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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 23, 2008 - Issue 1
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Research Article

Quantitative structure-activity relationship study of novel rhinacanthins and related naphthoquinone esters as anticancer agents

B. K. Sharma Department of Chemistry, S.K. Government College, Sikar, 332 001, India
,
P. Singh Department of Chemistry, S.K. Government College, Sikar, 332 001, India
,
R. Kumar Department of Chemistry, S.K. Government College, Sikar, 332 001, India
&
Susheela Sharma Department of Engineering Chemistry, Sobhasaria Engineering College, Sikar, 332 021, India
Pages 50-55 | Received 22 Dec 2006, Accepted 19 Mar 2007, Published online: 04 Oct 2008

References

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  • Wu TS, Hsu HC, Wu PL, Teng CM, Wu YC. Rhinacanthin-Q a naphthoquinone from rhinacanthus nasutus and its biological activity. Phytochemistry 1998; 49: 2001–2003
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  • Kongkathip N, Luangkamin S, Kongkathip B, Sangma C, Grigg R, Kongsaeree P, Prabpai S, Pradidphol N, Piyaviriyagul S, Siripong P. Synthesis of novel rhinacanthins and related anticancer naphthoquinone esters. J Med Chem 2004; 47: 4427–4438
  • Hansch C, Fujita T. p-σ-π-Analysis: A method for the correlation of biological activity and chemical structure. J Am Chem Soc 1964; 86: 1616–1626
  • Hansch C. A quantitative approach to biochemical structure-activity relationships. Acc Chem Res 1969; 2: 232–239
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  • Hansch C, Leo A. Substituents constants for correlation analysis in chemistry and biology. John Wiley, New York 1979
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  • Singh P, Ojha TN, (Km) Tiwari S, Sharma RC. Fujita-Ban and Hansch analyses of A1- and A2-adenosine receptor binding affinities of some 4-amino[1,2,4]triazolo [4,3-a]quinoxalines. Ind J Chem 1996; 35B: 929–934
  • Kumar R, Singh P. Diarylspiro[2.4]heptenes as selective cyclooxygenase-2 inhibitors: A quantitative structure-activity relationship analysis. Ind J Chem 1997; 36B: 1164–1168
  • Singh P, Kumar R. Novel inhibitors of cyclooxygenase-2: The sulfones and sulfonamides of 1,2-diaryl-4,5-difluorobenzene. Analysis of quantitative structure-activity relationship. J Enz Inhib 1998; 13: 409–417
  • Singh P, Kumar R. 1,2-Diarylimidazoles as inhibitors of cyclooxygenase-2: A quantitative structure-activity relationship study. J Enz Inhib 1999; 14: 277–288
  • Singh P, Kumar R. Inhibitors of the epidermal growth factor receptor protein tyrosine kinase: A quantitative structure-activity relationship analysis. J Enz Inhib 1998; 13: 125–134
  • Singh P, Kumar Rajesh, Sharma BK. Quantitative structure-activity relationship study of 5-iodo- and diaryl-analogues of tubercidin: Inhibitors of adenosine kinase. J Enz Inhib Med Chem 2003; 18: 395–402
  • Singh P, Sharma BK. Quantitative structure-activity relationship study of benzylsulfanyl imidazoles as cytokine release inhibitors. J Enz Inhib Med Chem 2007; 22: 15–21
  • Sharma BK, Kumar Rajendra, Singh P. Quantitative structure-activity relationship study of 1-arylsulfonyl-6-substituted benzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Enz Inhib Med Chem 2002; 17: 219–225
  • Singh P, Sharma BK, Kumar R. Quantitative structure-activity relationship study on N-(pyridine-4-yl)-(indol-3-yl)alkylamides as antiallergic agents. Indian J Biochem Biophys 2002; 39: 351–355

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