Adipose-derived stem cell therapies for bone regeneration

References

• Romagnoli C, Brandi ML. Adipose mesenchymal stem cells in the field of bone tissue engineering. World J Stem Cells. 2014;6(2):144–152. DOI:10.4252/wjsc.v6.i2.144
   PubMedGoogle Scholar
• Zhang G, Brion A, Willemin A-S, et al. Nacre, a natural, multi-use, and timely biomaterial for bone graft substitution. J Biomed Mater Res A. 2017;105(2):662–671. DOI:10.1002/jbm.a.35939
   PubMed Web of Science ®Google Scholar
• Fillingham Y, Jacobs J. Bone grafts and their substitutes. Bone Joint J. 2016;98-B(1 Suppl A):6–9. DOI:10.1302/0301-620X.98B.36350
   PubMed Web of Science ®Google Scholar
• Emara KM, Diab RA, Emara A. Recent biological trends in management of fracture non-union. World J Orthop. 2015;6(8):623–628. DOI:10.5312/wjo.v6.i8.623
   PubMedGoogle Scholar
• Campana V, Milano G, Pagano E, et al. Bone substitutes in orthopaedic surgery: from basic science to clinical practice. J Mater Sci Mater Med. 2014;25(10):2445–2461. DOI:10.1007/s10856-014-5240-2
   PubMed Web of Science ®Google Scholar
• Barba M, Cicione C, Bernardini C, et al. Spinal fusion in the next generation: gene and cell therapy approaches. Scientific World J. 2014;2014:1–9. Article ID: 406159, 9 pages. DOI:10.1155/2014/406159
   Web of Science ®Google Scholar
• Parrilla C, Lattanzi W, Rita FA, et al. Ex vivo gene therapy using autologous dermal fibroblasts expressing hLMP3 for rat mandibular bone regeneration. Head Neck. 2010;32:310–318.
   PubMed Web of Science ®Google Scholar
• Calori GM, Mazza E, Colombo M, et al. The use of bone-graft substitutes in large bone defects: any specific needs? Injury. 2011;42 Suppl 2: S56–63. DOI:10.1016/j.injury.2011.06.011
   Google Scholar
• Bueno EM, Glowacki J. Cell-free and cell-based approaches for bone regeneration. Nat Rev Rheumatol. 2009 Dec;5(12):685–697. DOI:10.1038/nrrheum.2009.228
   PubMed Web of Science ®Google Scholar
• Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13(12):4279–4295.
   PubMed Web of Science ®Google Scholar
• Desiderio V, De Francesco F, Schiraldi C, et al. Human Ng2+ adipose stem cells loaded in vivo on a new crosslinked hyaluronic acid-Lys scaffold fabricate a skeletal muscle tissue. J Cell Physiol. 2013;228(8):1762–1773. DOI:10.1002/jcp.24336
   PubMed Web of Science ®Google Scholar
• Lattanzi W, Parolisi R, Barba M, et al. Osteogenic and neurogenic stem cells in their own place: unraveling differences and similarities between niches. Front Cell Neurosci. 2015;9:455. DOI:10.3389/fncel.2015.00455
   PubMed Web of Science ®Google Scholar
• Lattanzi W, Barba M, Novegno F, et al. Lim mineralization protein is involved in the premature calvarial ossification in sporadic craniosynostoses. Bone. 2013;52:474–484.12.
   PubMed Web of Science ®Google Scholar
• Vériter S, Gianello P, Igarashi Y, et al. Improvement of subcutaneous bioartificial pancreas vascularization and function by coencapsulation of pig islets and mesenchymal stem cells in primates. Cell Transplant. 2014;23(11):1349–1364. DOI:10.3727/096368913X663550
   PubMed Web of Science ®Google Scholar
• De CP, Bartsch G Jr, Siddiqui MM, et al. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 2007;25:100–106.
   PubMed Web of Science ®Google Scholar
• Fierabracci A, Lazzari L, Muraca M, et al. How far are we from the clinical use of placental-derived mesenchymal stem cells? Expert Opin Biol Ther. 2015;15(5):613–617. DOI:10.1517/14712598.2015.1000856
   PubMed Web of Science ®Google Scholar
• Lou X. Induced pluripotent stem cells as a new strategy for osteogenesis and bone regeneration. Stem Cell Rev. 2015;11(4):645–651. DOI:10.1007/s12015-015-9594-8
   PubMed Web of Science ®Google Scholar
• Wu Q, Yang B, Hu K, et al. Deriving osteogenic cells from induced pluripotent stem cells for bone tissue engineering. Tissue Eng Part B Rev. 2017;23(1):1–8. DOI:10.1089/ten.TEB.2015.0559
   PubMed Web of Science ®Google Scholar
• Bastami F, Nazeman P, Moslemi H, et al. Induced pluripotent stem cells as a new getaway for bone tissue engineering: A systematic review. Cell Prolif. 2017;50(2). DOI:10.1111/cpr.12321
   PubMed Web of Science ®Google Scholar
• Barruet E, Hsiao EC. Using human induced pluripotent stem cells to model skeletal diseases. Methods Mol Biol. 2016;1353:101–118. DOI:10.1007/7651_2014_171
   PubMedGoogle Scholar
• Hamazaki T, El Rouby N, Fredette NC, et al. Concise review: induced pluripotent stem cell research in the era of precision medicine. Stem Cells. 2017;35(3):545–550. DOI:10.1002/stem.2570
   PubMed Web of Science ®Google Scholar
• Longo UG, Loppini M, Berton A, et al. Stem cells from umbilical cord and placenta for musculoskeletal tissue engineering. Curr Stem Cell Res Ther. 2012;7:272–281.
   PubMed Web of Science ®Google Scholar
• Barba M, Pirozzi F, Saulnier N, et al. Lim mineralization protein 3 induces the osteogenic differentiation of human amniotic fluid stromal cells through Kruppel-like factor-4 downregulation and further bone-specific gene expression. J Biomed Biotechnol. 2012;2012:813894. DOI:10.1155/2012/813894
   PubMedGoogle Scholar
• Klontzas ME, Kenanidis EI, Heliotis M, et al. Bone and cartilage regeneration with the use of umbilical cord mesenchymal stem cells. Expert Opin Biol Ther. 2015;15(11):1541–1552. DOI:10.1517/14712598.2015.1068755
   PubMed Web of Science ®Google Scholar
• Magatti M, De Munari S, Vertua E, et al. Human amnion mesenchyme harbors cells with allogeneic T-cell suppression and stimulation capabilities. Stem Cells. 2008;26(1):182–192.
   PubMed Web of Science ®Google Scholar
• Loukogeorgakis SP, De Coppi P. Amniotic fluid stem cells: the known, the unknown and potential regenerative medicine applications. Stem Cells. 2016. DOI:10.1002/stem.2553
   PubMedGoogle Scholar
• Pianta S, Magatti M, Vertua E, et al. Amniotic mesenchymal cells from pre-eclamptic placentae maintain immunomodulatory features as healthy controls. J Cell Mol Med. 2016;20(1):157–169. DOI:10.1111/jcmm.12715
   PubMed Web of Science ®Google Scholar
• Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7(2):211–228.
   PubMedGoogle Scholar
• Kern S, Eichler H, Stoeve J, et al. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells Dayt Ohio. 2006;24(5):1294–1301.
   PubMed Web of Science ®Google Scholar
• Schubert T, Xhema D, Vériter S, et al. The enhanced performance of bone allografts using osteogenic-differentiated adipose-derived mesenchymal stem cells. Biomaterials. 2011;32(34):8880–8891. DOI:10.1016/j.biomaterials.2011.08.009
   PubMed Web of Science ®Google Scholar
• Saulnier N, Puglisi MA, Lattanzi W, et al. Gene profiling of bone marrow- and adipose tissue-derived stromal cells: a key role of Kruppel-like factor 4 in cell fate regulation. Cytotherapy. 2011;13:329–340.
   PubMed Web of Science ®Google Scholar
• De Francesco F, Tirino V, Desiderio V, et al. Human CD34/CD90 ASCs are capable of growing as sphere clusters, producing high levels of VEGF and forming capillaries. Plos One. 2009;4(8):e6537. DOI:10.1371/journal.pone.0006537
   Google Scholar
• Vériter S, Aouassar N, Adnet P-Y, et al. The impact of hyperglycemia and the presence of encapsulated islets on oxygenation within a bioartificial pancreas in the presence of mesenchymal stem cells in a diabetic Wistar rat model. Biomaterials. 2011;32(26):5945–5956. DOI:10.1016/j.biomaterials.2011.02.061
   PubMed Web of Science ®Google Scholar
• Lafosse A, Desmet C, Aouassar N, et al. Autologous adipose stromal cells seeded on a human collagen matrix for dermal regeneration in chronic wounds: clinical proof of concept. Plast Reconstr Surg. 2015;136(2):279–295. DOI:10.1097/PRS.0000000000001437
   PubMed Web of Science ®Google Scholar
• Schubert T, Lafont S, Beaurin G, et al. Critical size bone defect reconstruction by an autologous 3D osteogenic-like tissue derived from differentiated adipose MSCs. Biomaterials. 2013a;34(18):4428–4438. DOI:10.1016/j.biomaterials.2013.02.053
   PubMed Web of Science ®Google Scholar
• Schubert T, Poilvache H, Galli C, et al. Galactosyl-knock-out engineered pig as a xenogenic donor source of adipose MSCs for bone regeneration. Biomaterials. 2013b;34(13):3279–3289. DOI:10.1016/j.biomaterials.2013.01.057
   PubMed Web of Science ®Google Scholar
• Ferraro GA, De Francesco F, Nicoletti G, et al. Human adipose CD34+ CD90+ stem cells and collagen scaffold constructs grafted in vivo fabricate loose connective and adipose tissues. J Cell Biochem. 2013;114(5):1039–1049. DOI:10.1002/jcb.24443
   PubMed Web of Science ®Google Scholar
• Tsuji W, Rubin JP, Marra KG. Adipose-derived stem cells: implications in tissue regeneration. World J Stem Cells. 2014;6(3):312–321. DOI:10.4252/wjsc.v6.i3.312
   PubMedGoogle Scholar
• Vériter S, André W, Aouassar N, et al. Human adipose-derived mesenchymal stem cells in cell therapy: safety and feasibility in different “hospital exemption” clinical applications. Plos One. 2015;10(10):e0139566. DOI:10.1371/journal.pone.0139566
   PubMed Web of Science ®Google Scholar
• Yoshimura K, Suga H, Eto H. Adipose-derived stem/progenitor cells: roles in adipose tissue remodeling and potential use for soft tissue augmentation. Regen Med. 2009;4:265–273.
   PubMed Web of Science ®Google Scholar
• Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112:1796–1808.
   PubMed Web of Science ®Google Scholar
• Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112:1821–1830.
   PubMed Web of Science ®Google Scholar
• Schipper BM, Marra KG, Zhang W, et al. Regional anatomic and age effects on cell function of human adipose-derived stem cells. Ann Plast Surg. 2008;60:568–572.
   PubMed Web of Science ®Google Scholar
• Levi B, James AW, Glotzbach JP, et al. Depot-specific variation in the osteogenic and adipogenic potential of human adipose derived stromal cells. Plast Reconstr Surg. 2010;126:822–834.
   PubMed Web of Science ®Google Scholar
• Gentile P, Scioli MG, Bielli A, et al. Concise review: the use of adipose-derived stromal vascular fraction cells and platelet rich plasma in regenerative plastic surgery. Stem Cells. 2017;35(1):117–134.
   Web of Science ®Google Scholar
• Guercio A, Di BS, Casella S, et al. Canine mesenchymal stem cells (MSCs): characterization in relation to donor age and adipose tissue-harvesting site. Cell Biol Int. 2013;37:789–798.
   PubMed Web of Science ®Google Scholar
• Requicha JF, Viegas CA, Albuquerque CM, et al. Effect of anatomical origin and cell passage number on the stemness and osteogenic differentiation potential of canine adipose-derived stem cells. Stem Cell Rev. 2012;8:1211–1222.
   PubMed Web of Science ®Google Scholar
• von Eyben FE, Kroustrup JP, Larsen JF, et al. Comparison of gene expression in intra-abdominal and subcutaneous fat: a study of men with morbid obesity and nonobese men using microarray and proteomics. Ann N Y Acad Sci. 2004;1030:508–536.
   PubMed Web of Science ®Google Scholar
• Grove KL, Fried SK, Greenberg AS, et al. A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice. Int J Obes (Lond). 2010;34:989–1000.
   PubMed Web of Science ®Google Scholar
• Prunet-Marcassus B, Cousin B, Caton D, et al. From heterogeneity to plasticity in adipose tissues: site-specific differences. Exp Cell Res. 2006;312:727–736.
   PubMed Web of Science ®Google Scholar
• Di Taranto G, Cicione C, Visconti G, et al. Qualitative and quantitative differences of adipose-derived stromal cells from superficial and deep subcutaneous lipoaspirates: a matter of fat. Cytotherapy. 2015;17(8):1076–1089. DOI:10.1016/j.jcyt.2015.04.004
   PubMed Web of Science ®Google Scholar
• Aksu AE, Rubin JP, Dudas JR, et al. Role of gender and anatomical region on induction of osteogenic differentiation of human adipose-derived stem cells. Ann Plast Surg. 2008;60:306e22.
   Web of Science ®Google Scholar
• Lee NE, Kim SJ, Yang SJ, et al. Comparative characterization of mesenchymal stromal cells from multiple abdominal adipose tissues and enrichment of angiogenic ability via CD146 molecule. Cytotherapy. 2016;S1465-3249(16):30581–30583. DOI:10.1016/j.jcyt.2016.11.002
   Web of Science ®Google Scholar
• Barba M, Cicione C, Bernardini C, et al. Adipose-derived mesenchymal cells for bone regeneration: state of the art. Biomed Res Int. 2013;2013:416391. DOI:10.1155/2013/416391
   PubMed Web of Science ®Google Scholar
• Cicione C, Di Taranto G, Barba M, et al. In vitro validation of a closed device enabling the purification of the fluid portion of liposuction aspirates. Plast Reconstr Surg. 2016;137(4):1157–1167. DOI:10.1097/PRS.0000000000002014
   PubMed Web of Science ®Google Scholar
• Aronowitz JA, Lockhart RA, Hakakian CS. Mechanical versus enzymatic isolation of stromal vascular fraction cells from adipose tissue. Springerplus. 2015;4:713. DOI:10.1186/s40064-015-1509-2.59
   PubMed Web of Science ®Google Scholar
• Oberbauer E, Steffenhagen C, Wurzer C, et al. Enzymatic and non-enzymatic isolation systems for adipose tissue-derived cells: current state of the art. Cell Regen (Lond). 2015;4:7. DOI:10.1186/s13619-015-0020-0.E
   PubMedGoogle Scholar
• SundarRaj S, Deshmukh A, Priya N, et al. Development of a system and method for automated isolation of stromal vascular fraction from adipose tissue lipoaspirate. Stem Cells Int. 2015;2015:109353. DOI:10.1155/2015/109353
   PubMed Web of Science ®Google Scholar
• Saulnier N, Lattanzi W, Puglisi MA, et al. Mesenchymal stromal cells multipotency and plasticity: induction toward the hepatic lineage. Eur Rev Med Pharmacol Sci. 2009;13(Suppl 1):71–78.
   PubMed Web of Science ®Google Scholar
• Sterodimas A, De FJ, Nicaretta B, et al. Tissue engineering with adipose-derived stem cells (ADSCs): current and future applications. J Plast Reconstr Aesthet Surg. 2010;63:1886–1892.
   PubMed Web of Science ®Google Scholar
• Dominici M, Le BK, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315–317.
   PubMed Web of Science ®Google Scholar
• Zimmerlin L, Donnenberg VS, Pfeifer ME, et al. Stromal vascular progenitors in adult human adipose tissue. Cytometry A. 2010;77:22–30.
   PubMed Web of Science ®Google Scholar
• Lin K, Matsubara Y, Masuda Y, et al. Characterization of adipose tissue-derived cells isolated with the Celution system. Cytotherapy. 2008;10:417–426.
   PubMed Web of Science ®Google Scholar
• Corselli M, Chen CW, Sun B, et al. The tunica adventitia of human arteries and veins as a source of mesenchymal stem cells. Stem Cells Dev. 2012;21:1299–1308.
   PubMed Web of Science ®Google Scholar
• Tran KV, Gealekman O, Frontini A, et al. The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab. 2012;15(2):222–229. DOI:10.1016/j.cmet.2012.01.008
   PubMed Web of Science ®Google Scholar
• Gupta RK, Mepani RJ, Kleiner S, et al. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab. 2012;15(2):230–239. DOI:10.1016/j.cmet.2012.01.010
   PubMed Web of Science ®Google Scholar
• Bajek A, Gurtowska N, Olkowska J, et al. Adipose-derived stem cells as a tool in cell-based therapies. Arch Immunol Ther Exp (Warsz). 2016;64(6):443–454.
   PubMed Web of Science ®Google Scholar
• Inserra I, Martelli C, Cipollina M, et al. Lipoaspirate fluid proteome: A preliminary investigation by LC-MS top-down/bottom-up integrated platform of a high potential biofluid in regenerative medicine. Electrophoresis. 2016;37(7–8):1015–1026. DOI:10.1002/elps.201500504
   PubMed Web of Science ®Google Scholar
• Francis MP, Sachs PC, Elmore LW, et al. Isolating adipose-derived mesenchymal stem cells from lipoaspirate blood and saline fraction. Organogenesis. 2010;6(1):11–14.
   PubMed Web of Science ®Google Scholar
• Frazier TP, Gimble JM, Kheterpal I, et al. Impact of low oxygen on the secretome of human adipose-derived stromal/stem cell primary cultures. Biochimie. 2013;95(12):2286–2296. DOI:10.1016/j.biochi.2013.07.011
   PubMed Web of Science ®Google Scholar
• Kalinina N, Kharlampieva D, Loguinova M, et al. Characterization of secretomes provides evidence for adipose-derived mesenchymal stromal cells subtypes. Stem Cell Res Ther. 2015 Nov 11;6:221. DOI:10.1186/s13287-015-0209-8
   PubMed Web of Science ®Google Scholar
• Gómez-Aristizábal A, Sharma A, Bakooshli MA, et al. Stage-specific differences in secretory profile of mesenchymal stromal cells (MSCs) subjected to early- vs late-stage OA synovial fluid. Osteoarthritis Cartilage. 2016;S1063-4584(16):30413–30417. DOI:10.1016/j.joca.2016.11.010
   Google Scholar
• Assoni A, Coatti G, Valadares MC, et al. Different donors mesenchymal stromal cells secretomes reveal heterogeneous profile of relevance for therapeutic use. Stem Cells Dev. 2016. DOI:10.1089/scd.2016.0218
   PubMed Web of Science ®Google Scholar
• Riis S, Stensballe A, Emmersen J, et al. Mass spectrometry analysis of adipose-derived stem cells reveals a significant effect of hypoxia on pathways regulating extracellular matrix. Stem Cell Res Ther. 2016;7(1):52. DOI:10.1186/s13287-016-0310-7
   PubMed Web of Science ®Google Scholar
• Feisst V, Meidinger S, Locke MB. From bench to bedside: use of human adipose-derived stem cells. Stem Cells Cloning. 2015;8:149–162. DOI:10.2147/SCCAA.S64373
   PubMed Web of Science ®Google Scholar
• Bruno S, Deregibus MC, Camussi G. The secretome of mesenchymal stromal cells: role of extracellular vesicles in immunomodulation. Immunol Lett. 2015;168(2):154–158. DOI:10.1016/j.imlet.2015.06.007
   PubMed Web of Science ®Google Scholar
• Rodríguez TM, Saldías A, Irigo M, et al. Effect of TGF-β1 stimulation on the secretome of human adipose-derived mesenchymal stromal cells. Stem Cells Transl Med. 2015;4(8):894–898. DOI:10.5966/sctm.2015-0012
   PubMed Web of Science ®Google Scholar
• Overman JR, Helder MN, Ten Bruggenkate CM, et al. Growth factor gene expression profiles of bone morphogenetic protein-2-treated human adipose stem cells seeded on calcium phosphate scaffolds in vitro. Biochimie. 2013;95(12):2304–2313. DOI:10.1016/j.biochi.2013.08.034
   PubMed Web of Science ®Google Scholar
• Varghese J, Griffin M, Mosahebi A, et al. Systematic review of patient factors affecting adipose stem cell viability and function: implications for regenerative therapy. Stem Cell Res Ther. 2017;8(1):45. DOI:10.1186/s13287-017-0483-8
   PubMed Web of Science ®Google Scholar
• Graja A, Schulz TJ. Mechanisms of aging-related impairment of brown adipocyte development and function. Gerontology. 2015;61(3):211–217. DOI:10.1159/000366557
   PubMed Web of Science ®Google Scholar
• Rogers NH, Landa A, Park S, et al. Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue. Aging Cell. 2012;11(6):1074–1083. DOI:10.1111/acel.12010
   PubMed Web of Science ®Google Scholar
• Zhu M, Kohan E, Bradley J, et al. The effect of age on osteogenic, adipogenic and proliferative potential of female adipose-derived stem cells. J Tissue Eng Regen Med. 2009;3(4):290–301. DOI:10.1002/term.165
   PubMed Web of Science ®Google Scholar
• Choudhery MS, Badowski M, Muise A, et al. Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation. J Transl Med. 2014;12:8. DOI:10.1186/1479-5876-12-8
   PubMed Web of Science ®Google Scholar
• Alt EU, Senst C, Murthy SN, et al. Aging alters tissue resident mesenchymal stem cell properties. Stem Cell Res. 2012;8(2):215–225. DOI:10.1016/j.scr.2011.11.002
   PubMed Web of Science ®Google Scholar
• Kornicka K, Marycz K, Tomaszewski KA, et al. The effect of age on osteogenic and adipogenic differentiation potential of human adipose derived stromal stem cells (hascs) and the impact of stress factors in the course of the differentiation process. Oxid Med Cell Longev. 2015;2015:309169.
   PubMed Web of Science ®Google Scholar
• Marędziak M, Marycz K, Tomaszewski KA, et al. The influence of aging on the regenerative potential of human adipose derived mesenchymal stemcells. Stem Cells Int. 2016;2016:2152435.
   PubMed Web of Science ®Google Scholar
• Ye X, Liao C, G L, et al. Age-related changes in the regenerative potential of adipose-derived stem cells isolated from the prominent fat pads in human lower eyelids. Plos One. 2016;11(11):e0166590. DOI:10.1371/journal.pone.0166590
   Google Scholar
• Madonna R, Renna FV, Cellini C, et al. Age-dependent impairment of number and angiogenic potential of adipose tissue-derived progenitor cells. Eur J Clin Invest. 2011;41(2):126–133. DOI:10.1111/j.1365-2362.2010.02384.x
   PubMed Web of Science ®Google Scholar
• Bianco P, Cao X, Frenette PS, et al. The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nat Med. 2013;19(1):35–42. DOI:10.1038/nm.3028
   PubMed Web of Science ®Google Scholar
• Gerstenfeld LC, Cullinane DM, Barnes GL, et al. Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem. 2003;88:873–884.
   PubMed Web of Science ®Google Scholar
• Levi B, Longaker MT. Concise review: adipose-derived stromal cells for skeletal regenerative medicine. Stem Cells. 2011 Apr;29(4):576–582.
   PubMed Web of Science ®Google Scholar
• Todorov A, Kreutz M, Haumer A, et al. Fat-derived stromal vascular fraction cells enhance the bone-forming capacity of devitalized engineered hypertrophic cartilage matrix. Stem Cells Transl Med. 2016;5(12):1684–1694.
   Web of Science ®Google Scholar
• Lee SJ, Kang SW, Do HJ, et al. Enhancement of bone regeneration by gene delivery of BMP2/Runx2 bicistronic vector into adipose-derived stromal cells. Biomaterials. 2010;31:5652–5659.
   PubMed Web of Science ®Google Scholar
• Man Y, Wang P, Guo Y, et al. Angiogenic and osteogenic potential of platelet-rich plasma and adipose-derived stem cell laden alginate microspheres. Biomaterials. 2012;33:8802–8811.
   PubMed Web of Science ®Google Scholar
• Liu G, Zhang Y, Liu B, et al. Bone regeneration in a canine cranial model using allogeneic adipose derived stem cells and coral scaffold. Biomaterials. 2013;34:2655–2664.
   PubMed Web of Science ®Google Scholar
• Choi JW, Park EJ, Shin HS, et al. In vivo differentiation of undifferentiated human adipose tissue-derived mesenchymal stem cells in critical-sized calvarial bone defects. Ann Plast Surg. 2014;72(2):225–233.
   Web of Science ®Google Scholar
• Shen FH, Werner BC, Liang H, et al. Implications of adipose-derived stromal cells in a 3D culture system for osteogenic differentiation: an in vitro and in vivo investigation. Spine J. 2013;13:32–43.
   PubMed Web of Science ®Google Scholar
• Li X, Liu H, Niu X, et al. The use of carbon nanotubes to induce osteogenic differentiation of human adipose-derived MSCs in vitro and ectopic bone formation in vivo. Biomaterials. 2012;33:4818–4827.
   PubMed Web of Science ®Google Scholar
• Chou YF, Zuk PA, Chang TL, et al. Adipose-derived stem cells and BMP2: part 1. BMP2-treated adipose-derived stem cells do not improve repair of segmental femoral defects. Connect Tissue Res. 2011;52:109–118.
   PubMed Web of Science ®Google Scholar
• Najman SJ, Cvetković VJ, Najdanović JG, et al. Ectopic osteogenic capacity of freshly isolated adipose-derived stromal vascular fraction cells supported with platelet-rich plasma: A simulation of intraoperative procedure. J Craniomaxillofac Surg. 2016;44(10):1750-1760.
   PubMed Web of Science ®Google Scholar
• Brocher J, Janicki P, Voltz P, et al. Inferior ectopic bone formation of mesenchymal stromal cells from adipose tissue compared to bone marrow: rescue by chondrogenic pre-induction. Stem Cell Res. 2013 Nov;11(3):1393–1406.
   PubMed Web of Science ®Google Scholar
• Laschke MW, Schank TE, Scheuer C, et al. In vitro osteogenic differentiation of adipose-derived mesenchymal stem cell spheroids impairs their in vivo vascularization capacity inside implanted porous polyurethane scaffolds. Acta Biomater. 2014 Oct;10(10):4226–4235.
   PubMed Web of Science ®Google Scholar
• Wang CZ, Chen SM, Chen CH, et al. The effect of the local delivery of alendronate on human adipose-derived stem cell-based bone regeneration. Biomaterials. 2010;31:8674–8683.
   PubMed Web of Science ®Google Scholar
• Lin CY, Chang YH, Li KC, et al. The use of ASCs engineered to express BMP2 or TGF-beta3 within scaffold constructs to promote calvarial bone repair. Biomaterials. 2013;34(37):9401–9412.
   Google Scholar
• Levi B, Nelson ER, Li S, et al. Dura mater stimulates human adipose-derived stromal cells to undergo bone formation in mouse calvarial defects. Stem Cells. 2011;29:1241–1255.
   PubMed Web of Science ®Google Scholar
• Deng Y, Zhou H, Zou D, et al. The role of miR-31-modified adipose tissue-derived stem cells in repairing rat critical-sized calvarial defects. Biomaterials. 2013;34:6717–6728.
   PubMed Web of Science ®Google Scholar
• Levi B, Hyun JS, Nelson ER, et al. Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair. Stem Cells. 2011;29:2018–2029.
   PubMed Web of Science ®Google Scholar
• Lo DD, Hyun JS, Chung MT, et al. Repair of a critical-sized calvarial defect model using adipose-derived stromal cells harvested from lipoaspirate. J Vis Exp. 2012;31(68):4221.
   Web of Science ®Google Scholar
• Levi B, James AW, Nelson ER, et al. Studies in adipose-derived stromal cells: migration and participation in repair of cranial injury after systemic injection. Plast Reconstr Surg. 2011;127:1130–1140.
   PubMed Web of Science ®Google Scholar
• Levi B, James AW, Nelson ER, et al. Acute skeletal injury is necessary for human adipose-derived stromal cell-mediated calvarial regeneration. Plast Reconstr Surg. 2011;127:1118–1129.
   PubMed Web of Science ®Google Scholar
• Rhee SC, Ji YH, Gharibjanian NA, et al. In vivo evaluation of mixtures of uncultured freshly isolated adipose-derived stem cells and demineralized bone matrix for bone regeneration in a rat critically sized calvarial defect model. Stem Cells Dev. 2011;20:233–242.
   PubMed Web of Science ®Google Scholar
• Hong JM, Kim BJ, Shim JH, et al. Enhancement of bone regeneration through facile surface functionalization of solid freeform fabrication-based three-dimensional scaffolds using mussel adhesive proteins. Acta Biomater. 2012;8:2578–2586.
   PubMed Web of Science ®Google Scholar
• Jo CH, Yoon PW, et al. Comparative evaluation of in vivo osteogenic differentiation of fetal and adult mesenchymal stem cell in rat critical-sized femoral defect model. Cell Tissue Res. 2013;353:41–52.
   PubMed Web of Science ®Google Scholar
• Yoon E, Dhar S, Chun DE, et al. In vivo osteogenic potential of human adipose-derived stem cells/poly lactide-co-glycolic acid constructs for bone regeneration in a rat critical-sized calvarial defect model. Tissue Eng. 2007;13:619–627.
   PubMedGoogle Scholar
• Cui L, Liu B, Liu G, et al. Repair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine model. Biomaterials. 2007;28:5477–5486.
   PubMed Web of Science ®Google Scholar
• Stockmann P, Park J, Von WC, et al. Guided bone regeneration in pig calvarial bone defects using autologous mesenchymal stem/progenitor cells - a comparison of different tissue sources. J Craniomaxillofac Surg. 2012;40:310–320.
   PubMed Web of Science ®Google Scholar
• Kim HP, Ji YH, Rhee SC, et al. Enhancement of bone regeneration using osteogenic-induced adipose-derived stem cells combined with demineralized bone matrix in a rat critically-sized calvarial defect model. Curr Stem Cell Res Ther. 2012;7:165–172.
   PubMed Web of Science ®Google Scholar
• Kim JY, Jin GZ, Park IS, et al. Evaluation of solid free-form fabrication-based scaffolds seeded with osteoblasts and human umbilical vein endothelial cells for use in vivo osteogenesis. Tissue Eng Part A. 2010;16:2229–2236.
   PubMed Web of Science ®Google Scholar
• Ko E, Yang K, Shin J, et al. Polydopamine-assisted osteoinductive Peptide immobilization of polymer scaffolds for enhanced bone regeneration by human adipose-derived stem cells. Biomacromolecules. 2013;14:3202–3213.
   PubMed Web of Science ®Google Scholar
• Smith DM, Cooper GM, Afifi AM, et al. Regenerative surgery in cranioplasty revisited: the role of adipose-derived stem cells and BMP-2. Plast Reconstr Surg. 2011;128:1053–1060.
   PubMed Web of Science ®Google Scholar
• Levi B, James AW, Nelson ER, et al. Human adipose-derived stromal cells stimulate autogenous skeletal repair via paracrine Hedgehog signaling with calvarial osteoblasts. Stem Cells Dev. 2011;20:243–257.
   PubMed Web of Science ®Google Scholar
• Behr B, Tang C, Germann G, et al. Locally applied vascular endothelial growth factor A increases the osteogenic healing capacity of human adipose-derived stem cells by promoting osteogenic and endothelial differentiation. Stem Cells. 2011;29:286–296.
   PubMed Web of Science ®Google Scholar
• Tajima S, Tobita M, Orbay H, et al. Direct and indirect effects of a combination of adipose-derived stem cells and platelet-rich plasma on bone regeneration. Tissue Eng Part A. 2015 Mar;21(5–6):895–905.
   PubMed Web of Science ®Google Scholar
• Di Bella C, Farlie P, Penington AJ. Bone regeneration in a rabbit critical-sized skull defect using autologous adipose-derived cells. Tissue Eng Part A. 2008 Apr;14(4):483–490.
   PubMed Web of Science ®Google Scholar
• Shah AR, Cornejo A, Guda T, et al. Differentiated adipose-derived stem cell cocultures for bone regeneration in polymer scaffolds in vivo. J Craniofac Surg. 2014 Jul;25(4):1504–1509.
   PubMed Web of Science ®Google Scholar
• Lappalainen OP, Karhula S, Haapea M, et al. Bone healing in rabbit calvarial critical-sized defects filled with stem cells and growth factors combined with granular or solid scaffolds. Childs Nerv Syst. 2016 Apr;32(4):681–688.
   PubMed Web of Science ®Google Scholar
• Daei-Farshbaf N, Ardeshirylajimi A, Seyedjafari E, et al. Bioceramic-collagen scaffolds loaded with human adipose-tissue derived stem cells for bone tissue engineering. Mol Biol Rep. 2014 Feb;41(2):741–749.
   PubMed Web of Science ®Google Scholar
• Kim Y, Lee SH, Kang BJ, et al. Comparison of osteogenesis between adipose-derived mesenchymal stem cells and their sheets on poly-ε-caprolactone/β-tricalcium phosphate composite scaffolds in canine bone defects. Stem Cells Int. 2016;2016:8414715.
   PubMed Web of Science ®Google Scholar
• Lappalainen OP, Haapea M, Serpi R, et al. Iron-labeled adipose stem cells and neovascularization in rabbit calvarial critical-sized defects. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 May;121(5):e104–10.
   PubMed Web of Science ®Google Scholar
• Cvetković VJ, Najdanović JG, Vukelić-Nikolić MĐ, et al. Osteogenic potential of in vitro osteo-induced adipose-derived mesenchymal stem cells combined with platelet-rich plasma in an ectopic model. Int Orthop. 2015 Nov;39(11):2173–2180.
   PubMed Web of Science ®Google Scholar
• Liao YH, Chang YH, Sung LY, et al. Osteogenic differentiation of adipose-derived stem cells and calvarial defect repair using baculovirus-mediated co-expression of BMP-2 and miR-148b. Biomaterials. 2014 Jun;35(18):4901–4910.
   PubMed Web of Science ®Google Scholar
• Calis M, Demirtas TT, Atilla P, et al. Estrogen as a novel agent for induction of adipose-derived mesenchymal stem cells for osteogenic differentiation: in vivo bone tissue-engineering study. Plast Reconstr Surg. 2014 Apr;133(4):499e–510e.
   PubMed Web of Science ®Google Scholar
• Ko E, Alberti K, Lee JS, et al. Nanostructured tendon-derived scaffolds for enhanced bone regeneration by human adipose-derived stem cells. ACS Appl Mater Interfaces. 2016 Sep 7;8(35):22819–22829.
   PubMed Web of Science ®Google Scholar
• Saçak B, Certel F, Akdeniz ZD, et al. Repair of critical size defects using bioactive glass seeded with adipose-derived mesenchymal stem cells. J Biomed Mater Res B Appl Biomater. 2016 DOI: 10.1002/jbm.b.33634.
   PubMedGoogle Scholar
• Carvalho PP, Leonor IB, Smith BJ, et al. Undifferentiated human adipose-derived stromal/stem cells loaded onto wet-spun starch-polycaprolactone scaffolds enhance bone regeneration: nude mice calvarial defect in vivo study. J Biomed Mater Res A. 2014 Sep;102(9):3102–3111.
   PubMed Web of Science ®Google Scholar
• Lee SW, Padmanabhan P, Ray P, et al. Stem cell-mediated accelerated bone healing observed with in vivo molecular and small animal imaging technologies in a model of skeletal injury. J Orthop Res. 2009;27:295–302.
   PubMed Web of Science ®Google Scholar
• Keibl C, Fugl A, Zanoni G, et al. Human adipose derived stem cells reduce callus volume upon BMP-2 administration in bone regeneration. Injury. 2011;42:814–820.
   PubMed Web of Science ®Google Scholar
• Qing W, Guang-Xing C, Lin G, et al. The osteogenic study of tissue engineering bone with BMP2 and BMP7 gene-modified rat adipose-derived stem cell. J Biomed Biotechnol. 2012;2012:410879.
   PubMedGoogle Scholar
• Shoji T, Ii M, Mifune Y, et al. Local transplantation of human multipotent adipose-derived stem cells accelerates fracture healing via enhanced osteogenesis and angiogenesis. Lab Invest. 2010;90:637–649.
   PubMed Web of Science ®Google Scholar
• Wallner C, Abraham S, Wagner JM, et al. Local application of isogenic adipose-derived stem cells restores bone healing capacity in a type 2 diabetes model. Stem Cells Transl Med. 2016 Jun;5(6):836–844.
   PubMed Web of Science ®Google Scholar
• Godoy Zanicotti D, Coates DE, Duncan WJ. In vivo bone regeneration on titanium devices using serum-free grown adipose-derived stem cells, in a sheep femur model. Clin Oral Implants Res. 2017;28(1):64-75.
   Web of Science ®Google Scholar
• Peterson B, Zhang J, Iglesias R, et al. Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue. Tissue Eng. 2005 Jan-Feb;11(1–2):120–129.
   PubMedGoogle Scholar
• Nomura I, Watanabe K, Matsubara H, et al. Uncultured autogenous adipose-derived regenerative cells promote bone formation during distraction osteogenesis in rats. Clin Orthop Relat Res. 2014 Dec;472(12):3798–3806.
   PubMed Web of Science ®Google Scholar
• Kang B-J, Ryu -H-H, Park SS, et al. Comparing the osteogenic potential of canine mesenchymal stem cells derived from adipose tissues, bone marrow, umbilical cord blood, and Wharton’s jelly for treating bone defects. J Vet Sci. 2012;13:299–310.
   PubMed Web of Science ®Google Scholar
• Hao W, Dong J, Jiang M, et al. Enhanced bone formation in large segmental radial defects by combining adipose-derived stem cells expressing bone morphogenetic protein 2 with nHA/RHLC/PLA scaffold. Int Orthop. 2010;34:1341–1349.
   PubMed Web of Science ®Google Scholar
• Arrigoni E, Stanco D, Dellavia C, et al. Adipose-derived stem cells and rabbit bone regeneration: histomorphometric, immunohistochemical and mechanical characterization. J Orthop Sci. 2013;18:331–339.
   PubMed Web of Science ®Google Scholar
• Sunay O, Can G, Cakir Z, et al. Autologous rabbit adipose tissue-derived mesenchymal stromal cells for the treatment of bone injuries with distraction osteogenesis. Cytotherapy. 2013 Jun;15(6):690–702.
   PubMed Web of Science ®Google Scholar
• Arrigoni E, De Girolamo L, Di Giancamillo A, et al. Adipose-derived stem cells and rabbit bone regeneration: histomorphometric, immunohistochemical and mechanical characterization. J Orthop Sci. 2013 Mar;18(2):331–339.
   PubMed Web of Science ®Google Scholar
• Cruz AC, Caon T, Menin Á, et al. Adipose-derived stem cells incorporated into platelet-rich plasma improved bone regeneration and maturation in vivo. Dent Traumatol. 2015 Feb;31(1):42–48.
   PubMed Web of Science ®Google Scholar
• Cao Z, Hou S, Sun D, et al. Osteochondral regeneration by a bilayered construct in a cell-free or cell-based approach. Biotechnol Lett. 2012;34:1151–1157.
   PubMed Web of Science ®Google Scholar
• Fernandez FB, Shenoy S, Suresh BS, et al. Short-term studies using ceramic scaffolds in lapine model for osteochondral defect amelioration. Biomed Mater. 2012;7:035005.
   Web of Science ®Google Scholar
• Sheyn D, Pelled G, Zilberman Y, et al. Nonvirally engineered porcine adipose tissue-derived stem cells: use in posterior spinal fusion. Stem Cells. 2008;26:1056–1064.
   PubMed Web of Science ®Google Scholar
• Sheyn D, Kallai I, Tawackoli W, et al. Gene-modified adult stem cells regenerate vertebral bone defect in a rat model. Mol Pharm. 2011;8:1592–1601.
   PubMed Web of Science ®Google Scholar
• Wilson SM, Goldwasser MS, Clark SG, et al. Adipose-derived mesenchymal stem cells enhance healing of mandibular defects in the ramus of swine. J Oral Maxillofac Surg. 2012;70:e193–e203.
   PubMed Web of Science ®Google Scholar
• Parrilla C, Saulnier N, Bernardini C, et al. Undifferentiated human adipose tissue-derived stromal cells induce mandibular bone healing in rats. Arch Otolaryngol Head Neck Surg. 2011;137:463–470.
   PubMedGoogle Scholar
• Fan J, Park H, Lee MK, et al. Adipose-derived stem cells and BMP-2 delivery in chitosan-based 3D constructs to enhance bone regeneration in a rat mandibular defect model. Tissue Eng Part A. 2014 Aug;20(15–16):2169–2179.
   PubMed Web of Science ®Google Scholar
• Bhumiratana S, Bernhard JC, Alfi DM, et al. Tissue-engineered autologous grafts for facial bone reconstruction. Sci Transl Med. 2016 Jun 15;8(343):343ra83.
   PubMed Web of Science ®Google Scholar
• Akita D, Kano K, Saito-Tamura Y, et al. Use of rat mature adipocyte-derived dedifferentiated fat cells as a cell source for periodontal tissue regeneration. Front Physiol. 2016 Feb;23(7):50.
   Google Scholar
• Janicki P. Schmidmaier G. What should be the characteristics of the ideal bone graft substitute? Combining scaffolds with growth factors and/or stem cells. Injury. 2011;42 Suppl 2:S77–81. DOI:10.1016/j.injury.2011.06.014
   Google Scholar
• Hernandez-Hurtado AA, Borrego-Soto G, Marino-Martinez IA, et al. Implant composed of demineralized bone and mesenchymal stem cells genetically modified with AdBMP2/AdBMP7 for the regeneration of bone fractures in ovis aries. Stem Cells Int. 2016;2016:7403890.
   PubMed Web of Science ®Google Scholar
• Dorozhkin SV. Calcium orthophosphates as bioceramics: state of the art. J Funct Biomater. 2010;1(1):22–107. DOI:10.3390/jfb1010022
   PubMedGoogle Scholar
• Van Esterik FA, Zandieh-Doulabi B, Kleverlaan CJ, et al. Enhanced Osteogenic and Vasculogenic Differentiation Potential of Human Adipose Stem Cells on Biphasic Calcium Phosphate Scaffolds in Fibrin Gels. Stem Cells Int. 2016;2016:1934270. DOI:10.1155/2016/1934270
   PubMed Web of Science ®Google Scholar
• Bellucci D, Sola A, Cannillo V. Hydroxyapatite and tricalcium phosphate composites with bioactive glass as second phase: state of the art and current applications. J Biomed Mater Res A. 2016;104(4):1030–1056. DOI:10.1002/jbm.a.35619
   PubMed Web of Science ®Google Scholar
• Jones JR. Review of bioactive glass: from Hench to hybrids. Acta Biomater. 2013;9(1):4457–4486. DOI:10.1016/j.actbio.2012.08.023
   PubMed Web of Science ®Google Scholar
• Varanasi VG, Odatsu T, Bishop T, et al. Enhanced osteoprogenitor elongated collagen fiber matrix formation by bioactive glass ionic silicon dependent on Sp7 (osterix) transcription. J Biomed Mater Res A. 2016;104(10):2604–2615. DOI:10.1002/jbm.a.35795
   PubMed Web of Science ®Google Scholar
• Ersoy B, Bayramiçli M, Ercan F, et al. Comparison of bone prefabrication with vascularized periosteal flaps, hydroxyapatite, and bioactive glass in rats. J Reconstr Microsurg. 2015;31(4):291–299. DOI:10.1055/s-0034-1396770
   PubMed Web of Science ®Google Scholar
• Popescu RA, Magyari K, Vulpoi A, et al. Bioactive and biocompatible copper containing glass-ceramics with remarkable antibacterial properties and high cell viability designed for future in vivo trials. Biomater Sci. 2016;4(8):1252–1265. DOI:10.1039/c6bm00270f
   PubMed Web of Science ®Google Scholar
• Kaur G, Pandey OP, Singh K, et al. A review of bioactive glasses: their structure, properties, fabrication and apatite formation. J Biomed Mater Res A. 2014;102(1):254–274. DOI:10.1002/jbm.a.34690
   PubMed Web of Science ®Google Scholar
• Galarraga-Vinueza ME, Mesquita-Guimarães J, Magini RS, et al. Anti-biofilm properties of bioactive glasses embedding organic active compounds. J Biomed Mater Res A. 2016. DOI:10.1002/jbm.a.35934
   PubMed Web of Science ®Google Scholar
• Lendeckel S, Jödicke A, Christophis P, et al. Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report. J Craniomaxillofac Surg. 2004;32:370–373.
   PubMed Web of Science ®Google Scholar
• Mesimaki K, Lindroos B, Tornwall J, et al. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg. 2009;38:201–209.
   PubMed Web of Science ®Google Scholar
• Thesleff T, Lehtimaki K, Niskakangas T, et al. Cranioplasty with adipose-derived stem cells and biomaterial: a novel method for cranial reconstruction. Neurosurgery. 2011;68:1535–1540.
   PubMed Web of Science ®Google Scholar
• Sandor GK, Tuovinen VJ, Wolff J, et al. Adipose stem cell tissue-engineered construct used to treat large anterior mandibular defect: a case report and review of the clinical application of good manufacturing practice-level adipose stem cells for bone regeneration. J Oral Maxillofac Surg 2013, 71: 938–950.
   Google Scholar
• Sandor GK, Numminen J, Wolff J, et al. Adipose stem cells used to reconstruct 13 cases with cranio-maxillofacial hard-tissue defects. Stem Cells Transl Med. 2014 Apr;3(4):530–540.
   PubMed Web of Science ®Google Scholar
• Pak J, Lee JH, Jeon JH, et al. Complete resolution of avascular necrosis of the human femoral head treated with adipose tissue-derived stem cells and platelet-rich plasma. J Int Med Res. 2014 Dec;42(6):1353–1362.
   PubMed Web of Science ®Google Scholar
• Castillo-Cardiel G, López-Echaury AC, Saucedo-Ortiz JA, et al. Bone regeneration in mandibular fractures after the application of autologous mesenchymal stem cells, a randomized clinical trial. Dent Traumatol. 2017;33(1):38-44.
   Web of Science ®Google Scholar
• Dufrane D, Docquier PL, Delloye C, et al. Scaffold-free Three-dimensional graft from autologous adipose-derived stem cells for large bone defect reconstruction: clinical proof of concept. Medicine (Baltimore). 2015 Dec;94(50):e2220.
   PubMed Web of Science ®Google Scholar
• Prins H-J, Schulten EAJM, Ten Bruggenkate CM, et al. Bone regeneration using the freshly isolated autologous stromal vascular fraction of adipose tissue in combination with calcium phosphate ceramics. Stem Cells Transl Med. 2016 Oct;5(10):1362–1374.
   PubMed Web of Science ®Google Scholar
• Gimble JM, Guilak F. Bunnell BA: clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells. Stem Cell Res Ther. 2010;1:19.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Garza MT, Cruz-Vega DE. Regenerative capacity of autologous stem cell transplantation in elderly: a report of biomedical outcomes. Regen Med. 2017;12(2):169–178.
   PubMed Web of Science ®Google Scholar
• Pak J, Chang JJ, Lee JH, et al. Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints. BMC Musculoskelet Disord. 2013;14:337.
   PubMed Web of Science ®Google Scholar
• Li F, Zhou C, Xu L, et al. Effect of stem cell therapy on bone mineral density: a meta-analysis of preclinical studies in animal models of osteoporosis. Plos One. 2016;11(2):e0149400. DOI:10.1371/journal.pone.0149400
   Google Scholar
• Ye X, Zhang P, Xue S, et al. Adipose-derived stem cells alleviate osteoporosis by enhancing osteogenesis and inhibiting adipogenesis in a rabbit model. Cytotherapy. 2014;16(12):1643–1655. DOI:10.1016/j.jcyt.2014.07.009
   PubMed Web of Science ®Google Scholar
• Liu HY, Chiou JF, Wu AT, et al. The effect of diminished osteogenic signals on reduced osteoporosis recovery in aged mice and the potential therapeutic use of adipose-derived stem cells. Biomaterials. 2012;33(26):6105–6112.
   PubMed Web of Science ®Google Scholar
• Akbar MA, Lu Y, Elshikha AS, et al. Transplantation of adipose tissue-derived mesenchymal stem cell (ATMSC) expressing alpha-1 antitrypsin reduces bone loss in ovariectomized osteoporosis mice. Hum Gene Ther. 2017;28(2):179–189. DOI:10.1089/hum.2016.069
   PubMed Web of Science ®Google Scholar
• Wang L, Huang C, Li Q, et al. Osteogenic differentiation potential of adipose-derived stem cells from ovariectomized mice. Cell Prolif. 2017;50(2). DOI:10.1111/cpr.12328
   Web of Science ®Google Scholar
• Pei M, Li J, McConda DB, et al. A comparison of tissue engineering based repair of calvarial defects using adipose stem cells from normal and osteoporotic rats. Bone. 2015;78:1–10. DOI:10.1016/j.bone.2015.04.040
   PubMed Web of Science ®Google Scholar
• Liu H, Li W, Liu Y, et al. Co-administration of aspirin and allogeneic adipose-derived stromal cells attenuates bone loss in ovariectomized rats through the anti-inflammatory and chemotactic abilities of aspirin. Stem Cell Res Ther. 2015;6:200. DOI:10.1186/s13287-015-0195-x
   PubMed Web of Science ®Google Scholar