Cell-free DNA as a potential biomarker for preeclampsia

References

• American College of Obstetricians and Gynecologists. Gestational Hypertension and preeclampsia: ACOG practice bulletin summary, number 222. Obstet Gynecol. 2020;135(6):1492–1495.
   PubMed Web of Science ®Google Scholar
• Shih T, Peneva D, Xu X, et al. The rising burden of preeclampsia in the United States impacts both maternal and child health. Am J Perinatol. 2016;33(4):329–338.
   PubMed Web of Science ®Google Scholar
• Redman CWG, Staff AC, and Roberts JM. Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways. Am J Obstet Gynecol. 2020;S0002-9378(20):31115–31117.
   Google Scholar
• AbdelHalim RM, Ramadan DI, Zeyada R, et al. Circulating maternal total cell-free DNA, cell-free fetal DNA and soluble endoglin levels in preeclampsia: predictors of adverse fetal outcome? A cohort study. Mol Diagn Ther. 2016;20(2):135–149.
   PubMed Web of Science ®Google Scholar
• Amaral LM, Sandrim VC, Kutcher ME, et al. Circulating total cell-free DNA levels are increased in hypertensive disorders of pregnancy and associated with prohypertensive factors and adverse clinical outcomes. Int J Mol Sci. 2021;22(2):2.
   Web of Science ®Google Scholar
• Eche S, Mackraj I, Moodley J. Circulating fetal and total cell-free DNA, and sHLA-G in black South African women with gestational hypertension and pre-eclampsia. Hypertens Pregnancy. 2017;36(4):295–301.
   PubMed Web of Science ®Google Scholar
• Munoz-Hernandez R, Medrano-Campillo P, Miranda ML, et al. Total and fetal circulating cell-free DNA, angiogenic, and antiangiogenic factors in preeclampsia and HELLP syndrome. Am J Hypertens. 2017;30(7):673–682.
   PubMed Web of Science ®Google Scholar
• Salvianti F, Inversetti A, Smid M, et al. Prospective evaluation of RASSF1A cell-free DNA as a biomarker of pre-eclampsia. Placenta. 2015;36(9):996–1001.
   PubMed Web of Science ®Google Scholar
• Sekizawa A, Farina A, Koide K, et al. beta-globin DNA in maternal plasma as a molecular marker of pre-eclampsia. Prenat Diagn. 2004;24(9):697–700.
   PubMed Web of Science ®Google Scholar
• Rolnik DL, O’Gorman N, Fiolna M, et al. Maternal plasma cell-free DNA in the prediction of pre-eclampsia. Ultrasound Obstet Gynecol. 2015;45(1):106–111.
   PubMed Web of Science ®Google Scholar
• Ао K, Оr B, Аа S, et al. Cell-free foetal DNA as a useful marker for preeclampsia prediction. Reprod Sci. 2021;28(5):1563–1569.
   PubMed Web of Science ®Google Scholar
• Farina A, Sekizawa A, Iwasaki M, et al. Total cell-free DNA (beta-globin gene) distribution in maternal plasma at the second trimester: a new prospective for preeclampsia screening. Prenat Diagn. 2004;24(9):722–726.
   PubMed Web of Science ®Google Scholar
• Rafaeli-Yehudai T, Imterat M, Douvdevani A, et al. Maternal total cell-free DNA in preeclampsia and fetal growth restriction: evidence of differences in maternal response to abnormal implantation. PLoS One. 2018;13(7):e0200360.
   PubMed Web of Science ®Google Scholar
• Marschalek J, Wohlrab P, Ott J, et al. Maternal serum mitochondrial DNA (mtDNA) levels are elevated in preeclampsia - A matched case-control study. Pregnancy Hypertens. 2018;14:195–199.
   PubMed Web of Science ®Google Scholar
• Qiu C, Enquobahrie DA, Gelaye B, et al. The association between leukocyte telomere length and mitochondrial DNA copy number in pregnant women: a pilot study. Clin Lab. 2015;61(3–4):363–369.
   PubMed Web of Science ®Google Scholar
• Busnelli A, Lattuada D, Ferrari S, et al. Mitochondrial DNA copy number in peripheral blood in the first trimester of pregnancy and different preeclampsia clinical phenotypes development: a pilot study. Reprod Sci. 2019;26(8):1054–1061.
   PubMed Web of Science ®Google Scholar
• Tjoa ML, Cindrova-Davies T, Spasic-Boskovic O, et al. Trophoblastic oxidative stress and the release of cell-free feto-placental DNA. Am J Pathol. 2006;169(2):400–404.
   PubMed Web of Science ®Google Scholar
• Lattuada D, Colleoni F, Martinelli A, et al. Higher mitochondrial DNA content in human IUGR placenta. Placenta. 2008;29(12):1029–1033.
   PubMed Web of Science ®Google Scholar
• Novielli C, Mando C, Tabano S, et al. Mitochondrial DNA content and methylation in fetal cord blood of pregnancies with placental insufficiency. Placenta. 2017;55:63–70.
   PubMed Web of Science ®Google Scholar
• Lau TW, Leung TN, Chan LY, et al. Fetal DNA clearance from maternal plasma is impaired in preeclampsia. Clin Chem. 2002;48(12):2141–2146.
   PubMed Web of Science ®Google Scholar
• Hahn S, Giaglis S, and Buser A, et al. Cell-free nucleic acids in (maternal) blood: any relevance to (reproductive) immunologists? J Reprod Immunol. 2014;104-105:26–31.
   PubMed Web of Science ®Google Scholar
• Scharfe-Nugent A, Corr SC, Carpenter SB, et al. TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia. J Immunol. 2012;188(11):5706–5712.
   PubMed Web of Science ®Google Scholar
• Conka J, Konecna B, Laukova L, et al. Fetal DNA does not induce preeclampsia-like symptoms when delivered in late pregnancy in the mouse. Placenta. 2017;52:100–105.
   PubMed Web of Science ®Google Scholar
• Konecna B, Borbelyova V, Celec P, et al. Does rat fetal DNA induce preeclampsia in pregnant rats? J Dev Orig Health Dis. 2015;6(1):5–9.
   PubMed Web of Science ®Google Scholar
• Bhagirath VC, Dwivedi DJ, and Liaw PC. Comparison of the proinflammatory and procoagulant properties of nuclear, mitochondrial, and bacterial DNA. Shock. 2015;44(3):265–271.
   PubMed Web of Science ®Google Scholar
• Goulopoulou S, Wenceslau CF, McCarthy CG, et al. Exposure to stimulatory CpG oligonucleotides during gestation induces maternal hypertension and excess vasoconstriction in pregnant rats. Am J Physiol Heart Circ Physiol. 2016;310(8):H1015–25.
   PubMed Web of Science ®Google Scholar
• Carbone IF, Conforti A, and Picarelli S, et al. Circulating nucleic acids in maternal plasma and serum in pregnancy complications: are they really useful in clinical practice? A systematic review. Mol Diagn Ther. 2020;24(4):409–431.
   PubMed Web of Science ®Google Scholar
• Contro E, Bernabini D, Farina A. Cell-free fetal DNA for the prediction of pre-eclampsia at the first and second trimesters: a systematic review and meta-analysis. Mol Diagn Ther. 2017;21(2):125–135.
   PubMed Web of Science ®Google Scholar
• Martin A, Krishna I, Badell M, et al. Can the quantity of cell-free fetal DNA predict preeclampsia: a systematic review. Prenat Diagn. 2014;34(7):685–691.
   PubMed Web of Science ®Google Scholar
• Vlkova B, Turna J, Celec P. Fetal DNA in maternal plasma in preeclamptic pregnancies. Hypertens Pregnancy. 2015;34(1):36–49.
   PubMed Web of Science ®Google Scholar