The impact of pneumococcal conjugate vaccines on serotype 19A nasopharyngeal carriage

References

• Myint TT, Madhava H, Balmer P, et al. The impact of 7-valent pneumococcal conjugate vaccine on invasive pneumococcal disease: a literature review. Adv Ther. 2013;30:127–151.
   PubMed Web of Science ®Google Scholar
• Williams SR, Mernagh PJ, Lee MH, et al. Changing epidemiology of invasive pneumococcal disease in Australian children after introduction of a 7-valent pneumococcal conjugate vaccine. Med J Aust. 2011;194:116–120.
   PubMed Web of Science ®Google Scholar
• Miller E, Andrews NJ, Waight PA, et al. Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales: an observational cohort study. Lancet Infect Dis. 2011;11:760–768.
   PubMed Web of Science ®Google Scholar
• Tin Tin Htar M, Madhava H, Balmer P, et al. A review of the impact of pneumococcal polysaccharide conjugate vaccine (7-valent) on pneumococcal meningitis. Adv Ther. 2013;30:748–762.
   PubMed Web of Science ®Google Scholar
• Almeida SC, Froes F, Valente C, et al. Streptococcus pneumoniae asymptomatic carriage can last several months in the healthy immunocompetent adult host [abstract ISPPD-0438]. Presented at: 11th International Symposium on Pneumococci and Pneumococcal Diseases; 2018 Apr 15–19; Melbourne, Australia.
   Google Scholar
• Prevnar 13® (pneumococcal 13-valent conjugate vaccine [diphtheria CRM197 protein]). Full Prescribing Information. Philadelphia, PA: Pfizer Inc; 2017.
   Google Scholar
• Isturiz R, Sings HL, Hilton B, et al. Streptococcus pneumoniae serotype 19A: worldwide epidemiology. Expert Rev Vaccines. 2017;16:1007–1027.
   PubMed Web of Science ®Google Scholar
• Varon E, Cohen R, Bechet S, et al. Invasive disease potential of pneumococci before and after the 13-valent pneumococcal conjugate vaccine implementation in children. Vaccine. 2015;33:6178–6185.
   PubMed Web of Science ®Google Scholar
• Weinberger DM, Harboe ZB, Sanders EA, et al. Association of serotype with risk of death due to pneumococcal pneumonia: a meta-analysis. Clin Infect Dis. 2010;51:692–699.
   PubMed Web of Science ®Google Scholar
• Madhi SA, Koen A, Jose L, et al. Vaccination with 10-valent pneumococcal conjugate vaccine in infants according to HIV status. Medicine (Baltimore). 2017;96:e5881.
   PubMed Web of Science ®Google Scholar
• Clarke CJ, Hausdorff WP. Further evidence for the effectiveness of PCV10 against Streptococcus pneumoniae serotype 19A. Lancet Respir Med. 2014;2:e7.
   PubMed Web of Science ®Google Scholar
• De Wals P, Lefebvre B, Markowski F, et al. Impact of 2+1 pneumococcal conjugate vaccine program in the province of Quebec, Canada. Vaccine. 2014;32:1501–1506.
   PubMed Web of Science ®Google Scholar
• Deceuninck G, De Serres G, Boulianne N, et al. Effectiveness of three pneumococcal conjugate vaccines to prevent invasive pneumococcal disease in Quebec, Canada. Vaccine. 2015;33:2684–2689.
   PubMed Web of Science ®Google Scholar
• Domingues CM, Verani JR, Montenegro REI, et al. Effectiveness of ten-valent pneumococcal conjugate vaccine against invasive pneumococcal disease in Brazil: a matched case-control study. Lancet Respir Med. 2014;2:464–471.
   PubMed Web of Science ®Google Scholar
• Jokinen J, Rinta-Kokko H, Siira L, et al. Impact of ten-valent pneumococcal conjugate vaccination on invasive pneumococcal disease in Finnish children – a population-based study. PLoS One. 2015;10:e0120290.
   PubMed Web of Science ®Google Scholar
• Simell B, Auranen K, Käyhty H, et al. The fundamental link between pneumococcal carriage and disease. Expert Rev Vaccines. 2012;11:841–855.
   PubMed Web of Science ®Google Scholar
• Morrison A, Polisena J, Husereau D, et al. The effect of English-language restriction on systematic review-based meta-analyses: a systematic review of empirical studies. Int J Technol Assess Health Care. 2012;28:138–144.
   PubMed Web of Science ®Google Scholar
• Sullivan KM, Dean A, Soe MM. OpenEpi: a web-based epidemiologic and statistical calculator for public health. Public Health Rep. 2009;124:471–474.
   PubMed Web of Science ®Google Scholar
• O’Brien KL, Millar EV, Zell ER, et al. Effect of pneumococcal conjugate vaccine on nasopharyngeal colonization among immunized and unimmunized children in a community-randomized trial. J Infect Dis. 2007;196:1211–1220.
   PubMed Web of Science ®Google Scholar
• Millar EV, O’Brien KL, Watt JP, et al. Effect of community-wide conjugate pneumococcal vaccine use in infancy on nasopharyngeal carriage through 3 years of age: a cross-sectional study in a high-risk population. Clin Infect Dis. 2006;43:8–15.
   PubMed Web of Science ®Google Scholar
• Millar EV, Watt JP, Bronsdon MA, et al. Indirect effect of 7-valent pneumococcal conjugate vaccine on pneumococcal colonization among unvaccinated household members. Clin Infect Dis. 2008;47:989–996.
   PubMed Web of Science ®Google Scholar
• van Gils EJ, Veenhoven RH, Hak E, et al. Effect of reduced-dose schedules with 7-valent pneumococcal conjugate vaccine on nasopharyngeal pneumococcal carriage in children: a randomized controlled trial. JAMA. 2009;302:159–167.
   PubMed Web of Science ®Google Scholar
• van Gils EJ, Veenhoven RH, Hak E, et al. Pneumococcal conjugate vaccination and nasopharyngeal acquisition of pneumococcal serotype 19A strains. JAMA. 2010;304:1099–1106.
   PubMed Web of Science ®Google Scholar
• Roca A, Hill PC, Townend J, et al. Effects of community-wide vaccination with PCV-7 on pneumococcal nasopharyngeal carriage in the Gambia: a cluster-randomized trial. PLoS Med. 2011;8:e1001107.
   PubMed Web of Science ®Google Scholar
• Egere U, Townend J, Roca A, et al. Indirect effect of 7-valent pneumococcal conjugate vaccine on pneumococcal carriage in newborns in rural Gambia: a randomised controlled trial. PLoS One. 2012;7:e49143.
   PubMed Web of Science ®Google Scholar
• Roca A, Dione MM, Bojang A, et al. Nasopharyngeal carriage of pneumococci four years after community-wide vaccination with PCV-7 in the Gambia: long-term evaluation of a cluster randomized trial. PLoS One. 2013;8:e72198.
   PubMed Web of Science ®Google Scholar
• Gisselsson-Solen M, Henriksson G, Hermansson A, et al. Effect of pneumococcal conjugate vaccination on nasopharyngeal carriage in children with early onset of acute otitis media - a randomized controlled trial. Acta Otolaryngol. 2015;135:7–13.
   PubMed Web of Science ®Google Scholar
• Adegbola RA, Hill PC, Secka O, et al. Serotype and antimicrobial susceptibility patterns of isolates of Streptococcus pneumoniae causing invasive disease in The Gambia 1996–2003. Trop Med Int Health. 2006;11:1128–1135.
   PubMed Web of Science ®Google Scholar
• Palmu AA, Jokinen J, Borys D, et al. Effectiveness of the ten-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) against invasive pneumococcal disease: a cluster randomised trial. Lancet. 2013;381:214–222.
   PubMed Web of Science ®Google Scholar
• Vesikari T, Forsten A, Seppa I, et al. Effectiveness of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D-conjugated vaccine (PHiD-CV) against carriage and acute otitis media-a double-blind randomized clinical trial in Finland. J Pediatric Infect Dis Soc. 2016;5:237–248.
   PubMed Web of Science ®Google Scholar
• van Den Bergh MR, Spijkerman J, Swinnen KM, et al. Effects of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D-conjugate vaccine on nasopharyngeal bacterial colonization in young children: a randomized controlled trial. Clin Infect Dis. 2013;56:e30–39.
   PubMed Web of Science ®Google Scholar
• Palmu AA, Toropainen M, Kaijalainen T, et al. Direct and indirect effectiveness of the 10-valent pneumococcal conjugate vaccine against carriage in a cluster randomized trial. Pediatr Infect Dis J. 2017;36:1193–1200.
   PubMed Web of Science ®Google Scholar
• Dagan R, Patterson S, Juergens C, et al. Comparative immunogenicity and efficacy of 13-valent and 7-valent pneumococcal conjugate vaccines in reducing nasopharyngeal colonization: a randomized double-blind trial. Clin Infect Dis. 2013;57:952–962.
   PubMed Web of Science ®Google Scholar
• Lund E, Henrichsen J. Chapter XI laboratory diagnosis, serology and epidemiology of Streptococcus pneumoniae. In: Bergan T, Norris JR, editors. Methods in microbiology. Cambridge (MA): Academic Press; 1978. p. 241–262.
   Google Scholar
• van Hoek AJ, Sheppard CL, Andrews NJ, et al. Pneumococcal carriage in children and adults two years after introduction of the thirteen valent pneumococcal conjugate vaccine in England. Vaccine. 2014;32:4349–4355.
   PubMed Web of Science ®Google Scholar
• Gounder PP, Brewster M, Bruce MG, et al. Impact of the pneumococcal conjugate vaccine and antibiotic use on nasopharyngeal colonization by antibiotic nonsusceptible Streptococcus pneumoniae, Alaska, 2000–2010. Pediatr Infect Dis J. 2015;34:1223–1229.
   PubMed Web of Science ®Google Scholar
• Hammitt LL, Bruden DL, Butler JC, et al. Indirect effect of conjugate vaccine on adult carriage of Streptococcus pneumoniae: an explanation of trends in invasive pneumococcal disease. J Infect Dis. 2006;193:1487–1494.
   PubMed Web of Science ®Google Scholar
• Keck JW, Wenger JD, Bruden DL, et al. PCV7-induced changes in pneumococcal carriage and invasive disease burden in Alaskan children. Vaccine. 2014;32:6478–6484.
   PubMed Web of Science ®Google Scholar
• Moore MR, Hyde TB, Hennessy TW, et al. Impact of a conjugate vaccine on community-wide carriage of nonsusceptible Streptococcus pneumoniae in Alaska. J Infect Dis. 2004;190:2031–2038.
   PubMed Web of Science ®Google Scholar
• Park SY, Moore MR, Bruden DL, et al. Impact of conjugate vaccine on transmission of antimicrobial-resistant Streptococcus pneumoniae among Alaskan children. Pediatr Infect Dis J. 2008;27:335–340.
   PubMed Web of Science ®Google Scholar
• Sharma D, Baughman W, Holst A, et al. Pneumococcal carriage and invasive disease in children before introduction of the 13-valent conjugate vaccine: comparison with the era before 7-valent conjugate vaccine. Pediatr Infect Dis J. 2013;32:e45–53.
   PubMed Web of Science ®Google Scholar
• Wroe PC, Lee GM, Finkelstein JA, et al. Pneumococcal carriage and antibiotic resistance in young children before 13-valent conjugate vaccine. Pediatr Infect Dis J. 2012;31:249–254.
   PubMed Web of Science ®Google Scholar
• Flasche S, Van Hoek AJ, Sheasby E, et al. Effect of pneumococcal conjugate vaccination on serotype-specific carriage and invasive disease in England: a cross-sectional study. PLoS Med. 2011;8:e1001017.
   PubMed Web of Science ®Google Scholar
• Sa-Leao R, Nunes S, Brito-Avo A, et al. Changes in pneumococcal serotypes and antibiotypes carried by vaccinated and unvaccinated day-care centre attendees in Portugal, a country with widespread use of the seven-valent pneumococcal conjugate vaccine. Clin Microbiol Infect. 2009;15:1002–1007.
   PubMed Web of Science ®Google Scholar
• Tocheva AS, Jefferies JM, Rubery H, et al. Declining serotype coverage of new pneumococcal conjugate vaccines relating to the carriage of Streptococcus pneumoniae in young children. Vaccine. 2011;29:4400–4404.
   PubMed Web of Science ®Google Scholar
• Tothpal A, Ordas A, Hajdu E, et al. A marked shift in the serotypes of pneumococci isolated from healthy children in Szeged, Hungary, over a 6-year period. Acta Microbiol Immunol Hung. 2011;58:239–246.
   PubMed Web of Science ®Google Scholar
• Vestrheim DF, Hoiby EA, Aaberge IS, et al. Impact of a pneumococcal conjugate vaccination program on carriage among children in Norway. Clin Vaccine Immunol. 2010;17:325–334.
   PubMed Web of Science ®Google Scholar
• Rodrigues F, Foster D, Caramelo F, et al. Progressive changes in pneumococcal carriage in children attending daycare in Portugal after 6 years of gradual conjugate vaccine introduction show falls in most residual vaccine serotypes but no net replacement or trends in diversity. Vaccine. 2012;30:3951–3956.
   PubMed Web of Science ®Google Scholar
• Nunes S, Félix S, Valente C, et al. The impact of private use of PCV7 in 2009 and 2010 on serotypes and antimicrobial resistance of Streptococcus pneumoniae carried by young children in Portugal: comparison with data obtained since 1996 generating a 15-year study prior to PCV13 introduction. Vaccine. 2016;34:1648–1656.
   PubMed Web of Science ®Google Scholar
• Paulo AC, Sá-Leão R. Periodic cycles of pneumococcal serotypes carried by children before and after 7-valent pneumococcal conjugate vaccine. PLoS One. 2017;12:e0176723.
   PubMed Web of Science ®Google Scholar
• Valente C, Hinds J, Pinto F, et al. Decrease in pneumococcal co-colonization following vaccination with the seven-valent pneumococcal conjugate vaccine. PLoS One. 2012;7:e30235.
   PubMed Web of Science ®Google Scholar
• Ho PL, Chiu SS, Chan MY, et al. Changes in nasopharyngeal carriage and serotype distribution of antibiotic-resistant Streptococcus pneumoniae before and after the introduction of 7-valent pneumococcal conjugate vaccine in Hong Kong. Diagn Microbiol Infect Dis. 2011;71:327–334.
   PubMed Web of Science ®Google Scholar
• Nzenze SA, Shiri T, Nunes MC, et al. Temporal changes in pneumococcal colonization in a rural African community with high HIV prevalence following routine infant pneumococcal immunization. Pediatr Infect Dis J. 2013;32:1270–1278.
   PubMed Web of Science ®Google Scholar
• Daana M, Rahav G, Hamdan A, et al. Measuring the effects of pneumococcal conjugate vaccine (PCV7) on Streptococcus pneumoniae carriage and antibiotic resistance: the Palestinian-Israeli Collaborative Research (PICR). Vaccine. 2015;33:1021–1026.
   PubMed Web of Science ®Google Scholar
• Parra EL, De La Hoz F, Diaz PL, et al. Changes in Streptococcus pneumoniae serotype distribution in invasive disease and nasopharyngeal carriage after the heptavalent pneumococcal conjugate vaccine introduction in Bogota, Colombia. Vaccine. 2013;31:4033–4038.
   PubMed Web of Science ®Google Scholar
• Ang JY, Lua JL, Asmar BI, et al. Nasopharyngeal carriage of Streptococcus pneumoniae in very low-birth-weight infants after administration of heptavalent pneumococcal conjugate vaccine. Arch Pediatr Adolesc Med. 2010;164:1173–1175.
   PubMedGoogle Scholar
• Rivera-Olivero IA, Del Nogal B, Fuentes M, et al. Immunogenicity of a 7-valent pneumococcal conjugate vaccine (PCV7) and impact on carriage in Venezuelan children at risk of invasive pneumococcal diseases. Vaccine. 2014;32:4006–4011.
   PubMed Web of Science ®Google Scholar
• Scott JR, Millar EV, Lipsitch M, et al. Impact of more than a decade of pneumococcal conjugate vaccine use on carriage and invasive potential in native American communities. J Infect Dis. 2012;205:280–288.
   PubMed Web of Science ®Google Scholar
• Nunes MC, Jones SA, Groome MJ, et al. Acquisition of Streptococcus pneumoniae in South African children vaccinated with 7-valent pneumococcal conjugate vaccine at 6, 14 and 40 weeks of age. Vaccine. 2015;33:628–634.
   PubMed Web of Science ®Google Scholar
• Olwagen CP, Adrian PV, Nunes MC, et al. Use of multiplex quantitative PCR to evaluate the impact of pneumococcal conjugate vaccine on nasopharyngeal pneumococcal colonization in African children. mSphere. 2017;2:e00404–00417.
   PubMed Web of Science ®Google Scholar
• Kwambana-Adams B, Hanson B, Worwui A, et al. Rapid replacement by non-vaccine pneumococcal serotypes may mitigate the impact of the pneumococcal conjugate vaccine on nasopharyngeal bacterial ecology. Sci Rep. 2017;7:8127.
   PubMed Web of Science ®Google Scholar
• Nelson KN, Grijalva CG, Chochua S, et al. Dynamics of colonization of Streptococcus pneumoniae strains in healthy Peruvian children. Open Forum Infect Dis. 2018;5:ofy039.
   PubMed Web of Science ®Google Scholar
• Hanke CR, Grijalva CG, Chochua S, et al. Bacterial density, serotype distribution and antibiotic resistance of pneumococcal strains from the nasopharynx of Peruvian children before and after pneumococcal conjugate vaccine 7. Pediatr Infect Dis J. 2016;35:432–439.
   PubMed Web of Science ®Google Scholar
• Jourdain S, Smeesters PR, Denis O, et al. Differences in nasopharyngeal bacterial carriage in preschool children from different socio-economic origins. Clin Microbiol Infect. 2011;17:907–914.
   PubMed Web of Science ®Google Scholar
• Mackenzie G, Carapetis J, Leach AJ, et al. Indirect effects of childhood pneumococcal vaccination on pneumococcal carriage among adults and older children in Australian Aboriginal communities. Vaccine. 2007;25:2428–2433.
   PubMed Web of Science ®Google Scholar
• Lee EK, Jun JK, Choi UY, et al. Nasopharyngeal carriage rate and serotypes of Streptococcus pneumoniae and antimicrobial susceptibility in healthy Korean children younger than 5 years old: focus on influence of pneumococcal conjugate vaccination. Infect Chemother. 2013;45:76–84.
   PubMedGoogle Scholar
• Spijkerman J, Prevaes SM, van Gils EJ, et al. Long-term effects of pneumococcal conjugate vaccine on nasopharyngeal carriage of S. pneumoniae, S. aureus, H. influenzae and M. catarrhalis. PLoS One. 2012;7:e39730.
   PubMed Web of Science ®Google Scholar
• Tothpal A, Kardos S, Laub K, et al. Radical serotype rearrangement of carried pneumococci in the first 3 years after intensive vaccination started in Hungary. Eur J Pediatr. 2015;174:373–381.
   PubMed Web of Science ®Google Scholar
• Hanage WP, Finkelstein JA, Huang SS, et al. Evidence that pneumococcal serotype replacement in Massachusetts following conjugate vaccination is now complete. Epidemics. 2010;2:80–84.
   PubMed Web of Science ®Google Scholar
• Huang SS, Hinrichsen VL, Stevenson AE, et al. Continued impact of pneumococcal conjugate vaccine on carriage in young children. Pediatrics. 2009;124:e1–11.
   PubMed Web of Science ®Google Scholar
• Huang SS, Platt R, Rifas-Shiman SL, et al. Post-PCV7 changes in colonizing pneumococcal serotypes in 16 Massachusetts communities, 2001 and 2004. Pediatrics. 2005;116:e408–413.
   PubMed Web of Science ®Google Scholar
• Cohen R, Levy C, de La Rocque F, et al. Impact of pneumococcal conjugate vaccine and of reduction of antibiotic use on nasopharyngeal carriage of nonsusceptible pneumococci in children with acute otitis media. Pediatr Infect Dis J. 2006;25:1001–1007.
   PubMed Web of Science ®Google Scholar
• Cohen R, Levy C, Bonnet E, et al. Dynamic of pneumococcal nasopharyngeal carriage in children with acute otitis media following PCV7 introduction in France. Vaccine. 2010;28:6114–6121.
   PubMed Web of Science ®Google Scholar
• Cohen R, Bingen E, Levy C, et al. Nasopharyngeal flora in children with acute otitis media before and after implementation of 7 valent pneumococcal conjugate vaccine in France. BMC Infect Dis. 2012;12:52.
   PubMed Web of Science ®Google Scholar
• Grivea IN, Panagiotou M, Tsantouli AG, et al. Impact of heptavalent pneumococcal conjugate vaccine on nasopharyngeal carriage of penicillin-resistant Streptococcus pneumoniae among day-care center attendees in central Greece. Pediatr Infect Dis J. 2008;27:519–525.
   PubMed Web of Science ®Google Scholar
• Grivea IN, Tsantouli AG, Michoula AN, et al. Dynamics of Streptococcus pneumoniae nasopharyngeal carriage with high heptavalent pneumococcal conjugate vaccine coverage in Central Greece. Vaccine. 2011;29:8882–8887.
   PubMed Web of Science ®Google Scholar
• Alexander E, Telfer P, Rashid H, et al. Nasopharyngeal carriage rate of Streptococcus pneumoniae in children with sickle cell disease before and after the introduction of heptavalent pneumococcal conjugate vaccine. J Infect Public Health. 2008;1:40–44.
   PubMedGoogle Scholar
• Brugger SD, Frey PM, Aebi S, et al. Multiple colonization with S. pneumoniae before and after introduction of the seven-valent conjugated pneumococcal polysaccharide vaccine. PLoS One. 2010;5:e11638–e11638.
   PubMed Web of Science ®Google Scholar
• Cho EY, Kang HM, Lee J, et al. Changes in serotype distribution and antibiotic resistance of nasopharyngeal isolates of Streptococcus pneumoniae from children in Korea, after optional use of the 7-valent conjugate vaccine. J Korean Med Sci. 2012;27:716–722.
   PubMed Web of Science ®Google Scholar
• Kuo CY, Hwang KP, Hsieh YC, et al. Nasopharyngeal carriage of Streptococcus pneumoniae in Taiwan before and after the introduction of a conjugate vaccine. Vaccine. 2011;29:5171–5177.
   PubMed Web of Science ®Google Scholar
• Ueno M, Ishii Y, Tateda K, et al. Changes in Streptococcus pneumoniae serotypes in the nasopharynx of Japanese children after inoculation with a heptavalent pneumococcal conjugate vaccine. Jpn J Infect Dis. 2014;67:40–43.
   PubMed Web of Science ®Google Scholar
• Hammitt LL, Akech DO, Morpeth SC, et al. Population effect of 10-valent pneumococcal conjugate vaccine on nasopharyngeal carriage of Streptococcus pneumoniae and non-typeable Haemophilus influenzae in Kilifi, Kenya: findings from cross-sectional carriage studies. Lancet Glob Health. 2014;2:e397–405.
   PubMed Web of Science ®Google Scholar
• Brandileone MC, Zanella RC, Almeida SC, et al. Effect of 10-valent pneumococcal conjugate vaccine on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae among children in Sao Paulo, Brazil. Vaccine. 2016;34:5604–5611.
   PubMed Web of Science ®Google Scholar
• Best EJ, Walls T, Souter M, et al. Pneumococcal vaccine impact on otitis media microbiology: a New Zealand cohort study before and after the introduction of PHiD-CV10 vaccine. Vaccine. 2016;34:3840–3847.
   PubMed Web of Science ®Google Scholar
• Vissers M, Wijmenga-Monsuur AJ, Knol MJ, et al. Increased carriage of non-vaccine serotypes with low invasive disease potential four years after switching to the 10-valent pneumococcal conjugate vaccine in the Netherlands. PLoS One. 2018;13:e0194823.
   PubMed Web of Science ®Google Scholar
• Leach AJ, Wigger C, Hare K, et al. Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine. BMC Pediatr. 2015;15:162.
   PubMed Web of Science ®Google Scholar
• Sigurdsson S, Erlendsdottir H, Quirk SJ, et al. Pneumococcal vaccination: direct and herd effect on carriage of vaccine types and antibiotic resistance in Icelandic children. Vaccine. 2017;35:5242–5248.
   PubMed Web of Science ®Google Scholar
• Heath CJ, Nayakwadi-Singer M, King CH, et al. Nasopharyngeal sarriage of Streptococcus pneumoniae in children in Coastal Kenya. Am J Trop Med Hyg. 2018;98:1046–1050.
   PubMed Web of Science ®Google Scholar
• Wyllie AL, Wijmenga-Monsuur AJ, van Houten MA, et al. Molecular surveillance of nasopharyngeal carriage of Streptococcus pneumoniae in children vaccinated with conjugated polysaccharide pneumococcal vaccines. Sci Rep. 2016;6:23809.
   PubMed Web of Science ®Google Scholar
• Bosch AA, van Houten MA, Bruin JP, et al. Nasopharyngeal carriage of Streptococcus pneumoniae and other bacteria in the 7th year after implementation of the pneumococcal conjugate vaccine in the Netherlands. Vaccine. 2016;34:531–539.
   PubMed Web of Science ®Google Scholar
• Devine VT, Cleary DW, Jefferies JM, et al. The rise and fall of pneumococcal serotypes carried in the PCV era. Vaccine. 2017;35:1293–1298.
   PubMed Web of Science ®Google Scholar
• Gounder PP, Bruce MG, Bruden DJ, et al. Effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae–alaska, 2008–2012. J Infect Dis. 2014;209:1251–1258.
   PubMed Web of Science ®Google Scholar
• Grant LR, Hammitt LL, O’Brien SE, et al. Impact of the 13-valent pneumococcal conjugate vaccine on pneumococcal carriage among American Indians. Pediatr Infect Dis J. 2016;35:907–914.
   PubMed Web of Science ®Google Scholar
• Gladstone RA, Jefferies JM, Tocheva AS, et al. Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction. Vaccine. 2015;33:2015–2021.
   PubMed Web of Science ®Google Scholar
• Southern J, Andrews N, Sandu P, et al. Pneumococcal carriage in children and their household contacts six years after introduction of the 13-valent pneumococcal conjugate vaccine in England. PLoS One. 2018;13:e0195799–e0195799.
   PubMed Web of Science ®Google Scholar
• Dunais B, Bruno P, Touboul P, et al. Impact of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage of Streptococcus pneumoniae among children attending group daycare in southeastern France. Pediatr Infect Dis J. 2015;34:286–288.
   PubMed Web of Science ®Google Scholar
• Allemann A, Frey PM, Brugger SD, et al. Pneumococcal carriage and serotype variation before and after introduction of pneumococcal conjugate vaccines in patients with acute otitis media in Switzerland. Vaccine. 2017;35:1946–1953.
   PubMed Web of Science ®Google Scholar
• Roca A, Bojang A, Bottomley C, et al. Effect on nasopharyngeal pneumococcal carriage of replacing PCV7 with PCV13 in the expanded programme of immunization in the Gambia. Vaccine. 2015;33:7144–7151.
   PubMed Web of Science ®Google Scholar
• Steens A, Caugant DA, Aaberge IS, et al. Decreased carriage and genetic shifts in the Streptococcus pneumoniae population after changing the seven-valent to the thirteen-valent pneumococcal vaccine in Norway. Pediatr Infect Dis J. 2015;34:875–883.
   PubMed Web of Science ®Google Scholar
• Galanis I, Lindstrand A, Darenberg J, et al. Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden. Eur Respir J. 2016;47:1208–1218.
   PubMed Web of Science ®Google Scholar
• Kaur R, Casey JR, Pichichero ME. Emerging Streptococcus pneumoniae strains colonizing the nasopharynx in children after 13-valent pneumococcal conjugate vaccination in comparison to the 7-valent era, 2006–2015. Pediatr Infect Dis J. 2016;35:901–906.
   PubMed Web of Science ®Google Scholar
• Nzenze SA, von Gottberg A, Shiri T, et al. Temporal changes in pneumococcal colonization in HIV-infected and HIV-uninfected mother-child pairs following transitioning from 7-valent to 13-valent pneumococcal conjugate vaccine, Soweto, South Africa. J Infect Dis. 2015;212:1082–1092.
   PubMed Web of Science ®Google Scholar
• Navne JE, Koch A, Slotved H-C, et al. Effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among Greenlandic children. Int J Circumpolar Health. 2017;76:1309504.
   PubMed Web of Science ®Google Scholar
• Camilli R, Vescio MF, Giufre M, et al. Carriage of Haemophilus influenzae is associated with pneumococcal vaccination in Italian children. Vaccine. 2015;33:4559–4564.
   PubMed Web of Science ®Google Scholar
• Zuccotti G, Mameli C, Daprai L, et al. Serotype distribution and antimicrobial susceptibilities of nasopharyngeal isolates of Streptococcus pneumoniae from healthy children in the 13-valent pneumococcal conjugate vaccine era. Vaccine. 2014;32:527–534.
   PubMed Web of Science ®Google Scholar
• Mameli C, Fabiano V, Daprai L, et al. A longitudinal study of streptococcus pneumoniae carriage in healthy children in the 13-valent pneumococcal conjugate vaccine era. Hum Vaccin Immunother. 2015;11:811–817.
   PubMed Web of Science ®Google Scholar
• Cohen R, Levy C, Bingen E, et al. Impact of 13-valent pneumococcal conjugate vaccine on pneumococcal nasopharyngeal carriage in children with acute otitis media. Pediatr Infect Dis J. 2012;31:297–301.
   PubMed Web of Science ®Google Scholar
• Janapatla RP, Su LH, Chen HH, et al. Epidemiology of culture-confirmed infections of Streptococcus pneumoniae (2012–2015) and nasopharyngeal carriage in children and households in Taiwan (2014–2015). J Med Microbiol. 2017;66:729–736.
   PubMed Web of Science ®Google Scholar
• Leach AJ, Wigger C, Beissbarth J, et al. General health, otitis media, nasopharyngeal carriage and middle ear microbiology in northern territory aboriginal children vaccinated during consecutive periods of 10-valent or 13-valent pneumococcal conjugate vaccines. Int J Pediatr Otorhinolaryngol. 2016;86:224–232.
   PubMed Web of Science ®Google Scholar
• Loughlin AM, Hsu K, Silverio AL, et al. Direct and indirect effects of PCV13 on nasopharyngeal carriage of PCV13 unique pneumococcal serotypes in Massachusetts’ children. Pediatr Infect Dis J. 2014;33:504–510.
   PubMed Web of Science ®Google Scholar
• Lee GM, Kleinman K, Pelton SI, et al. Impact of 13-valent pneumococcal conjugate vaccination on carriage in young children in Massachusetts. J Pediatric Infect Dis Soc. 2014;3:23–32.
   PubMedGoogle Scholar
• Yildirim I, Little BA, Finkelstein J, et al. Surveillance of pneumococcal colonization and invasive pneumococcal disease reveals shift in prevalent carriage serotypes in Massachusetts’ children to relatively low invasiveness. Vaccine. 2017;35:4002–4009.
   PubMed Web of Science ®Google Scholar
• Desai AP, Sharma D, Crispell EK, et al. Decline in pneumococcal nasopharyngeal carriage of vaccine serotypes after the introduction of the 13-valent pneumococcal conjugate vaccine in children in Atlanta, Georgia. Pediatr Infect Dis J. 2015;34:1168–1174.
   PubMed Web of Science ®Google Scholar
• Lee GM, Kleinman K, Pelton S, et al. Immunization, antibiotic use, and pneumococcal colonization over a 15-year period. Pediatrics. 2017;140:e20170001.
   PubMed Web of Science ®Google Scholar
• Cohen R, Varon E, Doit C, et al. A 13-year survey of pneumococcal nasopharyngeal carriage in children with acute otitis media following PCV7 and PCV13 implementation. Vaccine. 2015;33:5118–5126.
   PubMed Web of Science ®Google Scholar
• Angoulvant F, Cohen R, Doit C, et al. Trends in antibiotic resistance of Streptococcus pneumoniae and Haemophilus influenzae isolated from nasopharyngeal flora in children with acute otitis media in France before and after 13 valent pneumococcal conjugate vaccine introduction. BMC Infect Dis. 2015;15:236.
   PubMed Web of Science ®Google Scholar
• Lindstrand A, Galanis I, Darenberg J, et al. Unaltered pneumococcal carriage prevalence due to expansion of non-vaccine types of low invasive potential 8 years after vaccine introduction in Stockholm, Sweden. Vaccine. 2016;34:4565–4571.
   PubMed Web of Science ®Google Scholar
• Ben-Shimol S, Givon-Lavi N, Greenberg D, et al. Pneumococcal nasopharyngeal carriage in children <5 years of age visiting the pediatric emergency room in relation to PCV7 and PCV13 introduction in southern Israel. Hum Vaccin Immunother. 2016;12:268–276.
   PubMed Web of Science ®Google Scholar
• Flasche S, Givon-Lavi N, Dagan R. Using pneumococcal carriage data to monitor postvaccination changes in the incidence of pneumococcal otitis media. Am J Epidemiol. 2016;184:652–659.
   PubMed Web of Science ®Google Scholar
• Lee JK, Yun KW, Choi EH, et al. Changes in the serotype distribution among antibiotic resistant carriage Streptococcus pneumoniae isolates in children after the introduction of the extended-valency pneumococcal conjugate vaccine. J Korean Med Sci. 2017;32:1431–1439.
   PubMed Web of Science ®Google Scholar
• Collins DA, Hoskins A, Snelling T, et al. Predictors of pneumococcal carriage and the effect of the 13-valent pneumococcal conjugate vaccination in the western Australian aboriginal population. Pneumonia (Nathan). 2017;9:14.
   PubMedGoogle Scholar
• Goldblatt D, Hussain M, Andrews N, et al. Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study. J Infect Dis. 2005;192:387–393.
   PubMed Web of Science ®Google Scholar
• Pennington SH, Pojar S, Mitsi E, et al. Polysaccharide-specific memory B cells predict protection against experimental human pneumococcal carriage. Am J Respir Crit Care Med. 2016;194:1523–1531.
   PubMed Web of Science ®Google Scholar
• Expert WHO. Committee on biological standarization. WHO Technical report series 927. [ cited 2015 Oct 30]. Available from: http://www.who.int/biologicals/WHO_TRS_%20927%20full%20tex.pdf
   Google Scholar
• Dagan R, Juergens C, Trammel J, et al. Modeling pneumococcal nasopharyngeal acquisition as a function of anticapsular serum antibody concentrations after pneumococcal conjugate vaccine administration. Vaccine. 2016;34:4313–4320.
   PubMed Web of Science ®Google Scholar
• Klugman K. Pneumococcal conjugate vaccine and pneumococcal common protein vaccines. In: Plotkin SA, Orenstein WA, Offit PA, editors. Vaccines. 6th ed. Philadelphia, PA: Saunders, Elsevier; 2012; 504–541.
   Google Scholar
• Dagan R, Melamed R, Muallem M, et al. Reduction of nasopharyngeal carriage of pneumococci during the second year of life by a heptavalent conjugate pneumococcal vaccine. J Infect Dis. 1996;174:1271–1278.
   PubMed Web of Science ®Google Scholar
• Russell FM, Carapetis JR, Satzke C, et al. Pneumococcal nasopharyngeal carriage following reduced doses of a 7-valent pneumococcal conjugate vaccine and a 23-valent pneumococcal polysaccharide vaccine booster. Clin Vaccine Immunol. 2010;17:1970–1976.
   PubMed Web of Science ®Google Scholar
• Hicks LA, Harrison LH, Flannery B, et al. Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998–2004. J Infect Dis. 2007;196:1346–1354.
   PubMed Web of Science ®Google Scholar
• Rinta-Kokko H, Palmu AA, Auranen K, et al. Long-term impact of 10-valent pneumococcal conjugate vaccination on invasive pneumococcal disease among children in Finland. Vaccine. 2018;36:1934–1940.
   PubMed Web of Science ®Google Scholar
• Cassiolato AP, Almeida SCG, Andrade AL, et al. Expansion of the multidrug-resistant clonal complex 320 among invasive Streptococcus pneumoniae serotype 19A after the introduction of a ten-valent pneumococcal conjugate vaccine in Brazil. PLoS One. 2018;13:e0208211.
   PubMed Web of Science ®Google Scholar
• Desmet S, Verhaegen J, Van Ranst M, et al. Switch in a childhood pneumococcal vaccination programme from PCV13 to PCV10: a defendable approach? Lancet Infect Dis. 2018;18:830–831.
   PubMed Web of Science ®Google Scholar
• Wouters I, Desmet S, Van Heirstraeten L, et al. Follow-up of serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae in child carriage after a PCV13-to-PCV10 vaccine switch in Belgium. Vaccine. 2019;37:1080–1086.
   PubMed Web of Science ®Google Scholar
• Wouters I, Van Heirstraeten L, Desmet S, et al. Nasopharyngeal S. pneumoniae carriage and density in Belgian infants after 9 years of pneumococcal conjugate vaccine programme. Vaccine. 2018;36:15–22.
   PubMed Web of Science ®Google Scholar