Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

References

• Ashraf MJ, Baweja P. 2013. Obesity: the ‘huge' problem in cardiovascular diseases. Missouri Medicine. 110:499–504.
   PubMedGoogle Scholar
• Bae J, Lee D, Yun KK, Gil M, Lee JY, Lee KJ. 2013. Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1. Mol Cells. 35:151–157.
   PubMed Web of Science ®Google Scholar
• Bao M, Cao Z, Yu D, Fu S, Zhang G, Yang P, Pan Y, Yang B, Han H, Zhou Q. 2012. Columbamine suppresses the proliferation and neovascularization of metastatic osteosarcoma U2OS cells with low cytotoxicity. Toxicol Lett. 215:174–180.
   PubMed Web of Science ®Google Scholar
• Bao TD, L YJ, Yang Q, Weng XG, Zhang YF, Dong Y, Wang YW, Zhu XX. 2010. LC/MS determination of berberine and palmatin in rats plasma after oral administration of extracts Rhizoma Coptidis and its pharmacokinetics study. Chin J Exp Trad Med Formul. 16:186–189.
   Google Scholar
• Bilian X, Daohua X, Wenshuang C. 2011. Effects of berberine on cancellous and cortical bone in rats induced by glucocorticoid. Chin Pharm Bull. 27:965–970.
   Google Scholar
• Bing L, Wang G, Jie Y, Pan X, Yang Z, Zang L. 2011. Berberine inhibits human hepatoma cell invasion without cytotoxicity in healthy hepatocytes. PLoS One. 6:e21416.
   PubMed Web of Science ®Google Scholar
• Boberek JM, Stach J, Good L. 2010. Genetic evidence for inhibition of bacterial division protein FtsZ by berberine. PLoS One. 5:e13745.
   PubMed Web of Science ®Google Scholar
• Cai Y, Xia Q, Luo R, Huang P, Sun Y, Shi Y, Jiang W. 2014. Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo. J Nat Med. 68:53–62.
   PubMed Web of Science ®Google Scholar
• Caliceti C, Rizzo P, Cicero AFG. 2015. Potential benefits of berberine in the management of perimenopausal syndrome. Oxid Med Cell Longev. 2015:1–9.
   Web of Science ®Google Scholar
• Calo L, Dong Y, Kumar R, Przyklenk K, Sanderson TH. 2013. Mitochondrial dynamics: An emerging paradigm in ischemia-reperfusion injury. Curr Pharm Des. 19:6848–6857.
   PubMed Web of Science ®Google Scholar
• Cao Y, Pan Q, Cai W, Shen F, Chen GY, Xu LM, Fan JG. 2016. Modulation of gut microbiota by berberine improves steatohepatitis in high-fat diet-fed BALB/C mice. Arch Iran Med. 19:197–203.
   PubMed Web of Science ®Google Scholar
• Cao Q, Hong S, Li Y, Chen H, Shen Y, Shao K, Lu M, Dai H, Ma S, Dai G. 2018. Coptisine suppresses tumor growth and progression by down-regulating MFG-E8 in colorectal cancer. RSC Adv. 8:30937–30945.
   PubMed Web of Science ®Google Scholar
• Chai FN, Ma WY, Zhang J, Xu HS, Li YF, Zhou QD, Li XG, Ye XL. 2018. Coptisine from Rhizoma Coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122. Biomed Pharm. 103:1002–1011.
   PubMed Web of Science ®Google Scholar
• Chakravarthy D, Muñoz AR, Su A, Hwang RF, Keppler BR, Chan DE, Halff G, Ghosh R, Kumar AP. 2018. Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1. Cancer Lett. 419:103–115.
   PubMed Web of Science ®Google Scholar
• Chang W, Li K, Guan F, Yao F, Yu Y, Zhang M, Hatch GM, Chen L. 2016. Berberine pretreatment confers cardioprotection against ischemia-reperfusion injury in a rat model of type 2 diabetes. J Cardiovasc Pharmacol Ther. 21:486–494.
   PubMed Web of Science ®Google Scholar
• Chang CH, Yu B, Su CH, Chen DS, Hou YC, Chen YS, Hsu YM. 2014. Coptidis rhizome and Si Jun Zi Tang can prevent Salmonella enterica Serovar Typhimurium infection in mice. PLoS One. 9:e105362.
   PubMed Web of Science ®Google Scholar
• Chen Z. 2006. Collation of complete effective preions for women’s diseases. Beijing: People's Medical Publishing House
   Google Scholar
• Chen J, Wang F, Liu J, Lee SC, Wang X, Yang H. 2008. Analysis of alkaloids in Coptis chinensis Franch. by accelerated solvent extraction combined with ultra-performance liquid chromatographic analysis with photodiode array and tandem mass spectrometry detections. Anal Chim Acta. 613:184–195.
   PubMed Web of Science ®Google Scholar
• Chen L, Wang L, Zhang Q, Zhang S, Ye W. 2012. Non-alkaloid chemical constituents from Coptis chinensis. Chin J Chin Mater Med. 37:1241–1244.
   Google Scholar
• Chen R, Wu Y, Tian W. 2016. Research progress in chemical constituents and related metabolic pathways of Coptidis Rhizoma. Hunan J Trad Chin Med. 32:190–192.
   Google Scholar
• Chen HY, Ye XL, Cui XL, He K, Jin YN, Chen Z, Li XG. 2012. Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells. Fitoterapia. 83:67–73.
   PubMed Web of Science ®Google Scholar
• Chen C, Zhang Y, Huang C. 2010. Berberine inhibits PTP1B activity and mimics insulin action. Biochem Biophy Res Commun. 397:543–547.
   PubMed Web of Science ®Google Scholar
• Chi L, Peng L, Pan N, Hu X, Zhang Y. 2014. The anti-atherogenic effects of berberine on foam cell formation are mediated through the upregulation of sirtuin 1. Int J Mol Med. 34:1087–1093.
   PubMed Web of Science ®Google Scholar
• Chidambara Murthy KN, Jayaprakasha GK, Patil BS. 2012. The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells. Eur J Pharmacol. 688:14–21.
   PubMed Web of Science ®Google Scholar
• Chinese Pharmacopoeia Commission. 2008. Xin yao zhuan zheng biao zhun. Vol. 70. Beijing: China Medical Science Press.
   Google Scholar
• Chinese Pharmacopoeia Commission. 2015. Chinese pharmacopoeia. Vol. 1. Beijing: Medical Science Press.
   Google Scholar
• Cho JY, Kim AR, Park MH. 2001. Lignans from the rhizomes of Coptis japonica differentially act as anti-inflammatory principles. Planta Med. 67:312–316.
   PubMed Web of Science ®Google Scholar
• Choi JS, Kim JH, Ali MY, Jung HJ, Min BS, Choi RJ, Kim GD, Jung HA. 2015. Anti-adipogenic effect of epiberberine is mediated by regulation of the RAF/MEK1/2/ERK1/2 and AMPKα/AKT pathways. Arch Pharm Res. 38:2153–2162.
   PubMed Web of Science ®Google Scholar
• Choi JS, Kim JH, Ali MY, Min BS, Kim GD, Jung HA. 2014. Coptis chinensis alkaloids exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBP-α and PPAR-γ. Fitoterapia. 98:199–208.
   PubMed Web of Science ®Google Scholar
• Choi UK, Kim MH, Lee NH. 2007. Optimization of antibacterial activity by gold-thread (Coptidis Rhizoma Franch) against streptococcus mutans using evolutionary operation-factorial design technique. J Microbiol Biotechnol. 17:1880–1884.
   PubMed Web of Science ®Google Scholar
• Chu M, Ding R, Chu ZY, Zhang MB, Liu XY, Xie SH, Zhai YJ, Wang YD. 2014. Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor. BMC Complement Altern Med. 14:89–97.
   PubMed Web of Science ®Google Scholar
• Chuanchong X. 2016. Berberine inhibits macrophages inflammatory depending on sirti [Master’s thesis]. Nanjing: Nanjing University of Chinese Medicine.
   Google Scholar
• Chueh WH, Lin JY. 2011. Berberine, an isoquinoline alkaloid in herbal plants, protects pancreatic islets and serum lipids in nonobese diabetic mice. J Agri Food Chem. 59:8021–8027.
   PubMed Web of Science ®Google Scholar
• Chueh WH, Lin JY. 2012. Berberine, an isoquinoline alkaloid, inhibits streptozotocin-induced apoptosis in mouse pancreatic islets through down-regulating Bax/Bcl-2 gene expression ratio. Food Chem. 132:252–260.
   PubMed Web of Science ®Google Scholar
• Cok A, Plaisier C, Salie MJ, Oram DS, Chenge J, Louters LL. 2011. Berberine acutely activates the glucose transport activity of GLUT1. Biochimie. 93:1187–1192.
   PubMed Web of Science ®Google Scholar
• Cooper SF, Mockle JA, Beliveau J. 1970. Alkaloids of Coptis groenlandica. Planta Med. 19:23–29.
   PubMed Web of Science ®Google Scholar
• Cui G, Huang X, Zhou K. 2008. Inhibitory effect of Rhizoma Coptidis and its main components berberine on the growth of human nasopharyngeal carcinoma CNE-2Z. Guangdong Med J. 29:737–739.
   Google Scholar
• Cui L, Liu M, Chang X, Sun K. 2016. The inhibiting effect of the Coptis chinensis polysaccharide on the type II diabetic mice. Biomed Pharmacother. 81:111–119.
   PubMed Web of Science ®Google Scholar
• Dan L, Guangshang C, Xixi S, Qianqian C, Hongsheng S. 2017. An overview of the antiarrhythmic study of alkaloids in Coptidis Rhizoma. Shandong J Trad Chin Med. 2017:164–166.
   Google Scholar
• Dhamgaye S, Devaux F, Vandeputte P, Khandelwal NK, Sanglard D, Mukhopadhyay G, Prasad R. 2014. Molecular mechanisms of action of herbal antifungal alkaloid berberine, in Candida albicans. PLoS One. 9:e104554.
   PubMed Web of Science ®Google Scholar
• Dong J. 2003. Lv she bei yao fang. Shanghai: Shanghai science and technology publishing house.
   Google Scholar
• Durairajan SSK, Liu LF, Lu JH, Chen LL, Yuan Q, Chung SK, Huang L, Li XS, Huang JD, Li M. 2012. Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model. Neurobiol Aging. 33:2903–2919.
   PubMed Web of Science ®Google Scholar
• Fan G, Tang C, Yan L, Yang YD, Zhang Y. 2014. Analysis of monosaccharide compositions of polysaccharides in Coptidis Rhizoma by pre-column derivatization HPLC method. Chin J Exp Trad Med Formul. 20:74–78.
   Google Scholar
• Fan DL, Xiao XH, Ma XJ. 2008. Calorimetric study of the effect of protoberberine alkaloids in Coptis chinensis Franch on Staphylococcus aureus growth. Thermochim Acta. 480:49–52.
   Web of Science ®Google Scholar
• Feng J. 2008. Clinical control study and propranolol in the treatment of arrhythmia associated with large doses of berberine and oryzanol and coenzyme Q10. Asia Pac Trad Med. 4:51–53.
   Google Scholar
• Feng M, Kong SZ, Wang ZX, He K, Zou ZY, Hu YR, Ma H, Li XG, Ye XL. 2017. The protective effect of coptisine on experimental atherosclerosis Apoe(-/-) mice is mediated by MAPK/NF-κB-dependent pathway. Biomed Pharmacother. 93:721–729.
   PubMed Web of Science ®Google Scholar
• Feng X, Yan D, Zhao KJ, Luo JY, Ren YS, Kong WJ, Han YM, Xiao XH. 2011. Applications of microcalorimetry in the antibacterial activity evaluation of various Rhizoma Coptidis. Pharmac Biol. 49:348–353.
   PubMed Web of Science ®Google Scholar
• Feng M, Zou Z, Zhou X, Hu Y, Ma H, Xiao Y, Li X, Ye X. 2017. Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE-/- mice. Int Immunopharmacol. 43:195–202.
   PubMed Web of Science ®Google Scholar
• Feng L, Hao Z, Hua H. 2007. The protective effect of coptisine on gastric mucosal injury induced by irritable mice. West Chin J Pharm Sci. 22:713–714.
   Google Scholar
• Flora of China Committee of Chinese Academy of Sciences. 2004. Flora of China. Vol. 27. Beijing: Science Press; p. 593.
   Google Scholar
• Friedemann T, Schumacher U, Tao Y, Leung KM, Schröder S. 2015. Neuroprotective activity of coptisine from Coptis chinensis (Franch). Evid Based Complement Alternat Med. 2015:827308–827316.
   PubMed Web of Science ®Google Scholar
• Friedemann T, Ying Y, Wang W, Kramer ER, Schumacher U, Fei J, Schröder S. 2016. Neuroprotective effect of Coptis chinensis in MPP+ and MPTP-Induced Parkinson's Disease Models. Am J Chinese Med. 44:907–925.
   PubMed Web of Science ®Google Scholar
• Fujiwara H, Nonaka G, Yagi A, Nishioka I. 1976. Studies on the components of the leaves of Coptis japonica Makino. I. The structures of coptiside I and II. Chem Pharm Bull. 24:407–413.
   PubMed Web of Science ®Google Scholar
• Gong Z, Chen Y, Zhang R, Wang Y, Guo Y, Yang Q, Zhang H, Dong Y, Weng X, Gao S, et al. 2014. Pharmacokinetic comparison of berberine in rat plasma after oral administration of berberine hydrochloride in normal and post inflammation irritable bowel syndrome rats. Int J Mol Sci. 15:456–467.
   PubMed Web of Science ®Google Scholar
• Gu N, Zhang X, Yu H. 2017. Based on sequencing of 16s rRNA gene elaborate effect of Coptis chinensis on intestinal microbial diversity in type 2 diabetes mellitus. Chin Trad Herbal Drugs. 48:3998–4004.
   Google Scholar
• Guo T, Shih-Lung W, Guo X, Li H, Zheng J, Rachel B, Liu M, Pei Y, Xu H, Cai Y. 2016. Berberine ameliorates hepatic steatosis and suppresses liver and adipose tissue inflammation in mice with diet-induced obesity. Sci Rep. 6:22612–22620.
   PubMed Web of Science ®Google Scholar
• Guo J, Wang SB, Yuan TY, Wu YJ, Yan Y, Li L, Xu XN, Gong LL, Qin HL, Fang LH. 2013. Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. Atherosclerosis. 231:384–391.
   PubMed Web of Science ®Google Scholar
• Guo. 2002. Guo jia zhong cheng yao biao zhun. Beijing: The State Drug Administration.
   Google Scholar
• Hamsa TP, Kuttan G. 2012. Antiangiogenic activity of berberine is mediated through the downregulation of hypoxia-inducible factor-1, VEGF, and proinflammatory mediators. Drug Chem Toxicol. 35:57–70.
   PubMed Web of Science ®Google Scholar
• Han B, Kou S, He K, Han Y, Wang Y, Huang T, Zhou X, Xiao Y, Ye X, Li X. 2017. Anti-hypercholesterolemic effect of berbamine isolated from Rhizoma Coptidis in hypercholesterolemic zebrafish induced by high-cholesterol diet. Iran J Pharm Res. 17:292–306.
   Web of Science ®Google Scholar
• Hayashi K, Minoda K, Nagaoka Y, Hayashi T, Uesato S. 2007. Antiviral activity of berberine and related compounds against human cytomegalovirus. Bioorganic Med Chem Lett. 17:1562–1564.
   PubMed Web of Science ®Google Scholar
• He K, Kou SM, Zou ZY, Hu YR, Feng M, Han B, Li XG, Ye XL. 2016. Hypolipidemic effects of alkaloids from Rhizoma Coptidis in diet-induced hyperlipidemic hamsters. Planta Med. 82:690–697.
   PubMed Web of Science ®Google Scholar
• He K, Ma H, Xu HS, Zou ZY, Feng M, Li X, Ye XL. 2017. Anti-hyperlipidemic effects of Rhizoma Coptidis alkaloids are achieved through modulation of the enterohepatic circulation of bile acid and cross-talk between the gut microbiota and the liver. J Funct Foods. 35:205–215.
   Web of Science ®Google Scholar
• Hirano H, Tokuhira T, Yokoi T, Shingu T. 1997. Isolation of free radical scavenger from Coptidis Rhizoma. Nat Med. 51:539–540.
   Google Scholar
• Ho CE, Goh YL, Zhang C. 2014. From prejudice to evidence: the case of Rhizoma Coptidis in Singapore. Evid Based Complement Alternat Med. 2014:871720.
   PubMed Web of Science ®Google Scholar
• Ho YT, Yang JS, Li TC, Lin JJ, Lin JG, Lai KC, Ma CY, Wood WG, Chung JG. 2009. Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, U-PA and MMP-2 and -9. Cancer Lett. 279:155–162.
   PubMed Web of Science ®Google Scholar
• Hsu WH, Hsieh YS, Kuo HC, Teng CY, Huang H, Wang CJ, Yang SF, Liou YS, Kuo WH. 2007. Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and Fasl. Arch Toxicol. 81:719–728.
   PubMed Web of Science ®Google Scholar
• Hsu YY, Tseng YT, Lo YC. 2013. Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth. Toxicol Appl Pharmacol. 272:719–728.
   Web of Science ®Google Scholar
• Huang Q. 2013. Effect of blood glucose on the expression of GLUT1 and GLUT4 in the myocardial of diabetic rats [Master's thesis]. Jinan: Shandong University.
   Google Scholar
• Huang Z, Han Z, Ye B, Dai Z, Shan P, Lu Z, Dai K, Wang C, Huang W. 2015. Berberine alleviates cardiac ischemia/reperfusion injury by inhibiting excessive autophagy in cardiomyocytes. Eur J Pharmacol. 762:1–10.
   PubMed Web of Science ®Google Scholar
• Huang Z, Wang L, Meng S, Wang Y, Chen T, Wang C. 2011. Berberine reduces both MMP-9 and emmprin expression through prevention of p38 pathway activation in PMA-induced macrophages. Int J Cardiol. 146:153–158.
   PubMed Web of Science ®Google Scholar
• Huang T, Xiao Y, Yi L, Li L, Wang M, Tian C, Ma H, He K, Wang Y, Han B, et al. 2017. Coptisine from Rhizoma Coptidis suppresses HCT-116 cells-related tumor growth in vitro and in vivo. Sci Rep. 7:38524–38534.
   PubMed Web of Science ®Google Scholar
• Hung TM, Na M, Min BS, Zhang X, Lee I, Ngoc TM, Thuong PT, Sok DE, Bae K. 2007. Protective effect of magnoflorine isolated from Coptidis Rhizoma on Cu2+-induced oxidation of human low density lipoprotein. Planta Med. 73:1281–1284.
   PubMed Web of Science ®Google Scholar
• Iii APO, Byrnes JR, Mackman N. 2014. Hyperlipidemia, tissue factor, coagulation, and simvastatin. Trends Cardiovasc Med. 24:95–98.
   PubMed Web of Science ®Google Scholar
• Iizuka N, Miyamoto K, Hazama S, Yoshino S, Yoshimura K, Okita K, Fukumoto T, Yamamoto S, Tangoku A, Oka M. 2000. Anticachectic effects of Coptidis Rhizoma, an anti-inflammatory herb, on esophageal cancer cells that produce Interleukin 6. Cancer Lett. 158:35–41.
   PubMed Web of Science ®Google Scholar
• Ikuta A, Itokawa H. 1989. Protoberberine alkaloids from Coptis quinquefolia. Plant Med. 43:81–82.
   Google Scholar
• Iwazaki RS, Endo EH, Ueda-Nakamura T, Nakamura CV, Garcia LB, Filho BPD. 2010. In vitro antifungal activity of the berberine and its synergism with fluconazole. Antonie Van Leeuwenhoek. 97:201–205.
   PubMed Web of Science ®Google Scholar
• Jeong HW, Hsu KC, Lee JW, Ham M, Huh JY, Shin HJ, Kim WS, Kim JB. 2009. Berberine suppresses proinflammatory responses through AMPK activation in macrophages. Am J Physiol Endocrinol Metab. 296:E955–E964.
   PubMed Web of Science ®Google Scholar
• Jia Z, Lin L, Huang S, Zhu Z, Huang W, Huang Z. 2017. Inhibition of autophagy by berberine enhances the survival of H9C2 myocytes following hypoxia. Mol Med Rep. 16:1677–1684.
   PubMed Web of Science ®Google Scholar
• Jia F, Zou G, Fan J, Yuan Z. 2010. Identification of palmatine as an inhibitor of West Nile Virus. Arch Virol. 155:1325–1329.
   PubMed Web of Science ®Google Scholar
• Jiang YY, Cui HM, Wang JL, Liu H, Dang MM, Zhang QY, Yang F, Kou JT, Tong XL. 2017. Protective role of berberine and Coptis chinensis extract on T2MD rats and associated islet Rin-5f cells. Mol Med Rep. 16:6981–6991.
   PubMed Web of Science ®Google Scholar
• Jiang S, Wang Y, Ren D, Li J, Yuan G, An L, Du P, Ma J. 2015. Antidiabetic mechanism of coptis chinensis polysaccharide through its antioxidant property involving the JNK pathway. Pharmaceutical Biol. 53:1022–1029.
   PubMed Web of Science ®Google Scholar
• Jie S, Li H, Tian Y, Guo D, Zhu J, Gao S, Jiang L. 2011. Berberine inhibits angiogenic potential of Hep G2 cell line through VEGF down-regulation in vitro. J Gastroenterol Hepatol. 26:179–185.
   PubMed Web of Science ®Google Scholar
• Jin H, Jin X, Cao B, Wang W. 2016. Berberine affects osteosarcoma via downregulating the caspase-1/IL-1β signaling axis. Oncol Rep. 37:729–736.
   PubMed Web of Science ®Google Scholar
• Kai H. 2017. Rhizoma Coptidis alkaloids exert their anti-hyperlipidemic effects through modulation of bile acids signaling and gut microbiota in hyperlipidemia C57BL/6J mice [Dissertation]. Chongqing: Southwest University.
   Google Scholar
• Kai H, Hu Y, Hang M, Zou Z, Xiao Y, Yong Y, Min F, Li X, Ye X. 2016. Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways. Biochim Biophys Acta. 1862:1696–1709.
   PubMed Web of Science ®Google Scholar
• Kang JX, Liu J, Wang J, He C, Li FP. 2005. The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cells. Carcinogenesis. 26:1934–1939.
   PubMed Web of Science ®Google Scholar
• Kang S, Li Z, Yin Z, Jia R, Song X, Li L, Chen Z, Peng L, Qu J, Hu Z, et al. 2015. The antibacterial mechanism of berberine against Actinobacillus Pleuropneumoniae. Nat Prod Res. 29:2203–2206.
   PubMed Web of Science ®Google Scholar
• Kaufmann D, Kaur DA, Tahrani A, Herrmann F, Wink M. 2016. Extracts from traditional Chinese medicinal plants inhibit acetylcholinesterase, a known Alzheimer's disease target. Molecules. 21:1161–1176.
   Web of Science ®Google Scholar
• Ke W. 2007. Study on the effect of Rhizoma Coptidis alkaloids on colon cancer and its molecular mechanism [Master's thesis]. Chongqing: ChongQing Medical University.
   Google Scholar
• Kim HY, Shin HS, Park H, Kim YC, Yun YG, Park S, Shin HJ, Kim K. 2008. In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga Rhizoma, Meliae Cortex, Coptidis Rhizoma, and Phellodendron Cortex. J Clin Virol. 41:122.
   PubMed Web of Science ®Google Scholar
• Kim YM, Ha YM, Jin YC, Shi LY, Lee YS, Kim HJ, Seo HG, Choi JS, Kim YS, Kang SS, et al. 2009. Palmatine from Coptidis Rhizoma reduces ischemia-reperfusion-mediated acute myocardial injury in the rat. Food Chem Toxicol. 47:2097–2102.
   PubMed Web of Science ®Google Scholar
• Kim S, Han J, Kim NY, Lee SK, Cho DH, Choi MY, Kim JS, Kim JH, Choe JH, Nam SJ, et al. 2012. Effect of berberine on p53 expression by TPA in breast cancer cells. Oncol Rep. 27:210–215.
   PubMed Web of Science ®Google Scholar
• Kim S, Oh SJ, Lee J, Han J, Jeon M, Jung T, Lee SK, Bae SY, Kim J, Gil WH, et al. 2013. Berberine suppresses TPA-induced fibronectin expression through the inhibition of VEGF secretion in breast cancer cells. Cell Physiol Biochem. 32:1541–1550.
   PubMed Web of Science ®Google Scholar
• Kim JS, Oh D, Yim MJ, Park JJ, Kang KR, Cho IA, Moon SM, Oh JS, You JS, Kim CS, et al. 2015. Berberine induces Fasl-related apoptosis through p38 activation in KB human oral cancer cells. Oncol Rep. 33:1775–1782.
   PubMed Web of Science ®Google Scholar
• Kim SH, Shin EJ, Kim ED, Bayaraa T, Frost SC, Hyun CK. 2007. Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytes. Biol Pharma Bull. 30:2120–2125.
   PubMed Web of Science ®Google Scholar
• Kong W, Li Z, Xiao X, Zhao Y, Zhang P. 2010. Activity of berberine on Shigella Dysenteriae investigated by microcalorimetry and multivariate analysis. J Therm Anal Calorim. 102:331–336.
   Web of Science ®Google Scholar
• Kong D, Lu L, Teng S, Sun T, Deng Z, Li Y. 2013. Research on export current situation and countermeasure of Coptis chinensis from Shizhu county. Morder Chin Med. 15:701–703.
   Google Scholar
• Kong W, Zhao Y, Xiao X, Cheng J, Liu Y, Li Z. 2009. Comparison of anti-bacterial activity of four kinds of alkaloids in Rhizoma Coptidis based on microcalorimetry. Chinese J Chem. 27:1186–1190.
   Web of Science ®Google Scholar
• Kong WJ, Zhang H, Song DQ, Xue R, Zhao W, Wei J, Wang YM, Shan N, Zhou ZX, Yang P, et al. 2009. Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression. Metab Clin Exp. 58:109–119.
   PubMed Web of Science ®Google Scholar
• Kou S, Bing H, Yue W, Tao H, Kai H, Han Y, Xia Z, Ye X, Li X. 2016. Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters. Life Sci. 151:50–60.
   PubMed Web of Science ®Google Scholar
• Kou Y, Li L, Li H, Tan Y, Li B, Wang K, Du B. 2016. Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3k/AKT and RARα/RARβ in melanoma cells. Biochem Biophys Res Commun. 479:290–296.
   PubMed Web of Science ®Google Scholar
• Kuo HP, Chuang TC, Tsai SC, Tseng HH, Hsu SC, Chen YC, Kuo CL, Kuo YH, Liu JY, Kao MC. 2012. Berberine, an isoquinoline alkaloid, inhibits the metastatic potential of breast cancer cells via AKT pathway modulation. J Agric Food Chem. 60:9649–9658.
   PubMed Web of Science ®Google Scholar
• La X, Zhang L, Li Z, Peng Y, Wang Y. 2017. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells. Oncotarget. 8:20909–20924.
   PubMedGoogle Scholar
• Lao-Ong T, Chatuphonprasert W, Nemoto N, Jarukamjorn K. 2012. Alteration of hepatic glutathione peroxidase and superoxide dismutase expression in streptozotocin-induced diabetic mice by berberine. Pharm Biol. 50:1007–1012.
   PubMed Web of Science ®Google Scholar
• Lee WC, Kim JK, Kang JW, Oh WY, Jung JY, Kim YS, Jung HA, Choi JS, Lee SM. 2010. Palmatine attenuates d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice. Food Chem Toxicol. 48:222–228.
   PubMed Web of Science ®Google Scholar
• Lee YH, Kim D, Lee MJ, Kim MJ, Jang HS, Park SH, Lee JM, Lee HY, Han BS, Son WC. 2014. Subchronic toxicity study of Coptidis Rhizoma in rats. J Ethnopharmacol. 152:457–463.
   PubMed Web of Science ®Google Scholar
• Lei X. 1985. Master lei's discourse on drug processing. Jinan: Phoenix Science Press.
   Google Scholar
• Lei G, Dun B. 2002. Technical guide for the processing of traditional Chinese Medicine. Xi'an: World Book Publishing Xi'an Company.
   Google Scholar
• Li S. 2013. Processing technology of traditional Chinese medicine. Beijing: Chemical Industry Press.
   Google Scholar
• Li X. 2015. Coptis chinensis and its processed products and the material basis of comparative study on the antibacterial spectrum. [Master's thesis]. Wuhan: Hubei University of Traditional Medicine.
   Google Scholar
• Li H, Cai X, Li XF. 2008. New applications and the side effects of Rhizoma Coptidis in clinic. Med J Chin People Armed Police Forces. 19:661–663.
   Google Scholar
• Li H, Guo L, Jie S, Liu W, Zhu J, Du W, Fan L, Wang X, Fu B, Huang S. 2008. Berberine inhibits SDF-1-induced aml cells and leukemic stem cells migration via regulation of SDF-1 level in bone marrow stromal cells. Biomed Pharm. 62:573–578.
   PubMed Web of Science ®Google Scholar
• Li S, Li H, Yang D, Yu X, Irwin DM, Niu G, Tan H. 2017. Excessive autophagy activation and increased apoptosis are associated with palmitic acid-induced cardiomyocyte insulin resistance. J Diabetes Res. 2017:1–11.
   Web of Science ®Google Scholar
• Li O, Pan Y, Wang Z. 2013. Berberine induced apoptosis of hepatoma cells by inhibiting the arachidonic acid metabolic pathway CPLA-COX2. Pharmacol Commun Chin. 4:31–32.
   Google Scholar
• Li J, Qiu DM, Chen SH, Cao SP, Xia XL. 2014. Suppression of human breast cancer cell metastasis by coptisine in vitro. Asian Pac J Cancer Prev. 15:5747
   PubMedGoogle Scholar
• Li ZF, Wang Q, Chen G, Hua HM, Yang SL, Feng YL, Pei YH. 2013. A new pyrrolidine derivative from the rhizome of Coptis chinensis. Chem Nat Compd. 49:493–494.
   Web of Science ®Google Scholar
• Li YM, Wang LQ, Deng F, Zhou Q, Sun SQ. 2004. Analysis and assessment of Coptis chinensis for different parts, ages, and heights using fourier transform infrared spectroscopy. Acta Acad Med Sin. 26:614–617.
   Google Scholar
• Li ZF, Wang Q, Feng YL, Luo XJ, Fan MM, Yang SL. 2012. Chemical constituents from Coptis chinensis. Zhong Yao Cai. 35:1438–1441.
   PubMedGoogle Scholar
• Li CH, Wu DF, Ding H, Zhao Y, Zhou KY, Xu DF. 2014. Berberine hydrochloride impact on physiological processes and modulation of twist levels in nasopharyngeal carcinoma CNE-1 cells. Asian Pac J Cancer Prev. 15:1851–1857.
   PubMedGoogle Scholar
• Li C, Xiong J, Cheng Z, Cheng S. 2014. Effect of berberine on proliferation and apoptosis of colon cancer HT-29 cells. World Chin J Digestol. 22:2572–2577.
   Google Scholar
• Li XG, Yang LG, Chen LX, Qiu F. 2012. Chemical constituents from the decoction of Coptis chinensis Franch. J Shenyang Pharm Univ. 29:193–198.
   Google Scholar
• Li B, Zhang M, Bao L. 1995. Study on the pharmacokinetics of berberine after oral administration in human being. J Harbin Med Univ. 29:382–385.
   Google Scholar
• Li M, Zhang M, Zhang ZL, Liu N, Han XY, Liu QC, Deng WJ, Liao CX. 2017. Induction of apoptosis by berberine in hepatocellular carcinoma HepG2 cells via downregulation of NF-κB. Oncol Res. 25:233
   PubMed Web of Science ®Google Scholar
• Li H, Zhou M, Zhao A, Jia W. 2009. Traditional Chinese medicine: balancing the gut ecosystem. Phytother Res. 23:1332–1335.
   PubMed Web of Science ®Google Scholar
• Li ZQ, Zuo DY, Qie XD, Qi H, Zhao MQ, Wu YL. 2012. Berberine acutely inhibits the digestion of maltose in the intestine. J Ethnopharmacol. 142:474–480.
   PubMed Web of Science ®Google Scholar
• Linn YC, Lu J, Lim LC, Sun H, Sun J, Zhou Y, Ng HS. 2012. Berberine-induced haemolysis revisited: Safety of Rhizoma Coptidis and Cortex Phellodendri in chronic haematological diseases. Phytotherapy Res. 26:682–686.
   PubMed Web of Science ®Google Scholar
• Liu R, Cao Z, Pan Y, Zhang G, Yang P, Guo P, Zhou Q. 2013. Jatrorrhizine hydrochloride inhibits the proliferation and neovascularization of C8161 metastatic melanoma cells. Anticancer Drugs. 24:667–676.
   PubMed Web of Science ®Google Scholar
• Liu D, Cao G, Si X, Chen Q, Sun H. 2017. An overview of the antiarrhythmic study of alkaloids in Coptidis Rhizoma. Shandong J Trad Chin Med. 3:164–166.
   Google Scholar
• Liu LZ, Cheung SC, Lan LL, Ho SK, Xu HX, Chan JC, Tong PC. 2010. Berberine modulates insulin signaling transduction in insulin-resistant cells. Mol Cell Endocrinol. 317:148–153.
   PubMed Web of Science ®Google Scholar
• Liu Y, Hao H, Xie H, Lai L, Wang Q, Liu C, Wang J. 2010. Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats. Drug Metab Disp Bio Fate Chem. 38:1779–1784.
   PubMed Web of Science ®Google Scholar
• Liu G, He W, Cai H, Sun X, Hou W, Lin M, Xie Z, Liao Q. 2014. The simultaneous determination of berberine, palmatine, coptisine, epiberberine and jatrorrhizine in rat plasma by LC-MS/MS and a pharmacokinetic comparison after the oral administration of Rhizoma Coptidis and Jiao-Tai-Wan extract. Anal Methods. 6:2998.
   Web of Science ®Google Scholar
• Liu T, Liang ZS, Ding MH, Zhao YH. 2010. Optimal extraction process of berberine hydrochloride from the leaves of Coptis chinensis. J Northwest Forest Univ. 25:144–147.
   Google Scholar
• Liu Z, Qiao L, Bing X, Wu J, Guo C, Zhu F, Yang Q, Gao G, Gong Y, Shao C. 2009. Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. Mutat Res. 662:75–83.
   PubMed Web of Science ®Google Scholar
• Liu SJ, Sun YM, Tian DF, He YC, Zeng L, He Y, Ling CQ, Sun SH. 2008. Downregulated MM23-H1 expression is associated with intracranial invasion of nasopharyngeal carcinoma. Br J Cancer. 98:363–369.
   PubMed Web of Science ®Google Scholar
• Liu L, Yu YL, Yang JS, Li Y, Liu YW, Liang Y, Liu XD, Xie L, Wang GJ. 2010. Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study. Naunyn Schmiedebergs Arch Pharmacol. 381:371–381.
   PubMed Web of Science ®Google Scholar
• Liu XT, Chen X, Jin R. 2010. Protective effects of Rhizoma Coptidis on acute myocardial ischemia injured cardiomyocytes in vivo and in vitro. Chin J Infor Trad Chin Med. 28–30.
   Google Scholar
• Liu B, Fu XQ, Li T, Su T, Guo H, Zhu PL, Tse AKW, Liu SM, Yu ZL. 2017. Computational and experimental prediction of molecules involved in the anti-melanoma action of berberine. J Ethnopharmacol. 208:225–235.
   PubMed Web of Science ®Google Scholar
• Li MH, Zhang YJ, Yu YH, Yang SH, Iqbal J, Mi QY, Li B, Wang ZM, Mao WX, Xie HG, et al. 2014. Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy. Eur J Pharmacol. 728:67–76.
   PubMed Web of Science ®Google Scholar
• Lou T, Zhang Z, Xi Z, Liu K, Li L, Liu B, Huang F. 2011. Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes. Inflammation. 34:659–667.
   PubMed Web of Science ®Google Scholar
• Lu YX. 2004. The complete works of Chinese traditional crafts the preparation of Chinese Medicine. Zhengzhou: Elephant Press.
   Google Scholar
• Luo T, Shen X, Li S, Ouyang T, Wang H. 2016. The protective effect of jatrorrhizine against oxidative stress in primary rat cortical neurons. CNS Neurol Disord Drug Targets. 16:617–623.
   Web of Science ®Google Scholar
• Ma H, Chen G, Pei YH. 2013. Isolation and identification of chemical constituents from rhizoma of Coptis chinensis and their cytotoxic activities. J Shenyang Pharm Univ. 63:1–9.
   Google Scholar
• Ma H, Hu YR, Zou ZY, Feng M, Ye XL, Li XG. 2016. Antihyperglycemia and antihyperlipidemia effect of protoberberine alkaloids from Rhizoma Coptidis in HepG2 cell and diabetic kk-ay mice. Drug Develop Res. 77:163–170.
   PubMed Web of Science ®Google Scholar
• Ma X, Liu H, Chen G. 2015. Effects of berberine combined with photodynamic on apoptosis of gastric cancer MGC-803 cell. Chin J Clin Pharm Ther. 20:961–966.
   Google Scholar
• Ma BL, Ma YM. 2013. Pharmacokinetic properties, potential herb-drug interactions and acute toxicity of oral Rhizoma Coptidis alkaloids. Exp Opin Drug Metab Toxicol. 9:51–61.
   PubMed Web of Science ®Google Scholar
• Ma BL, Ma YM, Gao CL, Wu JS, Qiu FR, Wang CH, Wang XH. 2011. Lipopolysaccharide increased the acute toxicity of the Rhizoma Coptidis extract in mice by increasing the systemic exposure to Rhizoma Coptidis alkaloids. J Ethnopharmacol. 138:169–174.
   PubMed Web of Science ®Google Scholar
• Ma BL, Ma YM, Shi R, Wang TM, Zhang N, Wang CH, Yang Y. 2010. Identification of the toxic constituents in Rhizoma Coptidis. J Ethnopharmacol. 128:357–364.
   PubMed Web of Science ®Google Scholar
• Ma B, Zhu L, Zang X, Chen Y, Li D, Wang Y. 2013. Coptis chinensis inflorescence and its main alkaloids protect against ultraviolet-B-induced oxidative damage. J Func Foods. 5:1665–1672.
   Web of Science ®Google Scholar
• Maiti M, Nandi R, Chaudhuri K. 1982. Sanguinarine: a monofunctional intercalating alkaloid. FEBS Lett. 142:280–284.
   PubMed Web of Science ®Google Scholar
• Mei J. 2008. Study on processing technology and quality control of Coptidis Rhizoma [Dissertation]. Wuhan: Hubei College of Traditional Chinese Medicine.
   Google Scholar
• Mei L. 2011. Analysis of 37 cases of frequent atrial premature beats in the treatment of berberine. Chin J Misdiagn. 11:4467–4467.
   Google Scholar
• Mendis S, Puska P, Norrving B. 2011. Global atlas on cardiovascular disease prevention and control. WHO. World Heart Federation and World Stroke Organization.
   Google Scholar
• Meng L, Shu X, Xu H, Zhang C, Yang L, Li Z, Ji G. 2016. Integrative analysis of metabolome and gut microbiota in diet-induced hyperlipidemic rats treated with berberine compounds. J Trans Med. 14:237–248.
   PubMed Web of Science ®Google Scholar
• Meng F, Wang L, Zhang J, Yin Z, Zhang Q, Ye W. 2013. Non-alkaloid chemical constituents from the rhizome of Coptis teeta. J Chin Pharm Univ. 44:307–310.
   Google Scholar
• Min ZD, Murata H, Mizuno M, Kojima H, Tanaka T, Iinuma M, Kimura R. 1987. Phenolic constituents from seeds of Coptis japonica var. Dissecta. Phytochemistry. 26:2071–2074.
   Web of Science ®Google Scholar
• Ming C, Zhang M, Liu Y, Kang J, Chu Z, Yin K, Ding L, Ran D, Xiao R, Yin Y. 2016. Role of berberine in the treatment of methicillin-resistant Staphylococcus aureus infections. Sci Rep. 6:24748–24756.
   PubMed Web of Science ®Google Scholar
• Mishan MA, Ahmadiankia N, Matin MM, Heirani-Tabasi A, Shahriyari M, Bidkhori HR, Naderi-Meshkin H, Bahrami AR. 2015. Role of berberine on molecular markers involved in migration of esophageal cancer cells. Cell Mol Biol (Noisy-le-Grand). 61:37–43.
   PubMed Web of Science ®Google Scholar
• Mizuno M, Kojima H, Iinuma M, Tanaka T, Goto K. 1992. Coumarin derivatives in Coptis trifolia. Ann Proc Gifu Coll Pharm. 42:717–719.
   Google Scholar
• Mizuno M, Kojima H, Tanaka T, Iinuma M, Min ZD, Murata H. 1988. Benzophenanthridine alkaloids from the seeds of Coptis japonica var. Gifu: Disscta Annual Proceedings of Gifu College of Pharmacy, 37.
   Google Scholar
• Mo C, Wang L, Zhang J, Numazawa S, Tang H, Tang X, Han XJuan, Li J, Yang M, Wang Z, et al. 2014. The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice. Antioxid Redox Signal. 20:574–588.
   PubMed Web of Science ®Google Scholar
• Ning N, Wang YZ, Zou ZY, Zhang DZ, Wang DZ, Li XG. 2015. Pharmacological and safety evaluation of fibrous root of Rhizoma Coptidis. Environ Toxicol Pharmacol. 39:53–69.
   PubMed Web of Science ®Google Scholar
• Noguchi M, Kubo M, Hayashi T, Ono M. 1978. Studies on the pharmaceutical quality evaluation of crude drug preparations used in orient medicine "kampoo". Iii. Precipitation reaction of glycyrrhizin with alkaloids or alkaloidal crude drugs in aqueous solution. Chem Pharm Bull. 26:3652–3657.
   PubMed Web of Science ®Google Scholar
• Park SH, Sung JH, Kim EJ, Chung N. 2015. Berberine induces apoptosis via ros generation in PANC-1 and MIA-PaCa2 pancreatic cell lines. Braz J Med Biol Res. 48:111–119.
   PubMed Web of Science ®Google Scholar
• Peng LC, Kang S, Yin ZQ, Jia RY, Song X, Li L, Li ZW, Zou YF, Liang XX, Li LX. 2015. Antibacterial activity and mechanism of berberine against Streptococcus agalactiae. Int J Clin Exp Pathol. 8:5217–5223.
   PubMed Web of Science ®Google Scholar
• Peng W, Shen H, Lin B, Han P, Li CH, Zhang QY, Ye BZ, Rahman K, Xin HL, Qin LP, et al. 2018. Docking study and antiosteoporosis effects of a dibenzylbutane lignan isolated from Litsea cubeba targeting Cathepsin K and MEK1. Med Chem Res. 27:2062–2070.
   Web of Science ®Google Scholar
• Pereira CV, Machado NG, Oliveira PJ. 2008. Mechanisms of berberine (natural yellow 18)-induced mitochondrial dysfunction: Interaction with the adenine nucleotide translocator. Toxicol Sci. 105:408–417.
   PubMed Web of Science ®Google Scholar
• Perrins JD. 1862. XLIII.-On berberine-contributions to its history and revision of its formula. J Chem Soc. 15:339–356.
   Google Scholar
• Qin-Wei Z, Yong-Guang LI. 2016. Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling. Exp Ther Med. 11:978–984.
   PubMed Web of Science ®Google Scholar
• Salehi S, Filtz TM. 2011. Berberine possesses muscarinic agonist-like properties in cultured rodent cardiomyocytes. Pharm Res. 63:335–340.
   Web of Science ®Google Scholar
• Schramm A, Baburin I, Hering S, Hamburger M. 2011. Herg channel inhibitors in extracts of Coptidis Rhizoma. Planta Med. 77:692–697.
   PubMed Web of Science ®Google Scholar
• Seo YS, Yim MJ, Kim BH, Kang KR, Lee SY, Oh JS, You JS, Kim SG, Yu SJ, Lee GJ, et al. 2015. Berberine-induced anticancer activities in fadu head and neck squamous cell carcinoma cells. Oncol Rep. 34:3025–3034.
   PubMed Web of Science ®Google Scholar
• Sha SM, Zhang YG, Bin XU, Wang HH, Kong XY. 2011. Effect of berberine on cell proliferation and apoptosis in gastric carcinoma cells. J Moder Oncol. 37:2109–2120.
   Google Scholar
• Shen J. 2006. The resource utilization and research progess of Coptidis Rhizoma. J Mod Med Health. 22:1038–1039.
   Google Scholar
• Shen N, Huan Y, Shen ZF. 2012. Berberine inhibits mouse insulin gene promoter through activation of amp activated protein kinase and may exert beneficial effect on pancreatic β-cell. Eur J Pharmacol. 694:120–126.
   PubMed Web of Science ®Google Scholar
• Sheng M, Sun Q, Wang H. 1993. Study on the pharmacokinetics of berberine hydrochloride in beagle dog vein and oral administration. Chin Pharmacol Bull. 9:64–67.
   Google Scholar
• Shi Y, Hu FB. 2014. The global implications of diabetes and cancer. Lancet. 383:1947–1948.
   PubMed Web of Science ®Google Scholar
• Shi HL, Wu XJ, Liu Y, Xie JQ. 2013. Berberine counteracts enhanced IL-8 expression of AGS cells induced by evodiamine. Life Sci. 93:830–839.
   PubMed Web of Science ®Google Scholar
• Shin HB, Choi MS, Yi CM, Lee J, Kim NJ, Inn KS. 2015. Inhibition of respiratory syncytial virus replication and virus-induced p38 kinase activity by berberine. Int Immunopharmacol. 27:65–68.
   PubMed Web of Science ®Google Scholar
• Shukla S, Rizvi F, Raisuddin S, Kakkar P. 2014. Foxo proteins′ nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells. Free Radical Biol Med. 76:185–199.
   PubMed Web of Science ®Google Scholar
• Song SW, Qiu M, Chu Y, Chen DY, Wang XH, Su AR, Wu ZW. 2014. Downregulation of cellular c-Jun N-terminal protein kinase and NF-kappa B activation by berberine may result in inhibition of herpes simplex virus replication. Antimicrob Agents Chemother. 58:5068–5078.
   PubMed Web of Science ®Google Scholar
• Steenbergen C, Frangogiannis NG. 2012. Chapter 36 - Ischemic heart disease. In: Joseph A. Hill, Eric N. Olson, editors. New York (NY): Muscle, Academic Press; p. 495–521.
   Google Scholar
• Su G, Wang H, Gao Y, Chen G, Pei Y, Bai J. 2017. 1H-NMR-based metabonomics of the protective effect of Coptis chinensis and berberine on cinnabar-induced hepatotoxicity and nephrotoxicity in rats. Molecules. 22:459–467.
   Web of Science ®Google Scholar
• Sun H, Wang N, Cang Z, Zhu C, Zhao L, Nie X, Cheng J, Xia F, Zhai H, Lu Y. 2016. Modulation of microbiota-gut-brain axis by berberine resulting in improved metabolic status in high-fat diet-fed rats. Obesity Facts. 9:365–378.
   PubMed Web of Science ®Google Scholar
• Sun S, Wang K, Lei H, Li L, Tu M, Zeng S, Zhou H, Jiang H. 2014. Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine. Progr Neuropsychopharmacol Biol Psychiatry. 49:1–6.
   PubMed Web of Science ®Google Scholar
• Sun Y, Xia M, Yan H, Han Y, Zhang F, Hu Z, Cui A, Ma F, Liu Z, Gong Q. 2017. Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21. Br J Pharmacol. 12:2139–2148.
   Google Scholar
• Tabas I, García-Cardeña G, Owens GK. 2015. Recent insights into the cellular biology of atherosclerosis. J Cell Biol. 209:13–22.
   PubMed Web of Science ®Google Scholar
• Tan HY, Wang N, Tsao SW, Zhang Z, Feng Y. 2014. Suppression of vascular endothelial growth factor via inactivation of eukaryotic elongation factor 2 by alkaloids in Coptidis Rhizome in hepatocellular carcinoma. Integr Cancer Ther. 13:425–434.
   PubMed Web of Science ®Google Scholar
• Tang S. 2011. Classified Materia Medica from historical classics for emergency. Beijing: China Medical Press.
   Google Scholar
• Tang LQ, Wei W, Chen LM, Liu S. 2006. Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J Ethnopharmacol. 108:109–115.
   PubMed Web of Science ®Google Scholar
• Tang F, Wang D, Duan C, Huang D, Wu Y, Chen Y, Wang W, Xie C, Meng J, Wang L, et al. 2009. Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting Rho kinase-mediated Ezrin phosphorylation at Threonine 567. J Biol Chem. 284:27456–27466.
   PubMed Web of Science ®Google Scholar
• Tan L, Li C, Chen H, Mo Z, Zhou J, Liu Y, Ma Z, Xu Y, Yang X, Xie J, et al. 2017. Epiberberine, a natural protoberberine alkaloid, inhibits urease of Helicobacter pylori and jack bean: Susceptibility and mechanism. Eur J Pharm Sci. 110:77–86.
   PubMed Web of Science ®Google Scholar
• Ti H. 2017. Effect of Rhizoma Coptidis decoction on intestinal flora and GPR43 pathway GLP-1 and PYY in SD rats with metabolic syndrome [Master's thesis]. Beijing: Beijing University of Chinese Medicine.
   Google Scholar
• Tjong Y, Ip S, Lao L, Fong HHS, Sung JJY, Berman B, Che C. 2011. Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome. J Ethnopharmacol. 135:754–761.
   PubMed Web of Science ®Google Scholar
• Tomita M, Kura S. 1956. Isolation of magnoflorine from Coptis japonica Makino. J Pharm Soc Jap. 76:1425–1426.
   Google Scholar
• Tsang CM, Cheung KC, Cheung YC, Man K, Lui VW, Feng Y, Tsao SW. 2015. Berberine suppresses ID-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma. Biochim Biophys Acta. 1852:541–551.
   PubMed Web of Science ®Google Scholar
• Varghese FS, Thaa B, Amrun SN, Simarmata D, Rausalu K, Nyman TA, Merits A, Mcinerney GM, Ng LF, Ahola T. 2016. The antiviral alkaloid berberine reduces chikungunya virus-induced mitogen-activated protein kinase signaling. J Virol. 90:9743–9757.
   PubMed Web of Science ®Google Scholar
• Wang G. 1991. Bo ji fang. Beijing: Zhonghua Book Company.
   Google Scholar
• Wang W. 2016. A review on pharmacologic effects of effective ingredients in huanglian. Clin J Chin Med. 8:147–148.
   Google Scholar
• Wang N, Feng Y, Lau EP, Tsang C, Ching Y, Man K, Tong Y, Nagamatsu T, Su W, Tsao S. 2010. F-actin reorganization and inactivation of Rho signaling pathway involved in the inhibitory effect of Coptidis Rhizoma on hepatoma cell migration. Integr Cancer Ther. 9:354–364.
   PubMed Web of Science ®Google Scholar
• Wang Y, Huang Y, Lam KSL, Li Y, Wong WT, Ye H, Lau CW, Vanhoutte PM, Xu A. 2009. Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardiovasc Res. 82:484–492.
   PubMed Web of Science ®Google Scholar
• Wang HQ, Li K, Ma LL, Wu S, Hu J, Yan HY, Jiang JD, Li YH. 2017. Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy. Virol J. 14:2–8.
   PubMed Web of Science ®Google Scholar
• Wang XJ, Lin S, Kang HF, Dai ZJ, Bai MH, Ma XL, Ma XB, Liu MJ, Liu XX, Wang BF. 2013. The effect of Rhizoma Coptidis and Coptis chinensis aqueous extract on radiation-induced skin injury in a rat model. BMC Compl Alt Med. 13:105–110.
   PubMed Web of Science ®Google Scholar
• Wang Y, Liu J, Ma A, Chen Y. 2015. Cardioprotective effect of berberine against myocardial ischemia/reperfusion injury via attenuating mitochondrial dysfunction and apoptosis. International J Clin Exp Med. 8:14513–14519.
   PubMed Web of Science ®Google Scholar
• Wang ZQ, Lu FE, Leng SH, Fang XS, Chen G, Wang ZS, Dong LP, Yan ZQ. 2008. Facilitating effects of berberine on rat pancreatic islets through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity. World J Gastroenterol. 14:6004–6011.
   PubMed Web of Science ®Google Scholar
• Wang N, Tan HY, Li L, Yuen MF, Feng Y. 2015. Berberine and Coptidis Rhizoma as potential anticancer agents: recent updates and future perspectives. J Ethnopharmacol. 176:35–48.
   PubMed Web of Science ®Google Scholar
• Wang M, Wang J, Tan R, Wu Q, Qiu H, Yang J, Jiang Q. 2013. Effect of berberine on PPAR α /NO activation in high glucose- and insulin-induced cardiomyocyte hypertrophy. Evid Based Complement Altern Med. 2013:285489–285497.
   PubMed Web of Science ®Google Scholar
• Wang X, Wang R, Xing D, Su H, Ma C, Ding Y, Du L. 2005. Kinetic difference of berberine between hippocampus and plasma in rat after intravenous administration of Coptidis Rhizoma extract. Life Sci. 77:3058–3067.
   PubMed Web of Science ®Google Scholar
• Wang L, Zhang SY, Chen L, Huang XJ, Zhang QW, Jiang RW, Yao F, Ye WC. 2014. New enantiomeric isoquinoline alkaloids from Coptis chinensis. Phytochem Lett. 7:89–92.
   Web of Science ®Google Scholar
• Wang W, Zhang QW, Wen-Cai YE. 2007. Isoquinoline alkaloids from the rhizoma of Coptis chinensis. Chin J Nat Med. 5:348–350.
   Google Scholar
• Wang Q, Zhi-Feng LI, Chen G, Feng YL, M Ma M F, Pei YH. 2012. Chemical constituents from Coptis chinensis Franch. Chin J Exp Trad Medi Form. 35:1438–1441.
   Google Scholar
• Wang Y, Wang Q, Zhang L, Ke Z, Zhao Y, Wang D, Chen H, Jiang X, Gu M, Fan S, et al. 2017. Coptisine protects cardiomyocyte against hypoxia/reoxygenation-induced damage via inhibition of autophagy. Biochem Biophys Res Commun. 490:231–238.
   PubMed Web of Science ®Google Scholar
• Wang Q, Zhang M, Liang B, Shirwany N, Zhu Y, Zou MH. 2011. Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: The role of uncoupling protein 2. PLoS One. 6:e25436.
   PubMed Web of Science ®Google Scholar
• Wijck KV, Buurman WA. 2002. Ischemia-reperfusion injury. J Surg Res. 105:248–306.
   PubMed Web of Science ®Google Scholar
• Wojtyczka RD, Dziedzic A, Kępa M, Kubina R, Kabała-Dzik A, Mularz T, Idzik D. 2014. Berberine enhances the antibacterial activity of selected antibiotics against coagulase-negative staphylococcus strains in vitro. Molecules. 19:6583–6596.
   PubMed Web of Science ®Google Scholar
• Wong HB. 1980. Singapore kernicterus. Singapore Med J. 21:556–567.
   PubMedGoogle Scholar
• Wu Y, Chen Z, Huang X, Liu J, Cha Y, Wang F, Xu J, Sheng L, Ding H. 2016. Berberine protected rats against adiposity induced by high-fat diets. Int J Clin Exp Med. 9:148–155.
   Web of Science ®Google Scholar
• Wu Y, Li JQ, Kim YJ, Wu J, Wang Q, Hao Y. 2011. In vivo and in vitro antiviral effects of berberine on influenza virus. Chin J Integr Med. 17:444–452.
   PubMed Web of Science ®Google Scholar
• Wu S, Xu L, Liu H, Tong X. 2015. Clinical application and dosage of Coptidis Rhizoma. Chin Clin Doctor. 43:92–94.
   Google Scholar
• Xiao P. 2002. Modern Chinese Materia Medica. Vol. 3. Beijing: Chemical Industry Press.
   Google Scholar
• Xie X, Chang X, Chen L, Huang K, Huang J, Wang S, Shen X, Liu P, Huang H. 2013. Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of Rhoa/Rock signaling. Mol Cell Endocrinol. 381:56
   PubMed Web of Science ®Google Scholar
• Xie W, Gu D, Li J, Cui K, Zhang Y. 2011. Effects and action mechanisms of berberine and Rhizoma Coptidis on gut microbes and obesity in high-fat diet-fed c57bl/6j mice. PLoS One. 6:e24520
   PubMed Web of Science ®Google Scholar
• Xie J, Huang XY, Yin-Yan XU, Wang L. 2012. Berberine induces apoptosis of breast cancer MCF-7 cells:Its related oxidative stress mechanism. J Med Postgrad. 2:135–139.
   Google Scholar
• Xie X, Li W, Lan T, Liu W, Peng J, Huang K, Huang J, Shen X, Liu P, Huang H. 2011. Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of AKT signaling pathway. Endocrine J. 58:761–768.
   PubMed Web of Science ®Google Scholar
• Xu Z, Feng W, Shen Q, Yu N, Yu K, Wang S, Chen Z, Shioda S, Guo Y. 2017. Rhizoma Coptidis and berberine as a natural drug to combat aging and aging-related diseases via anti-oxidation and AMPK activation. Aging Dis. 8:760–777.
   PubMed Web of Science ®Google Scholar
• Xu RX, Sun XC, Ma CY, Yao YH, Li XL, Guo YL, Zhang Y, Li S, Li JJ. 2017. Impacts of berberine on oxidized ldl-induced proliferation of human umbilical vein endothelial cells. Am J Transl Res. 9:4375–4389.
   PubMed Web of Science ®Google Scholar
• Xue D, Zou Z, Chen B. 2015. Study on membrane injury mechanism of total alkaloids and berberine from Coptidis Rhizoma on aeromonas hydrophila. Chin J Chin Mater Med. 40:1787–1792.
   Google Scholar
• Xue B, Zhao Y, Miao Q, Miao P, Yang X, Sun G, Su J, Ye J, Wei B, Zhang Y, et al. 2015. In vitro and in vivo identification of metabolites of magnoflorine by LC LTQ-Orbitrap MS and its potential pharmacokinetic interaction in Coptidis Rhizoma decoction in rat. Biomed Chromatogr. 29:1235–1248.
   PubMed Web of Science ®Google Scholar
• Yahara S, Satoshiro M, Nishioka I, Nagasawa T, Oura H. 1985. Isolation and characterization of phenolic compounds from Coptidis Rhizoma. Chem Pharm Bull. 33:527–531.
   Web of Science ®Google Scholar
• Yang TC, Chao HF, Shi LS, Chang TC, Lin HC, Chang WL. 2014. Alkaloids from Coptis chinensis root promote glucose uptake in C2C12 myotubes. Fitoterapia. 93:239–244.
   PubMed Web of Science ®Google Scholar
• Yang Y, Kang N, Xia H, Li J, Cheng L, Qiu F. 2010. Metabolites of protoberberine alkaloids in human urine following oral administration of Coptidis Rhizoma decoction. Planta Med. 16:1859–1863.
   Web of Science ®Google Scholar
• Yang Y, Li Y, Yin D, Chen S, Gao X. 2016. Coptis chinensis polysaccharides inhibit advanced glycation end product formation. J Med Food. 19:593–600.
   PubMed Web of Science ®Google Scholar
• Yang W, She L, Yu K, Yan S, Zhang X, Tian X, Ma S, Zhang X. 2016. Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model. Mol Med Rep. 14:3277–3284.
   PubMed Web of Science ®Google Scholar
• Yao Z. 2014. The prognosis role of prognostic nutritional index in malignant pleural mesothelioma and the mechanisms of berberine-induccd apoptosis and autophagy [Master's thesis]. Jinan: Shandong University.
   Google Scholar
• Yao W, Wang X, Xiao K. 2018. Protective effect of berberine against cardiac ischemia/reperfusion injury by inhibiting apoptosis through the activation of Smad7. Mole Cell Prob. 38:38–44.
   PubMed Web of Science ®Google Scholar
• Ye L. 2007. The study of berberine inhibition of Cyclin D1 related signaling pathway in tumor cells [Master's thesis]. Beijing: Beijing University of Chinese Medicine.
   Google Scholar
• Ye L, Liang S, Guo C, Yu X, Zhao J, Zhang H, Shang W. 2016. Inhibition of M1 macrophage activation in adipose tissue by berberine improves insulin resistance. Life Sci. 166:82–91.
   PubMed Web of Science ®Google Scholar
• Yi J, Ye X, Wang D, He K, Yang Y, Liu X, Li X. 2013. Safety evaluation of main alkaloids from Rhizoma Coptidis. J Ethnopharmacol. 145:303–310.
   PubMed Web of Science ®Google Scholar
• Yi T, Zhuang L, Song G, Zhang B, Li G, Hu T. 2015. AKT signaling is associated with the berberine-induced apoptosis of human gastric cancer cells. Nutr Cancer. 67:523–531.
   PubMed Web of Science ®Google Scholar
• Yin J, Hu R, Chen M, Tang J, Li F, Yang Y, Chen J. 2002. Effects of berberine on glucose metabolism in vitro. Metabolism. 51:1439–1443.
   PubMed Web of Science ®Google Scholar
• Yong Y, Baoshun Z, Chunya C. 2011. Cardiovascular pharmacological activity of berberine. Chin Trad Pat Med. 33:867–869.
   Google Scholar
• Yong Y, Xiaoli Y, Xuegang L. 2007. Antimicrobial effect of four alkaloids from Coptidis Rhizome. Lishizhen Med Mater Med Res. 18:3013–3014.
   Google Scholar
• Yoshikawa K, Hiroshi Kinoshita A, Arihara S. 1997a. Woorenol, a novel sesquineolignan with a unique spiro skeleton, from the rhizomes of Coptis japonica var. J Nat Prod. 60:511–513.
   Web of Science ®Google Scholar
• Yoshikawa K, Hiroshi Kinoshita A, Arihara S. 1997b. Non-basic components of Coptis Rhizoma: Four new hemiterpenoid glucosides, two new phenylpropanoid glucosides and a new flavonoid glycoside from Coptis japonica var. dissecta. Nat Med. 51:244–248.
   Google Scholar
• Yoshikawa K, Hiroshi Kinoshita A, Kan Y, Arihara S. 1995. Neolignans and phenylpropanoids from the rhizomes of Coptis japonica var. Dissecta. Chem Pharm Bull. 43:578–581.
   Web of Science ®Google Scholar
• Yu D, Fu S, Cao Z, Bao M, Zhang G, Pan Y, Liu W, Zhou Q. 2014. Unraveling the novel anti-osteosarcoma function of coptisine and its mechanisms. Toxicol Lett. 226:328–336.
   PubMed Web of Science ®Google Scholar
• Yu L, Li Q, Yu B, Yang Y, Jin Z, Duan W, Zhao G, Zhai M, Liu L, Yi D, et al. 2016. Berberine attenuates myocardial ischemia/reperfusion injury by reducing oxidative stress and inflammation response: Role of silent information regulator 1. Oxidative Med Cell Long. 2016:1689602–1689617.
   PubMed Web of Science ®Google Scholar
• Yu L, Li F, Zhao G, Yang Y, Jin Z, Zhai M, Yu W, Zhao L, Chen W, Duan W. 2015. Protective effect of berberine against myocardial ischemia reperfusion injury: Role of notch1/hes1-pten/AKT signaling. Apoptosis. 20:796–810.
   PubMed Web of Science ®Google Scholar
• Yu Y, Liu L, Wang X, Liu X, Liu X, Xie L, Wang G. 2010. Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies. Biochem Pharmacol. 79:1000–1006.
   PubMed Web of Science ®Google Scholar
• Yu S, Pang X, Deng Y, Liu L, Liang Y, Liu X, Xie L, Wang G, Wang X. 2007. A sensitive and specific liquid chromatography mass spectrometry method for simultaneous determination of berberine, palmatine, coptisine, epiberberine and jatrorrhizine from Coptidis Rhizoma in rat plasma. Int J Mass Spectrom. 268:30–37.
   Web of Science ®Google Scholar
• Yu S, Yu Y, Liu L, Wang X, Lu s, Liang Y, Liu X, Xie L, Wang G. 2010. Increased plasma exposures of five protoberberine alkaloids from Coptidis Rhizoma in streptozotocin-induced diabetic rats: is P-GP involved? Planta Med. 76:876–881.
   PubMed Web of Science ®Google Scholar
• Yu S, Yu Y, Lu S, Liu L, Liu X. 2008. Pharmacokinetics of berberine, palmatine, coptisine, epiberberine and jatrorr-hizine from Coptidis Rhizoma in diabetic rats. J Chin Pharm Univ. 39:526–529.
   Google Scholar
• Yu C, Zhang H, Pan J, Hong Y, Ren J, Zhu D, Xiu H. 2000. Determination and preliminary studies of metabolism of berberine in human urine after oral administration. Chin J Clin Pharmacol. 1:36–39.
   Google Scholar
• Yu R, Zhang ZQ, Wang B, Jiang HX, Cheng L, Shen LM. 2014. Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation. Cancer Cell Int. 14:1–8.
   PubMed Web of Science ®Google Scholar
• Yuan X, Wang J, Tang X, Li Y, Xia P, Gao X. 2015. Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles. J Transl Med. 13:24–34.
   PubMed Web of Science ®Google Scholar
• Zhang J. 1996. Jingyue’s complete works. Shanghai: Shanghai Scientific & Technical Publishers.
   Google Scholar
• Zhang B, Cao A, Zhou J, Hu Z, Wu D. 2012. Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus. J Pharm Pharmacol. 64:413–419.
   PubMed Web of Science ®Google Scholar
• Zhang C, Jing P, Li N. 2013. Berberine inhibits the proliferation and induces apoptosis of human ovarian cancer SKOV3 cells. Basic Clin Med. 33:225–226.
   Google Scholar
• Zhang J, Tang H, Deng R, Wang N, Zhang Y, Wang Y, Liu Y, Li F, Wang X, Zhou L. 2015. Berberine suppresses adipocyte differentiation via decreasing CREB transcriptional activity. PLoS One. 10:e0125667–e0125675.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Xiao X, Li M, Li W, Yu M, Zhang H, Fan P, Wang Z, Zheng J. 2014. Berberine moderates glucose metabolism through the GNRH-GLP-1 and MAPK pathways in the intestine. BMC Complement Altern Med. 14:188–197.
   PubMed Web of Science ®Google Scholar
• Zhang T, Yang S, Du J. 2014. Protective effects of berberine on isoproterenol-induced acute myocardial ischemia in rats through regulating HMGB1-TLR4 axis. Evid Based Complement Alternat Med. 2014:1–8.
   Web of Science ®Google Scholar
• Zhang Z, Li B, Meng X, Yao S, Jin L, Yang J, Wang J, Zhang H, Zhang Z, Cai D, et al. 2016. Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress. Sci Rep. 6:20848–20860.
   PubMed Web of Science ®Google Scholar
• ZHANG W, XU Yc, GUO Fj, MENG Y, LI Ml. 2008. Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus. Chin Med J. 121:2124–2128.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Adjei AA. 2015. Targeting angiogenesis in cancer therapy: moving beyond vascular endothelial growth factor. Oncologist. 20:660–673.
   PubMed Web of Science ®Google Scholar
• Zhao M, Xian YF, Ip SP, Fong HH, Che CT. 2010. A new and weakly antispasmodic protoberberine alkaloid from Rhizoma Coptidis. Phytother Res. 24:1414–1416.
   PubMed Web of Science ®Google Scholar
• Zhao Gl, Yu Lm, Gao Wl, Duan Wx, Jiang B, Liu Xd, Zhang B, Liu Zh, Zhai Me, Jin Zx, et al. 2016. Berberine protects rat heart from ischemia/reperfusion injury via activating JAK2/STAT3 signaling and attenuating endoplasmic reticulum stress. Acta Pharmacol Sin. 37:354–367.
   PubMed Web of Science ®Google Scholar
• Zhong. 1991. Zhong yao cheng fang zhi ji. Vol 4. Beijing: Pharmacopoeia Committee of the People's Republic of China Ministry of Health.
   Google Scholar
• Zhong. 1998. Zhong yao cheng fang zhi ji. Vol 17. Beijing: Pharmacopoeia Committee of the People's Republic of China Ministry of Health.
   Google Scholar
• Zhou L, Yang F, Li G, Huang J, Liu Y, Zhang Q, Tang Q, Hu C, Zhang R. 2018. Coptisine induces apoptosis in human hepatoma cells through activating 67-kDa Laminin receptor/cGMP signaling. Front Pharmacol. 9:517–533.
   PubMed Web of Science ®Google Scholar
• Zhou JY, Zhou SW. 2011. Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver. Fitoterapia. 82:184–189.
   PubMed Web of Science ®Google Scholar
• Zhou X, Li H, Shi Z, Gao S, Wei S, Li K, Wang J, Li J, Wang R, Gong M, et al. 2017. Inhibition activity of a traditional chinese herbal formula Huang-Lian-Jie-Du-Tang and its major components found in its plasma profile on neuraminidase-1. Sci Rep. 7:15549–15558.
   PubMed Web of Science ®Google Scholar
• Zhu DX. 2012. Danxi's mastery of medicine. Beijing: China Medical Science Press
   Google Scholar
• Zhu G. 2015. Lei zheng huo ren shu. Tianjin: Tianjin Scientific & Techenical Press
   Google Scholar
• Zhu T, Li LL, Xiao GF, Luo QZ, Liu QZ, Yao KT, Xiao GH. 2015. Berberine increases doxorubicin sensitivity by suppressing STAT3 in lung cancer. Am J Chinese Med. 43:1487–1502.
   PubMed Web of Science ®Google Scholar
• Zhu Q, Li Y. 2016. Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling. Exp Ther Med. 11:978–984.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Ma N, Li HX, Tian L, Ba YF, Hao B. 2014. Berberine induces apoptosis and DNA damage in MG-63 human osteosarcoma cells. Mol Med Rep. 10:1734–1738.
   PubMed Web of Science ®Google Scholar
• Zou ZY, Hu YR, Ma H, Feng M, Li XG, Ye XL. 2016. Epiberberine reduces serum cholesterol in diet-induced dyslipidemia syrian golden hamsters via network pathways involving cholesterol metabolism. Eur J Pharmacol. 774:1–9.
   PubMed Web of Science ®Google Scholar
• Zuo F, Nakamura N, Akao T, Hattori M. 2006. Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry. Drug Metab Dispos. 34:2064–2072.
   PubMed Web of Science ®Google Scholar