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Research Reports

Evaluation of sFLT1 protein levels in human eyes with the FLT1 rs9943922 polymorphism

, , , , , , & show all
Pages 68-72 | Received 14 Dec 2016, Accepted 13 Aug 2017, Published online: 26 Sep 2017

References

  • Friedman, D. S., et al. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol. 2004;122:564–72. doi:10.1001/archopht.122.4.564.
  • Jager RD, Mieler WF, Miller JW. Age-related macular degeneration. N Engl J Med 2008;358:2606–17. doi:10.1056/NEJMra0801537.
  • Whitmore, S. S., et al. Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy. Prog Retin Eye Res. 2015;45:1–29. doi:10.1016/j.preteyeres.2014.11.005.
  • Ferris FL, Fine SL, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol 1984;102:1640–42. doi:10.1001/archopht.1984.01040031330019.
  • Bora NS, Matta B, Lyzogubov VV, Bora PS. Relationship between the complement system, risk factors and prediction models in age-related macular degeneration. Mol Immunol 2015;63:176–83. doi:10.1016/j.molimm.2014.07.012.
  • Chirco KR, Sohn EH, Stone EM, Tucker BA, Mullins RF. Structural and molecular changes in the aging choroid: implications for age-related macular degeneration. Eye 2016. doi:10.1038/eye.2016.216.
  • Salminen A, Kauppinen A, Hyttinen JM, Toropainen E, Kaarniranta K. Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization. Mol Med 2010;16:535–42. doi:10.2119/molmed.2010.00070.
  • Klettner, A., et al. Cellular and molecular mechanisms of age-related macular degeneration: from impaired autophagy to neovascularization. Int J Biochem Cell Biol. 2013;45:1457–67. doi:10.1016/j.biocel.2013.04.013.
  • Grossniklaus, H. E., et al. Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization. Mol Vis 2002;8:119–26.
  • Xu, J., et al. Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration. Faseb J. 2011;25:2221–33. doi:10.1096/fj.10-178350.
  • Ecker SM, Pfahler SM, Hines JC, Lovelace AS, Glaser BM. Sequential in-office vitreous aspirates demonstrate vitreous matrix metalloproteinase 9 levels correlate with the amount of subretinal fluid in eyes with wet age-related macular degeneration. Mol Vis 2012;18:1658–67.
  • Nita M, Strzałka-Mrozik B, Grzybowski A, Mazurek U, Romaniuk W. Age-related macular degeneration and changes in the extracellular matrix. Med Sci Monit 2014;20:1003–16. doi:10.12659/MSM.889887.
  • Ferrara N. Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy. Nat Med 2010;16:1107–11. doi:10.1038/nm1010-1107.
  • Bakall, B., et al. Aflibercept therapy for exudative age-related macular degeneration resistant to bevacizumab and ranibizumab. Am J Ophthalmol. 2013;156:15–22.e1. doi:10.1016/j.ajo.2013.02.017.
  • Bressler, N. M., et al. Estimated cases of legal blindness and visual impairment avoided using ranibizumab for choroidal neovascularization: non-Hispanic white population in the United States with age-related macular degeneration. Arch Ophthalmol. 2011;129:709–17. doi:10.1001/archophthalmol.2011.140.
  • Brown, D. M., et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1432–44. doi:10.1056/NEJMoa062655.
  • Folk JC, Stone EM. Ranibizumab therapy for neovascular age-related macular degeneration. N Engl J Med 2010;363:1648–55. doi:10.1056/NEJMct1000495.
  • Heier, J. S., et al. Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology. 2012;119:2537–48. doi:10.1016/j.ophtha.2012.09.006.
  • Young, M., et al. Exacerbation of choroidal and retinal pigment epithelial atrophy after anti-vascular endothelial growth factor treatment in neovascular age-related macular degeneration. Retina. 2014;34:1308–15. doi:10.1097/IAE.0000000000000081.
  • Leonard, F., et al. Adenosine modifies the balance between membrane and soluble forms of Flt-1. J Leukoc Biol. 2011;90:199–204. doi:10.1189/jlb.0910505.
  • Luo, L., et al. Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. Elife. 2013;2:e00324. doi:10.7554/eLife.00324.
  • Owen, L. A., et al. FLT1 genetic variation predisposes to neovascular AMD in ethnically diverse populations and alters systemic FLT1 expression. Invest Ophthalmol Vis Sci. 2014;55:3543–54. doi:10.1167/iovs.14-14047.
  • Uehara, H., et al. The reduction of serum soluble Flt-1 in patients with neovascular age-related macular degeneration. Am J Ophthalmol. 2015;159:92–100.e1–2. doi:10.1016/j.ajo.2014.09.036.
  • Mullins, R. F., et al. Elevated membrane attack complex in human choroid with high risk complement factor H genotypes. Exp Eye Res. 2011;93:565–67. doi:10.1016/j.exer.2011.06.015.
  • Fritsche, L. G., et al. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet. 2016;48:134–43. doi:10.1038/ng.3448.
  • Grassmann, F., et al. Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration. PLoS ONE. 2015;10:e0126636. doi:10.1371/journal.pone.0126636.
  • Yang, Z., et al. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science. 2006;314:992–93. doi:10.1126/science.1133811.

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