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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 16
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Antidiarrheal and antispasmodic activities of Trillium govanianum rhizomes extract: involvement of calcium channel blockade

Naveed Muhammada Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan
,
Shafiq Ur Rahmanb Department of Pharmacy, Shaheed Benazir Bhutto University, Sheringal, Dir, Pakistan;c Department of Pharmacy, University of Peshawar, Peshawar, PakistanCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-0162-4478
ORCID Icon,
Hilal Uddina Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan
,
Omer Shehzada Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan
,
Muhammad Ismailc Department of Pharmacy, University of Peshawar, Peshawar, Pakistan
,
Niaz Alid Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan
,
Aslam Khane College of Science and Health Professions King Saud bin, Abdulaziz University for Health Sciences Jeddah, Kingdom of Saudi Arabia
,
Muhammad Shahidf Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan
,
Abid Ullahb Department of Pharmacy, Shaheed Benazir Bhutto University, Sheringal, Dir, Pakistan
,
Shujaat Ahmadb Department of Pharmacy, Shaheed Benazir Bhutto University, Sheringal, Dir, Pakistan
,
Haya Hussainb Department of Pharmacy, Shaheed Benazir Bhutto University, Sheringal, Dir, Pakistan
,
Ikram ul Haqg National Institute of Health, Islamabad, Pakistan
,
Sara Vitalinii Phytochem Lab, Department of Agricultural and Environmental Sciences, Università degli Studi di Milano, Milano, Italy;j National Interuniversity Consortium of Materials Science and Technology (INSTM), Firenze, Italy;k BAT Center-Interuniversity Center for Studies on Bioispired Agro-Environmental Technology, University of Napoli “Federico II”, Portici, Napoli, Italy
&
Marcello Iritih Department of Agricultural and Environmental Sciences, Università degli Studi di Milano, Milano, Italy;i Phytochem Lab, Department of Agricultural and Environmental Sciences, Università degli Studi di Milano, Milano, Italy;j National Interuniversity Consortium of Materials Science and Technology (INSTM), Firenze, Italy;k BAT Center-Interuniversity Center for Studies on Bioispired Agro-Environmental Technology, University of Napoli “Federico II”, Portici, Napoli, ItalyCorrespondence[email protected] [email protected]
 show all
Pages 4238-4242 | Received 17 May 2021, Accepted 31 Jul 2021, Published online: 15 Oct 2021

References

  • Gilani AH, Khan A, Khan AU, Bashir S, Rehman N, Mandukhail SR. 2010. Pharmacological basis for the medicinal use of Holarrhena antidysenterica in gut motility disorders. Pharm Biol. 48(11):1240–1246.
  • Islam NU, Khan I, Rauf A, Muhammad N, Shahid M, Shah MR. 2015. Antinociceptive, muscle relaxant and sedative activities of gold nanoparticles generated by methanolic extract of Euphorbia milii. BMC Complem Altern Med. 15(1):1–11.
  • Khan KM, Nahar L, Mannan A, Ul-Haq I, Arfan M, Ali Khan G, Hussain I, Sarker S. 2018. Cytotoxicity, In vitro anti-leishmanial and fingerprint HPLC- photodiode array analysis of the roots of Trillium govanianum. Nat Prod Res. 32(18):2193–2201.
  • Khan KM, Sarker SD, Khan GA, Saleem H, Khan SA, Mannan A. 2020. Phytochemical profiling and evaluation of modified resazurin microtiter plate assay of the roots of Trillium govanianum. Nat Prod Res. 34(19):2837–2841.
  • Mahmood A, Mahmood A, Malik RN, Malik RN. 2012. Indigenous knowledge of medicinal plants from Leepa valley, Azad Jammu and Kashmir, Pakistan. J Ethnopharmacol. 143(1):338–346.
  • Petrovska BB. 2012. Historical review of medicinal plants' usage. Pharmacogn Rev. 6(11):1–5.
  • Rani S, Rana J, Rana P. 2013. Ethnomedicinal plants of Chamba district, Himachal Pradesh, India. J Med Plants Res. 7:3147–3157.
  • Shah A, Bharati KA, Ahmad J, Sharma M. 2015. New ethnomedicinal claims from Gujjar and Bakerwals tribes of Rajouri and Poonch districts of Jammu and Kashmir, India. J Ethnopharmacol. 166:119–128.
  • Shahid M, Subhan F, Ahmad N, Ullah I. 2017. A bacosides containing Bacopa monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction injury model of neuropathic pain in rats. BMC Complem Altern Med. 17(1):293.
  • Sharma OR, Arya D, Goel S, Vyas K, Shinde P. 2018. Trillium govanianum Wall. Ex D. Don (Nagchatri): An important Ethno medicinal Plant of Himalayan region (Himachal Pradesh). J Med Plants. 6:11–13.
  • Singh PP, Suresh PS, Bora PS, Bhatt V, Sharma U. 2020. Govanoside B, a new steroidal saponin from rhizomes of Trillium govanianum. Nat Prod Res. :1–9.
  • Thiagarajah JR, Donowitz M, Verkman AS. 2015. Secretory diarrhoea: mechanisms and emerging therapies. Nat Rev Gastroenterol Hepatol. 12(8):446–457.
  • Ur Rahman S, Adhikari A, Ismail M, Shah MR, Khurram M, Anis I, Ali F. 2017. A new trihydroxylated fatty acid and phytoecdysteroids from rhizomes of Trillium govanianum. Rec Nat Prod. 11:323–327.
  • Ur Rahman S, Adhikari A, Ismail M, Shah MR, Khurram M, Shahid M, Ali F, Haseeb A, Akbar F, Iriti M. 2016. Beneficial effects of Trillium govanianum rhizomes in pain and inflammation. Molecules. 21:1095.
  • Ur Rahman S, Ismail M, Shah MR, Adhikari A, Anis I, Ahmad MS, Khurram M. 2015. Govanoside A, a new steroidal saponin from rhizomes of Trillium govanianum. Steroids. 104:270–275.

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