM, Sadovsky R. Evolving issues in male hypogonadism: evaluation, management, and related comorbidities. Cleve Clin J Med. 2007;74:S38–S38.
   PubMedGoogle Scholar
• Swerdloff RS, Wang C. The testis and male sexual function. In: Goldman’s Cecil Medicine. 24th ed. Philadelphia (PA): Elsevier Saunders; 2012. p. 1519–1529.
   Google Scholar
• Andersen ML, Alvarenga TF, Mazaro-Costa R. The association of testosterone, sleep, and sexual function in men and women. Brain Res. 2011;1416:80–104.
   PubMed Web of Science ®Google Scholar
• Cheung KK, Luk AO, So WY, et al. Testosterone level in men with type 2 diabetes mellitus and related metabolic effects: a review of current evidence. J Diabetes Invest. 2015;6:112–123.
   PubMed Web of Science ®Google Scholar
• Grossmann M. Testosterone and glucose metabolism in men: current concepts and controversies. J Endocrinol. 2014;220:R37–R55.
   PubMed Web of Science ®Google Scholar
• Schipf S, Haring R, Friedrich N, et al. Low total testosterone is associated with increased risk of incident type 2 diabetes mellitus in men: results from the Study of Health in Pomerania (SHIP). Aging Male: Off J Int Soc Study Aging Male. 2011;14:168–175.
   PubMed Web of Science ®Google Scholar
• Rabijewski M, Papierska L, Piątkiewicz P. The prevalence of prediabetes in population of Polish men with late-onset hypogonadism. Aging Male: Off J Int Soc Study Aging Male. 2014;17:141–146.
   PubMed Web of Science ®Google Scholar
• Saad F, Yassin A, Almehmadi Y, et al. Effects of long-term testosterone replacement therapy, with a temporary intermission, on glycemic control of nine hypogonadal men with type 1 diabetes mellitus – a series of case reports. Aging Male: Off J Int Soc Study Aging Male. 2015;18:164–168.
   PubMed Web of Science ®Google Scholar
• Yassin AA, Saad F, Haider A, et al. The role of the urologist in the prevention and early detection of cardiovascular disease. Arab J Urol. 2011;9:57–62.
   PubMedGoogle Scholar
• Mazur A, Westerman R, Werdecker A, et al. Testosterone and type 2 diabetes in men. Aging Male: Off J Int Soc Study Aging Male. 2014;17:18–24.
   PubMed Web of Science ®Google Scholar
• Haidar A, Yassin A, Saad F, et al. Effects of androgen deprivation on glycaemic control and on cardiovascular biochemical risk factors in men with advanced prostate cancer with diabetes. Aging Male: Off J Int Soc Study Aging Male. 2007;10:189–196.
   PubMed Web of Science ®Google Scholar
• Corona G, Vignozzi L, Sforza A, et al. Obesity and late-onset hypogonadism. Mol Cell Endocrinol. 2015;418:120–133.
   PubMed Web of Science ®Google Scholar
• Salman M, Yassin DJ, Shoukfeh H, et al. Early weight loss predicts the reduction of obesity in men with erectile dysfunction and hypogonadism undergoing long-term testosterone replacement therapy. Aging Male: Off J Int Soc Study Aging Male. 2017;20:45–48.
   PubMed Web of Science ®Google Scholar
• Yassin A, Nettleship JE, Talib RA, et al. Effects of testosterone replacement therapy withdrawal and re-treatment in hypogonadal elderly men upon obesity, voiding function and prostate safety parameters. Aging Male: Off J Int Soc Study Aging Male. 2016;19:64–69.
   PubMed Web of Science ®Google Scholar
• Boyanov MA, Boneva Z, Christov VG. Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. DAGM. 2003;6:1–7.
   Google Scholar
• Mazur A, Westerman R. Changing testosterone had no direct effect on HbA1c or weight in diabetic men when TRT was interrupted and then resumed. Clin Endocrinol. 2016;85:499–500.
   PubMed Web of Science ®Google Scholar
• Almehmadi Y, Yassin DJ, Yassin AA. Erectile dysfunction is a prognostic indicator of comorbidities in men with late onset hypogonadism. Aging Male: Off J Int Soc Study Aging Male. 2015;18:186–194.
   PubMed Web of Science ®Google Scholar
• Corona G, Forti G, Maggi M. Why can patients with erectile dysfunction be considered lucky? The association with testosterone deficiency and metabolic syndrome. Aging Male: Off J Int Soc Study Aging Male. 2008;11:193–199.
   PubMed Web of Science ®Google Scholar
• Ho CH, Wu CC, Chen KC, et al. Erectile dysfunction, loss of libido and low sexual frequency increase the risk of cardiovascular disease in men with low testosterone. Aging Male: Off J Int Soc Study Aging Male. 2016;19:96–101.
   PubMed Web of Science ®Google Scholar
• Smith ML, Honore Goltz H, Ahn S, et al. Correlates of chronic disease and patient-provider discussions among middle-aged and older adult males: Implications for successful aging and sexuality. Aging Male: Off J Int Soc Study Aging Male. 2012;15:115–123.
   PubMed Web of Science ®Google Scholar
• Yassin AA, Nettleship JE, Almehmadi Y, et al. Is there a relationship between the severity of erectile dysfunction and the comorbidity profile in men with late onset hypogonadism? Arab J Urol. 2015;13:162–168.
   PubMed Web of Science ®Google Scholar
• Leoni LA, Fukushima AR, Rocha LY, et al. Physical activity on endothelial and erectile dysfunction: a literature review. Aging Male: Off J Int Soc Study Aging Male. 2014;17:125–130.
   PubMed Web of Science ®Google Scholar
• Sharma R, Oni OA, Gupta K, et al. Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men. Eur Heart J. 2015;36:2706–2715.
   PubMed Web of Science ®Google Scholar
• Alexandersen P, Christiansen C. The aging male: testosterone deficiency and testosterone replacement. An up-date. Atherosclerosis. 2004;173:157–169.
   PubMed Web of Science ®Google Scholar
• Chahla EJ, Hayek ME, Morley JE. Testosterone replacement therapy and cardiovascular risk factors modification. Aging Male: Off J Int Soc Study Aging Male. 2011;14:83–90.
   PubMed Web of Science ®Google Scholar
• Vigen R, O’Donnell CI, Baron AE, et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA 2013;310:1829–1836.
   PubMed Web of Science ®Google Scholar
• Xu L, Freeman G, Cowling BJ, et al. Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials. BMC Med. 2013;11:108.
   PubMed Web of Science ®Google Scholar
• Finegold JA, Asaria P, Francis DP. Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations. Int J Cardiol. 2013;168:934–945.
   PubMed Web of Science ®Google Scholar
• MacRae CA, Vasan RS. The future of genetics and genomics: closing the phenotype gap in precision medicine. Circulation. 2016;133:2634–2639.
   PubMed Web of Science ®Google Scholar
• Mendis S, Puska P, Norrving B, et al. Global atlas on cardiovascular disease prevention and control. Geneva: World Health Organization in Collaboration with the World Heart Federation and the World Stroke Organization; 2011. p. 3–18.
   Google Scholar
• Micha R, Michas G, Mozaffarian D. Unprocessed red and processed meats and risk of coronary artery disease and type 2 diabetes – an updated review of the evidence. Curr Atheroscler Rep. 2012;14:515–524.
   PubMed Web of Science ®Google Scholar
• Rivas AM, Mulkey Z, Lado-Abeal J, et al. Diagnosing and managing low serum testosterone. Proc (Bayl Univ Med Cent). 2014;27:321–324.
   PubMedGoogle Scholar
• Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2010;95:2536–2559.
   PubMed Web of Science ®Google Scholar
• Namiki M, Akaza H, Shimazui T, et al. Clinical practice manual for late-onset hypogonadism syndrome. Int J Urol. 2008;15:377–388.
   PubMed Web of Science ®Google Scholar
• Wang C, Nieschlag E, Swerdloff R, et al. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations. Eur J Endocrinol. 2008;159:507–514.
   PubMed Web of Science ®Google Scholar
• Stanworth RD, Jones TH. Testosterone for the aging male; current evidence and recommended practice. Clin Interv Aging. 2008;3:25–44.
   PubMed Web of Science ®Google Scholar
• DeFina LF, Radford NB, Leonard D, et al. Testosterone level in men is lower with increasing BMI and decreasing cardiorespiratory fitness but is not related to age. Endocrine Society’s 96th annual meeting and expo; 2014 June 21–24; Chicago.
   Google Scholar
• Stanworth RD, Kapoor D, Channer KS, et al. Testosterone levels correlate positively with HDL cholesterol levels in men with Type 2 diabetes. Endocrine Abstracts. 2007;14:P628.
   Google Scholar
• Steeves JA, Fitzhugh EC, Bradwin G, et al. Cross-sectional association between physical activity and serum testosterone levels in US men: results from NHANES 1999-2004. Andrology. 2016;4:465–472.
   PubMed Web of Science ®Google Scholar
• Kelsey TW, Li LQ, Mitchell RT, et al. A validated age-related normative model for male total testosterone shows increasing variance but no decline after age 40 years. PLoS One. 2014;9:e109346.
   PubMed Web of Science ®Google Scholar
• Svartberg J, Jorde R. Endogenous testosterone levels and smoking in men. The fifth Tromso study. Int J Androl. 2007;30:137–143.
   PubMedGoogle Scholar
• Wang W, Yang X, Liang J, et al. Cigarette smoking has a positive and independent effect on testosterone levels. Hormones (Athens). 2013;12:567–577.
   PubMedGoogle Scholar
• Schooling CM. Smoking, sex, risk factors and abdominal aortic aneurysm: is it all down to testosterone? J Epidemiol Community Health. 2015;69:495.
   PubMed Web of Science ®Google Scholar
• Mallaina P, Lionis C, Rol H, et al. Smoking cessation and the risk of cardiovascular disease outcomes predicted from established risk scores: results of the Cardiovascular Risk Assessment among Smokers in Primary Care in Europe (CV-ASPIRE) study. BMC Public Health. 2013;13:362.
   PubMed Web of Science ®Google Scholar
• Wu FC, Tajar A, Pye SR, et al. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European male aging study. J Clin Endocrinol Metab. 2008;93:2737–2745.
   PubMed Web of Science ®Google Scholar
• Jeppesen LL, Jorgensen HS, Nakayama H, et al. Decreased serum testosterone in men with acute ischemic stroke. Arterioscler Thromb Vasc Biol. 1996;16:749–754.
   PubMed Web of Science ®Google Scholar
• Santos MR, Sayegh AL, Groehs RV, et al. Testosterone deficiency increases hospital readmission and mortality rates in male patients with heart failure. Arq Bras Cardiol. 2015;105:256–264.
   PubMed Web of Science ®Google Scholar
• Budoff MJ, Ellenberg SS, Lewis CE, et al. Testosterone treatment and coronary artery plaque volume in older men with low testosterone. JAMA 2017;317:708–716.
   PubMed Web of Science ®Google Scholar
• Jankowska EA, Biel B, Majda J, et al. Anabolic deficiency in men with chronic heart failure: prevalence and detrimental impact on survival. Circulation. 2006;114:1829–1837.
   PubMed Web of Science ®Google Scholar