The menopausal hot flush: a review

References

• Archer DF, Sturdee DW, Baber R, et al. Menopausal hot flushes and night sweats: where are we now? Climacteric 2011;14:515–28
   PubMed Web of Science ®Google Scholar
• McLaren HC. The induced menopause. J Obstet Gynaecol Brit Empire 1941;48:23–40
   Google Scholar
• Chakravarti S, Collins WP, Newton JR, et al. Endocrine changes and symptomatology after oophorectomy in premenopausal women. Br J Obstet Gynaecol 1977;84:769–75
   PubMedGoogle Scholar
• Gupta P, Sturdee DW, Palin SL, et al. Menopausal symptoms in women treated for breast cancer: the prevalence and severity of symptoms and their perceived effects on quality of life. Climacteric 2006;9:49–58
   PubMed Web of Science ®Google Scholar
• Chang HY, Jotwani AC, Lai YH, et al. Hot flashes in breast cancer survivors: frequency, severity and impact. Breast 2016;27:116–21
   PubMed Web of Science ®Google Scholar
• Voda AM. Climacteric hot flash. Maturitas 1981;3:73–90
   PubMed Web of Science ®Google Scholar
• Sturdee DW, Wilson KA, Pipili E, Crocker AD. Physiological aspects of menopausal hot flush. Br Med J 1978;2:79–80
   PubMed Web of Science ®Google Scholar
• Col NF, Guthrie JR, Politi M, Dennerstein L. Duration of vasomotor symptoms in middle-aged women: a longitudinal study. Menopause 2009;16:453–7
   PubMed Web of Science ®Google Scholar
• Hunter MS, Gentry-Maharaj A, Ryan A, et al. Prevalence, frequency and problem rating of hot flushes persist in older postmenopausal women: impact of age, body mass index, hysterectomy, hormone therapy use, lifestyle and mood in a cross-sectional cohort study of 10,418 British women aged 54–65. BJOG 2012;119:40–50
   PubMed Web of Science ®Google Scholar
• Avis NE, Crawford SL, Greendale G, et al. Duration of menopausal vasomotor symptoms over the menopause transition. Jama Intern Med 2015;175:531–9
   PubMed Web of Science ®Google Scholar
• Freeman EW, Sammel MD, Sanders RJ. Risk of long-term hot flashes after natural menopause: evidence from the Penn Ovarian Aging Study cohort. Menopause 2014;21:924–32
   PubMed Web of Science ®Google Scholar
• Zeleke BM, Davis SR, Bell RJ. Vasomotor symptoms and urogenital atrophy in older women: a systematic review. Climacteric 2015;18:112–20
   PubMed Web of Science ®Google Scholar
• Freeman EW, Sammel MD, Rinaudo PJ, Shemg L. Premenstrual syndrome as a predictor of menopausal symptoms. Obstet Gynecol 2004;103:960–6
   PubMed Web of Science ®Google Scholar
• Freeman EW, Sherif K. Prevalence of hot flushes and night sweats around the world: a systematic review. Climacteric 2007;10:197–214
   PubMed Web of Science ®Google Scholar
• Kronenberg F. Menopausal hot flashes: a review of physiology and biosociocultural perspectives on methods of assessment. J Nutr 2010;140:1380–5S
   PubMed Web of Science ®Google Scholar
• Brown DE, Leidy Sievert L, Morrison LA, Reza AM, Mills PS. Do Japanese American women really have fewer hot flashes than European Americans? The Hilo Women’s Health Study. Menopause 2009;16:870–6
   PubMed Web of Science ®Google Scholar
• Gupta P, Sturdee DW, Hunter MS. Mid-age health in women from the Indian subcontinent (MAHWIS): general health and the experience of menopause in women. Climacteric 2006;9:13–22
   PubMed Web of Science ®Google Scholar
• Hunter MS, Gupta P, Chedraui P, et al. The International Menopause Study of Climate, Altitude, Temperature (IMS-CAT) and vasomotor symptoms. Climacteric 2013;16:8–16
   PubMed Web of Science ®Google Scholar
• Stefanopoulou E, Gupta P, Mostafa RM, et al. IMS study of climate, altitude, temperature and vasomotor symptoms in the United Arab Emirates. Climacteric 2014;17:425–32
   PubMed Web of Science ®Google Scholar
• Thurston RC, Bromberger JT, Joffe H, et al. Beyond frequency: who is most bothered by vasomotor symptoms? Menopause 2008;15:841–7
   PubMed Web of Science ®Google Scholar
• Porter M, Penney GC, Russell D, et al. A population based survey of women's experience of the menopause. Br J Obstet Gynaecol 1996;103:1025–8
   PubMedGoogle Scholar
• Carpenter J. The Hot Flash Related Daily Interference Scale: a tool for assessing the impact of hot flashes on quality of life following breast cancer. J Pain Symptom Manage 2001;22:979–89
   PubMed Web of Science ®Google Scholar
• Hunter MS, Liao KLM. A psychological analysis of menopausal hot flushes. Br J Clin Psychol 1995;34:589–99
   PubMed Web of Science ®Google Scholar
• Rand KL, Otte JL, Flockhart D, et al. Modeling hot flushes and quality of life in breast cancer survivors. Climacteric 2011;14:171–80
   PubMed Web of Science ®Google Scholar
• Ayers B, Hunter MS. Health-related quality of life of women with menopausal hot flushes and night sweats. Climacteric 2012;16:235–9
   PubMed Web of Science ®Google Scholar
• Carmody JF, Crawford S, Salmoirago-Blotcher E, et al. Mindfulness training for coping with hot flashes: results of a randomized trial. Menopause 2011;18:611–20
   PubMed Web of Science ®Google Scholar
• Duijts SF, van Beurden M, Oldenburg HS, et al. Efficacy of cognitive behavioral therapy and physical exercise in alleviating treatment-induced menopausal symptoms in patients with breast cancer: results of a randomized, controlled, multicenter trial. J Clin Oncol 2012;30:4124–33
   PubMed Web of Science ®Google Scholar
• Elkins GR, Fisher WI, Johnson AK, et al. Clinical hypnosis in the treatment of post-menopausal hot flashes: a randomized controlled trial. Menopause 2013;20:291–8
   PubMed Web of Science ®Google Scholar
• Freeman EW, Guthrie KA, Caan B, et al. Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial. JAMA 2011;305:267–74
   PubMed Web of Science ®Google Scholar
• Joffe H, Guthrie KA, LaCroix AZ, et al. Low-dose estradiol and the serotonin-norepinephrine reuptake inhibitor venlafaxine for vasomotor symptoms: a randomized clinical trial. JAMA Intern Med 2014;174:1058–66
   PubMed Web of Science ®Google Scholar
• Mann E, Smith MJ, Hellier J, et al. Cognitive behavioural treatment for women who have menopausal symptoms after breast cancer treatment (MENOS 1): a randomised controlled trial. Lancet Oncol 2012;13:309–18
   PubMed Web of Science ®Google Scholar
• Sternfeld B, LaCroix A, Caan BJ, et al. Design and methods of a multi-site, multi-behavioural treatment trial for menopausal symptoms: the MsFLASH experience. Contemp Clin Trials 2013;35:25–34
   PubMed Web of Science ®Google Scholar
• Baber RJ, Panay N, Fenton A. for the IMS Writing Group. 2016 IMS Recommendations on women's midlife health and menopause hormone therapy. Climacteric 2016;19:109–50
   PubMed Web of Science ®Google Scholar
• National Institutes of Health and Care Excellence (NICE). NICE guidance on Diagnosis and Management of Menopause, 2015; Available from: https://www.nice.org.uk/guidance/NG23
   Google Scholar
• Nonhormonal management of menopause-associated vasomotor symptoms: 2015 Position Statement of The North American Menopause Society. Menopause 2015;22:1155–74
   PubMed Web of Science ®Google Scholar
• Yeom H, Heidrich SM. Effect of perceived barriers to symptom management on quality of life in older breast cancer survivors. Cancer Nurs 2009;32:309–16
   PubMed Web of Science ®Google Scholar
• Ayers B, Forshaw M, Hunter MSA. The impact of attitudes towards the menopause on women's symptom experience: a systematic review. Maturitas 2010;65:28–36
   PubMed Web of Science ®Google Scholar
• Freeman EW, Sammel MD, Lin H, et al. The role of anxiety and hormonal changes in menopausal hot flashes. Menopause 2005;12:258–66
   PubMed Web of Science ®Google Scholar
• Hunter MS, Gupta P, Papitsch-Clarke A, Sturdee DW. Mid-aged health in women from the Indian Subcontinent (MAHWIS): a quantitative and qualitative study of experience of menopause in UK Asian women, compared to UK Caucasian and women living in Delhi. Climacteric 2009;12:26–37
   PubMed Web of Science ®Google Scholar
• Stefanopoulou E, Shah D, Shah R, et al. An International Menopause Society study of Climate, Altitude, Temperature (IMS-CAT) and vasomotor symptoms in urban Indian regions. Climacteric 2013;16:417–24
   PubMed Web of Science ®Google Scholar
• Hunter MS, Mann E. A cognitive model of menopausal hot flushes and night sweats. J Psychosom Res 2010;69:491–501
   PubMed Web of Science ®Google Scholar
• Hunter MS, Chilcot J. Testing a cognitive model of menopausal hot flushes and night sweats. J Psychosom Res 2013;74:307–12
   PubMed Web of Science ®Google Scholar
• Ayers B, Smith M, Hellier J, et al. Effectiveness of group and self-help cognitive behavior therapy in reducing problematic menopausal hot flushes and night sweats (MENOS 2): a randomized controlled trial. Menopause 2012;19:749–59
   PubMed Web of Science ®Google Scholar
• Hunter MS, Smith M. Managing Hot Flushes with Group Cognitive Behaviour Therapy: an Evidence Based Treatment Manual for Health Professionals. New York: Routledge; 2015
   Google Scholar
• Hunter MS, Smith M. Managing Hot Flushes and Night Sweats: A Cognitive Behavioural Self-Help Guide to the Menopause. New York: Routledge; 2014
   Google Scholar
• Chilcot J, Norton S, Hunter MS. Cognitive behaviour therapy for menopausal symptoms following breast cancer treatment: who benefits and how does it work? Maturitas 2014;78:56–61
   PubMed Web of Science ®Google Scholar
• Norton S, Chilcot J, Hunter MS. Cognitive behavior therapy for menopausal symptoms (hot flushes and night sweats): moderators and mediators of treatment effects. Menopause 2014;21:574–8
   PubMed Web of Science ®Google Scholar
• Stefanopoulou E, Hunter MS. Does pattern recognition software using the Bahr monitor improve sensitivity, specificity and concordance of ambulatory skin conductance monitoring of hot flushes? Menopause 2013;20:1133–8
   PubMed Web of Science ®Google Scholar
• Sievert LL. Menopause across cultures: clinical considerations. Menopause 2014;21:421–3
   PubMed Web of Science ®Google Scholar
• Rendall MJ, Simmons LM, Hunter MS. The Hot Flush Beliefs Scale: a tool for assessing thoughts and beliefs associated with experience of menopausal hot flushes and night sweats. Maturitas 2008;60:158–69
   PubMed Web of Science ®Google Scholar
• Hunter MS, O’Dea I. Menopause: bodily changes and multiple meanings. In: Ussher JM, ed. Body Talk: The Material and Discursive Regulation of Sexuality, Madness and Reproduction. London: Routledge, 1997:199–218
   Google Scholar
• Hvas L. Menopausal women's positive experience of growing older. Maturitas 2006;54:245–51
   PubMed Web of Science ®Google Scholar
• Busch H, Barth-Olofsson AS, Rosenhagen S, et al. Menopausal transition and psychological development. Menopause 2003;10:179–87
   PubMed Web of Science ®Google Scholar
• Morrison LA, Brown DE, Sievert LL. Voices from the Hilo Women's Health Study: talking story about menopause. Health Care Women Int 2014;35:529–48
   PubMed Web of Science ®Google Scholar
• Griffiths A, Hunter MS. Psychosocial factors and menopause: the impact of menopause on personal and working life. In: Davies SC, ed. Annual Report of the Chief Medical Officer 2014, The Health of 51%: Women. London: Department of Health; 2015:109–20
   Google Scholar
• Jack G, Riach K, Bariola E, et al. Menopause in the workplace: what employers should be doing. Maturitas 2016;85:88–95
   PubMed Web of Science ®Google Scholar
• Molnar GW. Body temperatures during menopausal hot flashes. J Appl Physiol 1975;38:499–503
   PubMed Web of Science ®Google Scholar
• Tataryn IV, Lomax P, Bajorek JG, et al. Postmenopausal hot flushes: a disorder of thermoregulation. Maturitas 1980;2:101–7
   PubMed Web of Science ®Google Scholar
• Ginsburg J, Swinhoe J, O’Reilly B. Cardiovascular responses during the menopausal hot flush. Br J Obstet Gynaecol 1981;88:925–30
   PubMedGoogle Scholar
• Silverman RW, Bajorek JG, Lomax P, Tataryn IV. Monitoring the pathophysiological correlates of post-menopausal hot flushes. Maturitas 1981;3:39–46
   PubMed Web of Science ®Google Scholar
• Kronenberg F, Cote LJ, Linkie DM, et al. Menopausal hot flashes: thermoregulatory, cardiovascular and circulating catecholamine and LH changes. Maturitas 1984;6:31–43
   PubMed Web of Science ®Google Scholar
• Hannan JH. The Flushings of the Menopause. London: Baillière, Tindall and Co; 1927:1–22
   Google Scholar
• Freedman RR. Menopausal hot flashes: mechanisms, endocrinology, treatment. J Steroid Biochem Mol Biol 2014;142:115–20
   PubMed Web of Science ®Google Scholar
• Sturdee DW, Reece BL. Thermography of menopausal hot flushes. Maturitas 1979;1:201–5
   PubMed Web of Science ®Google Scholar
• Tataryn IV, Meldrum DR, Lu KH, et al. LH, FSH and skin temperature during the menopausal hot flush. J Clin Endocrinol Metab 1979;49:152–4
   PubMed Web of Science ®Google Scholar
• Thurston RC, Christie IC, Matthews KA. Hot flashes and cardiac vagal control: a link to cardiovascular risk? Menopause 2010;17:456–61
   PubMed Web of Science ®Google Scholar
• Carpenter JS, Storniolo AM, Johns S, et al. Randomized, double-blind, placebo-controlled crossover trials of venlafaxine for hot flashes after breast cancer. Oncologist 2007;12:124–35
   PubMed Web of Science ®Google Scholar
• Maki PM, Rubin LH, Fornelli D, et al. Effects of botanicals and combined hormone therapy on cognition in postmenopausal women. Menopause 2009;16:1167–77
   PubMed Web of Science ®Google Scholar
• Sievert LL. Subjective and objective measures of hot flashes. Am J Hum Biol 2013;25:573–80
   PubMed Web of Science ®Google Scholar
• Walega DR, Rubin LH, Banuvar S, et al. Effects of stellate ganglion block on vasomotor symptoms: findings from a randomized controlled clinical trial in postmenopausal women. Menopause 2014;21:807–14
   PubMed Web of Science ®Google Scholar
• Shaw RW, Kerr-Wilson RHJ, Fraser HM, et al. The effect of an intranasal LHRH agonist on gonadotrophins and hot flushes in postmenopausal women. Maturitas 1985;7:161–7
   PubMed Web of Science ®Google Scholar
• Simpkins JW, Kalra SP. Central sites of norepinephrine and LHRH interaction. Fed Proc 1979;38:1107
   Google Scholar
• Berendsen HH. The role of serotonin in hot flushes. Maturitas 2000;36:155–64
   PubMed Web of Science ®Google Scholar
• Netherlands Pharmacovigilance Centrelareb. SSRIs and flushing, hot flushes and blushing. Available from https:/databankws.lareb.nl/Downloads/kwb_2011_2_ssri.pdf [last accessed 27 Mar 2017]
   Google Scholar
• Stearns V, Ullmer L, López JF, et al. Hot flushes. Lancet 2002;360:1851–61
   PubMed Web of Science ®Google Scholar
• Freedman RR. Biochemical, metabolic and vascular mechanisms in menopausal hot flashes. Fertil Steril 1998;70:332–7
   PubMed Web of Science ®Google Scholar
• Freedman RR, Dinsay R. Clonidine raises the sweating threshold in symptomatic but not in asymptomatic postmenopausal women. Fertil Steril 2000;74:20–3
   PubMed Web of Science ®Google Scholar
• Diwadkar VA, Murphy ER, Freedman RR. Temporal sequencing of brain activations during naturally occurring thermoregulatory events. Cereb Cortex 2014;24:3006–13
   PubMed Web of Science ®Google Scholar
• Freedman RR, Benton MD, Genik RJ II, Graydon FX. Cortical activation during menopausal hot flashes. Fertil Steril 2006;85:674–8
   PubMed Web of Science ®Google Scholar
• Seminara SB, Messager S, Chatzidaki EE, et al. The GPR54 gene as a regulator of puberty. N Engl J Med 2003;349:1614–27
   PubMed Web of Science ®Google Scholar
• Rance NE, McMullen NT, Smialek JE, et al. Postmenopausal hypertrophy of neurons expressing the estrogen receptor gene in the human hypothalamus. J Clin Endocrinol Metab 1990;71:79–85
   PubMed Web of Science ®Google Scholar
• Skorupskaite K, George JT, Anderson RA. The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update 2014;20:485–500
   PubMed Web of Science ®Google Scholar
• Rometo AM, Krajewski SJ, Voytko ML, Rance NE. Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. J Clin Endocrinol Metab 2007;92:2744–50
   PubMed Web of Science ®Google Scholar
• Abel TW, Voytko ML, Rance NE. The effects of hormone replacement therapy on hypothalamic neuropeptide gene expression in a primate model of menopause. J Clin Endocrinol Metab 1999;84:2111–18
   PubMed Web of Science ®Google Scholar
• Jayasena CN, Comninos AN, Stefanopoulou E, et al. Neurokinin B administration induces hot flushes in women. Sci Rep 2015;5:8466
   PubMed Web of Science ®Google Scholar
• Sassarini J, Fox H, Ferrell W, et al. Vascular function and cardiovascular risk factors in women with severe flushing. Clin Endocrinol (Oxf) 2011;74:97–103
   PubMed Web of Science ®Google Scholar
• Krajewski SJ, Burke MC, Anderson MJ, et al. Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat. Neuroscience 2010;166:680–97
   PubMed Web of Science ®Google Scholar
• Berendsen HHG, Weekers AHJ, Kloosterboer HJ. Effect of tibolone and raloxifene on the tail temperature of oestrogen-deficient rats. Eur J Pharmacol 2001;419:47–54
   PubMed Web of Science ®Google Scholar
• Dacks PA, Rance NE. Effects of estradiol on the thermoneutral zone and core temperature in ovariectomized rats. Endocrinology 2010;151:1187–93
   PubMed Web of Science ®Google Scholar
• Rance NE, Dacks PA, Mittelman-Smith MA, et al. Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesis on the mechanism of hot flushes. Front Neuroendocrinol 2013;34:211–27
   PubMed Web of Science ®Google Scholar
• Kinsey-Jones JS, Li XF, Knox AM, et al. Corticotrophin-releasing factor alters the timing of puberty in the female rat. J Neuroendocrinol 2010;22:102–9
   PubMed Web of Science ®Google Scholar
• Dacks PA, Krajewski SJ, Rance NE. Activation of neurokinin 3 receptors in the median preoptic nucleus decreases core temperature in the rat. Endocrinology 2011;152:4894–905
   PubMed Web of Science ®Google Scholar
• Mittelman-Smith MA, Williams H, Krajewski-Hall S, et al. Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature. Proc Natl Acad Sci USA 2012;109:19846–51
   PubMed Web of Science ®Google Scholar
• Russell FA, King R, Smillie SJ, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev 2014;94:1099–142
   PubMed Web of Science ®Google Scholar
• Gupta P, Harte AL, da Silva NF, et al. Expression of calcitonin gene related peptide, adrenomedullin and receptor modifying proteins in human adipose tissue and alteration in their expression with menopausal status. Menopause 2007;14:1031–8
   PubMed Web of Science ®Google Scholar
• Brain SD, Williams TJ, Tippins JR, et al. Calcitonin gene related peptide is a potent vasodilator. Nature 1985;313:54–6
   PubMed Web of Science ®Google Scholar
• Franco-Cereceda A, Gennari C, Nami R, et al. Cardiovascular effects of calcitonin gene-related peptides I and II in man. Circ Res 1987;60:393–7
   PubMed Web of Science ®Google Scholar
• Struthers AD, Brown MJ, Macdonald DW, et al. Human calcitonin gene related peptide: a potent endogenous vasodilator in man. Clin Sci (Lond) 1986;70:389–93
   PubMed Web of Science ®Google Scholar
• Mulderry PK, Nicholl CG, Ghatei MA, et al. quoted in Goodman EC, Iversen LL. Life Sci 1986;38:2169–78
   PubMed Web of Science ®Google Scholar
• Landis SC, Fredieu JR. Coexistence of calcitonin gene-related peptide and vasoactive intestinal peptide in cholinergic sympathetic innervation of rat sweat glands. Brain Res 1986;377:177–81
   PubMed Web of Science ®Google Scholar
• Kumazawa K, Sobue G, Mitsuma T, Ogawa T. Local effects of calcitonin gene-related peptide on human sweat gland function. Rinsho Shinkeigaku 1991;31:564–6
   PubMedGoogle Scholar
• Noguchi K, Senba E, Morita Y, et al. Alpha-CGRP and beta-CGRP mRNAs are differentially regulated in the rat spinal cord and dorsal root ganglion. Brain Res Mol Brain Res 1990;7:299–304
   PubMedGoogle Scholar
• Kobayashi T, Ushijima O, Chen JT, et al. Basal tail skin temperature elevation and augmented response to calcitonin gene-related peptide in ovariectomized rats. J Endocrinol 1995;146:431–7
   PubMed Web of Science ®Google Scholar
• Braasch DC, Deegan EM, Grimm ER, Griffin JD. Calcitonin gene-related peptide alters the firing rates of hypothalamic temperature sensitive and insensitive neurons. BMC Neurosci 2008;9:64
   PubMed Web of Science ®Google Scholar
• Wallengren J, Hakanson R. Effects of substance P, neurokinin A and calcitonin gene-related peptide in human skin and their involvement in sensory nerve-mediated responses. Eur J Pharmacol 1987;143:267–73
   PubMed Web of Science ®Google Scholar
• Wimalawensa SJ. Effects of in vivo stimulation on molecular forms of circulatory calcitonin and calcitonin gene-related peptide in man. Mol Cell Endocrinol 1990;71:13–19
   PubMed Web of Science ®Google Scholar
• Chen JT, Hirai Y, Seimiya Y, Hasumi K, Shiraki M. Menopausal flushes and calcitonin-gene-related peptide. Lancet 1993;342:49
   PubMed Web of Science ®Google Scholar
• Wyon Y, Spetz AE, Theodorsson GE, Hammar ML. Concentration of calcitonin gene-related peptide and neuropeptide Y in plasma increases during flushes in postmenopausal women. Menopause 2000;7:5–30
   PubMed Web of Science ®Google Scholar
• Spetz AE, Pettersson B, Varenhorst E, et al. Momentary increase in plasma calcitonin gene-related peptide is involved in hot flashes in men treated with castration for carcinoma of the prostate. J Urol 2001;166:1720–3
   PubMed Web of Science ®Google Scholar
• Spinetti A, Margutti A, Bertolini S, et al. Hormonal replacement therapy affects calcitonin gene-related peptide and atrial natriuretic peptide secretion in postmenopausal women. Eur J Endocrinol 1997;137:664–9
   PubMed Web of Science ®Google Scholar
• Valentini A, Petraglia F, Vita DD, et al. Changes of plasma calcitonin gene-related peptide levels in postmenopausal women. Am J Obstet Gynecol 1996;173:638–42
   Google Scholar
• Ma QL, Zhou HY, Sun M. Relationship between sex hormone levels and blood calcitonin gene-related peptide/endothelin-1 in postmenopausal women with coronary heart disease. Hunan Yi Ke Da Xue Xue Bao 2001;26:146–8
   PubMedGoogle Scholar
• Maki PM, Drogos LL, Rubin LH, et al. Objective hot flashes are negatively related to verbal memory performance in midlife women. Menopause 2008;15:848–56
   PubMed Web of Science ®Google Scholar
• Thurston RC, Aizenstein HJ, Derby CA, et al. Menopausal hot flashes and white matter hyperintensities. Menopause 2016;23:27–32
   PubMed Web of Science ®Google Scholar
• Thurston RC, Maki PM, Derby CA, Sejdić E, Aizenstein HJ. Menopausal hot flashes and the default mode network. Fertil Steril 2015;103:1572–8. e1
   PubMed Web of Science ®Google Scholar
• Debette S, Markus HS. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 2010;341:c3666
   PubMed Web of Science ®Google Scholar
• Daselaar SM, Prince SE, Cabeza R. When less means more: deactivations during encoding that predict subsequent memory. Neuroimage 2004;23:921–7
   PubMed Web of Science ®Google Scholar
• Lucas RA, Ganio MS, Pearson J, Crandall CG. Brain blood flow and cardiovascular responses to hot flashes in postmenopausal women. Menopause 2013;20:299–304
   PubMed Web of Science ®Google Scholar
• Meldrum DR, Defazio JD, Erlik Y, et al. Pituitary hormones during the menopausal hot flash. Obstet Gynecol 1984;64:752–6
   PubMed Web of Science ®Google Scholar
• Herber-Gast G, Brown WJ, Mishra GD. Hot flushes and night sweats are associated with coronary heart disease risk in midlife: a longitudinal study. BJOG 2015;122:1560–7
   PubMed Web of Science ®Google Scholar
• Franco OH, Muka T, Colpani V, et al. Vasomotor symptoms in women and cardiovascular risk markers: systematic review and meta-analysis. Maturitas 2015;81:353–61
   PubMed Web of Science ®Google Scholar
• Thurston RC, El Khoudary SR, Sutton-Tyrrell K, et al. Vasomotor symptoms and insulin resistance in the Study of women's health across the nation. J Clin Endocrinol Metab 2012;97:3487–94
   PubMed Web of Science ®Google Scholar
• Silveira JS, Clapauch R, Souza M, Bouskela E. Hot flashes: emerging cardiovascular risk factors in recent and late postmenopause and their association with higher blood pressure. Menopause 2016;23:846–55
   PubMed Web of Science ®Google Scholar
• Thurston R, Barinas-Mitchell E, Santoro N, et al. Physiologically-assessed hot flashes are associated with poorer endothelial function among early midlife women. J Am Coll Cardiol 2015;65:A1513
   Web of Science ®Google Scholar
• Jackson EA, El Khoudary SR, Crawford SL, et al. Hot flash frequency and blood pressure: data from the Study of Women's Health across the Nation. J Womens Health 2016;25:1204–9
   PubMed Web of Science ®Google Scholar
• Tuomikoski P, Ylikorkala O, Mikkola TS. Menopausal hot flushes and vascular health. Ann Med 2011;43:283–91
   PubMed Web of Science ®Google Scholar
• Hitchcock CL, Elliott TG, Norman EG, Stalic V, Teede H, Prior JC. Hot flushes and night sweats differ in associations with cardiovascular markers in healthy early postmenopausal women. Menopause 2012;19:1208–14
   PubMed Web of Science ®Google Scholar