Efficacy of pharmacological and non-pharmacological interventions on low sexual interest/arousal of peri- and post-menopausal women: a meta-analysis

References

• Aghamiri, V., Mirghafourvand, M., Mohammad-Alizadeh-Charandabi, S., & Nazemiyeh, H. (2016). The effect of Hop (Humulus lupulus L.) on early menopausal symptoms and hot flashes: A randomized placebo-controlled trial. Complementary Therapies in Clinical Practice, 23, 130–135.
   PubMed Web of Science ®Google Scholar
• Al-Azzawi, F., Bitzer, J., Brandenburg, U., Castelo-Branco, C., Graziottin, A., Kenemans, P., … Palacios, S. (2010). Therapeutic options for postmenopausal female sexual dysfunction. Climacteric: The Journal of the International Menopause Society, 13(2), 103–120.
   PubMed Web of Science ®Google Scholar
• Alexander, J. L., Kotz, K., Dennerstein, L., Kutner, S. J., Wallen, K., & Notelovitz, M. (2004). Menopause, 11(6 Pt 2), 749–765.
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders: DSM-IV. Arlington, VA: Author.
   Google Scholar
• American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®). Arlington, VA: Author.
   Google Scholar
• Barnhart, K. T., Freeman, E., Grisso, J. A., Rader, D. J., Sammel, M., Kapoor, S., & Nestler, J. E. (1999). The effect of deydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life. The Journal of Clinical Endocrinology & Metabolism, 84(11), 3896–3902.
   PubMed Web of Science ®Google Scholar
• Basaria, S., Wisniewski, A., Dupree, K., Bruno, T., Song, M. Y., Yao, F., … Dobs, A. S. (2009). Effect of high-dose isoflavones on cognition, quality of life, androgens, and lipoprotein in post-menopausal women. Journal of Endocrinological Investigation, 32(2), 150–155.
   PubMed Web of Science ®Google Scholar
• Biddle, A. K., West, S. L., D'Aloisio, A. A., Wheeler, S. B., Borisov, N. N., & Thorp, J. (2009). Hypoactive sexual desire disorder in postmenopausal women: Quality of life and health burden. Value in Health: The Journal of the International Society for Pharmacoeconomics and Outcomes Research, 12(5), 763–772.
   PubMed Web of Science ®Google Scholar
• Bloch, M., Meiboom, H., Zaig, I., Schreiber, S., & Abramov, L. (2013). The use of dehydroepiandrosterone in the treatment of hypoactive sexual desire disorder: A report of gender differences. European Neuropsychopharmacology : The Journal of the European College of Neuropsychopharmacology, 23(8), 910–918.
   PubMed Web of Science ®Google Scholar
• Blumel, J. E., Castelo-Branco, C., Binfa, L., Aparicio, R., & Mamani, L. (2001). A scheme of combined oral contraceptives for women more than 40 years old. Menopause (New York, N.Y.), 8(4), 286–289.
   PubMed Web of Science ®Google Scholar
• Blumel, J. E., Del Pino, M., Aprikian, D., Vallejo, S., Sarra, S., & Castelo-Branco, C. (2008). Effect of androgens combined with hormone therapy on quality of life in post-menopausal women with sexual dysfunction. Gynecological Endocrinology, 24(12), 691–695.
   PubMed Web of Science ®Google Scholar
• Braunstein, G. D., Sundwall, D. A., Katz, M., Shifren, J. L., Buster, J. E., Simon, J. A., … Watts, N. B. (2005). Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: A randomized, placebo-controlled trial. Archives of Internal Medicine, 165(14), 1582–1589.
   PubMedGoogle Scholar
• Buster, J. E., Kingsberg, S. A., Aguirre, O., Brown, C., Breaux, J. G., Buch, A., … Casson, P. (2005). Testosterone patch for low sexual desire in surgically menopausal women: A randomized trial. Obstetrics and Gynecology, 105(5 Pt 1), 944–952.
   PubMed Web of Science ®Google Scholar
• Cappelletti, M., & Wallen, K. (2016). Increasing women's sexual desire: The comparative effectiveness of estrogens and androgens. Hormones and Behavior, 78, 178–193.
   PubMed Web of Science ®Google Scholar
• Cavalcanti, A. L., Bagnoli, V. R., Fonseca, A. M., Pastore, R. A., Cardoso, E. B., Paixao, J. S., … Baracat, E. C. (2008). Effect of sildenafil on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction. International Journal of Gynecology & Obstetrics, 102(2), 115–119.
   PubMed Web of Science ®Google Scholar
• Chien, L. W., Liu, S. J., Chang, Y., & Liu, C. F. (2011). Local thermal therapy effects on menopausal symptoms and bone mineral density. Journal of Alternative and Complementary Medicine, 17(12), 1133–1140.
   PubMed Web of Science ®Google Scholar
• Choi, S. Y., Kang, P., Lee, H. S., & Seol, G. H. (2014). Effects of inhalation of essential oil of Citrus aurantium L. var. amara on menopausal symptoms, stress, and estrogen in postmenopausal women: A randomized controlled trial. Evidence-Based Complementary and Alternative Medicine, 2014. 1–7.
   Google Scholar
• Cohen, J. (1969). Statistical Power Analysis for the Behavioral Sciences. New York, NY: Academic Press.
   Google Scholar
• Cohen, J. (1987). Statistical Power Analysis for the Behavioral Sciences. Hillside, NJ: Lawrence,Erlbaum Associates.
   Google Scholar
• Davis, S. R., Goldstat, R. Kulkarni, J., Donath, S., & Bell, R. J. (2006). Effects of aromatase inhibition on sexual function and well-being in postmenopausal women treated with testosterone : A randomized, placebo-controlled trial 13.
   Google Scholar
• Davis, S. R., Moreau, M., Kroll, R., Bouchard, C., Panay, N., Gass, M., … Studd, J. (2008). Testosterone for low libido in postmenopausal women not taking estrogen. The New England Journal of Medicine, 359, 2005–2017.
   PubMed Web of Science ®Google Scholar
• Davis, S. R., van der Mooren, M. J., van Lunsen, R. H., Lopes, P., Ribot, C., Rees, M., … Purdie, D. W. (2006). Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: A randomized, placebo-controlled trial. Menopause (New York, N.Y.), 13(3), 387–396.
   PubMed Web of Science ®Google Scholar
• Davison, S. L., Bell, R. J., Robinson, P., Jane, F., Leech, J., Maruff, P., … Davis, S. R. (2013). Continuous-combined oral estradiol/drospirenone has no detrimental effect on cognitive performance and improves estrogen deficiency symptoms in early postmenopausal women: A randomized placebo-controlled trial. Menopause (New York, N.Y.), 20(10), 1020–1026.
   PubMed Web of Science ®Google Scholar
• De Villiers, T. J., Pines, A., Panay, N., Gambacciani, M., Archer, D. F., Baber, R. J., … Langer, R. (2013). Updated 2013 International Menopause Society recommendations on menopausal hormone therapy and preventive strategies for midlife health. Climacteric: The Journal of the International Menopause Society, 16(3), 316–337.
   PubMed Web of Science ®Google Scholar
• Del Giorno, C., da Fonseca, A. M., Bagnoli, V. R., de Assis, J. S., Soares, J. M., Jr., & Baracat, E. C. (2010). Effects of trifolium pratense on the climacteric and sexual symptoms in postmenopause. Revista Da Associacao Medica Brasileira, 56(5), 558–562.
   PubMed Web of Science ®Google Scholar
• El-Hage, G., Eden, J. A., & Manga, R. Z. (2007). A double-blind, randomized, placebo-controlled trial of the effect of testosterone cream on the sexual motivation of menopausal hysterectomized women with hypoactive sexual desire disorder. Climacteric: The Journal of the International Menopause Society, 10(4), 335–343.
   PubMed Web of Science ®Google Scholar
• Elraiyah, T., Sonbol, M. B., Wang, Z., Khairalseed, T., Asi, N., Undavalli, C., … Prokop, L. (2014). The benefits and harms of systemic testosterone therapy in postmenopausal women with normal adrenal function: A systematic review and meta-analysis. The Journal of Clinical Endocrinology & Metabolism, 99(10), 3543–3550.
   PubMed Web of Science ®Google Scholar
• Feinberg, M. J., Lumia, A. R., & McGinnis, M. Y. (1997). The effect of anabolic-androgenic steroids on sexual behavior and reproductive tissues in male rats. Physiology & Behavior, 62(1), 23–30.
   PubMed Web of Science ®Google Scholar
• Fernandes, T., Costa-Paiva, L. H., & Pinto-Neto, A. M. (2014). Efficacy of vaginally applied estrogen, testosterone, or polyacrylic acid on sexual function in postmenopausal women: A randomized controlled trial. The Journal of Sexual Medicine, 11(5), 1262–1270.
   PubMed Web of Science ®Google Scholar
• Floter, A., Nathorst-Boos, J., Carlstrom, K., & von Schoultz, B. (2002). Addition of testosterone to estrogen replacement therapy in oophorectomized women: Effects on sexuality and well-being. Climacteric: The Journal of the International Menopause Society, 5(4), 357–365.
   PubMed Web of Science ®Google Scholar
• Forouhari, S., Khajehei, M., Moattari, M., Mohit, M., Rad, M. S., & Ghaem, H. (2010). The effect of education and awareness on the Quality-of-Life in postmenopausal women. Indian Journal of Community Medicine, 35(1), 109–114.
   PubMedGoogle Scholar
• Fruhauf, S., Gerger, H., Schmidt, H. M., Munder, T., & Barth, J. (2013). Efficacy of psychological interventions for sexual dysfunction: A systematic review and meta-analysis. Archives of Sexual Behavior, 42(6), 915–933.
   PubMed Web of Science ®Google Scholar
• Genazzani, A. R., Stomati, M., Valentino, V., Pluchino, N., Pot, E., Casarosa, E., … Luisi, M. (2011). Effect of 1-year, low-dose DHEA therapy on climacteric symptoms and female sexuality. Climacteric: The Journal of the International Menopause Society, 14(6), 661–668.
   PubMed Web of Science ®Google Scholar
• Glanz, K., Rimer, B. K., & Viswanath, K. (2008). Health behavior and health education: Theory, research, and practice (pp. 100–105). San Francisco: Wiley.
   Google Scholar
• Gozuyesil, E., & Baser, M. (2016). The effect of foot reflexology applied to women aged between 40 and 60 on vasomotor complaints and quality of life. Complementary Therapies in Clinical Practice, 24, 78–85.
   PubMed Web of Science ®Google Scholar
• Hackbert, L., & Heiman, J. R. (2002). Acute dehydroepiandrosterone (DHEA) effects on sexual arousal in postmenopausal women. Journal of Women's Health & Gender-Based Medicine, 11(2), 155–162.
   PubMedGoogle Scholar
• Hayes, R. D., Dennerstein, L., Bennett, C. M., Sidat, M., Gurrin, L. C., & Fairley, C. K. (2008). Risk factors for female sexual dysfunction in the general population: Exploring factors associated with low sexual function and sexual distress. The Journal of Sexual Medicine, 5(7), 1681–1693.
   PubMed Web of Science ®Google Scholar
• Hays, J., Ockene, J. K., Brunner, R. L., Kotchen, J. M., Manson, J. E., Patterson, R. E., … Valanis, B. G. (2003). Effects of estrogen plus progestin on health-related quality of life. The New England Journal of Medicine, 348(19), 1839–1854.
   PubMed Web of Science ®Google Scholar
• Heard-Davison, A., Heiman, J. R., & Kuffel, S. (2007). Genital and subjective measurement of the time course effects of an acute dose of testosterone vs. placebo in postmenopausal women. The Journal of Sexual Medicine, 4(1), 209–217.
   PubMed Web of Science ®Google Scholar
• Higgins, J. P. T., Altman, D. G., Gøtzsche, P. C., Jüni, P., Moher, D., Oxman, D., … Sterne, J. A. C. (2011). The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. The BMJ, 343, d5928.
   PubMed Web of Science ®Google Scholar
• Javadivala, Z. (2013). Assessing the effectiveness of “physical activity persuasion educational program ” on quality of life of menopaused women (PhD thesis). Tabriz, Iran: Tabriz University of Medical Sciences.
   Google Scholar
• Joshi, S., Khandwe, R., Bapat, D., & Deshmukh, U. (2011). Effect of yoga on menopausal symptoms. Menopause International, 17(3), 78–81.
   PubMedGoogle Scholar
• Kleinplatz, P. J., Dana Ménard, A., Paquet, M. P., Paradis, N., Campbell, M., Zuccarino, D., & Mehak, L. (2009). The components of optimal sexuality: A portrait of “great sex.” The Canadian Journal of Human Sexuality, 18(1–2), 1–13.
   Google Scholar
• Kotlarczyk, M. P., Lassila, H. C., O'Neil, C. K., D'Amico, F., Enderby, L. T., Witt-Enderby, P. A., & Balk, J. L. (2012). Melatonin osteoporosis prevention study (MOPS): A randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women. Journal of Pineal Research, 52(4), 414–426.
   PubMed Web of Science ®Google Scholar
• Laan, E., van Lunsen, R. H., & Everaerd, W. (2001). The effects of tibolone on vaginal blood flow, sexual desire and arousability in postmenopausal women. Climacteric: The Journal of the International Menopause Society, 4(1), 28–41.
   PubMedGoogle Scholar
• Latif, E. Z., & Diamond, M. P. (2013). Arriving at the diagnosis of female sexual dysfunction. Fertility and Sterility, 100(4), 898–904.
   PubMed Web of Science ®Google Scholar
• Lobo, R. A., Rosen, R. C., Yang, H. M., Block, B., & Van Der Hoop, R. G. (2003). Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertility and Sterility, 79(6), 1341–1352.
   PubMed Web of Science ®Google Scholar
• Malakouti, J., Farshbaf Khalili, A., Asghari Jafarabadi, M., & Jabbari, F. (2016). Effect of combined inhaler aromatherapy on sexual function in postmenopausal women: A randomized controlled trial. The Iranian Journal of Obstetrics, Gynecology and Infertility, 19(1), 9–15.
   Google Scholar
• Malary, M., Khani, S., Pourasghar, M., Moosazadeh, M., & Hamzehgardeshi, Z. (2015). Biopsychosocial determinants of hypoactive sexual desire disorder in women: A narrative review. Materia Socio Medica, 27(6), 383–389.
   PubMedGoogle Scholar
• Merghati-Khoei, E., Sheikhan, F., Shamsalizadeh, N., Haghani, H., Yousofnia Pasha, Y. R., & Killeen, T. (2014). Menopause negatively impacts sexual lives of middle-aged Iranian women: A cross-sectional study. Journal of Sex & Marital Therapy, 40(6), 552–560.
   PubMed Web of Science ®Google Scholar
• Meston, C. M., & Worcel, M. (2002). The effects of yohimbine plus L-arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder. Archives of Sexual Behavior, 31(4), 323–332.
   PubMed Web of Science ®Google Scholar
• Mirghafourvand, M., Mohammad-Alizadeh-Charandabi, S., Nedjat, S., & Asghari, M. (2014). Effects of aerobic exercise on quality of life in premenopausal and postmenopausal women: A randomized controlled trial. IJOGI, 17(114), 19–26.
   Google Scholar
• Mohammad-Alizadeh-Charandabi, S., Shahnazi, M., Nahaee, J., & Bayatipayan, S. (2013). Efficacy of black cohosh (Cimicifuga racemosa L.) in treating early symptoms of menopause: A randomized clinical trial. Chinese Medicine, 8(1), 20–27.
   PubMedGoogle Scholar
• Monjezi, F., & Iravani, M. R. (2013). Teaching of communication verbal, emotional and sexual based on Islamic views on married Couple's satisfaction. Asian Journal of Social Science, 2(1), 12–19.
   Google Scholar
• Moore, T. R., Franks, R. B., & Fox, C. (2017). Review of efficacy of complementary and alternative medicine treatments for menopausal symptoms. Journal of Midwifery & Women's Health, 62(3), 286–297.
   PubMed Web of Science ®Google Scholar
• Mortazavi, M., Bakhshayesh, A., Fatehizadeh, M., & Emaminiya, S. (2014). The relationship between sexual frigidity and marital conflect in women residing in Yazd. Urmia Medical Journal, 24(11), 913–921.
   Google Scholar
• Nappi, R. E., & Polatti, F. (2009). The use of estrogen therapy in women's sexual functioning ( CME). J Sex Med, 6(3), 603–616.
   PubMed Web of Science ®Google Scholar
• Nappi, R. E., Martini, E., Martella, S., Capuano, F., Bosoni, D., Giacomini, S., … Spinillo, A. (2014). Maintaining sexuality in menopause. Post Reproductive Health, 20(1), 22–29.
   PubMedGoogle Scholar
• Nappi, R. E., Martini, E., Terreno, E., Albani, F., Santamaria, V., Tonani, S., … Polatti, F. (2010). Management of hypoactive sexual desire disorder in women: Current and emerging therapies. International Journal of Women's Health, 2, 167–175.
   PubMedGoogle Scholar
• Nastri, C. O., Lara, L. A., Ferriani, R. A., Rosa, E., Silva, A. C., Figueiredo, J. B., & Martins, W. P. (2013). Hormone therapy for sexual function in perimenopausal and postmenopausal women. The Cochrane Database of Systematic Reviews, (6), CD009672.
   PubMed Web of Science ®Google Scholar
• Ngowsiri, K., Tanmahasamut, P., & Sukonthasab, S. (2014). Rusie Dutton traditional Thai exercise promotes health related physical fitness and quality of life in menopausal women. Complementary Therapies in Clinical Practice, 20(3), 164–171.
   PubMed Web of Science ®Google Scholar
• Nielsen, T. F., Ravn, P., Pitkin, J., & Christiansen, C. (2006). Pulsed estrogen therapy improves postmenopausal quality of life: A 2-year placebo-controlled study. Maturitas, 53(2), 184–190.
   PubMed Web of Science ®Google Scholar
• Nourozi, M., Haghollahi, F., Ramezanzadeh, F., & Hanachi, P. (2015). Effect of soy milk consumption on quality of life in Iranian postmenopausal women. Journal of Family and Reproductive Health, 9(2), 93–100.
   PubMedGoogle Scholar
• Nurnberg, H., Hensley, P. L., Heiman, J. R., Croft, H. A., Debattista, C., & Paine, S. (2008). Sildenafil treatment of women with antidepressant-associated sexual dysfunction: A randomized controlled trial. JAMA, 300(4), 395–404.
   PubMed Web of Science ®Google Scholar
• Oh, K. J., Chae, M. J., Lee, H. S., Hong, H. D., & Park, K. (2010). Effects of Korean red ginseng on sexual arousal in menopausal women: Placebo-controlled, double-blind crossover clinical study. The Journal of Sexual Medicine, 7(4), 1469–1477.
   PubMed Web of Science ®Google Scholar
• Osmanagaoglu, M. A., Atasaral, T., Baltaci, D., & Bozkaya, H. (2006). Effect of different preparations of hormone therapy on sexual dysfunction in naturally postmenopausal women. Climacteric: The Journal of the International Menopause Society, 9(6), 464–472.
   PubMed Web of Science ®Google Scholar
• Panay, N. P., Al-Azzawi, F., Bouchard, C., Davis, S. R., Eden, J., Lodhi, I., … Sturdee, D. W. (2010). Testosterone treatment of HSDD in naturally menopausal women: The ADORE study. Climacteric: The Journal of the International Menopause Society, 13(2), 121–131.
   PubMed Web of Science ®Google Scholar
• Panjari, M., Bell, R. J., Jane, F., Wolfe, R., Adams, J., Morrow, C., & Davis, S. (2009). A randomized trial of oral DHEA treatment for sexual function, well-being, and menopausal symptoms in postmenopausal women with low libido. The Journal of Sexual Medicine, 6(9), 2579–2590.
   PubMed Web of Science ®Google Scholar
• Peixoto, C., Carrilho, C. G., Barros, J. A., Ribeiro, T. T. S. B., Silva, L. M., Nardi, A. E., … Veras, A. B. (2017). The effects of dehydroepiandrosterone on sexual function: A systematic review. Climacteric: The Journal of the International Menopause Society, 20(2), 129–137.
   PubMed Web of Science ®Google Scholar
• Pinkerton, J. A. V., Aguirre, F. S., Blake, J., Cosman, F., Hodis, H., Hoffstetter, S., ... & Marchbanks, P. (2017). The 2017 hormone therapy position statement of the North American Menopause Society. Menopause, 24(7), 728–753.
   PubMed Web of Science ®Google Scholar
• Postigo, S., Lima, S. M. R. R., Yamada, S. S., dos Reis, B. F., da Silva, G. M. D., & Aoki, T. (2016). Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Revista Brasileira De Ginecologia E Obstetricia, 38(3), 140–146.
   Web of Science ®Google Scholar
• Pyke, R. E., & Clayton, A. H. (2015). Psychological treatment trials for hypoactive sexual desire disorder: A sexual medicine critique and perspective. The Journal of Sexual Medicine, 12(12), 2451–2458.
   PubMed Web of Science ®Google Scholar
• Reis, S. L. B., & Abdo, C. H. N. (2014). Benefits and risks of testosterone treatment for hypoactive sexual desire disorder in women: A critical review of studies published in the decades preceding and succeeding the advent of phosphodiesterase type 5 inhibitors. Clinics, 69(4), 294–303.
   PubMed Web of Science ®Google Scholar
• Ross, S. M. (2012). A standardized isopropanolic black cohosh extract (remifemin) is found to be safe and effective for menopausal symptoms. Holistic Nursing Practice, 26, 58–61.
   PubMed Web of Science ®Google Scholar
• Saadat, S. H., Kabir, A., Rahmani, K., Panahi, Y., Hosseinialhashemi, M., & Sahebkar, A. (2017). Systematic review and meta-analysis of Flibanserin's Effects and adverse events in women with hypoactive sexual desire disorder. Current Drug Metabolism, 18(1), 78–85.
   PubMed Web of Science ®Google Scholar
• Savolainen-Peltonen, H., Hautamaki, H., Tuomikoski, P., Ylikorkala, O., & Mikkola, T. S. (2014). Health-related quality of life in women with or without hot flashes: A randomized placebo-controlled trial with hormone therapy. Menopause (New York, N.Y.), 21(7), 732–739.
   PubMed Web of Science ®Google Scholar
• Sehhatie Shafaie, F., Mirghafourvand, M., & Jafari, M. (2014). Effect of education through support -group on early symptoms of menopause: A randomized controlled trial. Journal of Caring Sciences, 3(4), 247–256.
   PubMedGoogle Scholar
• Shifren, J. L., Braunstein, G. D., Simon, J. A., Casson, P. R., Buster, J. E., Redmond, G. P., … Mazer, N. A. (2000). Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. The New England Journal of Medicine, 343(10), 682–688.
   PubMed Web of Science ®Google Scholar
• Shifren, J. L., Davis, S. R., Moreau, M., Waldbaum, A., Bouchard, C., DeRogatis, L., … Kroll, R. (2006). Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: Results from the INTIMATE NM1 Study. Menopause (New York, N.Y.), 13(5), 770–779.
   PubMed Web of Science ®Google Scholar
• Simon, J., Braunstein, G., Nachtigall, L., Utian, W., Katz, M., Miller, S., … Davis, S. (2005). Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. The Journal of Clinical Endocrinology & Metabolism, 90(9), 5226–5233.
   PubMed Web of Science ®Google Scholar
• Simon, J. A., Kingsberg, S. A., Shumel, B., Hanes, V., Garcia, M., Jr., & Sand, M. (2014). Efficacy and safety of flibanserin in postmenopausal women with hypoactive sexual desire disorder: Results of the SNOWDROP trial. Menopause (New York, N.Y.), 21(6), 633–640.
   PubMed Web of Science ®Google Scholar
• Somboonporn, W., Davis, S., Seif, M. W., & Bell, R. (2005). Testosterone for peri and postmenopausal women. The Cochrane Database of Systematic Reviews, (4), CD004509.
   PubMed Web of Science ®Google Scholar
• U. S. Food & Drug Administration. (2015). FDA drug safety communication: FDA cautions about using testosterone products for low testosterone due to aging; requires labeling change to inform of possible increased risk of heart attack and stroke with use. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm436280.htm. Accessed March 4, 2015.
   Google Scholar
• Vélez Toral, M., Godoy-Izquierdo, D., Padial García, A., Lara Moreno, R., Mendoza Ladrón de Guevara, N., Salamanca Ballesteros, A., … Godoy García, J. F. (2014). Psychosocial interventions in perimenopausal and postmenopausal women: A systematic review of randomised and non-randomised trials and non-controlled studies. Maturitas, 77(2), 93–110.
   PubMed Web of Science ®Google Scholar
• Wampold, C. H. (2014). The components of great sex: Sexuality education for people who desire to scale the heights of optimal sexuality. American Journal of Sexuality Education, 9(2), 219–228.
   Google Scholar
• Welton, A. J., Vickers, M. R., Kim, J., Ford, D., Lawton, B. A., MacLennan, A. H., … Meade, T. W. (2009). Health-related quality of life after combined hormone-replacement therapy: Randomized controlled trial: Women's international study of long duration estrogen after the menopause. Obstetrical & Gynecological Survey, 64(4), 238–240.
   Google Scholar
• West, S. L., D'Aloisio, A. A., Agans, R. P., Kalsbeek, W. D., Borisov, N. N., & Thorp, J. M. (2008). Prevalence of low sexual desire and hypoactive sexual desire disorder in a nationally representative sample of us women. Archives of Internal Medicine, 168(13), 1441–1449.
   PubMedGoogle Scholar
• Wierman, M. E., Nappi, R. E., Avis, N., Davis, S. R., Labrie, F., Rosner, W., & Shifren, J. L. (2010). Endocrine aspects of women's sexual function. The Journal of Sexual Medicine, 7(1 Pt 2), 561–585.
   PubMed Web of Science ®Google Scholar
• Wiklund, I., Karlberg, J., & Mattsson, L. A. (1993). Quality of life of postmenopausal women on a regimen of transdermal estradiol therapy: A double-blind placebo-controlled study. American Journal of Obstetrics & Gynecology, 168(3 Pt 1), 824–830.
   PubMed Web of Science ®Google Scholar
• Wilbur, J., Miller, A. M., McDevitt, J., Wang, E., & Miller, J. (2005). Menopausal status, moderate-intensity walking, and symptoms in midlife women. Research and Theory for Nursing Practice, 19(2), 163–180.
   PubMedGoogle Scholar
• Yang, T. S., Wang, H. L., Chen, Y. J., Chang, S. P., & Yuan, C. C. (2004). Effect of continuous administration of conjugated estrogen plus medroxyprogesterone acetate (Premelle®) in postmenopausal women in Taiwan. Journal of the Chinese Medical Association, 67(7), 336–343.
   PubMedGoogle Scholar
• Yazdkhasti, M., Keshavarz, M., Mahmoodi, Z., & Hosseini, A. F. (2014). Self-directed learning and its impact on menopausal symptoms. Iranian Red Crescent Medical Journal, 16(5), e13259.
   PubMed Web of Science ®Google Scholar
• Yazdkhasti, M., Keshavarz, M., Merghaati Khoei, E. S., Hosseini, A. F., Smaeilzadeh, S. E., Amiri Pebdani, M., & Jafarzadeh, H. (2012). The effect of support group method on quality of life in post-menopausal women. Iranian Journal of Public Health, 41(11), 80–84.
   Web of Science ®Google Scholar
• Zhang, J., Chen, G., Lu, W., Yan, X., Zhu, S., Dai, Y., … Bai, W. (2014). Effects of physical exercise on health-related quality of life and blood lipids in perimenopausal women: A randomized placebo-controlled trial. Menopause (New York, N.Y.), 21(12).1–8.
   PubMedGoogle Scholar
• Ziaei, S., Moghasemi, M., & Faghihzadeh, S. (2010). Comparative effects of conventional hormone replacement therapy and tibolone on climacteric symptoms and sexual dysfunction in postmenopausal women. Climacteric: The Journal of the International Menopause Society, 13(2), 147–156.
   PubMed Web of Science ®Google Scholar
• Çayan, F., Dilek, U., Pata, Ö., & Dilek, S. (2008). Comparison of the effects of hormone therapy regimens, oral and vaginal estradiol, Estradiol+Drospirenone and tibolone, on sexual function in healthy postmenopausal women. The Journal of Sexual Medicine, 5(1), 132–138.
   PubMed Web of Science ®Google Scholar