Supplementation of n-3 fatty acids during pregnancy and lactation reduces maternal plasma lipid levels and provides DHA to the infants

References

• Makrides M, Neumann M, Simmer K, Pater J, Gibson R. Are long-chain polyunsaturated fatty acids essential nutrients in infancy?. Lancet 1995; 345: 1463–1468
   PubMed Web of Science ®Google Scholar
• Dutta-Roy A K. Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. Am J Clin Nutr 2000; 71: 315S–322S
   PubMed Web of Science ®Google Scholar
• Harris W S, Connor W E, Lindsey S. Will dietary omega-3 fatty acids change the composition of human milk?. Am J Clin Nutr 1984; 40: 780–785
   PubMed Web of Science ®Google Scholar
• Makrides M, Neumann M A, Gibson R A. Effect of maternal docosahexaenoic acid (DHA) supplementation on breast milk composition. Eur J Clin Nutr 1996; 50: 352–357
   PubMed Web of Science ®Google Scholar
• Helland I B, Saarem K, Saugstad O D, Drevon C A. Fatty acid composition in maternal milk and plasma during supplementation with cod liver oil. Eur J Clin Nutr 1998; 52: 839–845
   PubMed Web of Science ®Google Scholar
• Al M D, Hornstra G, van der Schouw Y T, Bulstra-Ramakers M T, Huisjes H J. Biochemical EFA status of mothers and their neonates after normal pregnancy. Early Hum Dev 1990; 24: 239–248
   PubMed Web of Science ®Google Scholar
• Connor W E, Lowensohn R, Hatcher L. Increased docosahexaenoic acid levels in human newborn infants by administration of sardines and fish oil during pregnancy. Lipids 1996; 31(Suppl)183–187
   PubMed Web of Science ®Google Scholar
• Dunstan J A, Mori T A, Barden A, Beilin L J, Holt P G, Calder P C, Taylor A L, Prescott S L. Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition. Eur J Clin Nutr 2004; 58: 429–437
   PubMed Web of Science ®Google Scholar
• Clandinin M T, Chappell J E, Leong S, Heim T, Swyer P R, Chance G W. Intrauterine fatty acid accretion rates in human brain: Implications for fatty acid requirements. Early Hum Dev 1980; 4: 121–129
   PubMed Web of Science ®Google Scholar
• Martinez M. Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr 1992; 120: 129–138
   PubMed Web of Science ®Google Scholar
• Al M D, van Houwelingen A C, Kester A D, Hasaart T H, de Jong A E, Hornstra G. Maternal essential fatty acid patterns during normal pregnancy and their relationship to the neonatal essential fatty acid status. Br J Nutr 1995; 74: 55–68
   PubMed Web of Science ®Google Scholar
• Hachey D L. Benefits and risks of modifying maternal fat intake in pregnancy and lactation. Am J Clin Nutr 1994; 59: 454S–463S
   PubMed Web of Science ®Google Scholar
• Herrera E. Metabolic adaptations in pregnancy and their implications for the availability of substrates to the fetus. Eur J Clin Nutr 2000; 54: S47–51
   PubMed Web of Science ®Google Scholar
• Montelongo A, Lasuncion M A, Pallardo L F, Herrera E. Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women. Diabetes 1992; 41: 1651–1659
   PubMed Web of Science ®Google Scholar
• Alvarez J J, Montelongo A, Iglesias A, Lasucion M A, Herrera E. Longitudinal study on lipoprotein profile, high density lipoprotein subclass, and postheparin lipases during gestation in women. J Lipid Res 1996; 37: 299–308
   PubMed Web of Science ®Google Scholar
• Napoli C, Glass C K, Witztum J L, Deutsch R, D'Armiento F P, Palinski W. Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study. Lancet 1999; 354: 1234–1241
   PubMed Web of Science ®Google Scholar
• Khoury J, Henriksen T, Christophersen B, Tonstad S. Effect of a cholesterol-lowering diet on maternal, cord, and neonatal lipids, and pregnancy outcome: A randomized clinical trial. Am J Obstet Gynecol 2005; 193: 1292–1301
   PubMed Web of Science ®Google Scholar
• Gibson R A, Neumann M A, Makrides M. Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. Eur J Clin Nutr 1997; 51: 578–584
   PubMed Web of Science ®Google Scholar
• Jensen C L, Maude M, Anderson R E, Heird W C. Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids. Am J Clin Nutr 2000; 71: 292S–299S
   PubMed Web of Science ®Google Scholar
• Smuts C M, Huang M, Mundy D, Plasse T, Major S, Carlson S E. A randomized trial of docosahexaenoic acid supplementation during third trimester of pregnancy. Obstet Gynecol 2003; 101: 469–479
   PubMed Web of Science ®Google Scholar
• Smuts C M, Borod E, Peeples J M, Carlson S E. High-DHA eggs: feasibility as a means to enhance circulating DHA in mother and infant. Lipids 2003; 38: 407–414
   PubMed Web of Science ®Google Scholar
• Helland I B, Smith L, Saarem K, Saugstad O D, Drevon C A. Maternal supplementation with very long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics 2003; 111: e39, Available from: http://pediatrics.org/cgi/content/full/111/1/e39
   PubMed Web of Science ®Google Scholar
• Nes M, Frost Andersen L, Solvoll K, Sandstad B, Hustvedt B E, Lovo A, Drevon C A. Accuracy of a quantitative food frequency questionnaire applied in elderly Norwegian women. Eur J Clin Nutr 1992; 46: 809–821
   PubMed Web of Science ®Google Scholar
• Solvoll K, Lund-Larsen K, Søyland E, Sandstad B, Drevon C A. A quantitative food frequency questionnaire evaluated in a group of dermatologic outpatients. Scand J Nutr 1993; 37: 150–155
   Google Scholar
• Andersen L F, Solvoll K, Drevon C A. Very-long-chain n-3 fatty acids as biomarkers for intake of fish and n-3 fatty acid concentrates. Am J Clin Nutr 1996; 64: 305–311
   PubMed Web of Science ®Google Scholar
• Bligh E G, Dyer W J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959; 37: 911–917
   PubMedGoogle Scholar
• Kaluzny M A, Duncan L A, Merritt M V, Epps D E. Rapid separation of lipid classes in high yield and purity using bonded phase columns. J Lipid Res 1985; 26: 135–140
   PubMed Web of Science ®Google Scholar
• Morrison W R, Smith L M. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol. J Lipid Res 1964; 5: 600–608
   PubMed Web of Science ®Google Scholar
• Clark R M, Roche M E. Gas chromatographic procedure for measuring total lipid in breast milk. J Pediatr Gastroenterol Nutr 1990; 10: 271–272
   PubMed Web of Science ®Google Scholar
• Helland I B, Saugstad O D, Smith L, Saarem K, Solvoll K, Ganes T, Drevon C A. Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women. Pediatrics 2001; 108: e82, Available from: http://pediatrics.org/cgi/content/full/108/5/e82
   PubMed Web of Science ®Google Scholar
• van Houwelingen A C, Sorensen J D, Hornstra G, Simonis M M, Boris J, Olsen S F, Secher N J. Essential fatty acid status in neonates after fish-oil supplementation during late pregnancy. Br J Nutr 1995; 74: 723–731
   PubMed Web of Science ®Google Scholar
• Al M D, van Houwelingen A C, Badart-Smook A, Hornstra G. Some aspects of neonatal essential fatty acid status are altered by linoleic acid supplementation of women during pregnancy. J Nutr 1995; 125: 2822–2830
   PubMed Web of Science ®Google Scholar
• Williams C, Birch E E, Emmett P M, Northstone K. Stereoacuity at age 3.5 y in children born full-term is associated with prenatal and postnatal dietary factors: A report from a population-based cohort study. Am J Clin Nutr 2001; 73: 316–322
   PubMed Web of Science ®Google Scholar
• Makrides M, Neumann M A, Byard R W, Simmer K, Gibson R. Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. Am J Clin Nutr 1994; 60: 189–194
   PubMed Web of Science ®Google Scholar
• Olsen S F, Sorensen J D, Secher N J, Hedegaard M, Henriksen T B, Hansen H S, Grant A. Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet 1992; 339: 1003–1007
   PubMed Web of Science ®Google Scholar
• Hornstra G, Al M D, van Houwelingen A C, Foreman-van Drongelen M M. Essential fatty acids in pregnancy and early human development. Eur J Obstet Gynecol Reprod Biol 1995; 61: 57–62
   PubMed Web of Science ®Google Scholar
• Reddy S, Sanders T A, Obeid O. The influence of maternal vegetarian diet on essential fatty acid status of the newborn. Eur J Clin Nutr 1994; 48: 358–368
   PubMed Web of Science ®Google Scholar
• Schmidt E B, Møller J M, Svaneborg N, Dyerberg J. Safety aspects of fish oils. Experiences with n-3 concentrate of re-esterified triglycerides. Drug Invest 1994; 7: 215–220
   Google Scholar
• Eritsland J, Arnesen H, Seljeflot I, Hostmark A T. Long-term metabolic effects of n-3 polyunsaturated fatty acids in patients with coronary artery disease. Am J Clin Nutr 1995; 61: 831–836
   PubMed Web of Science ®Google Scholar
• Alberti-Fidanza A, Parizkova J, Fruttini D. Relationship between mothers' and newborns' nutritional and blood lipid variables. Eur J Clin Nutr 1995; 49: 289–298
   PubMed Web of Science ®Google Scholar
• Kinosian B, Glick H, Garland G. Cholesterol and coronary heart disease: Predicting risks by levels and ratios. Ann Intern Med 1994; 121: 641–647
   PubMed Web of Science ®Google Scholar
• Napoli C, D'Armiento F P, Mancini F P, Postiglione A, Witztum J L, Palumbo G, Palinski W. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions. J Clin Invest 1997; 100: 2680–2690
   PubMed Web of Science ®Google Scholar
• Palinski W, Napoli C. The fetal origins of atherosclerosis: maternal hypercholesterolemia, and cholesterol-lowering or antioxidant treatment during pregnancy influence in utero programming and postnatal susceptibility to atherogenesis. FASEB J 2002; 16: 1348–1360
   PubMed Web of Science ®Google Scholar