Preterm Labor and Birth Management: Recommendations from the European Association of Perinatal Medicine

References

• Di Renzo GC, Cabero Roura L. European Association of Perinatal Medicine-Study Group on Preterm Birth. Guidelines for the management of spontaneous preterm labor. J Perinat Med. 2006;34:359–366.
   PubMed Web of Science ®Google Scholar
• Di Renzo GC, Roura LC, Facchinetti F, et al. Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth. J Matern Fetal Neonatal Med. 2011;24:659–667.
   PubMed Web of Science ®Google Scholar
• Group E, Fellman V, Hellstrom-Westas L, et al. One-year survival of extremely preterm infants after active perinatal care in Sweden. JAMA. 2009;301:2225–2233.
   PubMed Web of Science ®Google Scholar
• Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science. 2014;345:760–765.
   PubMed Web of Science ®Google Scholar
• Rubens CE, Sadovsky Y, Muglia L, et al. Prevention of preterm birth: harnessing science to address the global epidemic. Sci Transl Med. 2014;6:262sr5.
   PubMed Web of Science ®Google Scholar
• Muglia LJ, Katz M. The enigma of spontaneous preterm birth. N Engl J Med. 2010;362:529–535.
   PubMed Web of Science ®Google Scholar
• Morken NH, Vogel I, Kallen K, et al. Reference population for international comparisons and time trend surveillance of PTD proportions in three countries. BMC Womens Health. 2008;8:16.
   PubMedGoogle Scholar
• Barros FC, Papageorghiou AT, Victora CG, et al. The distribution of clinical phenotypes of preterm birth syndrome: implications for prevention. JAMA Pediatr. 2015;169:220–229.
   PubMed Web of Science ®Google Scholar
• Morken NH, Kallen K, Hagberg H, et al. Preterm birth in Sweden 1973–2001: rate, subgroups, and effect of changing patterns in multiple births, maternal age, and smoking. Acta Obstet Gynecol Scand. 2005;84:558–565.
   PubMed Web of Science ®Google Scholar
• Romero R, Espinoza J, Kusanovic JP, et al. The preterm parturition syndrome. BJOG. 2006;113:17–42.
   PubMed Web of Science ®Google Scholar
• Romero R, Espinoza J, Mazor M, et al. The preterm parturition syndrome. In: Critchely H, Bennett P, Thornton S, editors. Preterm birth. London: RCOG Press; 2004. p. 28–60.
   Google Scholar
• Jacobsson B, Aaltonen R, Rantakokko-Jalava K, et al. Quantification of Ureaplasma urealyticum DNA in the amniotic fluid from patients in PTL and pPROM and its relation to inflammatory cytokine levels. Acta Obstet Gynecol Scand. 2009;88:63–70.
   PubMed Web of Science ®Google Scholar
• Kacerovsky M, Pliskova L, Bolehovska R, et al. The microbial load with genital mycoplasmas correlates with the degree of histologic chorioamnionitis in preterm PROM. Am J Obstet Gynecol. 2011;205:213 e1–217.
   PubMed Web of Science ®Google Scholar
• Kacerovsky M, Musilova I, Khatibi A, et al. Intraamniotic inflammatory response to bacteria: analysis of multiple amniotic fluid proteins in women with preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2012;25:2014–2019.
   PubMed Web of Science ®Google Scholar
• Cobo T, Kacerovsky M, Andrys C, et al. Umbilical cord blood IL-6 as predictor of early-onset neonatal sepsis in women with preterm prelabour rupture of membranes. PLoS One. 2013;8:e69341.
   PubMed Web of Science ®Google Scholar
• Musilova I, Kutova R, Pliskova L, et al. Intraamniotic Inflammation in Women with Preterm Prelabor Rupture of Membranes. PLoS One. 2015;10:e0133929.
   PubMed Web of Science ®Google Scholar
• Aagaard K, Ma J, Antony KM, et al. The placenta harbors a unique microbiome. Sci Transl Med. 2014;6:237ra65.
   PubMed Web of Science ®Google Scholar
• Myhre R, Brantsaeter AL, Myking S, et al. Intake of probiotic food and risk of spontaneous preterm delivery. Am J Clin Nutr. 2011;93:151–157.
   PubMed Web of Science ®Google Scholar
• Brantsaeter AL, Myhre R, Haugen M, et al. Intake of probiotic food and risk of preeclampsia in primiparous women: the Norwegian Mother and Child Cohort Study. Am J Epidemiol. 2011;174:807–815.
   PubMed Web of Science ®Google Scholar
• Yeganegi M, Watson CS, Martins A, et al. Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor. Am J Obstet Gynecol. 2009;200:532 e1–538.
   PubMed Web of Science ®Google Scholar
• Plunkett J, Muglia LJ. Genetic contributions to preterm birth: implications from epidemiological and genetic association studies. Ann Med. 2008;40:167–195.
   PubMed Web of Science ®Google Scholar
• Plunkett J, Feitosa MF, Trusgnich M, et al. Mother's genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth. Hum Hered. 2009;68:209–219.
   PubMed Web of Science ®Google Scholar
• Pennell CE, Jacobsson B, Williams SM, et al. Genetic epidemiologic studies of preterm birth: guidelines for research. Am J Obstet Gynecol. 2007;196:107–118.
   PubMed Web of Science ®Google Scholar
• Myking S, Boyd HA, Myhre R, et al. X-chromosomal maternal and fetal SNPs and the risk of spontaneous preterm delivery in a Danish/Norwegian genome-wide association study. PLoS One. 2013;8:e61781.
   PubMed Web of Science ®Google Scholar
• Alleman BW, Myking S, Ryckman KK, et al. No observed association for mitochondrial SNPs with preterm delivery and related outcomes. Pediatr Res. 2012;72:539–544.
   PubMed Web of Science ®Google Scholar
• Englund-Ogge L, Brantsaeter AL, Haugen M, et al. Association between intake of artificially sweetened and sugar-sweetened beverages and preterm delivery: a large prospective cohort study. Am J Clin Nutr. 2012;96:552–559.
   PubMed Web of Science ®Google Scholar
• Englund-Ogge L, Brantsaeter AL, Sengpiel V, et al. Maternal dietary patterns and preterm delivery: results from large prospective cohort study. BMJ. 2014;348:g1446.
   PubMed Web of Science ®Google Scholar
• Morken NH, Kallen K, Jacobsson B. Predicting risk of spontaneous preterm delivery in women with a singleton pregnancy. Paediatr Perinat Epidemiol. 2014;28:11–22.
   PubMed Web of Science ®Google Scholar
• Di Renzo GC, Giardina I, Rosati A, et al. Maternal risk factors for preterm birth: a country-based population analysis. Eur J Obstet Gynecol Reprod Biol. 2011;159:342–346.
   PubMed Web of Science ®Google Scholar
• Grimes-Dennis J, Berghella V. Cervical length and prediction of preterm delivery. Curr Opin Obstet Gynecol. 2007;19:191–195.
   PubMed Web of Science ®Google Scholar
• Peaceman AM, Andrews WW, Thorp JM, et al. Fetal fibronectin as a predictor of preterm birth in patients with symptoms: a multicenter trial. Am J Obstet Gynecol. 1997;177:13–18.
   PubMed Web of Science ®Google Scholar
• Skoll A, St Louis P, Amiri N, et al. The evaluation of the fetal fibronectin test for prediction of preterm delivery in symptomatic patients. J Obstet Gynaecol Can. 2006;28:206–213.
   PubMedGoogle Scholar
• Bruijn M, Vis JY, Wilms FF, et al. Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women. BJOG. 2016;123:1965–1971.
   PubMed Web of Science ®Google Scholar
• Joffe GM, Jacques D, Bemis-Heys R, et al. Impact of the fetal fibronectin assay on admissions for preterm labor. Am J Obstet Gynecol. 1999;180:581–586.
   PubMed Web of Science ®Google Scholar
• Giles W, Bisits A, Knox M, et al. The effect of fetal fibronectin testing on admissions to a tertiary maternal-fetal medicine unit and cost savings. Am J Obstet Gynecol. 2000;182:439–442.
   PubMed Web of Science ®Google Scholar
• Berghella V, Hayes E, Visintine J, et al. Fetal fibronectin testing for reducing the risk of preterm birth. Cochrane Database Syst Rev. 2008;CD006843. doi: 10.1002/14651858.CD006843.pub2.
   PubMed Web of Science ®Google Scholar
• American College of Obstetricians and Gynecologists; Committee on Practice Bulletins—Obstetrics. ACOG practice bulletin no. 127: Management of preterm labor. Obstet Gynecol. 2012;119:1308–1317.
   PubMedGoogle Scholar
• Deshpande SN, van Asselt AD, Tomini F, et al. Rapid fetal fibronectin testing to predict preterm birth in women with symptoms of premature labour: a systematic review and cost analysis. Health Technol Assess. 2013;17:1–138.
   Web of Science ®Google Scholar
• Plaut MM, Smith W, Kennedy K. Fetal fibronectin: the impact of a rapid test on the treatment of women with preterm labor symptoms. Am J Obstet Gynecol. 2003;188:1588–1593. discussion 1593-5.
   PubMed Web of Science ®Google Scholar
• Grobman WA, Welshman EE, Calhoun EA. Does fetal fibronectin use in the diagnosis of preterm labor affect physician behavior and health care costs? A randomized trial. Am J Obstet Gynecol. 2004;191:235–240.
   PubMed Web of Science ®Google Scholar
• Ness A, Visintine J, Ricci E, et al. Does knowledge of cervical length and fetal fibronectin affect management of women with threatened preterm labor? A randomized trial. Am J Obstet Gynecol. 2007;197:426.e1–427.
   PubMed Web of Science ®Google Scholar
• Akercan F, Kazandi M, Sendag F, et al. Value of cervical phosphorylated insulinlike growth factor binding protein-1 in the prediction of preterm labor. J Reprod Med. 2004;49:368–372.
   PubMed Web of Science ®Google Scholar
• Conde-Agudelo A, Romero R. Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis. Am J Obstet Gynecol. 2016;214:57–73.
   PubMed Web of Science ®Google Scholar
• McLaren JS, Hezelgrave NL, Ayubi H, et al. Prediction of spontaneous preterm birth using quantitative fetal fibronectin after recent sexual intercourse. Am J Obstet Gynecol. 2015;212:89.e1–85.
   PubMed Web of Science ®Google Scholar
• Petrunin DD, Griaznova IM, Petrunina IUA, et al. Immunochemical identification of organ specific human placental al-globulin and its concentration in amniotic fluid. Akush Ginekol. 1977;1:62–64.
   PubMedGoogle Scholar
• Lee SM, Lee J, Seong HS, et al. The clinical significance of a positive Amnisure test in women with term labor with intact membranes. J Matern Fetal Neonatal Med. 2009;22:305–310.
   PubMed Web of Science ®Google Scholar
• Lee SM, Romero R, Park JW, et al. The clinical significance of a positive Amnisure test in women with preterm labor and intact membranes. J Matern Fetal Neonatal Med. 2012;25:1690–1698.
   PubMed Web of Science ®Google Scholar
• Sukchaya K, Phupong V. A comparative study of positive rate of placental α-microglobulin-1 test in pre-term pregnant women with and without uterine contraction. J Obstet Gynaecol. 2013;33:566–568.
   PubMedGoogle Scholar
• Ehsanipoor RM, Swank ML, Jwa SC, et al. Placental α-Microglobulin-1 in Vaginal Secretions of Women with Evidence of Preterm Labor. Am J Perinatol. 2016;33:208–213.
   PubMed Web of Science ®Google Scholar
• Nikolova T, Bayev O, Nikolova N, et al. Evaluation of a novel placental alpha microglobulin-1 (PAMG-1) test to predict spontaneous preterm delivery. J Perinat Med. 2014;42:473–477.
   PubMed Web of Science ®Google Scholar
• Nikolova T, Bayev O, Nikolova N, et al. Comparison of a novel test for placental alpha microglobulin-1 with fetal fibronectin and cervical length measurement for the prediction of imminent spontaneous preterm delivery in patients with threatened preterm labor. J Perinat Med. 2015;43:395–402.
   PubMed Web of Science ®Google Scholar
• Bolotskikh VM, Borisova VY. Role of biochemical tests and cervicometry in the diagnosis of threatened preterm birth. Akusherstvo i Ginekologiya/Obstetrics and Gynecology 2015;2:(in Russian). 127:384–389.
   Google Scholar
• Werlen S, Raia T, Di Bartolomeo A, et al. [Preterm labor: Reproducibility of detection test of PAMG-1 before and after digital examination, and transvaginal ultrasound cervical length]. Gynecol Obstet Fertil. 2015;43:640–645. French.
   PubMedGoogle Scholar
• Revah A, Hannah ME, Sue-A-Quan AK. Fetal fibronectin as a predictor of preterm birth: an overview. Am J Perinatol. 1998;15:613–621.
   PubMed Web of Science ®Google Scholar
• Khalifeh A, Quist-Nelson J, Berghella V. Universal cervical length screening for preterm birth prevention in the United States. J Matern Fetal Neonatal Med. 2017;30:1500–1503
   PubMed Web of Science ®Google Scholar
• Mella MT, Berghella V. Prediction of preterm birth: cervical sonography. Semin Perinatol. 2009;33:317–324.
   PubMed Web of Science ®Google Scholar
• FIGO Working Group On Best Practice In Maternal-Fetal Medicine; International Federation of Gynecology and Obstetrics. Best practice in maternal-fetal medicine. Int J Gynaecol Obstet. 2015;128:80–82.
   PubMed Web of Science ®Google Scholar
• Simhan HN, Caritis SN. Prevention of preterm delivery. N Engl J Med. 2007;357:477–487.
   PubMed Web of Science ®Google Scholar
• Smith R, Walker MC, Ohlsson A, et al. Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm labor. N Engl J Med. 2007; 356:2066–2074.
   Google Scholar
• Ferre F, Uzan M, Janssens Y, et al. Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium. Am J Obstet Gynecol. 1984;148:26–34.
   PubMed Web of Science ®Google Scholar
• Baumbach J, Shi S-Q, Shi L, et al. Inhibition of uterine contractility with various tocolytics with and without progesterone: in vitro studies. Am J Obstet Gynecol. 2012;206:254.e1–255.
   PubMed Web of Science ®Google Scholar
• Chanrachakul B, Broughton Pipkin F, Warren AY, et al. Progesterone enhances the tocolytic effect of ritodrine in isolated pregnant human myometrium. Am J Obstet Gynecol. 2005;192:458–463.
   PubMed Web of Science ®Google Scholar
• Noblot G, Audra P, Dargent D, et al. The use of micronized progesterone in the treatment of menace of preterm delivery. Eur J Obstet Gynecol Reprod Biol. 1991;40:203–209.
   PubMed Web of Science ®Google Scholar
• Meis PJ, Klebanoff M, Thom E, National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, et al. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med. 2003;348:2379–2385.
   PubMed Web of Science ®Google Scholar
• Saccone G, Khalifeh A, Elimian A, et al. Vaginal progesterone compared to intramuscular 17-alpha-hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth in singleton gestations: a systematic review and meta-analysis of randomized controlled trials. Ultrasound Obstet Gynecol. 2017;49:315–321.
   PubMed Web of Science ®Google Scholar
• Fonseca EB, Bittar RE, Carvalho MH, et al. Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study. Am J Obstet Gynecol. 2003;188:419–424.
   PubMed Web of Science ®Google Scholar
• Fonseca EB, Celik E, Parra M, Fetal Medicine Foundation Second Trimester Screening Group, et al. Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med. 2007;357:462–469.
   PubMed Web of Science ®Google Scholar
• DeFranco EA, O'Brien JM, Adair CD, et al. Vaginal progesterone is associated with a decrease in risk for early preterm birth and improved neonatal outcome in women with a short cervix: a secondary analysis from a randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol. 2007;30:697–705.
   PubMed Web of Science ®Google Scholar
• Hassan SS, Romero R, Vidyadhari D, PREGNANT Trial, et al. Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol. 2011;38:18–31.
   PubMed Web of Science ®Google Scholar
• Romero R, Nicolaides K, Conde-Agudelo A, et al. Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data. Am J Obstet Gynecol. 2012;206:124.e1–119.
   PubMed Web of Science ®Google Scholar
• Grobman WA, Thom EA, Spong CY, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network, et al. 17 alpha-hydroxyprogesterone caproate to prevent prematurity in nulliparas with cervical length less than 30 mm. Am J Obstet Gynecol. 2012;207:390.e1–398.
   PubMed Web of Science ®Google Scholar
• Norman JE, Marlow N, Messow C-M, et al. Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet. 2016;387:2106–2116. Published Online February 23, 2016. http://dx.doi.org/10.1016/S0140-6736(16)00350-0.
   PubMed Web of Science ®Google Scholar
• Romero R, Nicolaides KH, Conde-Agudelo A, et al. Vaginal progesterone decreases preterm birth ≤34 weeks of gestation in women with singleton gestation and a short cervix: an updated meta-analysis including data from the Opptimum Study. Ultrasound Obstet Gynecol. 2016;48:308–317.
   PubMed Web of Science ®Google Scholar
• Areia A, Fonseca E, Moura P. Progesterone use after successful treatment of threatened pre-term delivery. J Obstet Gynaecol. 2013;33:678–681.
   PubMedGoogle Scholar
• Sentilhes L, Sénat MV, Ancel PY, et al. Prevention of spontaneous preterm birth (excluding preterm premature rupture of membranes): guidelines for clinical practice. J Gynecol Obstet Biol Reprod (Paris). 2016;45:1446–1456.
   PubMed Web of Science ®Google Scholar
• Suhag A, Saccone G, Berghella V. Vaginal progesterone for maintenance tocolysis: a systematic review and metaanalysis of randomized trials. Am J Obstet Gynecol. 2015;213:479–487.
   PubMed Web of Science ®Google Scholar
• Saccone G, Suhag A, Berghella V. 17-alpha-hydroxyprogesterone caproate for maintenance tocolysis: a systematic review and metaanalysis of randomized trials. Am J Obstet Gynecol. 2015;213:16–22.
   PubMed Web of Science ®Google Scholar
• Schuit E, Stock S, Rode L, Global Obstetrics Network (GONet) collaboration, et al. Effectiveness of progestogens to improve perinatal outcome in twin pregnancies: an individual participant data meta-analysis. BJOG. 2015;122:27–37.
   PubMed Web of Science ®Google Scholar
• Caritis SN, Simhan HN, Zhao Y, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, et al. Relationship between 17-hydroxyprogesterone caproate concentrations and gestational age at delivery in twin gestation. Am J Obstet Gynecol. 2012;207:396.e1–398.
   PubMed Web of Science ®Google Scholar
• Berghella V, Odibo AO, To MS, et al. Cerclage for short cervix on ultrasonography: meta-analysis of trials using individual patient-level data. Obstet Gynecol. 2005;106:181–189.
   PubMed Web of Science ®Google Scholar
• Story L, Shennan A. Cervical cerclage: an established intervention with neglected potential? Eur J Obstet Gynecol Reprod Biol. 2014;176:17–19.
   PubMed Web of Science ®Google Scholar
• Saccone G, Rust O, Althuisius S, et al. Cerclage for short cervix in twin pregnancies: systematic review and meta-analysis of randomized trials using individual patient-level data. Acta Obstet Gynecol Scand. 2015;94:352–358.
   PubMed Web of Science ®Google Scholar
• Suhag A, Reina J, Sanapo L, et al. Prior ultrasound-indicated cerclage: comparison of cervical length screening or history-indicated cerclage in the next pregnancy. Obstet Gynecol. 2015;126:962–968.
   PubMed Web of Science ®Google Scholar
• Berghella V, Mackeen AD. Cervical length screening with ultrasound-indicated cerclage compared with history-indicated cerclage for prevention of preterm birth: a meta-analysis. Obstet Gynecol. 2011;118:148–155.
   PubMed Web of Science ®Google Scholar
• Conde-Agudelo A, Romero R, Nicolaides K, et al. Vaginal progesterone vs cervical cerclage for the prevention of preterm birth in women with a sonographic short cervix, previous preterm birth, and singleton gestation: a systematic review and indirect comparison metaanalysis. Am J Obstet Gynecol. 2013;208:42.e1–18.
   PubMed Web of Science ®Google Scholar
• Alfirevic Z, Stampalija T, Roberts D, et al. Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. Cochrane Database Syst Rev. 2012;4:CD008991.
   PubMed Web of Science ®Google Scholar
• Goya M, Pratcorona L, Merced C, et al. Cervical pessary in pregnant women with a short cervix (PECEP): an open-label randomised controlled trial. Lancet. 2012;379:1800–1806.
   PubMed Web of Science ®Google Scholar
• Hui SY, Chor CM, Lau TK, et al. Cerclage pessary for preventing preterm birth in women with a singleton pregnancy and a short cervix at 20 to 24 weeks: a randomized controlled trial. Am J Perinatol. 2013;30:283–288.
   PubMed Web of Science ®Google Scholar
• Liem S, Schuit E, Hegeman M, et al. Cervical pessaries for prevention of preterm birth in women with a multiple pregnancy (ProTWIN): a multicentre, open-label randomized controlled trial. Lancet. 2013;382:1341–1349.
   PubMed Web of Science ®Google Scholar
• Nicolaides KH, Syngelaki A, Poon LC, et al. Cervical pessary placement for prevention of preterm birth in unselected twin pregnancies: a randomized controlled trial. Am J Obstet Gynecol. 2016;214:3.e1–9.
   PubMed Web of Science ®Google Scholar
• Goya M, de la Calle M, Pratcorona L, et al. PECEP-Twins Trial Group.Cervical pessary to prevent preterm birth in women with twin gestation and sonographic short cervix: a multicenter randomized controlled trial (PECEP-Twins). Am J Obstet Gynecol. 2016;214:145–152.
   PubMed Web of Science ®Google Scholar
• Menon R. Preterm birth: a global burden on maternal and child health. Pathog Glob Health. 2012;106:139–140.
   PubMed Web of Science ®Google Scholar
• Nour NM. Premature delivery and the millennium development goal. Rev Obstet Gynecol. 2012; 5:100–105.
   PubMedGoogle Scholar
• Blencowe H, Cousens S, Oestergaard MZ, et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet (London, England). 2012;379:2162–2172.
   PubMed Web of Science ®Google Scholar
• Radzinsky VE. Obstetric aggression. M. Publishing house of the Status. Praesens J. 2011;688:178–186.
   Google Scholar
• Radzinsky VE. Reproductive Health: Student Book. M. RPFU; 2011;727:281–291.
   Google Scholar
• Lee HC, Lyndon A, Blumenfeld YJ, et al. Antenatal steroid administration for premature neonates in California. Obstet Gynecol. 2011;117603–609.
   PubMed Web of Science ®Google Scholar
• Royal College of Obstetricians and Gynaecologists (RCOG). Tocolysis for women in preterm labour: Green-top Guideline N° 18. London (UK): Royal College of Obstetricians and Gynaecologists (RCOG). London (UK), 2011.
   Google Scholar
• Haram K, Mortensen JHS, Morrison JC. Tocolysis for acute preterm labor: does anything? J Maternal-Fetal Neonatal Med. 2015;28:371–378.
   PubMed Web of Science ®Google Scholar
• Serov VN, Tyutyunnik VL. Treatment of threatening preterm birth. Reprod Endocrinol. 2012;445:22–24.
   Google Scholar
• Salim R, Garmi G, Nachum Z, et al. Nifedipine compared with atosiban for treating preterm labor: a randomized controlled trial. Obstetrics and Gynecology. 2012;120:1323–1331.
   PubMed Web of Science ®Google Scholar
• Vogel JP, Nardin JM, Dowswell T, et al. Combination of tocolytic agents for inhibiting preterm labour. Cochrane Database Syst Rev. 2014;7:CD00616.
   Google Scholar
• Driul L, Londero AP, Adorati-Menegato A, et al. Therapy side-effects and predictive factors for preterm delivery in patients undergoing tocolysis with atosiban or ritodrine for threatened preterm labour. J Obstet Gynaecol. 2014;34:684–689.
   PubMedGoogle Scholar
• Flenady V, Wojcieszek AM, Papatsonis DNM, et al. Calcium channel blockers for inhibiting preterm labour and birth. Cochrane Database of Systematic Reviews Ed. The Cochrane Collaboration. Chichester, UK: John Wiley & Sons, Ltd; 2014.
   Google Scholar
• Flenady V, Reinebrant HE, Liley HG, et al. Oxytocin receptor antagonists for inhibiting preterm labour.V. Cochrane Database of Systematic Reviews. The Cochrane Collaboration. Chichester, UK: John Wiley & Sons, Ltd; 2014.
   Google Scholar
• Beck S, Wojdyla D, Say L, et al. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Org. 2010;88:31–38.
   PubMed Web of Science ®Google Scholar
• Lyell DJ, Pullen KM, Mannan J, et al. Maintenance nifedipine tocolysis compared with placebo: a randomized controlled trial. Obstet Gynecol. 2008;112:1221–1226.
   PubMed Web of Science ®Google Scholar
• Reinebrant HE, Flenady V, Cole S, et al. Cyclo-oxygenase (COX) inhibitors for treating preterm labour. Cochrane Database Syst Rev. 2015;6:CD001992.
   Google Scholar
• Loe SM, Sanchez-Ramos L, Kaunitz AM. Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis. Obstet Gynecol. 2005;106:173–179.
   PubMed Web of Science ®Google Scholar
• American College of Obstetricians and Gynecologists Committee on Obstetric Practice; Society for Maternal-Fetal Medicine. Committee Opinion No. 455: Magnesium sulfate before anticipated preterm birth for neuroprotection. Obstet Gynecol. 2010;115:669–671.
   PubMedGoogle Scholar
• Doyle LW, Crowther CA, Middleton P, et al. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev. 2009;(1):CD004661.
   Google Scholar
• Sweet DG, Carnielli V, Greisen G, et al. European Consensus Guidelines on the management of neonatal respiratory distress syndrome: 2016 update. Neonatology. 2016;111:107–125.
   PubMed Web of Science ®Google Scholar
• Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2017;(3):CD004454.
   PubMedGoogle Scholar
• Manktelow BN, Lal MK, Field DJ, et al. Antenatal corticosteroids and neonatal outcomes according to gestational age: a cohort study. Arch Dis Child Fetal Neonatal Ed. 2010;95:F95–F98.
   PubMed Web of Science ®Google Scholar
• Boghossian NS, McDonald SA, Bell EF, et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network: Association of antenatal corticosteroids with mortality, morbidity, and neurodevelopmental outcomes in extremely preterm multiple gestation infants. JAMA Pediatr. 2016;170:593–601.
   PubMed Web of Science ®Google Scholar
• Gyamfi-Bannerman C, Thom EA, Blackwell SC, et al. Antenatal betamethasone for women at risk for late preterm delivery. N Engl J Med. 2016;374:1311–1320.
   PubMed Web of Science ®Google Scholar
• Sotiriadis A, Makrydimas G, Papatheodorou S, et al. Corticosteroids for preventing neonatal respiratory morbidity after elective caesarean section at term. Cochrane Database Syst Rev. 2009;(4):CD006614.
   PubMed Web of Science ®Google Scholar
• Crowther CA, McKinlay CJD, Middleton P, et al. Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes. Cochrane Database Syst Rev. 2015; CD003935. doi: 10.1002/14651858.CD003935.pub4.
   PubMed Web of Science ®Google Scholar
• WHO recommendations on interventions to improve preterm birth outcomes. WHO 2015. WHO/RHR/15.16 - WHO/MCA 15.02.
   Google Scholar
• Asztalos EV, Murphy KE, Willan AR, et al. Multiple courses of antenatal corticosteroids for preterm birth study: outcomes in children at 5 years of age (MACS-5). JAMA Pediatr. 2013;167:1102–1110.
   PubMed Web of Science ®Google Scholar
• Mulder EJH, Derks JB, Visser GHA. Antenatal corticosteroid therapy and fetal behaviour: a randomised study of the effects of betamethasone and dexamethasone. Br J Obstet Gynaecol. 1997;104:1239–1247.
   PubMedGoogle Scholar
• Cohlen BJ, Stigter RH, Derks JB, et al. Absence of significant hemodynamic changes in the fetus following maternal betamethasone administration. Ultrasound Obstet Gynecol. 1996;8:252–255.
   PubMed Web of Science ®Google Scholar
• Althabe F, Belizán JM, McClure EM, et al. A population-based, multifaceted strategy to implement antenatal corticosteroid treatment versus standard care for the reduction of neonatal mortality due to preterm birth in low-income and middle-income countries: the ACT cluster-randomised trial. Lancet. 2015; 385:629–639.
   PubMed Web of Science ®Google Scholar
• Visser GHA, Di Renzo GC. Antenatal corticosteroids for preterm births in resource-limited settings; correspondence. Lancet. 2015;385:1943–1944. doi: 10.1016/S0140-6736(15)60953-9.
   PubMed Web of Science ®Google Scholar
• Murphy KE, Hannah ME, Willan AR, MACS Collaborative Group, et al. Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial. Lancet. 2008;372:2143–2151.
   PubMed Web of Science ®Google Scholar
• Tijsseling D, Wijnberger LD, Derks JB, et al. Effects of antenatal glucocorticoid therapy on hippocampal histology of preterm infants. PLoS One. 2012;7:e33369.
   PubMed Web of Science ®Google Scholar
• Sawady J, Mercer BM, Wapner RJ, National Institute of Child Health and Human Development Maternal Fetal Medicine Units Network. The National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, et al. Beneficial Effects of Antenatal Repeated Steroids study: impact of repeated doses of antenatal corticosteroids on placental growth and histologic findings. Am J Obstet Gynecol. 2007;197:281.e1–288.
   PubMed Web of Science ®Google Scholar
• Van Baaren GJ, Vis JY, Wilms FF, et al. Predictive value of cervical length measurement and fibronectin testing in threatened preterm labor. Obstet Gynecol. 2014;123:1185–1192.
   PubMed Web of Science ®Google Scholar
• American College of Obstetricians and Gynecologists ACOG committee opinion no. 559: Cesarean delivery on maternal request. Obstet Gynecol. 2013;121:904–907.
   PubMedGoogle Scholar
• Darlow B, Austin N, French N, et al. School-age outcomes of very preterm infants after antenatal treatment with magnesium sulfate vs placebo. JAMA. 2014;312:1105–1113.
   PubMed Web of Science ®Google Scholar
• Hay PE, Lamont RF, Taylor-Robinson D, et al. Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage. BMJ (Clinical Research Ed). 1994;308:295–298.
   PubMed Web of Science ®Google Scholar
• Kurki T, Sivonen A, Renkonen OV, et al. Bacterial vaginosis in early pregnancy and pregnancy outcome. Obstet Gynecol. 1992;80:173–177.
   PubMed Web of Science ®Google Scholar
• Lamont RF. Advances in the prevention of infection-related preterm birth. Front Immunol. 2015;6:566.
   PubMed Web of Science ®Google Scholar
• Lamont RF, Nhan-Chang CL, Sobel JD, et al. Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: a systematic review and metaanalysis. Am J Obstet Gynecol. 2011;205:177–190.
   PubMed Web of Science ®Google Scholar
• Lamont RF, Sobel JD, Akins RA, et al. The vaginal microbiome: new information about genital tract flora using molecular based techniques. BJOG. 2011;118:533–549.
   PubMed Web of Science ®Google Scholar
• Farr A, Kiss H, Hagmann M, et al. Routine use of an antenatal infection screen-and-treat program to prevent preterm birth: long-term experience at a Tertiary Referral Center. Birth. 2015;42:173–180.
   PubMed Web of Science ®Google Scholar
• Grant A, Glazener CM. Elective caesarean section versus expectant management for delivery of the small baby. Cochrane Database Syst Rev. 2001;(2):CD000078.
   Google Scholar
• Tejani N, Verma U, Hameed C, et al. Method and route of delivery in the low birth weight vertex presentation correlated with early periventricular/intraventricular hemorrhage. Obstet Gynecol. 1987;69:1–4.
   PubMed Web of Science ®Google Scholar
• Wylie BJ, Davidson LL, Batra M, et al. Method of delivery and neonatal outcome in very low-birthweight vertex-presenting fetuses. Am J Obstet Gynecol. 2008;198:640.e1–647.
   PubMed Web of Science ®Google Scholar
• Bauer J, Hentschel R, Zahradnik H, et al. Vaginal delivery and neonatal outcome in extremely-low-birth-weight infants below 26 weeks of gestational age. Am J Perinatol. 2003;20:181–188.
   PubMed Web of Science ®Google Scholar
• Mercer BM. Mode of delivery for periviable birth. Semin Perinatol. 2013;37:417–421.
   PubMed Web of Science ®Google Scholar
• Werner EF, Han CS, Savitz DA, et al. Health outcomes for vaginal compared with cesarean delivery of appropriately grown preterm neonates. Obstet Gynecol. 2013;121:1195–1200.
   PubMed Web of Science ®Google Scholar
• Alfirevic Z, Milan SJ, Livio S. Caesarean section versus vaginal delivery for preterm birth in singletons. Cochrane Database Syst Rev. 2013;9:CD000078.
   PubMed Web of Science ®Google Scholar
• Grant A, Penn ZJ, Steer PJ. Elective or selective caesarean delivery of the small baby? A systematic review of the controlled trials. Br J Obstet Gynaecol. 1996;103:1197–1200.
   PubMedGoogle Scholar
• Lee HC, Gould JB. Survival rates and mode of delivery for vertex preterm neonates according to small- or appropriate-for-gestational-age status. Pediatrics. 2006;118:e1836–e1844.
   PubMed Web of Science ®Google Scholar
• Malloy MH, Doshi S. Cesarean section and the outcome of very preterm and very low-birthweight infants. Clin Perinatol. 2008;35:421–435.
   PubMed Web of Science ®Google Scholar
• Furukawa S, Sameshima H, Ikenoue T. The impact of cesarean section on neonatal outcome of infants born at 23weeks of gestation. Early Hum Dev. 2014;90:113–118.
   PubMed Web of Science ®Google Scholar
• Vidovics M, Jacobs VR, Fischer T, et al. Comparison of fetal outcome in premature vaginal or cesarean breech delivery at 24–37 gestational weeks. Arch Gynecol Obstet. 2014;290:271–281.
   PubMed Web of Science ®Google Scholar
• Penn ZJ, Steer PJ, Grant A. A multicentre randomised controlled trial comparing elective and selective caesarean section for the delivery of the preterm breech infant. BJOG. 1996;103:684–689.
   Web of Science ®Google Scholar
• Bergenhenegouwen LA, Meertens LJ, Schaaf J, et al. Vaginal delivery versus caesarean section in preterm breech delivery: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2014;172:1–6.
   PubMed Web of Science ®Google Scholar
• Barzilay E, Mazaki-Tovi S, Amikam U, et al. Mode of delivery of twin gestation with very low birthweight: is vaginal delivery safe? Am J Obstet Gynecol. 2015;213:219.e1–218.
   PubMed Web of Science ®Google Scholar
• Sentilhes L, Oppenheimer A, Bouhours AC, et al. Neonatal outcome of very preterm twins: policy of planned vaginal or cesarean delivery. Am J Obstet Gynecol. 2015;213:73.e1–77.
   PubMed Web of Science ®Google Scholar
• Choudhari K, Choudhari Y. Posterior fossa haemorrhage in a preterm infant following vacuum assisted delivery. BJOG. 2003;110:787.
   PubMed Web of Science ®Google Scholar
• Morales R, Adair CD, Sanchez-Ramos L, et al. Vacuum extraction of preterm infants with birth weights of 1,500–2,499 grams. J Reprod Med. 1995;40:127–130.
   PubMed Web of Science ®Google Scholar
• Corcoran S, Daly N, Eogan M, et al. How safe is preterm operative vaginal delivery and which is the instrument of choice? J Perinat Med. 2013;41:57–60.
   PubMed Web of Science ®Google Scholar
• Åberg K, Norman M, Ekéus C. Preterm birth by vacuum extraction and neonatal outcome: a population-based cohort study. BMC Pregnancy Childbirth. 2014;14:42.
   PubMed Web of Science ®Google Scholar
• Operative Vaginal Delivery. Green: Top Guideline no. 26, January 2011. Royal College of Obstetrics and Gynecology; 2011.
   Google Scholar
• Brocato B, Holliday N, Whitehurst RM Jr., et al. Delayed cord clamping in preterm neonates: a review of benefits and risks. Obstet Gynecol Surv. 2016;71:39–42.
   PubMed Web of Science ®Google Scholar
• Mercer JS, Erickson-Owens DA, Vohr BR, et al. Effects of placental transfusion on neonatal and 18 month outcomes in preterm infants: a randomized controlled trial. J Pediatr. 2016;168:50–55.e1.
   PubMed Web of Science ®Google Scholar