722
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Activity of Schisandrin C Isolated from Schisandra chinensis against Human Cancer Cell Lines

, , &
Pages 906-913 | Accepted 09 May 2008, Published online: 20 Jan 2009

References

  • KA Chinkwo. (2005). Sutherlandia frutescens extracts can induce apoptosis in cultured carcinoma cells. J Ethnopharmacol 98:163–170.
  • PY Chiu, DHF Mak, MKT Poon, and KM Ko. (2005). Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver. Life Sci 77:2887–2895.
  • PY Chiu, MH Tang, DHF Mak, MKT Poon, and KM Ko. (2003). Hepatoprotective mechanism of schisandrin B: Role of mitochondrial glutathione antioxidant status and heat shock proteins. Free Radical Bio Med 35:368–380.
  • JL Hancke, RA Burgos, and F Ahumada. (1999). Schisandra chinensis (Turcz.) Baill. Fitoterapia 70:451–471.
  • XG He, LZ Lian, and LZ Lin. (1997). Analysis of lignan constituents from Schisandra chinensis by liquid chromatography-electrospray mass spectrometry. J Chromatogr A 757:81–87.
  • H Hikino, Y Kiso, H Taguchi, and Y Ikeya. (1984). Antihepatotoxic actions of lignoids from Schizandra chinensis fruits. Planta Med 50:213–218.
  • SP Ip, and KM Ko. (1996). The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: A comparative study with butylated hydroxytoluene. Biochem Pharmacol 52:1687–1693.
  • SP Ip, CY Ma, CT Che, and KM Ko. (1997). Methylenedioxy group as determinant of schisandrin in enhancing hepatic mitochondrial glutathione in carbon tetrachloride-intoxicated mice. Biochem Pharmacol 54:317–319.
  • SP Ip, MKT Poon, SS Wu, CT Che, KH Ng, YC Kong, and KM Ko. (1995). Effect of schisandrin B on hepatic glutathione antioxidant system in mice: Protection against carbon tetrachloride toxicity. Planta Med 61:398–401.
  • SP Ip, HY Yiu, and KM Ko. (2000). Differential effect of schisandrin B and dimethyl diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated mice. Mol Cell Biochem 205:111–114.
  • DH Kim, TM Hung, KH Bae, JW Jung, S Lee, BH Yoon, JH Cheong, KH Ko, and JH Ryu. (2006). Gomisin A improves scopolamine-induced memory impairment in mice. Eur J Pharmacol 542:129–135.
  • SR Kim, MK Lee, KA Koo, SH Kim, SH Sung, NG Lee, GJ Markelonis, TH Oh, JH Yang, and YC Kim. (2004). Dibenzocyclooctadiene lignans from Schizandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity. J Neurosci Res 76:397–405.
  • Y Kiso, M Tohkin, H Hikino, Y Ikeya, and H Taguchi. (1985). Mechanism of antihepatotoxic activity of wuweizisu C and gomisin A. Planta Med 51:331–334.
  • G Kroemer, and SJ Martin. (2005). Caspase-independent cell death. Nature Med 11:725–730.
  • EJ Lee, HY Min, HJ Park, HJ Chung, S Kim, YN Han, and SK Lee. (2004). G2/M cell cycle arrest and induction of apoptosis of by a stilbenoid, 3,4,5-trimethoxy-4′-bromo-cis-stilbene, in human lung cancer cells. Life Sci 75:2829–2839.
  • IS Lee, HK Lee, NT Dat, MS Lee, JW Kim, DS Na, and YH Kim. (2003). Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis. Planta Med 69:63–64.
  • L Li, Q Lu, and X Hu. (2006). Schisandrin B enhances doxorubicin-induced apoptosis of cancer cells but not normal cells. Biochem Pharmacol 71:584–595.
  • L Li, QR Pan, M Sun, QH Lu, and X Hu. (2007). Dibenzocyclooctadiene lignans—A class of novel inhibitors of multidrugresistance-associated protein 1. Life Sci 80:741–748.
  • KT Liu, and P Lesca. (1982). Pharmacological properties of dibenzo[a c]cyclooctene derivatives isolated from Fructus Schizandrae chinensis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachloride to lipids. Chem-Biol Interact 41:39–47.
  • YB Liu. (1999). Understanding the biological activity of amyloid proteins in vitro: From inhibited cellular MTT reduction to altered cellular cholesterol homeostatis. Prog Neuro-Psycho 23:377–395.
  • H Lu, and GT Liu. (1991). Effect of dibenzo[ac]cyclooctene lignans isolated from Fructus schizandrae on lipid peroxidation and antioxidative enzyme activity. Chem-Biol Interact 78:77–84.
  • DHF Mak, and KM Ko. (1997). Alterations in susceptibility to carbon tetrachloride toxicity and hepatic antioxidant/detoxification system in streptozotocin-induced short-term diabetic rats: Effects of insulin and schisandrin B treatment. Mol Cell Biochem 175:225–232.
  • T Mosmann. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55–63.
  • Pharmacopoeia Commission of PRC (2005): Pharmacopoeia of the People's Republic of China Version 2005, Vol. 1. Beijing, Chemical Industry Press.
  • Q Pan, Q Lu, K Zhang, and X Hu. (2006). Dibenzocyclooctadiene lignans-A class of novel inhibitors of P-glycoproteins. Cancer Chemoth Pharm 58:99–106.
  • QR Pan, T Wang, and X Hu. (2005). Schisandrin B-a novel inhibitor of pglycoprotein. Biochem Bioph Res Co 335:406–411.
  • M Sun, XL Xu, Q Lu, Q Pan, and X Hu. (2007). Schisandrin B-A dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1. Cancer Lett 246:300–307.
  • CK Wan, GY Zhu, XL Shen, A Chattopadhyay, S Dey, and WF Fong. (2006). Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells. Biochem Pharmacol 72:824–837.
  • YF Wu, MF Cao, YP Gao, F Chen, T Wang, EP Zumbika, and KX Qian. (2004). Down-modulation of heat shock protein 70 and up-modulation of caspase-3 during schisandrin B-induced apoptosis in human hepatoma SMMC-7721 cells. World J Gastroenterol 10:2944–2948.
  • CL Ye, JW Liu, DZ Wei, YH Lu, and F Qian. (2004). In vitro anti-tumor activity of 2′,4′ -dihydroxy-6′ -methoxy-3′,5′ -dimethylchalcone against six established human cancer cell lines. Pharmacol Res 50:505–510.
  • TK Yim, and KM Ko. (1999). Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats. Biochem Pharmacol 57:77–81.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.