Effects of exercise on vasomotor symptoms in menopausal women: a systematic review and meta-analysis

References

• Brockie J, Lambrinoudaki I, Ceausu I, et al. EMAS position statement: menopause for medical students. Maturitas. 2014;78(1):67–69.
   PubMed Web of Science ®Google Scholar
• American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 141: management of menopausal symptoms. Obstet Gynecol. 2014;123(1):202–216.
   PubMed Web of Science ®Google Scholar
• Archer DF, Sturdee DW, Baber R, et al. Menopausal hot flushes and night sweats: where are we now? Climacteric. 2011;14(5):515–528.
   PubMed Web of Science ®Google Scholar
• Freedman RR. Menopausal hot flashes: mechanisms, endocrinology, treatment. J Steroid Biochem Mol Biol. 2014;142:115–120.
   PubMed Web of Science ®Google Scholar
• Avis NE, Crawford SL, Green R. Vasomotor symptoms across the menopause transition: differences among women. Obstet Gynecol Clin North Am. 2018;45(4):629–640.
   PubMed Web of Science ®Google Scholar
• Avis NE, Crawford SL, Greendale G, et al. Duration of menopausal vasomotor symptoms over the menopause transition. JAMA Intern Med. 2015;175(4):531–539.
   PubMed Web of Science ®Google Scholar
• Zhu D, Chung HF, Dobson AJ, et al. Vasomotor menopausal symptoms and risk of cardiovascular disease: a pooled analysis of six prospective studies. Am J Obstet Gynecol. 2020;223(6):898.e1–898.e16.
   PubMed Web of Science ®Google Scholar
• Maclennan AH, Broadbent JL, Lester S, et al. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. Cochrane Database Syst Rev. 2004;2004(4):Cd002978.
   PubMedGoogle Scholar
• Baber RJ, Panay N, Fenton A. 2016 IMS Recommendations on women’s midlife health and menopause hormone therapy. Climacteric. 2016;19(2):109–150.
   PubMed Web of Science ®Google Scholar
• Utian WH, Lederman SA, Williams BM, et al. Relief of hot flushes with new plant-derived 10-component synthetic conjugated estrogens. Obstet Gynecol. 2004;103(2):245–253.
   PubMed Web of Science ®Google Scholar
• Simin J, Tamimi R, Lagergren J, et al. Menopausal hormone therapy and cancer risk: an overestimated risk? Eur J Cancer. 2017;84:60–68.
   PubMed Web of Science ®Google Scholar
• Anagnostis P, Paschou SA, Katsiki N, et al. Menopausal hormone therapy and cardiovascular risk: Where are we now? Curr Vasc Pharmacol. 2019;17(6):564–572.
   PubMed Web of Science ®Google Scholar
• Thomas A, Daley AJ. Women’s views about physical activity as a treatment for vasomotor menopausal symptoms: a qualitative study. BMC Womens Health. 2020;20(1):203.
   PubMed Web of Science ®Google Scholar
• Daley A, Stokes‐Lampard H, Thomas A, et al. Exercise for vasomotor menopausal symptoms. Cochrane Database of Syst Rev. 2014;28(11):CD006108.
   Google Scholar
• Bailey TG, Cable NT, Aziz N, et al. Exercise training reduces the acute physiological severity of post-menopausal hot flushes. J Physiol. 2016;594(3):657–667.
   PubMed Web of Science ®Google Scholar
• Bailey TG, Cable NT, Aziz N, et al. Exercise training reduces the frequency of menopausal hot flushes by improving thermoregulatory control. Menopause. 2016;23(7):708–718.
   PubMed Web of Science ®Google Scholar
• Elhosary EAM, Ewidea MM, Ahmed HAH, et al. Effect of aerobic exercises versus laser acupuncture in treatment of postmenopausal hot flushes: a randomized controlled trial. J Phys Ther Sci. 2018;30(2):328–331.
   PubMedGoogle Scholar
• Kai Y, Nagamatsu T, Kitabatake Y, et al. Effects of stretching on menopausal and depressive symptoms in middle-aged women: a randomized controlled trial. Menopause. 2016;23(8):827–832.
   PubMed Web of Science ®Google Scholar
• Berin E, Hammar M, Lindblom H, et al. Resistance training for hot flushes in postmenopausal women: a randomised controlled trial. Maturitas. 2019;126:55–60.
   PubMed Web of Science ®Google Scholar
• Newton KM, Reed SD, Guthrie KA, et al. Efficacy of yoga for vasomotor symptoms: a randomized controlled trial. Menopause. 2014;21(4):339–346.
   PubMed Web of Science ®Google Scholar
• Sternfeld B, Guthrie KA, Ensrud KE, et al. Efficacy of exercise for menopausal symptoms: a randomized controlled trial. Menopause. 2014;21(4):330–338.
   PubMed Web of Science ®Google Scholar
• Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009;62(10):e1–e34.
   PubMed Web of Science ®Google Scholar
• Chandler J, Cumpston M, Thomas J, et al. Cochrane handbook for systematic reviews of interventions version 6.3 (updated February 2022). Cochrane, 2022. Available from www.training.cochrane.org/handbook.
   Google Scholar
• World Health Organization. Physical activity. 2019; [cited 2021 Apr 29]. Available from: https://www.who.int/ncds/prevention/physical-activity/introduction/en/.
   Google Scholar
• Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.
   PubMed Web of Science ®Google Scholar
• Aiello EJ, Yasui Y, Tworoger SS, et al. Effect of a yearlong, moderate-intensity exercise intervention on the occurrence and severity of menopause symptoms in postmenopausal women. Menopause. 2004;11(4):382–388.
   PubMed Web of Science ®Google Scholar
• Lindh-Åstrand L, Nedstrand E, Wyon Y, et al. Vasomotor symptoms and quality of life in previously sedentary postmenopausal women randomised to physical activity or estrogen therapy. Maturitas. 2004;48(2):97–105.
   PubMed Web of Science ®Google Scholar
• Elavsky S, McAuley E. Physical activity and mental health outcomes during menopause: a randomized controlled trial. Ann Behav Med. 2007;33(2):132–142.
   PubMed Web of Science ®Google Scholar
• Chattha R, Raghuram N, Venkatram P, et al. Treating the climacteric symptoms in Indian women with an integrated approach to yoga therapy: a randomized control study. Menopause. 2008;15(5):862–870.
   PubMed Web of Science ®Google Scholar
• Hanachi P, Golkho S. Assessment of soy phytoestrogens and exercise on lipid profiles and menopause symptoms in menopausal women. J. Biol Sci. 2008;8(4):789–793.
   Google Scholar
• Moriyama CK, Oneda B, Bernardo FR, et al. A randomized, placebo-controlled trial of the effects of physical exercises and estrogen therapy on health-related quality of life in postmenopausal women. Menopause. 2008;15(4 Pt 1):613–618.
   PubMed Web of Science ®Google Scholar
• Carson JW, Carson KM, Porter LS, et al. Yoga of Awareness program for menopausal symptoms in breast cancer survivors: results from a randomized trial. Support Care Cancer. 2009;17(10):1301–1309.
   PubMed Web of Science ®Google Scholar
• Ogwumike OO, Sanya AO, Arowojolu AO. Endurance exercise effect on quality of life and menopausal symptoms in Nigerian women. Afr J Med Med Sci. 2011;40(3):187–195.
   PubMedGoogle Scholar
• Duijts SF, van Beurden M, Oldenburg HS, et al. Efficacy of cognitive behavioral therapy and physical exercise in alleviating treatment-induced menopausal symptoms in patients with breast cancer: results of a randomized, controlled, multicenter trial. J Clin Oncol. 2012;30(33):4124–4133.
   PubMed Web of Science ®Google Scholar
• Luoto R, Moilanen J, Heinonen R, et al. Effect of aerobic training on hot flushes and quality of life–a randomized controlled trial. Ann Med. 2012;44(6):616–626.
   PubMed Web of Science ®Google Scholar
• Moilanen JM, Mikkola TS, Raitanen JA, et al. Effect of aerobic training on menopausal symptoms – a randomized controlled trial. Menopause. 2012;19(6):691–696.
   PubMed Web of Science ®Google Scholar
• Hayes SC, Rye S, Disipio T, et al. Exercise for health: a randomized, controlled trial evaluating the impact of a pragmatic, translational exercise intervention on the quality of life, function and treatment-related side effects following breast cancer. Breast Cancer Res Treat. 2013;137(1):175–186.
   PubMed Web of Science ®Google Scholar
• Avis NE, Legault C, Russell G, et al. A pilot study of integral yoga for menopausal hot flashes. Menopause. 2014;21(8):846–854.
   PubMed Web of Science ®Google Scholar
• Zhang J, Chen G, Lu W, et al. Effects of physical exercise on health-related quality of life and blood lipids in perimenopausal women: a randomized placebo-controlled trial. Menopause. 2014;21(12):1269–1276.
   PubMed Web of Science ®Google Scholar
• Daley AJ, Thomas A, Roalfe AK, et al. The effectiveness of exercise as treatment for vasomotor menopausal symptoms: randomised controlled trial. BJOG. 2015;122(4):565–575.
   PubMed Web of Science ®Google Scholar
• Lee H, Caguicla JM, Park S, et al. Effects of 8-week Pilates exercise program on menopausal symptoms and lumbar strength and flexibility in postmenopausal women. J Exerc Rehabil. 2016;12(3):247–251.
   PubMedGoogle Scholar
• Asghari M, Mirghafourvand M, Mohammad-Alizadeh-Charandabi S, et al. Effect of aerobic exercise and nutrition educationon quality of life and early menopause symptoms: a randomized controlled trial. Women Health. 2017;57(2):173–188.
   PubMed Web of Science ®Google Scholar
• Baena-García L, Flor-Alemany M, Marín-Jiménez N, et al. A 16-week multicomponent exercise training program improves menopause-related symptoms in middle-aged women. The FLAMENCO project randomized control trial. Menopause. 2022;29(5):537–537.
   PubMed Web of Science ®Google Scholar
• Higgins JP, Thomas J, Chandler J, et al. Cochrane handbook for systematic reviews of interventions: John Wiley & Sons; 2019. Hoboken (NJ): Wiley-Blackwell; 2019.
   Google Scholar
• Faraone SV. Interpreting estimates of treatment effects: implications for managed care. P T. 2008;33(12):700–711.
   PubMedGoogle Scholar
• Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924–926.
   PubMed Web of Science ®Google Scholar
• Guyatt GH, Oxman AD, Vist G, et al. GRADE guidelines: rating the quality of evidence–study limitations (risk of bias). J Clin Epidemiol. 2011;64(4):407–415.
   PubMed Web of Science ®Google Scholar
• Blümel JE, Chedraui P, Baron G, et al. A large multinational study of vasomotor symptom prevalence, duration, and impact on quality of life in middle-aged women. Menopause. 2011;18(7):778–785.
   PubMed Web of Science ®Google Scholar
• Nisar N, Sohoo NA. Frequency of menopausal symptoms and their impact on the quality of life of women: a hospital based survey. J Pak Med Assoc. 2009;59(11):752–756.
   PubMedGoogle Scholar
• Nio AQX, Rogers S, Mynors-Wallis R, et al. The menopause alters aerobic adaptations to high-intensity interval training. Med Sci Sports Exerc. 2020;52(10):2096–2106.
   PubMed Web of Science ®Google Scholar