5,322
Views
12
CrossRef citations to date
0
Altmetric
Research Article

A comprehensive study on the relieving effect of Lilium brownii on the intestinal flora and metabolic disorder in p-chlorphenylalanine induced insomnia rats

, , , , ORCID Icon, , , , & show all
Pages 131-143 | Received 09 Sep 2021, Accepted 10 Dec 2021, Published online: 03 Jan 2022

References

  • Agus A, Planchais J, Sokol H. 2018. Gut microbiota regulation of tryptophan metabolism in health and disease. Cell Host Microbe. 23(6):716–724.
  • Bhat A, Pires AS, Tan VE, Chidambaram SB, Guillemin GJ. 2020. Effects of sleep deprivation on the tryptophan metabolism. Int J Tryptophan Res. 13:1178646920970902.
  • Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF. 2011. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 108(38):16050–16055.
  • Breit S, Kupferberg A, Rogler G, Hasler G. 2018. Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders. Front Psychiatry. 9:44.
  • Brunkwall L, Orho-Melander M. 2017. The gut microbiome as a target for prevention and treatment of hyperglycemia in type 2 diabetes: from current human evidence to future possibilities. Diabetologia. 60(6):943–951.
  • Chen Y, Leon-Ponte M, Pingle SC, O’Connell PJ, Ahern GP. 2015. T lymphocytes possess the machinery for 5-HT synthesis, storage, degradation and release. Acta Physiol (Oxf). 213(4):860–867.
  • Colpo GD, Venna VR, McCullough LD, Teixeira AL. 2019. Systematic review on the involvement of the kynurenine pathway in stroke: pre-clinical and clinical evidence. Front Neurol. 10:778.
  • Cryan JF, Dinan TG. 2012. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 13(10):701–712.
  • Davies SK, Ang JE, Revell VL, Holmes B, Mann A, Robertson FP, Cui N, Middleton B, Ackermann K, Kayser M, et al. 2014. Effect of sleep deprivation on the human metabolome. Proc Natl Acad Sci U S A. 111(29):10761–10766.
  • De-Miguel FF, Trueta C. 2005. Synaptic and extrasynaptic secretion of serotonin. Cell Mol Neurobiol. 25(2):297–312.
  • Diaz Heijtz R, Wang SG, Anuar F, Qian Y, Björkholm B, Samuelsson A, Hibberd ML, Forssberg H, Pettersson S. 2011. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci U S A. 108(7):3047–3052.
  • Doghramji K. 2006. The epidemiology and diagnosis of insomnia. Am J Manag Care. 12:214–220.
  • Feng Q, Chen WD, Wang YD. 2018. Gut microbiota: an integral moderator in health and disease. Front Microbiol. 9:151.
  • Foster JA, McVey Neufeld KA. 2013. Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci. 36(5):305–312.
  • Gao X, Liu X, Xu J, Xue C, Xue Y, Wang Y. 2014. Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet. J Biosci Bioeng. 118(4):476–481.
  • Golombek DA, Pandi-Perumal SR, Brown GM, Cardinali DP. 2015. Some implications of melatonin use in chronopharmacology of insomnia. Eur J Pharmacol. 762:42–48.
  • He J, Zhu Y, Aa J, Smith PF, De Ridder D, Wang G, Zheng Y. 2017. Corrigendum: brain metabolic changes in rats following acoustic trauma. Front Neurosci. 11:260.
  • Iannucci LF, Cioffi F, Senese R, Goglia F, Lanni A, Yen PM, Sinha RA. 2017. Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet. Sci Rep. 7(1):2023.
  • Johnston GA. 2002. Medicinal chemistry and molecular pharmacology of GABA(C) receptors. Curr Top Med Chem. 2(8):903–913.
  • Johnston JD, Ordovás JM, Scheer FA, Turek FW. 2016. Circadian rhythms, metabolism, and chrononutrition in rodents and humans. Adv Nutr. 7(2):399–406.
  • Kepplinger B, Baran H, Kainz A, Ferraz-Leite H, Newcombe J, Kalina P. 2005. Age-related increase of kynurenic acid in human cerebrospinal fluid - IgG and beta2-microglobulin changes. Neurosignals. 14(3):126–135.
  • Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, et al. 2013. Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 19(5):576–585.
  • Kunze KN, Hanlon EC, Prachand VN, Brady MJ. 2016. Peripheral circadian misalignment: contributor to systemic insulin resistance and potential intervention to improve bariatric surgical outcomes. Am J Physiol Regul Integr Comp Physiol. 311(3):R558–63.
  • Lepetit P, Touret M, Grange E, Gay N, Bobillier P. 1991. Inhibition of methionine incorporation into brain proteins after the systemic administration of p-chlorophenylalanine andL l-5-hydroxytryptophan. Eur J Pharmacol. 209(3):207–212.
  • Ley RE, Turnbaugh PJ, Klein S, Gordon JI. 2006. Microbial ecology: human gut microbes associated with obesity. Nature. 444(7122):1022–1023.
  • Li Y, Chang D, Yang H, Wang J, Shi H. 2018. Metabolome and molecular basis for carbohydrate increase and nitrate reduction in burley tobacco seedlings by glycerol through upregulating carbon and nitrogen metabolism. Sci Rep. 8(1):13300.
  • Li YY, Hao YL, Fan F, Zhang B. 2018. The role of microbiome in insomnia, circadian disturbance and depression. Front Psychiatry. 9:669.
  • Lovelace MD, Varney B, Sundaram G, Lennon MJ, Lim CK, Jacobs K, Guillemin GJ, Brew BJ. 2017. Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases. Neuropharmacology. 112(Pt B):373–388.
  • Luna RA, Foster JA. 2015. Gut brain axis: diet microbiota interactions and implications for modulation of anxiety and depression. Curr Opin Biotechnol. 32:35–41.
  • Macpherson AJ, Harris NL. 2004. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol. 4(6):478–485.
  • Mahowald MW, Schenck CH. 2005. Insights from studying human sleep disorders. Nature. 437(7063):1279–1285.
  • Mawe GM, Hoffman JM. 2013. Serotonin signalling in the gut-functions, dysfunctions and therapeutic targets. Nat Rev Gastroenterol Hepatol. 10(8):473–486.
  • Mousseau DD, Butterworth RF. 1994. The kinetics and distribution of [3H] tryptamine binding sites in human brain. J Neurochem. 63(3):1052–1059.
  • Muller N, Schwarz M. 2006. Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission. Neurotox Res. 10(2):131–148.
  • Munafo JP, Gianfagna TJ. 2015. Chemistry and biological activity of steroidal glycosides from the Lilium genus. Nat Prod Rep. 32(3):454–477.
  • National Institutes Of Health 2005. National institutes of health state of the science conference statement on manifestations and management of chronic insomnia in adults. Sleep. 28:1049–1057.
  • Nau SD, McCrae CS, Cook KG, Lichstein KL. 2005. Treatment of insomnia in older adults. Clin Psychol Rev. 25(5):645–672.
  • Raybould HE. 2010. Gut chemosensing: interactions between gut endocrine cells and visceral afferents. Auton Neurosci. 153(1–2):41–46.
  • Rick JT, Taberner PV, Kerkut GA. 1973. gamma-Hydroxybutyric acid, imidazoleacetic acid, cerebral metabolism and induced sleep. Isr J Med Sci. 9:S55–S62.
  • Roberts AB, Gu X, Buffa JA, Hurd AG, Wang Z, Zhu W, Gupta N, Skye SM, Cody DB, Levison BS, et al. 2018. Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential. Nat Med. 24(9):1407–1417.
  • Schulze TG, Akula N, Breuer R, Steele J, Nalls MA, Singleton AB, Degenhardt FA, Nöthen MM, Cichon S, Rietschel M, et al. 2014. Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder. World J Biol Psychiatry. 15(3):200–208.
  • Sender R, Fuchs S, Milo R. 2016. Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell. 164(3):337–340.
  • Shao J, Zheng X, Qu L, Zhang H, Yuan H, Hui J, Mi Y, Ma P, Fan D. 2020. Ginsenoside Rg5/Rk1 ameliorated sleep via regulating the GABAergic/serotoninergic signaling pathway in a rodent model. Food Funct. 11(2):1245–1257.
  • Shi HY, Lu Y, Li YX, Tian FZ. 2018. Research progress of treatment with Chinese medicine for insomnia rats induced by PCPA. China. Med. Her. 15:33–36.
  • Si YP, Chen XH, Guo T, Wei WJ, Wang LL, Zhang F, Sun XY, Liu MQ. 2021. Comprehensive 16S rDNA sequencing and LC-MS/MS-based metabolomics to investigate intestinal flora and metabolic profiles of the serum, hypothalamus and hippocampus in p‑chlorophenylalanine-induced insomnia rats treated with Lilium brownie. Neurochem Res. DOI:10.1007/s11064-021-03466-z.
  • Song P, Ramprasath T, Wang H, Zou MH. 2017. Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases. Cell Mol Life Sci. 74(16):2899–2916.
  • Song YM. 2004. The evolution of insomnia herbs in different historical periods. J Shandong Univ Chin Med. 28:452–455.
  • Takaki M, Mawe GM, Barasch JM, Gershon MD, Gershon MD. 1985. Physiological responses of guinea-pig myenteric neurons secondary to the release of endogenous serotonin by tryptamine. Neuroscience. 16(1):223–240.
  • Tremaroli V, Bäckhed F. 2012. Functional interactions between the gut microbiota and host metabolism. Nature. 489(7415):242–249.
  • Wang TT, Huang HH, Zhang Y, Li X, Li HF, Jiang QQ, Gao WY. 2015. Role of effective composition on antioxidant, anti-inflammatory, sedative-hypnotic capacities of 6 common edible Lilium varieties. J Food Sci. 80:857–868.
  • Wang X, Yang B, Sun H, Zhang A. 2012. Pattern recognition approaches and computational systems tools for ultra performance liquid chromatography-mass spectrometry-based comprehensive metabolomic profiling and pathways analysis of biological data sets. Anal Chem. 84(1):428–439.
  • Wang Y, Zhu DF, Chen YH, Jiang RZ, Xu H, Qiu ZD, Liu D, Luo HM. 2019. Metabonomics study of ginseng glycoproteins on improving sleep quality in mice. Biomed Res Int. 2019:2561828.
  • Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung Y-M, et al. 2011. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 472(7341):57–63.
  • Williams BB, Van Benschoten AH, Cimermancic P, Donia MS, Zimmermann M, Taketani M, Ishihara A, Kashyap PC, Fraser JS, Fischbach MA. 2014. Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host Microbe. 16(4):495–503.
  • Wu T, Yang L, Jiang J, Ni Y, Zhu J, Zheng X, Wang Q, Lu X, Fu Z. 2018. Chronic glucocorticoid treatment induced circadian clock disorder leads to lipid metabolism and gut microbiota alterations in rats. Life Sci. 192:173–182.
  • Xu H, Zheng X, Qian Y, Guan J, Yi H, Zou J, Wang Y, Meng L, Zhao A, Yin S, et al. 2016. Metabolomics profiling for obstructive sleep apnea and simple snorers. Sci Rep. 6:30958.
  • Yang B, Zhang A, Sun H, Dong W, Yan G, Li T, Wang X. 2012. Metabolomic study of insomnia and intervention effects of Suanzaoren decoction using ultra-performance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry. J Pharm Biomed Anal. 58:113–124.
  • Zhang J, Li AM, Kong AP, Lai KY, Tang NL, Wing YK. 2009. A community-based study of insomnia in Hong Kong Chinese children: prevalence, risk factors and familial aggregation. Sleep Med. 10(9):1040–1046.
  • Zhang LS, Davies SS. 2016. Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions. Genome Med. 8(1):46.
  • Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, et al. 2016. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell. 165(1):111–124.