476
Views
14
CrossRef citations to date
0
Altmetric
Research Article

3D Pharmacophore, hierarchical methods, and 5-HT4 receptor binding data

, , , , , & show all
Pages 593-603 | Received 06 Nov 2007, Accepted 07 May 2008, Published online: 20 Oct 2008

References

  • NM Barnes, and T Sharp. (1999). A review of central 5-HT receptors and their function. Neuropharmacology 38:1083–1152.
  • J Bockaert, M Sebben, and A Dumuis. (1990). Pharmacological characterization of 5-hydroxytryptamine4(5-HT4) receptors positively coupled to adenylate cyclase in adult guinea pig hippocampal membranes: Effect of substituted benzamide derivatives. Mol Pharmacol 37:408–411.
  • JL Plassat, U Boschert, N Amlaiky, and R Hen. (1992). The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family. EMBO J 11:4779–4786.
  • FJ MonsmaJr, Y Shen, RP Ward, MW Hamblin, and DR Sibley. (1993). Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol 43:320–327.
  • M Ruat, E Traiffort, JM Arrang, J Tardivel-Lacombe, J Diaz, R Leurs, and JC Schwartz. (1993). A novel rat serotonin (5-HT6) receptor: Molecular cloning, localization and stimulation of cAMP accumulation. Biochem Biophys Res Commun 193:268–276.
  • M Ruat, E Traiffort, R Leurs, J Tardivel-Lacombe, J Diaz, JM Arrang, and JC Schwartz. (1993). Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. Proc Natl Acad Sci USA 90:8547–8551.
  • RM Eglen. (1997). 5-Hydroxytryptamine (5-HT)4 receptors and central nervous system function: An update. Prog Drug Res 49:9–24.
  • S Consolo, S Arnaboldi, S Giorgi, G Russi, and H Ladinsky. (1994). 5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex. Neuroreport 5:1230–1232.
  • S Consolo, R Bertorelli, G Russi, M Zambelli, and H Ladinsky. (1994). Serotonergic facilitation of acetylcholine release in vivo from rat dorsal hippocampus via serotonin 5-HT3 receptors. J Neurochem 62:2254–2261.
  • S Benloucif, MJ Keegan, and MP Galloway. (1993). Serotonin-facilitated dopamine release in vivo: Pharmacological characterization. J Pharmacol Exp Ther 265:373–377.
  • PJ Karstaedt, H Kerasidis, JH Pincus, R Meloni, J Graham, and K Gale. (1994). Unilateral destruction of dopamine pathways increases ipsilateral striatal serotonin turnover in rats. Exp Neurol 126:25–30.
  • DE Patterson, RD Cramer, AM Ferguson, RD Clark, and LE Weinberger. (1996). Neighborhood behavior: A useful concept for validation of “molecular diversity” descriptors. J Med Chem 39:3049–3059.
  • DJ Fontana, SE Daniels, EH Wong, RD Clark, and RM Eglen. (1997). The effects of novel, selective 5-hydroxytryptamine (5-HT)4 receptor ligands in rat spatial navigation. Neuropharmacology 36:689–696.
  • N Galeotti, C Ghelardini, and A Bartolini. (1998). Role of 5-HT4 receptors in the mouse passive avoidance test. J Pharmacol Exp Ther 286:1115–1121.
  • S Letty, R Child, A Dumuis, A Pantaloni, J Bockaert, and G Rondouin. (1997). 5-HT4 receptors improve social olfactory memory in the rat. Neuropharmacology 36:681–687.
  • E Marchetti, A Dumuis, J Bockaert, B Soumireu-Mourat, and FS Roman. (2000). Differential modulation of the 5-HT(4) receptor agonists and antagonist on rat learning and memory. Neuropharmacology 39:2017–2027.
  • E Marchetti-Gauthier, FS Roman, A Dumuis, J Bockaert, and B Soumireu-Mourat. (1997). BIMU1 increases associative memory in rats by activating 5-HT4 receptors. Neuropharmacology 36:697–706.
  • C Daveu, R Bureau, I Baglin, H Prunier, JC Lancelot, and S Rault. (1999). Definition of a pharmacophore for partial agonists of serotonin 5-HT3 receptors. J Chem Inf Comput Sci 39:362–369.
  • A Hinschberger, S Butt, V Lelong, M Boulouard, A Dumuis, F Dauphin, R Bureau, B Pfeiffer, P Renard, and S Rault. (2003). New benzo[h][1,6]naphthyridine and azepino[3,2-c]quinoline derivatives as selective antagonists of 5-HT4 receptors: Binding profile and pharmacological characterization. J Med Chem 46:138–147.
  • R Bureau, C Daveu, S Lemaitre, F Dauphin, H Landelle, JC Lancelot, and S Rault. (2002). Molecular design based on 3D-pharmacophore. Application to 5-HT4 receptor. J Chem Inf Comput Sci 42:962–967.
  • M Halkidi, Y Batistakis, and M Vazirgiannis. (2001). On clustering validation techniques. JIIS 17:107–145.
  • CHEMAXON., < http://www.chemaxon.com/jchem/doc/user/Screen.html>. Accessed.
  • UNITY, Version 7.3, Tripos Inc., 2006., 1699 S. Hanley Road, St. Louis, MO 63144, USA.
  • RD Brown, and YC Martin. (1996). Use of structure-activity data to compare structure-based clustering methods and descriptors for use in compound selection. J Chem Inf Comput Sci 36:572–584.
  • R Project., < http://www.r-project.org/>. Accessed.
  • J Gower, and P Legendre. (1986). Metric and euclidean properties of dissimilarity coefficients. J Classification 3:5–48.
  • RR Sokal, and CD Michener. (1958). A statistical method for evaluating systematic relationships. Univ Kans Sci Bull 38:1409–1438.
  • P Jaccard. (1901). Etude comparative de la distribution florale dans une portion des Alpes et du Jura. Bull Soc Vaudoise Sci Nat 37:547–579.
  • M Fligner, JS Verducci, and PE Blower. (2002). A modification of the Jaccard-Tanimoto similarity index for diverse selection of chemical compounds using binary strings. Technometrics 44:110–119.
  • JD Holliday, N Salim, M Whittle, and P Willett. (2003). Analysis and display of the size dependence of chemical similarity coefficients. J Chem Inf Comput Sci 43:819–828.
  • LR Dice. (1945). Measures of the amount of ecologic association between species. Ecology 26:297–302.
  • R Project. 2006., version 2.4.0.
  • GN Lance, and WT Williams. (1967). Mixed-data classificatory programs. I. Agglomerative systems. Aus Comput J 1:15–20.
  • GJ Szekely, and ML Rizzo. (2005). Hierarchical clustering via joint between-within distances: Extending Ward's minimum variance method. J Classification 22:151–183.
  • K Florek, J Lukaszewiez, J Perkal, H Steinhaus, and S Zubrzchi. (1951). Sur la liaison et la division des points d'un ensemble fini. Colloquium Mathematicae 2:282–285.
  • T Sorensen. (1948). A method of establishing groups of equal amplitude in plant society based on similarity of species content. K. Danske Vidensk Selsk 5:34.
  • CA Glasbey. (1987). Complete linkage as a multiple stopping rule for single linkage clustering. J Classification 4:103–109.
  • JH Ward. (1963). Hierarchical grouping to optimize an objective function. J Am Stat Assoc 58:236–244.
  • JW Raymond, CJ Blankley, and P Willett. (2003). Comparison of chemical clustering methods using graph- and fingerprint-based similarity measures. J Mol Graph Modell 21:421–433.
  • DJ Wild, and CJ Blankley. (2000). Comparison of 2D fingerprint types and hierarchy level selection methods for structural grouping using Ward's clustering. J Chem Inf Comput Sci 40:155–162.
  • GW Adamson, and JA Bush. (1975). A comparison of the performance of some similarity and dissimilarity measures in the automatic classification of chemical structures. J Chem Inf Comput Sci 15:55–58.
  • GM Downs, P Willett, and W Fisanick. (1994). Similarity searching and clustering of chemical-structure databases using molecular property data. J Chem Inf Comput Sci 34:1094–1102.
  • H Matter, and T Poetter. (1999). Comparing 3D pharmacophore triplets and 2D fingerprints for selecting diverse compound subsets. J Chem Inf Comput Sci 39:1211–1225.
  • H Matter. (1997). Selecting optimally diverse compounds from structure databases: A validation study of two-dimensional and three-dimensional molecular descriptors. J Med Chem 40:1219–1229.
  • E Dimitriadou, S Dolnicar, and A Weingessel. (2002). An examination of indexes for determining the number of clusters in binary data sets. Psychometrika 67:137–159.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.