Usefulness of the LDL-C/apoB ratio in the overall evaluation of atherogenicity of lipid profile

References

• Arai H, Kokubo Y, Watanabe M, et al. (2013). Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the Suita study. J Atheroscler Thromb, 20:195–203
   PubMed Web of Science ®Google Scholar
• Auger A, Truong TQ, Rhainds D, et al. (2001). Low and high density lipoprotein metabolism in primary cultures of hepatic cells from normal and apolipoprotein E knockout mice. Eur J Biochem, 268:2322–30
   PubMedGoogle Scholar
• Berneis K, Rizzo M. (2004). LDL size: does it matter? Swiss Med Wkly, 134:720–4
   PubMed Web of Science ®Google Scholar
• Berneis KK, Krauss RM. (2002). Metabolic origins and clinical significance of LDL heterogeneity. J Lipid Res, 43:1363–79
   PubMed Web of Science ®Google Scholar
• Bhalodkar NC, Blum S, Enas EA. (2006). Accuracy of the ratio of triglycerides to high-density lipoprotein cholesterol for predicting low-density lipoprotein cholesterol particle sizes, phenotype B, and particle concentrations among Asian Indians. Am J Cardiol, 97:1007–9
   PubMed Web of Science ®Google Scholar
• Bioletto S, Golay A, Munger R, et al. (2000). Acute hyperinsulinemia and very-low-density and low-density lipoprotein subfractions in obese subjects. Am J Clin Nutr, 71:443–9
   PubMed Web of Science ®Google Scholar
• Contois JH, McNamara JR, Lammi-Keefe CJ, et al. (1996a). Reference intervals for plasma apolipoprotein A-I determined with a standardized commercial immunoturbidimetric assay: results from the Framingham Offspring Study. Clin Chem, 42:507–14
   PubMed Web of Science ®Google Scholar
• Contois JH, McNamara JR, Lammi-Keefe CJ, et al. (1996b). Reference intervals for plasma apolipoprotein B determined with a standardized commercial immunoturbidimetric assay: results from the Framingham Offspring Study. Clin Chem, 42:515–23
   PubMed Web of Science ®Google Scholar
• Décary S, Dumont G, Lamarche B, et al. (2010). Assessment of the validity of the frequently used lipid indices for predicting LDL peak particle diameter in a large cohort of 1955 normal and dyslipidemic subjects. Clin Biochem, 43:401–6
   PubMed Web of Science ®Google Scholar
• Dobiasova M, Frohlich J. (2001). The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)). Clin Biochem, 34:583–8
   PubMed Web of Science ®Google Scholar
• El Harchaoui K, van der Steeg WA, Stroes ES, et al. (2007). Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study. J Am Coll Cardiol, 49:547–53
   PubMed Web of Science ®Google Scholar
• Friedewald WT, Levy RI, Fredrickson DS. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem, 18:499–502
   PubMed Web of Science ®Google Scholar
• Furuya D, Yagihashi A, Nasu S, et al. (2000). LDL particle size by gradient-gel electrophoresis cannot be estimated by LDL-cholesterol/apolipoprotein B ratios. Clin Chem, 46:1202–3
   PubMed Web of Science ®Google Scholar
• Gazi IF, Tsimihodimos V, Tselepis AD, et al. (2007). Clinical importance and therapeutic modulation of small dense low-density lipoprotein particles. Expert Opin Biol Ther, 7:53–72
   PubMed Web of Science ®Google Scholar
• Hanak V, Munoz J, Teague J, et al. (2004). Accuracy of the triglyceride to high-density lipoprotein cholesterol ratio for prediction of the low-density lipoprotein phenotype B. Am J Cardiol, 94:219–22
   PubMed Web of Science ®Google Scholar
• Hattori Y, Suzuki M, Tsushima M, et al. (1998). Development of approximate formula for LDL-chol, LDL-apo B and LDL-chol/LDL-apo B as indices of hyperapobetalipoproteinemia and small dense LDL. Atherosclerosis, 138:289–99
   PubMed Web of Science ®Google Scholar
• Havel RJ. (2010). Triglyceride-rich lipoproteins and plasma lipid transport. Arterioscler Thromb Vasc Biol, 30:9–19
   PubMed Web of Science ®Google Scholar
• Hirano T, Ito Y, Yoshino G. (2005). Measurement of small dense low-density lipoprotein particles. J Atheroscler Thromb, 12:67–72
   PubMed Web of Science ®Google Scholar
• Hirayama S, Miida T. (2012). Small dense LDL: an emerging risk factor for cardiovascular disease. Clin Chim Acta, 414:215–24
   PubMed Web of Science ®Google Scholar
• Huang LH, Elvington A, Randolph GJ. (2015). The role of the lymphatic system in cholesterol transport. Front Pharmacol, 6:182
   PubMed Web of Science ®Google Scholar
• Hulthe J, Bokemark L, Wikstrand J, Fagerberg B. (2000). The metabolic syndrome, LDL particle size, and atherosclerosis: the Atherosclerosis and Insulin Resistance (AIR) study. Arterioscler Thromb Vasc Biol, 20:2140–7
   PubMed Web of Science ®Google Scholar
• Jang EH, Park YM, Hur J, et al. (2013). Higher levels of small dense low-density lipoprotein (LDL) are associated with cardiac autonomic neuropathy in patients with type 2 diabetes. Diabet Med, 30:694–701
   PubMed Web of Science ®Google Scholar
• Julius U, Dittrich M, Pietzsch J. (2007). Factors influencing the formation of small dense low-density lipoprotein particles in dependence on the presence of the metabolic syndrome and on the degree of glucose intolerance. Int J Clin Pract, 61:1798–804
   PubMed Web of Science ®Google Scholar
• Kaneva AM, Bojko ER, Potolitsyna NN, Odland JO. (2013). Plasma levels of apolipoprotein-E in residents of the European North of Russia. Lipids Health Dis, 12:43
   PubMed Web of Science ®Google Scholar
• Linn S, Fulwood R, Carroll M, et al. (1991). Serum total cholesterol: HDL cholesterol ratios in US white and black adults by selected demographic and socioeconomic variables (HANES II). Am J Public Health, 81:1038–43
   PubMed Web of Science ®Google Scholar
• Magkos F, Mohammed BS, Mittendorfer B. (2008). Effect of obesity on the plasma lipoprotein subclass profile in normoglycemic and normolipidemic men and women. Int J Obes (Lond) 32:1655–64
   PubMed Web of Science ®Google Scholar
• Mahley RW, Innerarite TL, Rall SC, Weisgraber KH. (1984). Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res, 25:1277–94
   PubMed Web of Science ®Google Scholar
• Mahley RW, Rall SC. Jr. (2000). Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet, 1:507–37
   PubMed Web of Science ®Google Scholar
• Maruyama C, Imamura K, Teramoto T. (2003). Assessment of LDL particle size by triglyceride/HDL-cholesterol ratio in non-diabetic, healthy subjects without prominent hyperlipidemia. J Atheroscler Thromb, 10:186–91
   PubMedGoogle Scholar
• Mikhailidis DP, Elisaf M, Rizzo M, et al. (2011). “European panel on low density lipoprotein (LDL) subclasses”: a statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses. Curr Vasc Pharmacol, 9:533–71
   PubMed Web of Science ®Google Scholar
• Millán J, Pintó X, Muñoz A, et al. (2009). Lipoprotein ratios: physiological significance and clinical usefulness in cardiovascular prevention. Vasc Health Risk Manag, 5:757–65
   PubMedGoogle Scholar
• Musunuru K. (2010). Atherogenic dyslipidemia: cardiovascular risk and dietary intervention. Lipids, 45:907–14
   PubMed Web of Science ®Google Scholar
• National Cholesterol Education Program (NCEP). Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). (2002). Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation, 106: 3143–421
   PubMed Web of Science ®Google Scholar
• Packard CJ. (2003). Triacylglycerol-rich lipoproteins and the generation of small, dense low-density lipoprotein. Biochem Soc Trans, 31:1066–9
   PubMed Web of Science ®Google Scholar
• Rainwater DL. (2000). Lipoprotein correlates of LDL particle size. Atherosclerosis, 148:151–8
   PubMed Web of Science ®Google Scholar
• Rasouli M, Kiasari AM, Mokhberi V. (2006). The ratio of apoB/apoAI, apoB and lipoprotein(a) are the best predictors of stable coronary artery disease. Clin Chem Lab Med, 44:1015–21
   PubMed Web of Science ®Google Scholar
• Rizzo M, Barbagallo CM, Severino M, et al. (2003). Low-density-lipoprotein peak particle size in a Mediterranean population. Eur J Clin Invest, 33:126–33
   PubMed Web of Science ®Google Scholar
• Rizzo M, Berneis K. (2005). Lipid triad or atherogenic lipoprotein phenotype: a role in cardiovascular prevention. J Atheroscler Thromb, 12:237–9
   PubMed Web of Science ®Google Scholar
• Rizzo M, Berneis K. (2006). Should we measure routinely the LDL peak particle size? Int J Cardiol, 107:166–70
   PubMed Web of Science ®Google Scholar
• Rizzo M, Mikhailidis DP. (2011). There is more to predicting vascular disease than just established risk factors. Curr Pharm Des, 17:3608–10
   PubMed Web of Science ®Google Scholar
• Sniderman AD, Tremblay AJ, De Graaf J, Couture P. (2014). Calculation of LDL apoB. Atherosclerosis, 234:373–6
   PubMed Web of Science ®Google Scholar
• St-Pierre AC, Ruel IL, Cantin B, et al. (2001). Comparison of various electrophoretic characteristics of LDL particles and their relationship to the risk of ischemic heart disease. Circulation, 104:2295–9
   PubMed Web of Science ®Google Scholar
• Tani S, Saito Y, Anazawa T, et al. (2011). Low-density lipoprotein cholesterol/apolipoprotein B ratio may be a useful index that differs in statin-treated patients with and without coronary artery disease: a case control study. Int Heart J, 52:343–7
   PubMed Web of Science ®Google Scholar
• Taylan E, Tuncel EP. (2016). Distribution of LDL subgroups in patients with hyperlipidemia. Turk J Med Sci, 46:374–80
   PubMed Web of Science ®Google Scholar
• Vekic J, Zeljkovic A, Jelic-Ivanovic Z, et al. (2009). Small, dense LDL cholesterol and apolipoprotein B: relationship with serum lipids and LDL size. Atherosclerosis, 207:496–501
   PubMed Web of Science ®Google Scholar
• Wägner AM, Jorba O, Rigla M, et al. (2002). LDL-cholesterol/apolipoprotein B ratio is a good predictor of LDL phenotype B in type 2 diabetes. Acta Diabetol, 39:215–20
   PubMed Web of Science ®Google Scholar
• Walldius G. (2012). The apoB/apoA-I ratio is a strong predictor of cardiovascular risk. In: Frank S, Kostner G, ed. Lipoproteins in health and diseases. Croatia: Rijeka, InTech, 95–148
   Google Scholar
• Walldius G, Jungner I. (2004). Apolipoprotein B and apolipoprotein A-I: risk indicators of coronary heart disease and targets for lipid-modifying therapy. J Intern Med, 255:188–205
   PubMed Web of Science ®Google Scholar
• Yoshida A, Kouwaki M, Matsutani Y, et al. (2004). Usefulness of serum total cholesterol/triglyceride ratio for predicting the presence of small, dense LDL. J Atheroscler Thromb, 11:215–9
   PubMedGoogle Scholar
• Yoshino G, Hirano T, Kazumi T. (2002). Treatment of small dense LDL. J Atheroscler Thromb, 9:266–75
   PubMedGoogle Scholar