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Reviews

Weight gain in menopause: systematic review of adverse events in women treated with black cohosh

ORCID Icon, ORCID Icon, , ORCID Icon, ORCID Icon, & ORCID Icon show all
Pages 220-227 | Received 15 Jun 2021, Accepted 24 Aug 2021, Published online: 05 Oct 2021

References

  • Kapoor E, Collazo-Clavell ML, Faubion SS. Weight gain in women at midlife: a concise review of the pathophysiology and strategies for management. Mayo Clin Proc. 2017;92(10):1552–1558.
  • Guthrie JR, Dennerstein L, Dudley EC. Weight gain and the menopause: a 5-year prospective study. Climacteric. 1999;2(3):205–211.
  • Blümel JE, et al. Changes in body mass index around menopause: a population study of chilean woman. Menopause. 2001;8(4):239–244.
  • Sternfeld B. Physical activity and changes in weight and waist circumference in midlife women: findings from the study of women's health across the nation. Am J Epidemiol. 2004;160(9):912–922.
  • Van Pelt RE, Gavin KM, Kohrt WM. Regulation of body composition and bioenergetics by estrogens. Endocrinol Metab Clin North Am. 2015;44(3):663–676.
  • Llaneza P, García-Portilla MP, Llaneza-Suárez D, et al. Depressive disorders and the menopause transition. Maturitas. 2012;71(2):120–130.
  • Fernandez-Alonso AM, et al. Life satisfaction, loneliness and related factors during female midlife. Maturitas. 2012;72(1):88–92.
  • Garbarino S, Lanteri P, Durando P, et al. Co-Morbidity, mortality, quality of life and the healthcare/welfare/social costs of disordered sleep: a rapid review. Int J Environ Res Public Health. 2016;13(8):831.
  • Karvonen-Gutierrez C, Kim C. Association of Mid-Life changes in body size, body composition and obesity status with the menopausal transition. Healthcare (Basel). 2016;4(3):42.
  • Davis SR, Writing Group of the International Menopause Society for World Menopause Day 2012, Castelo-Branco C, Chedraui P, et al. Understanding weight gain at menopause. Climacteric. 2012;15(5):419–429.
  • Rossouw JE, Writing Group for the Women's Health Initiative Investigators, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. JAMA. 2002;288(3):321–333.
  • Cobin RH, AACE Menopause Guidelines Revision Task Force, Futterweit W, Ginzburg SB, et al. American association of clinical endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of menopause. Endocr Pract. 2006;12(3):315–337.
  • Umland EM. Treatment strategies for reducing the burden of menopause-associated vasomotor symptoms. J Manag Care Pharm. 2008;14(3 Suppl):14–19.
  • Hall E, Frey BN, Soares CN. Non-hormonal treatment strategies for vasomotor symptoms: a critical review. Drugs. 2011;71(3):287–304.
  • Beral V, et al. Type and timing of menopausal hormone therapy and breast cancer risk: individual participant Meta-analysis of the worldwide epidemiological evidence. Lancet. 2019;394(10204):1159–1168.
  • Molla MD, Hidalgo-Mora JJ, Soteras MG. Phytotherapy as alternative to hormone replacement therapy. Front Biosci (Schol Ed)). 2011;3:191–204.
  • Beer AM, Neff A. Differentiated evaluation of Extract-Specific evidence on cimicifuga racemosa's efficacy and safety for climacteric complaints. Evid Based Complement Alternat Med. 2013;2013:1–21.
  • Ruan X, Mueck AO, Beer A-M, et al. Benefit-risk profile of black cohosh (isopropanolic cimicifuga racemosa extract) with and without St john's wort in breast cancer patients. Climacteric. 2019;22(4):339–347.
  • Castelo-Branco C, Gambacciani M, Cano A, et al. Review & Meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence. Climacteric. 2021;24(2):109–119.
  • CEBM. Oxford Centre for Evidence-based Medicine – Levels of Evidence (March 2009). 2009. [23-July-2019]; Available from: https://www.cebm.net/2009/06/oxford-centre-evidence-based-medicine-levels-evidence-march-2009/.
  • Edwards IR, Biriell C. Harmonisation in pharmacovigilance. Drug Saf. 1994;10(2):93–102.
  • Zimmermann R, Witte A, Voll RE, et al. Coagulation activation and fluid retention associated with the use of black cohosh: a case study. Climacteric. 2010;13(2):187–191.
  • Stoll W. Phytotherapeutikum beeinflußt atrophisches vaginalepithel: Doppelblindversuch cimicifuga vs. Oestrogenpräparat. Therapeutikon. 1987;1:23–31.
  • Bai W, Henneicke-von Zepelin HH, Zheng S. Black cohosh versus tibolone in menopausal symptoms relief in chinese women. Maturitas. 2006;54:17.
  • Chen J-y. 莉芙敏与利维爱治疗围绝经期综合征的临床疗效观察 [comparison on the efficacy and safety of remifemin and livial in the treatment of perimenopausal symptoms]. Hainan Med J. 2013;24(10):1454–1457.
  • Osmers R, et al. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol. 2005;105(5 Pt 1):1074–1083.
  • Chung D-J, Kim H-Y, Park K-H, et al. Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms. Yonsei Med J. 2007;48(2):289–294.
  • Mulugeta W, Desalegn H, Solomon S. Impact of the COVID-19 pandemic lockdown on weight status and factors associated with weight gain among adults in Massachusetts. Clin Obes. 2021;11(4):e12453.
  • Sammel MD, Grisso JA, Freeman EW, et al. Weight gain among women in the late reproductive years. Fam Pract. 2003;20(4):401–409.
  • Bai W, Henneicke-von Zepelin H-H, Wang S, et al. Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone. Maturitas. 2007;58(1):31–41.
  • Ambikairajah A, Walsh E, Tabatabaei-Jafari H, et al. Fat mass changes during menopause: a metaanalysis. Am J Obstet Gynecol. 2019;221(5):393–409. e50.
  • Sun Y, Yu Q, Shen Q, et al. Black cohosh ameliorates metabolic disorders in female ovariectomized rats. Rejuvenation Res. 2016;19(3):204–214.
  • Moser C, Vickers SP, Brammer R, et al. Antidiabetic effects of the cimicifuga racemosa extract Ze 450 in vitro and in vivo in ob/ob mice. Phytomedicine. 2014;21(11):1382–1389.
  • Yuan J, Shi Q, Chen J, et al. Effects of 23-epi-26-deoxyactein on adipogenesis in 3T3-L1 preadipocytes and diet-induced obesity in C57BL/6 mice. Phytomedicine. 2020;76:153264.
  • Rachon D, et al. Effects of black cohosh extract on body weight gain, intra-abdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague-Dawley rats. Maturitas. 2008;60(3-4):209–215.
  • Martin BR. Complementary medicine therapies that may assist with weight loss: a narrative review. J Chiropr Med. 2019;18(2):115–126.
  • Friederichsen L, Nebel S, Zahner C, et al. Effect of CIMicifuga racemosa on metaBOLIC parameters in women with menopausal symptoms: a retrospective observational study (CIMBOLIC). Arch Gynecol Obstet. 2020;301(2):517–523.
  • Pkhaladze L, et al. Actaea racemosa L. Is more effective in combination with rhodiola rosea L. for relief of menopausal symptoms: a randomized, Double-Blind, Placebo-Controlled study. Pharmaceuticals. 2020;13(5):102.
  • Mehrpooya M, et al. A comparative study on the effect of “black cohosh” and “evening primrose oil” on menopausal hot flashes. J Educ Health Promot. 2018;7:36.
  • Tanmahasamut P, Vichinsartvichai P, Rattanachaiyanont M, et al. Cimicifuga racemosa extract for relieving menopausal symptoms: a randomized controlled trial. Climacteric. 2015;18(1):79–85.
  • Zhang Q, Zhuang Z, Chen T. 莉芙敏治疗围绝经期综合征的安全性和疗效研究 [the efficacy and safety of remifemin in the treatment of perimenopausae syndrome]. Journal of Chengdu Medical College. 2015;10(2):229–232.
  • Jiang K, Jin Y, Huang L, et al. Black cohosh improves objective sleep in postmenopausal women with sleep disturbance. Climacteric. 2015;18(4):559–567.
  • Chen J, et al. Efficacy and safety of remifemin on peri-menopausal symptoms induced by post-operative GnRH-a therapy for endometriosis: a randomized study versus tibolone. Med Sci Monit. 2014;20:1950–1957.
  • Mohammad-Alizadeh-Charandabi S, Shahnazi M, Nahaee J, et al. Efficacy of black cohosh (cimicifuga racemosa L.) in treating early symptoms of menopause: a randomized clinical trial. Chin Med. 2013;8(1):20.
  • Huang J. 莉芙敏治疗子宫切除术后绝经症状临床疗效观察 [clinical observation of remifemin efficacy on menopausal symptoms after hysterectomy]. Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine. 2013;13(8):35–44.
  • Huang YX, et al. [Clinical study of combined treatment of remifemin and paroxetine for perimenopausal depression]. Zhonghua Yi Xue Za Zhi. 2013;93(8):600–602.
  • Schellenberg R, Saller R, Hess L, et al. Dose-Dependent effects of the cimicifuga racemosa extract Ze 450 in the treatment of climacteric complaints: a randomized, Placebo-Controlled study. Evid Based Complement Alternat Med. 2012;2012:1–10.
  • Sun N-X, Jin Z-J, Jia X-F, et al. Black cohosh improves vaginal atrophy in postmenopausal women. Academic Journal of Second Military Medical University. 2012;32(3):339–341.
  • Hong SN, Kim JH, Kim HY, et al. Effect of black cohosh on genital atrophy and its adverse effect in postmenopausal women. J Korean Soc Menopause. 2012;18(2):106.
  • Li Y, Cui M, Gao S. Efficacy of remifemin for control of climacteric symptoms. Prog Obstet Gynecol. 2011;20(6):462–465.
  • Bebenek M, Kemmler W, von Stengel S, et al. Effect of exercise and cimicifuga racemosa (CR BNO 1055) on bone mineral density, 10-year coronary heart disease risk, and menopausal complaints: the randomized controlled training and cimicifuga racemosa erlangen (TRACE) study. Menopause. 2010;17(4):791–800.
  • Geller SE, Shulman LP, van Breemen RB, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause. 2009;16(6):1156–1166.
  • Amsterdam JD, Yao Y, Mao JJ, et al. Randomized, double-blind, placebo-controlled trial of cimicifuga racemosa (black cohosh) in women with anxiety disorder due to menopause. J Clin Psychopharmacol. 2009;29(5):478–483.
  • Oktem M, Eroglu D, Karahan HB, et al. Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial. Adv Ther. 2007;24(2):448–461.
  • Wuttke W, Rauš K, Gorkow C. Efficacy and tolerability of the black cohosh (actaea racemosa) ethanolic extract BNO 1055 on climacteric complaints: a double-blind, placebo- and conjugated estrogens-controlled study. Maturitas. 2006;55:S83–S91.
  • Wuttke W, Seidlova-Wuttke D, Gorkow C. The cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas. 2003;44 (Suppl 1):S67–S77.
  • Newton KM, Reed SD, LaCroix AZ, et al. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med. 2006;145(12):869–879.
  • Uebelhack R, Blohmer J-U, Graubaum H-J, et al. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol. 2006;107(2, Part 1):247–255.
  • Frei-Kleiner S, Schaffner W, Rahlfs VW, et al. Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial. Maturitas. 2005;51(4):397–404.
  • Nappi RE, Malavasi B, Brundu B, et al. Efficacy of cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol. Gynecol Endocrinol. 2005;20(1):30–35.
  • Lee BI, et al. Comparative study on treatment of postmenopausal symptoms with black cohosh root extract and hormone replacement therapy. Korean J Obstet Gynecol. 2002;45(8):1330–1335.
  • Liske E, Hänggi W, Henneicke-von Zepelin H-H, et al. Physiological investigation of a unique extract of black cohosh (cimicifugae racemosae rhizoma): a 6-month clinical study demonstrates no systemic estrogenic effect. J Womens Health Gend Based Med. 2002;11(2):163–174.
  • Lehmann-Willenbrock E, Riedel HH. Clinical and endocrinologic studies of the treatment of ovarian insufficiency manifestations following hysterectomy with intact adnexa. Zentralbl Gynakol. 1988;110(10):611–618.
  • Warnecke G. Beeinflussung klimakterischer beschwerden durch ein phytotherapeutikum [influencing menopausal symptoms with a phytotherapeutic agent]. Med Welt. 1985;36:871–874.