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Review

Intrapartum beta-lactam antibiotics for preventing group B streptococcal early-onset disease: can we abandon the concept of ‘inadequate’ intrapartum antibiotic prophylaxis?

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Pages 37-46 | Received 03 Sep 2019, Accepted 21 Nov 2019, Published online: 06 Dec 2019

References

  • Verani JR, McGee L, Schrag SJ. Prevention of perinatal group B Streptococcal disease. Revised guidelines from CDC, 2010. MMWR Recomm Rep. 2010;59:1–36.
  • Edwards MS, Nizet V, Baker CJ. Group B Streptococcal infections. In: Remington and Klein’s. Infectious diseases of the fetus and newborn infant. 8th ed. Elsevier; 2016. p. 411–456.
  • Melin P, Efstratiou A. Group B streptococcal epidemiology and vaccine needs in developed countries. Vaccine. 2013;28:31–42.
  • Di Renzo GC, Melin P, Berardi A, et al. Intrapartum GBS screening and antibiotic prophylaxis: a European consensus conference. J Matern Fetal Neonatal Med. 2015;28(7):766–782.
  • Benitz WE, Gould JB, Druzin ML. Risk factors for early-onset group B streptococcal sepsis: estimation of odds ratios by critical literature review. Pediatrics. 1999;103:e77.
  • Boyer KM, Gotoff SP. Strategies for chemoprophylaxis of GBS early-onset infections. Antibiot Chemother. 1985;35:267–280.
  • Berardi A, Cattelani C, Creti R, et al. Group B streptococcal infections in the newborn infant and the potential value of maternal vaccination. Expert Rev Anti Infect Ther. 2015;13:1387–1399.
  • Ohlsson A, Shah VS. Intrapartum antibiotics for known maternal group B streptococcal colonization. Cochrane Database Syst Rev. 2014;6:CD007467.
  • Matorras R, García-Perea A, Omeñaca F, et al. Intrapartum chemoprophylaxis of early-onset group B streptococcal disease. Eur J Obstet Gynecol Reprod Biol. 1991;40:57–62.
  • Lim DV, Morales WJ, Walsh AF, et al. Reduction of morbidity and mortality rates for neonatal group B streptococcal disease through early diagnosis and chemoprophylaxis. J Clin Microbiol. 1986;23:489–492.
  • Boyer KM, Gotoff SP. Prevention of early-onset neonatal group B streptococcal disease with selective intrapartum chemoprophylaxis. N Engl J Med. 1986;314:1665–1669.
  • Tuppurainen N, Hallman M. Prevention of neonatal group B streptococcal disease: intrapartum detection and chemoprophylaxis of heavily colonized parturients. Obstet Gynecol. 1989;73(4):583–587.
  • Garland SM, Fliegner JR. Group B streptococcus (GBS) and neonatal infections: the case for intrapartum chemoprophylaxis. Aust N Z J Obstet Gynaecol. 1991;31(2):119–122.
  • Schrag SJ, Zywicki S, Farley MM, et al. Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis. N Engl J Med. 2000;342(1):15–20.
  • Nanduri SA, Petit S, Smelser C, et al. Epidemiology of invasive early-onset and late-onset group B streptococcal disease in the United States, 2006 to 2015: multistate laboratory and population-based surveillance. JAMA Pediatr. 2019;173(3):224–233.
  • Hughes RG, Brocklehurst P, Steer PJ, et al. Prevention of early-onset neonatal group B streptococcal disease. Green-top guideline no. 36. BJOG. 2017;124:e280–305.
  • Alós Cortés JI, Andreu Domingo A, Arribas Mir L, et al. Prevention of perinatal group B streptococcal disease. Updated Spanish recommendations 2012. Rev Esp Quimioter. 2012;25(1):79–88.
  • Darlow B, Campbell N, Austin N, et al. The prevention of early-onset neonatal group B streptococcus infection: new Zealand consensus guidelines 2014. N Z Med J. 2015;128(1425):69–76.
  • American College of Obstetricians and Gynecologists. Prevention of group B streptococcal early-onset disease in newborns: ACOG committee opinion, number 782. Obstet Gynecol. 2019;134(1):e19–e40.
  • Money D, Allen VM. The prevention of early-onset neonatal group B streptococcal disease. J Obstet Gynaecol Can. 2018;40:e665–74.
  • Puopolo KM, Lynfield R, Cummings JJ. Management of infants at risk for group B streptococcal disease. Pediatrics. 2019;144(2):e20191881.
  • Lee B, Newland JG, Jhaveri R. Reductions in neonatal listeriosis: “Collateral benefit” of group B streptococcal prophylaxis? J Infect. 2016;72(3):317–323.
  • Schuchat A, Zywicki SS, Dinsmoor MJ, et al. Risk factors and opportunities for prevention of early-onset neonatal sepsis: a multicenter case-control study. Pediatrics. 2000;105(1):21–26.
  • Puopolo KM, Benitz WE, Zaoutis TE. Management of neonates born at ≥35 0/7 weeks’ gestation with suspected or proven early-onset bacterial sepsis. Pediatrics. 2018;142:e2018–894.
  • Schrag SJ, Farley MM, Petit S, et al. Epidemiology of invasive early-onset neonatal sepsis, 2005 to 2014. Pediatrics. 2016;138(6):e20162013.
  • Vergnano S, Menson E, Kennea N, et al. Neonatal infections in England: the NeonIN surveillance network. Arch Dis Child Fetal Neonatal Ed. 2011;96:F9–14.
  • Berardi A, Baroni L, Bacchi Reggiani ML, et al. GBS prevention working group Emilia-Romagna. The burden of early-onset sepsis in Emilia-Romagna (Italy): a 4-year, population-based study. J Matern Fetal Neonatal Med. 2016;29(19):3126–3131.
  • Berardi A, Fornaciari S, Rossi C, et al. Safety of physical examination alone for managing well-appearing neonates ≥ 35 weeks’ gestation at risk for early-onset sepsis. J Matern Fetal Neonatal Med. 2015;28:1123–1127.
  • van Herk W, Stocker M, van Rossum AM. Recognising early onset neonatal sepsis: an essential step in appropriate antimicrobial use. J Infect. 2016;72:S77–82.
  • Flidel-Rimon O, Galstyan S, Juster-Reicher A, et al. Limitations of the risk factor based approach in early neonatal sepsis evaluations. Acta Paediatr. 2012;101:e540.
  • Randis TM, Polin RA, Saade G. Chorioamnionitis: time for a new approach. Curr Opin Pediatr. 2017;29:159–164.
  • Hooven TA, Randis TM, Polin RA. What’s the harm? Risks and benefits of evolving rule-out sepsis practices. J Perinatol. 2018;(38):614–622.
  • Cotten CM, Taylor S, Stoll B, et al. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009;123:58–66.
  • Kuppala VS, Meinzen-Derr J, Morrow AL, et al. Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants. J Pediatr. 2011;159:720–725.
  • Ficara M, Pietrella E, Spada C, et al. Changes of intestinal microbiota in early life. J Matern Fetal Neonatal Med. 2018:1–8  [Epub ahead of print].
  • Berardi A, Rossi C, Spada C, et al. GBS prevention working group Emilia-Romagna. Strategies for preventing early-onset sepsis and for managing neonates at-risk: wide variability across six Western countries. J Matern Fetal Neonatal Med. 2019;32(18):3102–3108.
  • Schrag S, Gorwitz R, Fultz-Butts K, et al. Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC. MMWR Recomm Rep. 2002;51(RR–11):1–22.
  • Creti R, Imperi M, Berardi A, et al. Neonatal group B streptococcus infections: prevention strategies, clinical and microbiologic characteristics in 7 Years of surveillance. Pediatr Infect Dis J. 2017;36(3):256–262.
  • Idsoe O, Guthe T, Willcox RR, et al. Nature and extent of penicillin side-reactions, with particular reference to fatalities from anaphylactic shock. Bull World Health Organ. 1968;38(2):159–188.
  • Kelkar PS, Li JT. Cephalosporin allergy. N Engl J Med. 2001;345(11):804–809.
  • Van Dyke MK, Phares CR, Lynfield R, et al. Evaluation of universal antenatal screening for group B streptococcus. N Engl J Med. 2009;360(25):2626–2636.
  • Berardi A, Rossi C, Bacchi Reggiani ML, et al. An area-based study on intrapartum antibiotic prophylaxis for preventing group B streptococcus early-onset disease: advances and limitations. J Matern Fetal Neonatal Med. 2017;30:1739–1744.
  • Bianco A, Larosa E, Pileggi C, et al. Collaborative working group.appropriateness of intrapartum antibiotic prophylaxis to prevent neonatal group B streptococcus disease. PLoS One. 2016;11(11):e0166179.
  • El Helali N, Giovangrandi Y, Guyot K, et al. Cost and effectiveness of intrapartum group B streptococcus polymerase chain reaction screening for term deliveries. Obstet Gynecol. 2012;119(4):822–829.
  • Lin FY, Brenner RA, Johnson YR, et al. The effectiveness of risk-based intrapartum chemoprophylaxis for the prevention of early-onset neonatal group B streptococcal disease. Am J Obstet Gynecol. 2001;184(6):1204–1210.
  • Davis RL, Hasselquist MB, Cardenas V, et al. Introduction of the new centers for disease control and prevention group B streptococcal prevention guideline at a large West Coast health maintenance organization. Am J Obstet Gynecol. 2001;184(4):603–610.
  • Berardi A, Di Fazzio G, Gavioli S, et al. GBS prevention working group, Emilia-Romagna. Universal antenatal screening for group B streptococcus in Emilia-Romagna. J Med Screen. 2011;18(2):60–64.
  • Eastwood KA, Craig S, Sidhu H, et al. Prevention of early-onset Group B streptococcal disease – the Northern Ireland experience. BJOG. 2015;122(3):361–367.
  • Fairlie T, Zell ER, Schrag S. Effectiveness of intrapartum antibiotic prophylaxis for prevention of early-onset group B streptococcal disease. Obstet Gynecol. 2013;121(3):570–577.
  • Goins WP, Talbot TR, Schaffner W, et al. Adherence to perinatal group B streptococcal prevention guidelines. Obstet Gynecol. 2010;115(6):1217–1224.
  • Turrentine MA, Greisinger AJ, Brown KS, et al. Duration of intrapartum antibiotics for group B streptococcus on the diagnosis of clinical neonatal sepsis. Infect Dis Obstet Gynecol. 2013;2013:525878.
  • Eisenberg E, Craig AS, Gautam S, et al. Beyond screening: identifying new barriers to early onset group B streptococcal disease prevention. Pediatr Infect Dis J. 2005;24(6):520–524.
  • Barber EL, Funai EF, Bracken MB, et al. Interpretation of 2002 centers for disease control guidelines for group B streptococcus and evolving provider practice patterns. Am J Perinatol. 2011;28(2):97–102.
  • Mukhopadhyay S, Dukhovny D, Mao W, et al. 2010 perinatal GBS prevention guideline and resource utilization. Pediatrics. 2014;133(2):196–203.
  • Mukhopadhyay S, Taylor JA, Von Kohorn I, et al. Variation in sepsis evaluation across a national network of nurseries. Pediatrics. 2017;139(3):e20162845.
  • Tzialla C, Berardi A, Farina C, et al. Strategies for preventing group B streptococcal infections in newborns: a nation-wide survey of Italian policies. Ital J Pediatr. 2017;43(1):98.
  • Scasso S, Laufer J, Rodriguez G, et al. Vaginal group B streptococcus status during intrapartum antibiotic prophylaxis. Int J Gynaecol Obstet. 2015;129(1):9–12.
  • McNanley AR, Glantz JC, Hardy DJ, et al. The effect of intrapartum penicillin on vaginal group B streptococcus colony counts. Am J Obstet Gynecol. 2007;197(6):583.e1–4.
  • Berardi A, Rossi C, Biasini A, et al. Efficacy of intrapartum chemoprophylaxis less than 4 hours duration. J Matern Fetal Neonatal Med. 2011;24(4):619–625.
  • Hickman ME, Rench MA, Ferrieri P, et al. Changing epidemiology of group B streptococcal colonization. Pediatrics. 1999;104:203–209.
  • Illuzzi JL, Bracken MB. Duration of intrapartum prophylaxis for neonatal group B streptococcal disease: a systematic review. Obstet Gynecol. 2006;108(5):1254–1265.
  • De Cueto M, Sanchez MJ, Sampedro A, et al. Timing of intrapartum ampicillin and prevention of vertical transmission of group B streptococcus. Obstet Gynecol. 1998;91(1):112–114.
  • Pylipow M, Gaddis M, Kinney JS. Selective intrapartum prophylaxis for group B streptococcus colonization: management and outcome of newborns. Pediatrics. 1994;93:31–35.
  • Boyer KM, Gadzala CA, Kelly PD, et al. Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. III. Interruption of mother-to-infant transmission. J Infect Dis. 1983;148:810–816.
  • Lijoi D, Di Capua E, Ferrero S, et al. The efficacy of 2002 CDC guidelines in preventing perinatal group B Streptococcal vertical transmission: a prospective study. Arch Gynecol Obstet. 2007;275(5):373–379.
  • Berardi A, Rossi C, Guidotti I, et al. Factors associated with intrapartum transmission of group B streptococcus. Pediatr Infect Dis J. 2014;33(12):1211–1215.
  • Bromberger P, Lawrence JM, Braun D, et al. The influence of intrapartum antibiotics on the clinical spectrum of early-onset group B streptococcal infection in term infants. Pediatrics. 2000;106:244–250.
  • Pinto NM, Soskolne EI, Pearlman MD, et al. Neonatal early-onset group B streptococcal disease in the era of intrapartum chemoprophylaxis: residual problems. J Perinatol. 2003;23(4):265–271.
  • Rosenstein NE, Schuchat A. Opportunities for prevention of perinatal group B streptococcal disease: a multistate surveillance analysis. The neonatal group B streptococcal disease study group. Obstet Gynecol. 1997;90(6):901–906.
  • Berardi A, Spada C, Reggiani ML, et al. GBS prevention working group of Emilia-Romagna. Group B streptococcus early-onset disease and observation of well-appearing newborns. PLoS One. 2019;14(3):e0212784.
  • Berardi A, Lugli L, Rossi C, et al. GBS prevention working group, Emilia-Romagna. Impact of perinatal practices for early-onset group B Streptococcal disease prevention. Pediatr Infect Dis J. 2013;32(ì):e265–71.
  • Cantey JB, Baird SD. Ending the culture of culture-negative sepsis in the. Neonatal ICU Pediatrics. 140(4):e20170044. 2017.
  • Berardi A, Spada C, Creti R, et al. Risk factors for group B streptococcus early-onset disease: an Italian, area-based, case-control study. J Matern Fetal Neonatal Med. 2019;17:1–7.
  • Puopolo KM, Madoff LC, Eichenwald EC. Early-onset group B streptococcal disease in the era of maternal screening. Pediatrics. 2005;115(5):1240–1246.
  • Velaphi S, Siegel JD, Wendel GD Jr, et al. Early-onset group B streptococcal infection after a combined maternal and neonatal group B streptococcal chemoprophylaxis strategy. Pediatrics. 2003;111(3):541–547.
  • Stafford IA, Stewart RD, Sheffield JS, et al. Efficacy of maternal and neonatal chemoprophylaxis for early-onset group B streptococcal disease. Obstet Gynecol. 2012;120(1):123–129.
  • Viel-Theriault I, Fell DB, Grynspan D, et al. The transplacental passage of commonly used intrapartum antibiotics and its impact on the newborn management: A narrative review. Early Hum Dev. 2019;135:6–10.
  • Syme MR, Paxton JW, Keelan JA. Drug transfer and metabolism by the human placenta. Clin Pharmacokinet. 2004;43(8):487–514.
  • Griffiths SK, Campbell JP. Placental structure, function and drug transfer. Contin Educ Anaesth Crit Care Pain. 2015;15(2):84–89.
  • Allegaert K, van Mieghem T, Verbesselt R, et al. Cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy. Am J Obstet Gynecol. 2008;200:170–171.
  • Lalic-Popovic M, Paunkovic J, Grujic Z, et al. Decreased placental and transcellular permeation of cefuroxime in pregnant women with diabetes. J Diabetes. 2016;8:238–245.
  • Brown CE, Christmas JT, Bawdon RE. Placental transfer of cefazolin and piperacillin in pregnancies remote from term complicated by Rh isoimmunization. Am J Obstet Gynecol. 1990;163(3):938–943.
  • Groff SM, Fallatah W, Yang S, et al. Effect of maternal obesity on maternal-fetal transfer of preoperative cefazolin at cesarean section. J Pediatr Pharmacol Ther. 2017;22(3):227–232.
  • Fiore Mitchell T, Pearlman MD, Chapman RL, et al. Maternal and transplacental pharmacokinetics of cefazolin. Obstet Gynecol. 2001;98(6):1075–1079.
  • Bloom SL, Cox SM, Bawdon RE, et al. Ampicillin for neonatal group B streptococcal prophylaxis: how rapidly can bactericidal concentrations be achieved? Am J Obstet Gynecol. 1996;175:974–976.
  • Colombo DF, Lew JL, Pedersen CA, et al. Optimal timing of ampicillin administration to pregnant women for establishing bactericidal levels in the prophylaxis of group B streptococcus. Am J Obstet Gynecol. 2006;194(2):466–470.
  • Barber EL, Zhao G, Buhimschi IA, et al. Duration of intrapartum prophylaxis and concentration of penicillin G in fetal serum at delivery. Obstet Gynecol. 2008;112:265–270.
  • Johnson JR, Colombo DF, Gardner D, et al. Optimal dosing of penicillin G in the third trimester of pregnancy for prophylaxis against group B Streptococcus. Am J Obstet Gynecol. 2001;185(4):850–853.
  • Berardi A, Pietrangiolillo Z, Bacchi Reggiani ML, et al. Are postnatal ampicillin levels actually related to the duration of intrapartum antibiotic prophylaxis prior to delivery? A pharmacokinetic study in 120 neonates. Arch Dis Child Fetal Neonatal Ed. 2018;103:F152–6.
  • Berardi A, Lugli L, Baronciani D, et al. GBS prevention working group of Emilia-Romagna. Group B streptococcal infections in a northern region of Italy. Pediatrics. 2007;120(3):e487–93.
  • Berardi A, Lugli L, Rossi C, et al. Intrapartum antibiotic prophylaxis failure and group-B streptococcus early-onset disease. J Matern Fetal Neonatal Med. 2011;24(10):1221–1224.
  • Tudela CM, Stewart RD, Roberts SW, et al. Intrapartum evidence of early-onset group B streptococcus. Obstet Gynecol. 2012;119(3):626–629.
  • Albers WH, Tyler CW, Boxerbaum B. Asymptomatic bacteremia in the newborn infant. J Pediatr. 1966;69:193.
  • Kuzniewicz MW, Puopolo KM, Fischer A, et al. A quantitative, risk-based approach to the management of neonatal early-onset sepsis. JAMA Pediatr. 2017;171:365–371.
  • Cantoni L, Ronfani L, Da Riol R, et al. Physical examination instead of laboratory tests for most infants born to mothers colonized with group B Streptococcus: support for the centers for disease control and prevention’s 2010 recommendations. J Pediatr. 2013;163:568–573.
  • Joshi NS, Gupta A, Allan JM, et al. Clinical monitoring of well-appearing infants born to mothers with chorioamnionitis. Pediatrics. 2018;141(4):e20172056.

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