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Drug Profile

The role of alectinib in the treatment of advanced ALK-rearranged non-small-cell lung cancer

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Pages 1227-1233 | Received 26 Apr 2016, Accepted 14 Oct 2016, Published online: 03 Nov 2016

References

  • Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer incidence and mortality worldwide: IARC cancerbase no. 11 [internet]. Lyon, France: International Agency for Research on Cancer; 2013. cited 2013 Dec . Available from: http://globocan.iarc.fr (link is external)
  • Ettinger DS, Akerley W, Bepler G, et al. Non-small cell lung cancer. J Natl Compr Canc Netw. 2010;8(7):740–801. Available from: http://www.jnccn.org/content/8/7/740.short
  • Gainor JF, Varghese AM, Ou SHI, et al. ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer. Clin Cancer Res. 2013;19(15):4273–4281. DOI:10.1158/1078-0432.CCR-13-0318
  • Sholl LM, Aisner DL, Varella-Garcia M, LCMC Investigators; et al. Multi-institutional oncogenic driver mutation analysis in lung adenocarcinoma: the lung cancer mutation consortium experience. J Thorac Oncol. 2015 May;10(5):768–777.
  • Toyokawa G, Seto T. Anaplastic lymphoma kinase rearrangement in lung cancer: its biological and clinical significance. Respir Investig. 2014;52(6):330–338.
  • Inamura K, Takeuchi K, Togashi Y, et al. EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. J Thorac Oncol. 2008;3(1):13–17. DOI:10.1097/JTO.0b013e31815e8b60
  • Liao B-C, Lin -C-C, Shih J-Y, et al. Treating patients with ALK-positive non-small cell lung cancer: latest evidence and management strategy. Ther Adv Med Oncol. 2015;7(5):274–290. DOI:10.1177/1758834015590593
  • Yoshida A, Tsuta K, Nakamura H, et al. Comprehensive histologic analysis of ALK-rearranged lung carcinomas. Am J Surg Pathol. 2011;35(8):1226–1234.
  • National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology non-small cell lung cancer. Version 4.2016. http://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf
  • Morris SW, Kirstein MN, Valentine MB, et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in Non-Hodgkin’s lymphoma. Science. 1994;263(5151):1281–1284.
  • Grande E, Bolós M-V, Arriola E. Targeting oncogenic ALK: a promising strategy for cancer treatment. Mol Cancer Ther. 2011;10(4):569–579. DOI:10.1158/1535-7163.MCT-10-0615
  • Kanaan Z, Kloecker GH, Paintal A, et al. Novel targeted therapies for resistant ALK-rearranged non-small-cell lung cancer: ceritinib and beyond. Onco Targets Ther. 2015;8:885–892. DOI:10.2147/OTT.S67262
  • Hallberg B, Palmer RH. Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology. Nat Rev Cancer. 2013;13(10):685–700.
  • Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448(7153):561–566. DOI:10.1038/nature05945
  • Sasaki T, Koivunen J, Ogino A, et al. A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res. 2011;71(18):6051–6060. DOI:10.1158/0008-5472.CAN-11-1340.
  • Iacono D, Chiari R, Metro G, et al. Future options for ALK-positive non-small cell lung cancer. Lung Cancer. 2015;87(3):211–219.
  • Cajaiba MM, Jennings LJ, Rohan SM, et al. ALK-rearranged renal cell carcinomas in children. Genes Chromosomes Cancer. 2016 May;55(5):442–451.
  • Costigan DC, Doyle LA. Advances in the clinicopathological and molecular classification of cutaneous mesenchymal neoplasms. Histopathology. 2016 May;68(6):776–795.
  • Ying J, Lin C, Wu J, et al. Anaplastic lymphoma kinase rearrangement in digestive tract cancer: implication for targeted therapy in Chinese population. PLoS One. 2015 Dec 17;10(12):e0144731.
  • Cameron L, Solomon B. Treatment of ALK-rearranged non-small cell lung cancer: recent progress and future directions. Drugs. 2015 Jul;75(10):1059–1070.
  • Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009;27(26):4247–4253.
  • Guérin A, Sasane M, Zhang J, et al. ALK rearrangement testing and treatment patterns for patients with ALK-positive non-small cell lung cancer. Cancer Epidemiol. 2015 Jun;39(3):307–312.
  • Lindeman NI, Cagle PT, Beasley MB, et al. Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the college of american pathologists, international association for the study of lung cancer, and association for molecular pathology. J Thorac Oncol. 2013;8(7):823–859.
  • Food and Drug Administration. Vysis ALK break apart FISH probe kit, with the vysis paraffin pretreatment IV and post hybridization wash buffer kit, ProbeChek ALK negative control slides, and ProbeChek ALK positive control slides. Available from: http://www.accessdata.fda.gov/cdrh_docs/pdf11/p110012a.pdf
  • Selinger CI, Rogers TM, Russell PA, et al. Testing for ALK rearrangement in lung adenocarcinoma: a multicenter comparison of immunohistochemistry and fluorescent in situ hybridization. Mod Pathol. 2013;26:1545–1553.
  • Rogers TM, Russell PA, Wright G, et al. Comparison of methods in the detection of ALK and ROS1 rearrangements in lung cancer. J Thorac Oncol. 2015 Apr;10(4):611–618.
  • Food and Drug Administration. VENTANA ALK (D5F3) CDX ASSAY approval order. 2015 Apr. Available from: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=P140025
  • Carneiro B, Costa R, Taxter T, et al. Is personalized medicine here? Oncology (Willinston Park). 2016 Apr;30(4):293–303.
  • Pailler E, Adam J, Barthélémy A, et al. Detection of circulating tumor cells harboring a unique ALK rearrangement in ALK-positive non-small-cell lung cancer. J Clin Oncol. 2013 Jun 20;31(18):2273–2281.
  • Costa DB. Identification of somatic genomic alterations in circulating tumors cells: another step forward in non-small-cell lung cancer? J Clin Oncol. 2013 Jun 20;31(18):2236–2239.
  • Hamilton G, Rath B, Burghuber O. Pharmacokinetics of crizotinib in NSCLC patients. Expert Opin Drug Metab Toxicol. 2015;11(5):835–842. DOI:10.1517/17425255.2015.1021685
  • Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010 Oct 28;363(18):1693–1703.
  • Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013 Jun 20;368(25):2385–2394.
  • Solomon BJ, Mok T, Kim D-W, et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014;371(23):2167–2177. DOI:10.1056/NEJMoa1408440
  • Costa DB, Kobayashi S, Pandya SS, et al. Concentration of the anaplastic lymphoma kinase inhibitor crizotinib. J Clin Oncol. 2011;29(15):443–445.
  • Weickhardt AJ, Dmedsc M, Scheier B, et al. Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitos in oncogene addicted non-small cell lung cancer. J Thorac Oncol. 2012;7(12):1807–1814.
  • Doebele RC, Pilling AB, Aisner DL, et al. Mechanisms of resistance to crizotinib in ALK gene rearranged non-small cell lung cancer. Clin Cancer Res. 2014;18:1472–1482.
  • Choi YL, Soda M, Yamashita Y, ALK Lung Cancer Study Group; et al. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med 2010;363(18):1734–1739.
  • Katayama R, Shaw AT, Khan TM, et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged kung cancers. Sci Transl Med. 2012;4(120):120ra17.
  • Friboulet L, Li N, Katayama R, et al. The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Cancer Discov. 2014;4(6):662–673. DOI:10.1158/2159-8290.CD-13-0846.
  • Katayama R, Friboulet L, Koike S, et al. Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib. Clin Cancer Res. 2014;20(22):5686–5696. DOI:10.1158/1078-0432.CCR-14-1511.
  • Lovly CM, McDonald NT, Chen H, et al. Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer. Nat Med. 2014;20:1027–1034.
  • Kogita A, Togashi Y, Hayashi H, et al. Hypoxia induces resistance to ALK inhibitors in the H3122 non-small cell lung cancer cell line with an ALK rearrangement via epithelial-mesenchymal transition. Int J Oncol. 2014 Oct;45(4):1430–1436.
  • Song Z, Wang M, Zhang A. Alectinib: a novel second generation anaplastic lymphoma kinase (ALK) inhibitor for overcoming clinically-acquired resistance. Acta Pharm Sin B. 2015 Jan;5(1):34–37.
  • Sakamoto H, Tsukaguchi T, Hiroshima S, et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011;19(5):679–690. DOI:10.1016/j.ccr.2011.04.004
  • Kodama T, Hasegawa M, Takanashi K, et al. Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastases. Cancer Chemother Pharmacol. 2014;74(5):1023–1028. DOI:10.1007/s00280-014-2578-6
  • Kodama T, Tsukaguchi T, Yoshida M, et al. Selective ALK-inhibitor alectinib with potent antitumor activity in models of crizotinib resistance. Cancer Lett. 2014;351:215–221.
  • Seto T, Kiura K, Nishio M, et al. CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small cell lung cancer (AF-001JP study): a single arm, open-lable, phase 1-2 study. Lancet Oncol. 2013;14:590–598.
  • Gadgeel S, Gandhi L, Riely GI, et al. Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small cell lung scancer (AF-002GJ): results from the dose-finding portion of phase 1/2 study. Lancet Oncol. 2014;15:1119–1128.
  • Shaw A, Ghandi L, Gadgeel S, et al. Alectinib in ALK-positive, crizotinib-resistant, non-small cell lung cancer: a single-group, multicentre, phase 2 trial. Lancet Oncol. 2016;17:234–242.
  • Ou S, Ahn JS, Petris LD, et al. Alectinib in crizotinib-refractory ALK-rearranged non-small cell lung cancer: a phase II global study. J Clin Oncol. 2015 Nov 23. published online. DOI:10.1200/JCO.2015.63.9443
  • Crinò L, Ahn MJ, De Marinis F, et al. Multicenter phase ii study of whole-body and intracranial activity with ceritinib in patients with ALK-rearranged non-small-cell lung cancer previously treated with chemotherapy and crizotinib: results from ASCEND-2. J Clin Oncol. 2016 Aug 20;34(24):2866–2873.
  • Kim DW, Mehra R, Tan DS, et al. Activity and safety of ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1): updated results from the multicentre, open-label, phase 1 trial. Lancet Oncol. 2016 Apr;17(4):452–463.

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