4,873
Views
6
CrossRef citations to date
0
Altmetric
Research Article

Anti-depressant effects of ethanol extract from Cannabis sativa (hemp) seed in chlorpromazine-induced Drosophila melanogaster depression model

, , , , , & show all
Pages 996-1005 | Received 08 Oct 2020, Accepted 24 Jun 2021, Published online: 06 Aug 2021

References

  • Alexander SPH. 2016. Therapeutic potential of cannabis-related drugs. Prog Neuropsychopharmacol Biol Psychiatry. 64:157–166.
  • Anjaneyulu M, Chopra K, Kaur I. 2003. Antidepressant activity of quercetin, a bioflavonoid, in streptozotocin-induced diabetic mice. J Med Food. 6(4):391–395.
  • Appendino G, Chianese G, Taglialatela-Scafati O. 2011. Cannabinoids: occurrence and medicinal chemistry. Curr Med Chem. 18(7):1085–1099.
  • Araujo SM, Bortolotto VC, Poetini MR, Dahleh MMM, Couto SF, Pinheiro FC, Meichtry LB, Musachio EAS, Ramborger BP, Roehrs R, et al. 2021. γ-Oryzanol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in Drosophila melanogaster. Stress. 24(3):282–212.
  • Aryal B, Lee Y. 2019. Disease model organism for Parkinson disease: Drosophila melanogaster. BMB Rep. 52(4):250–258.
  • Bellen HJ, Tong C, Tsuda H. 2010. 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future. Nat Rev Neurosci. 11(7):514–522.
  • Bolus H, Crocker K, Boekhoff-Falk G, Chtarbanova S. 2020. Modeling neurodegenerative disorders in Drosophila melanogaster. IJMS. 21(9):3055.
  • Brennenstuhl H, Jung-Klawitter S, Assmann B, Opladen T. 2019. Inherited disorders of neurotransmitters: classification and practical approaches for diagnosis and treatment. Neuropediatrics. 50(1):2–14.
  • Brenton AG, Godfrey AR. 2010. Accurate mass measurement: terminology and treatment of data. J Am Soc Mass Spectrom. 21(11):1821–1835.
  • Callaway J. 2004. Hempseed as a nutritional resource: an overview. Euphytica. 140(1–2):65–72.
  • Campos AC, Fogaca MV, Sonego AB, Guimaraes FS. 2016. Cannabidiol, neuroprotection and neuropsychiatric disorders. Pharmacol Res. 112:119–127.
  • Cassar M, Issa AR, Riemensperger T, Petitgas C, Rival T, Coulom H, Iché-Torres M, Han KA, Birman S. 2015. A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum Mol Genet. 24(1):197–212.
  • Chandrasekhar Y, Ramya EM, Navya K, Phani Kumar G, Anilakumar KR. 2017. Antidepressant like effects of hydrolysable tannins of Terminalia catappa leaf extract via modulation of hippocampal plasticity and regulation of monoamine neurotransmitters subjected to chronic mild stress (CMS). Biomed Pharmacother. 86:414–425.
  • Chia SJ, Tan EK, Chao YX. 2020. Historical perspective: models of Parkinson's disease. IJMS. 21(7):2464.
  • Citti C, Linciano P, Panseri S, Vezzalini F, Forni F, Vandelli MA, Cannazza G. 2019. Cannabinoid profiling of hemp seed oil by liquid chromatography coupled to high-resolution mass spectrometry. Front Plant Sci. 10:120.
  • Cowen PJ, Browning M. 2015. What has serotonin to do with depression? World Psychiatry. 14(2):158–160.
  • de Mello Schier AR, de Oliveira Ribeiro NP, Coutinho DS, Machado S, Arias-Carrion O, Crippa JA, Zuardi AW, Nardi AE, Silva AC. 2014. Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS Neurol Disord Drug Targets. 13(6):953–960.
  • Dean J, Keshavan M. 2017. The neurobiology of depression: an integrated view. Asian J Psychiatr. 27:101–111.
  • Delcourte S, Etievant A, Haddjeri N. 2021. Role of central serotonin and noradrenaline interactions in the antidepressants' action: electrophysiological and neurochemical evidence. Prog Brain Res. 259:7–81.
  • Denno ME, Privman E, Venton BJ. 2015. Analysis of neurotransmitter tissue content of Drosophila melanogaster in different life stages. ACS Chem Neurosci. 6(1):117–123.
  • Dunlop BW, Nemeroff CB. 2007. The role of dopamine in the pathophysiology of depression. Arch Gen Psychiatry. 64(3):327–337.
  • El-Alfy AT, Ivey K, Robinson K, Ahmed S, Radwan M, Slade D, Khan I, ElSohly M, Ross S. 2010. Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacol Biochem Behav. 95(4):434–442.
  • Fakhoury M. 2015. New insights into the neurobiological mechanisms of major depressive disorders. Gen Hosp Psychiatry. 37(2):172–177.
  • Fernandez-Ruiz J, Moreno-Martet M, Rodriguez-Cueto C, Palomo-Garo C, Gomez-Canas M, Valdeolivas S, Guaza C, Romero J, Guzman M, Mechoulam R, et al. 2011. Prospects for cannabinoid therapies in basal ganglia disorders. Br J Pharmacol. 163(7):1365–1378.
  • Harrold MW, Chang YA, Wallace RA, Farooqui T, Wallace LJ, Uretsky N, Miller DD. 1987. Charged analogues of chlorpromazine as dopamine antagonists. J Med Chem. 30(9):1631–1635.
  • Hendricks JC, Finn SM, Panckeri KA, Chavkin J, Williams JA, Sehgal A, Pack AI. 2000. Rest in Drosophila is a sleep-like state. Neuron. 25(1):129–138.
  • Hood S, Amir S. 2017. Neurodegeneration and the circadian clock. Front Aging Neurosci. 9:170.
  • Jiang MD, Zheng Y, Wang JL, Wang YF. 2017. Drug induces depression-like phenotypes and alters gene expression profiles in Drosophila. Brain Res Bull. 132:222–231.
  • Katz RJ, Roth KA, Carroll BJ. 1981. Acute and chronic stress effects on open field activity in the rat: implications for a model of depression. Neurosci Biobehav Rev. 5(2):247–251.
  • Kaur K, Simon AF, Chauhan V, Chauhan A. 2015. Effect of bisphenol A on Drosophila melanogaster behavior-a new model for the studies on neurodevelopmental disorders. Behav Brain Res. 284:77–84.
  • Keles B, McCrae N, Grealish A. 2020. A systematic review: the influence of social media on depression, anxiety and psychological distress in adolescents. Int J Adolesc Youth. 25(1):79–93.
  • Kim S, Hong KB, Kim S, Suh HJ, Jo K. 2020. Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK/BDNF pathways. Sci Rep. 10(1):11370.
  • Ko CH, Koon CM, Yu SL, Lee KY, Lau CBS, Chan EHY, Wing YK, Fung KP, Leung PC. 2016. Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model. Chin J Integr Med. 22(5):335–343.
  • Kobayashi K. 2001. Role of catecholamine signaling in brain and nervous system functions: new insights from mouse molecular genetic study. J Investig Dermatol Symp Proc. 6(1):115–121.
  • Krishnan V, Nestler EJ. 2011. Animal models of depression: molecular perspectives. Curr Top Behav Neurosci. 7:121–147.
  • Kulkarni SK, Bhutani MK, Bishnoi M. 2008. Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology. 201(3):435–442.
  • Kumar A, Sharma B, 2020. Phytochemicals as antidepressants. In: Patra JK, Shukla AC, Das G, editors. Advances in pharmaceutical biotechnology. New York (NY): Springer; p. 115–131.
  • Kurkin V, Dubishchev A, Ezhkov V, Titova I, Avdeeva E. 2006. Antidepressant activity of some phytopharmaceuticals and phenylpropanoids. Pharm Chem J. 40(11):614–619.
  • Kwon S, Lee B, Kim M, Lee H, Park HJ, Hahm DH. 2010. Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test. Prog Neuropsychopharmacol Biol Psychiatry. 34(2):265–270.
  • Lachenmeier DW, Walch SG. 2005. Analysis and toxicological evaluation of cannabinoids in hemp food products–a review. Elec J Env Agric Food Chem. 4:812–826.
  • Lavergne F, Jay TM. 2010. A new strategy for antidepressant prescription. Front Neurosci. 4:192.
  • Lee SH, Min KJ. 2015. Life-extending effect of phytochemicals in Drosophila. In: Vaiserman AM, Moskalev AA, Pasyukova EG, editors. Life extension. New York (NY): Springer; p. 229–244.
  • Ligresti A, De Petrocellis L, Di Marzo V. 2016. From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology. Physiol Rev. 96(4):1593–1659.
  • Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25(4):402–408.
  • Mandrioli M, Tura M, Scotti S, Toschi TG. 2019. Fast detection of 10 cannabinoids by RP-HPLC-UV method in Cannabis sativa L. Molecules. 24(11):2113.
  • Manji HK, Drevets WC, Charney DS. 2001. The cellular neurobiology of depression. Nat Med. 7(5):541–547.
  • Martin CA, Krantz DE. 2014. Drosophila melanogaster as a genetic model system to study neurotransmitter transporters. Neurochem Int. 73:71–88.
  • Messina F, Rosati O, Curini M, Marcotullio MC. 2015. Cannabis and bioactive cannabinoids: Studies in natural products chemistry. In: Atta U, editor. Studies in natural products chemistry. Oxford: Elsevier; p. 17–57.
  • Mori A, Ohashi S, Nakai M, Moriizumi T, Mitsumoto Y. 2005. Neural mechanisms underlying motor dysfunction as detected by the tail suspension test in MPTP-treated C57BL/6 mice. Neurosci Res. 51(3):265–274.
  • Moraga-Amaro R, Gonzalez H, Pacheco R, Stehberg J. 2014. Dopamine receptor D3 deficiency results in chronic depression and anxiety. Behav Brain Res. 274:186–193.
  • Nathan PJ. 2001. Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology. J Psychopharmacol. 15(1):47–54.
  • Noldner M, Schotz K. 2002. Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test. Planta Med. 68:577–580.
  • O'Kane CJ. 2011. Drosophila as a model organism for the study of neuropsychiatric disorders. Curr Top Behav Neurosci. 7:37–60.
  • Pathak L, Agrawal Y, Dhir A. 2013. Natural polyphenols in the management of major depression. Expert Opin Investig Drugs. 22(7):863–880.
  • Resstel LB, Joca SR, Moreira FA, Correa FM, Guimaraes FS. 2006. Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats. Behav Brain Res. 172(2):294–298.
  • Reus GZ, Stringari RB, Ribeiro KF, Luft T, Abelaira HM, Fries GR, Aguiar BW, Kapczinski F, Hallak JE, Zuardi AW, et al. 2011. Administration of cannabidiol and imipramine induces antidepressant-like effects in the forced swimming test and increases brain-derived neurotrophic factor levels in the rat amygdala. Acta Neuropsychiatr. 23(5):241–248.
  • Ries AS, Hermanns T, Poeck B, Strauss R. 2017. Serotonin modulates a depression-like state in Drosophila responsive to lithium treatment. Nat Commun. 8(1):1–11.
  • Russo EB. 2007. History of cannabis and its preparations in saga, science, and sobriquet. Chem Biodivers. 4(8):1614–1648.
  • Sarchiapone M, Carli V, Camardese G, Cuomo C, Di Giuda D, Calcagni ML, Focacci C, De Risio S. 2006. Dopamine transporter binding in depressed patients with anhedonia. Psychiatry Res. 147(2–3):243–248.
  • Shohat-Ophir G, Kaun KR, Azanchi R, Mohammed H, Heberlein U. 2012. Sexual deprivation increases ethanol intake in Drosophila. Science. 335(6074):1351–1355.
  • Shukla AK, Pragya P, Chaouhan HS, Patel DK, Abdin MZ, Kar Chowdhuri D. 2014. Mutation in Drosophila methuselah resists paraquat induced Parkinson-like phenotypes. Neurobiol Aging. 35(10):2419.e1–2419.e6.
  • Silote GP, Sartim A, Sales A, Eskelund A, Guimarães FS, Wegener G, Joca S. 2019. Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms. J Chem Neuroanat. 98:104–116.
  • Thanacoody R. 2020. Antidepressant and antipsychotic poisoning. Medicine. 48(3):194–196.
  • United Nations Office on Drug and Crime. 2009. Recommended methods for the identification and analysis of Cannabis and Cannabis products: manual for use by national drug testing laboratories. New York (NY): United Nations Publications; p. 1–50.
  • Vadnie CA, McClung CA. 2017. Circadian rhythm disturbances in mood disorders: insights into the role of the suprachiasmatic nucleus. Neural Plast. 2017:1504507.
  • Venzala E, Garcia-Garcia AL, Elizalde N, Tordera RM. 2013. Social vs. environmental stress models of depression from a behavioural and neurochemical approach. Eur Neuropsychopharmacol. 23(7):697–708.
  • Weston-Green K. 2018. The united chemicals of cannabis: Beneficial effects of cannabis phytochemicals on the brain and cognition. In: Costain W, Lapraire RB, editors. Recent advances in cannabinoid research. Ukraine: InTechOpen; p. 1–19.
  • Willner P. 1990. Animal models of depression: an overview. Pharmacol Therapeut. 45(3):425–455.
  • Xu Y, Li S, Chen R, Li G, Barish PA, You W, Chen L, Lin M, Ku B, Pan J, et al. 2010. Antidepressant-like effect of low molecular proanthocyanidin in mice: involvement of monoaminergic system. Pharmacol Biochem Behav. 94(3):447–453.
  • Yang Z, Bertolucci F, Wolf R, Heisenberg M. 2013. Flies cope with uncontrollable stress by learned helplessness. Curr Biol. 23(9):799–803.
  • Zanelati TV, Biojone C, Moreira FA, Guimarães FS, Joca SR. 2010. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. Br J Pharmacol. 159(1):122–128.
  • Zhu X, Li W, Li Y, Xu W, Yuan Y, Zheng V, Zhang H, O'Donnell JM, Xu Y, Yin X. 2019. The antidepressant- and anxiolytic-like effects of resveratrol: involvement of phosphodiesterase-4D inhibition. Neuropharmacology. 153:20–31.
  • Zuardi AW, Crippa JA, Hallak JE, Moreira FA, Guimaraes FS. 2006. Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug. Braz J Med Biol Res. 39(4):421–429.
  • Zuardi AW, Shirakawa I, Finkelfarb E, Karniol IG. 1982. Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects. Psychopharmacology. 76(3):245–250.