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Original Articles

Focusing on Children's Inhalation Dosimetry and Health Effects for Risk Assessment: An Introduction

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Pages 149-165 | Published online: 20 Dec 2007

REFERENCES

  • Ahluwalia , I. B. , Grummer-Strawn , L. and Scanlon , K. S. 1997 . Exposure to environmental tobacco smoke and birth outcome: Increased effects on pregnant women aged 30 years or older . Am. J. Epidemiol. , 146 : 42 – 47 .
  • Anderson , H. R. 1999 . “ Health effects of air pollution episodes ” . In Air pollution and health , Edited by: Holgate , S. T. , Samet , J. M. , Koren , H. S. and Maynard , R .L. 461 – 484 . London : Academic Press .
  • Anderson , I. and Proctor , D. F. 1982 . “ The fate and effects of inhaled materials ” . In The nose: Upper airway physiology and the atmospheric environment , Edited by: Proctor , D. F. and Anderson , I. 423 – 443 . New York : Elsevier Biomedical Press .
  • Bayer-Oglesby , L. , Grize , L. , Gassner , M. , Takken-Sahli , K. , Sennhauser , F. H. , Neu , U. , Schindler , C. and Braun-Fahrlander , C. 2005 . Decline of ambient air pollution levels and improved respiratory health in Swiss children . Environ. Health Perspect. , 113 : 1632 – 1637 .
  • Becquemin , M.H. , Roy , M. , Bouchikhi , A. and Teillac , A. Deposition of inhaled particles in healthy children . Proceedings of the 2nd Int. Symposium on Deposition and Clearance of Aerosols in the Human Respiratory Tract . Salzburg, Austria. pp. 18 – 20 .
  • Becquemin , M. H. , Swift , D. L. , Bouchikhi , A. , Roy , M. and Teillac , A. 1991 . Particle deposition and resistance in the noses of adults and children . Eur. Respir. J. , 4 : 694 – 702 .
  • Becquemin , M. H. , Berthalon , J. F. , Bouchikhi , A. , Malarbet , J. L. and Roy , M. 1999 . Oronasal ventilation partitioning in adults and children: effect on aerosol deposition in airways . Radiat. Protect.Dosim. , 81 : 221 – 228 .
  • Bedi , J. F. , Horvath , S. M. and Dreschler-Parks , D. M. 1988 . Reproducibility of the pulmonary function response of older men and women to a 2-hour ozone exposure . J. Air Pollut. Control Assoc. , 38 : 1016 – 1019 .
  • Bennett , W. D. and Smaldone , G. C. 1987 . Human variation in the peripheral air-space deposition of inhaled particles . J. Appl. Physiol. , 62 : 1603 – 1610 .
  • Bennett , W. D. and Zeman , K. L. 1998 . Deposition of fine particles in children spontaneously breathing at rest . Inhal. Toxicol. , 10 : 831 – 842 .
  • Bennett , W. D. and Zeman , K. L. 2004 . Effect of body size on breathing pattern and fine particle deposition in children . J. Appl. Physiol. , 97 : 821 – 826 .
  • Bennett , W. D. , Zeman , K. L. and Kim , C. S. 1996 . Variability of fine particle deposition in healthy adults: Effect of age and gender . Am. J. Respir. Crit. Care Med. , 153 : 1641 – 1647 .
  • Bennett , W. D. , Zeman , K. L. and Jarabek , A. 2003 . Nasal contribution to breathing with exercise: effect of race and gender . J. Appl. Physiol. , 95 : 497 – 503 .
  • Bennett , W. D. , Zeman , K. L. and Jarabek , A. M. 2007 . Nasal contribution to breathing and fine particulate deposition in children versus adults . J. Toxicol. Environ. Health A , 71 : 227 – 237 .
  • Bobak , M. and Leon , D. A. 1992 . Air pollution and infant mortality in the Czech Republic, 1986–88 . Lancet , 340 : 1010 – 1014 .
  • Bobak , M. and Leon , D. A. 1999a . Pregnancy outcomes and outdoor air pollution: an ecological study in districts of the Czech republic 1986–1988 . Occup. Environ. Med. , 56 : 539 – 543 .
  • Bobak , M. and Leon , D. A. 1999b . The effect of air pollution on infant mortality appears specific for respiratory causes in the postneonatal period . Epidemiology , 10 : 666 – 670 .
  • Bobak , M. 2000 . Outdoor air pollution, low birth weight, and prematurity . Environ. Health Perspect. , 108 : 173 – 176 .
  • Bobak , M. , Richards , M. and Wadsworth , M. 2001 . Air pollution and birth weight in Britain in 1946 . Epidemiology , 12 : 358 – 359 .
  • Braun-Fahrlander , C. , Vuille , J. C. , Sennhauser , F. H. , Neu , U. , Kunzle , T. , Grize , L. , Gassner , M. , Minder , C. , Schindler , C. , Varonier , H. S. and Wuthrich , B. 1997 . Respiratory health and long term exposure to air pollutants in Swiss schoolchildren. SCARPOL team . Am. J. Respir. Crit. Care Med. , 155 : 1042 – 1049 .
  • Brunekreef , B. , Janssen , N. A. , de Hartog , J. , Harssema , H. , Knape , M. and van Vliet , P. 1997 . Air pollution from truck traffic and lung function in children living near motorways . Epidemiology , 8 : 298 – 303 .
  • Centers for Disease Control. 2001. National Health and Nutrition Examination Survey (2001–2002) http://www.cdc.gov/nchs/about/major/nhanes/nhanes01-02.htm (Accessed: 20 October 2006 ).
  • Cheng , K. H. , Cheng , Y. S. , Yeh , H. C. , Guilmette , R. A. , Simpson , S. Q. , Yang , Y. H. and Swift , D. L. 1996 . In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways . J. Aerosol. Sci. , 27 : 785 – 801 .
  • Conceicao , G. M. , Miraglia , S. G. , Kishi , H. S. , Saldiva , P. H. and Singer , J. M. 2001 . Air pollution and child mortality: A time-series study in Sao Paulo, Brazil . Environ. Health Perspect. , 109 ( Suppl. 3 ) : 347 – 350 .
  • Dejin-Karlsson , E. , Hanson , B. S. , Ostergren , P. O. , Sjoberg , N. O. and Marsal , K. 1998 . Does passive smoking in early pregnancy increase the risk for small-for-gestational age infants? . Am. J. Public Health , 88 : 1523 – 1527 .
  • Dejmek , J. , Selevan , S.G. , Benes , I. , Solansky , I. and Sram , R. J. 1999 . Fetal growth and maternal exposure to particulate matter during pregnancy . Environ. Health Perspect. , 107 : 475 – 480 .
  • Dejmek , J. , Solansky , I. , Podrazilova , K. and Sram , R. J. 2002 . The exposure of nonsmoking and smoking mothers to environmental tobacco smoke during different gestational phases and fetal growth . Environ. Health Perspect. , 110 : 601 – 606 .
  • Diaz-Sanchez , D. , Tsien , A. , Fleming , J. and Saxon , A. 1997 . Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper 2-type pattern . J. Immunol. , 158 : 2406 – 2413 .
  • Diaz-Sanchez , D. , Penichet-Garcia , M. , Wang , M. , Jyrala , M. and Saxon , A. 1999 . Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa . J. Allergy Clin. Immunol. , 118 : 3 – 1188 .
  • Diaz-Sanchez , D. , Penichet-Garcia , M. and Saxon , A. 2000 . Diesel exhaust particles directly induce activated mast cells to degranulate and increase histamine levels and symptom severity . J. Allergy Clin. Immunol. , 106 : 1140 – 1146 .
  • Diaz-Sanchez , D. , Proietti , L. and Polosa , R. 2003 . Diesel fumes and the rising prevalence of atopy: An urban legend? . Curr. Allergy Asthma Rep. , 3 : 146 – 152 .
  • Dietert , R. R. , Etzel , R. A. , Chen , D. , Halonen , M. , Holladay , S. D. , Jarabek , A. M. , Landreth , K. , Peden , D. B. , Pinkerton , K. , Smialowicz , R. J. and Zoetis , T. 2000 . Windows of Vulnerability for the Immune and Respiratory Systems . Environ. Health Perspect. , 108 ( Suppl. 3 ) : 483 – 490 .
  • Dockery , D. W. , Speizer , F. E. , Stram , D. O. , Ware , J. H. , Spengler , J. D. and Ferris , B. G. Jr. 1989 . Effects of inhaled particles on respiratory health of children . Am. Rev. Respir. Dis. , 139 : 587 – 594 .
  • Dockery , D. W. , Cunningham , J. , Damokosh , A. I. , Neas , L. M. , Spengler , J. D. , Koutrakis , P. , Ware , J. H. , Raizenne , M. and Speizer , F. E. 1996 . Health effects of acid aerosols on North American children: Respiratory symptoms . Environ. Health Perspect. , 105 : 500 – 505 .
  • Dunnill , M. S. 1962 . Postnatal Growth of the Lung . Thorax , 17 : 329
  • Executive Order 13045 . 1997 . Protection of children from environmental health risks and safety risks . Fed. Reg. , 62 ( 78 ) : 19883 – 19888 .
  • Galizia , A. and Kinney , P.L. 1999 . Long-term residence in areas of high ozone: Associations with respiratory health in a nationwide sample of nonsmoking young adults . Environ. Health Perspect. , 107 : 675 – 679 .
  • Gauderman , W. J. , McConnell , R. , Gilliland , F. , London , S. , Thomas , D. , Avol , E. , Vora , H. , Berhane , K. , Rappaport , E. B. , Lurmann , F. , Margolis , H. G. and Peters , J. 2000 . Association between air pollution and lung function growth in Southern California children . Am. J. Respir. Crit. Care Med. , 162 : 1383 – 1390 .
  • Gauderman , W. J. , Avol , E. , Gilliland , C. F. , Vora , H. , Thomas , D. , Berhane , K. , McConnell , R. , Kuenzli , N. , Lurmann , F. , Rappaport , E. , Margolis , H. , Bates , D. and Peters , J. 2004 . The effect of air pollution on lung development from 10 to 18 years of age . N. Engl. J. Med. , 351 : 1057 – 1067 .
  • Gauderman , W. J. , Avol , E. , Lurmann , F. , Kuenzli , N. , Gilliland , F. , Peters , J. and McConnell , R. 2005 . Childhood asthma and exposure to traffic and nitrogen dioxide . Epidemiology , 16 : 1 – 7 .
  • Gent , J. F. , Triche , E. W. , Holford , T. R. , Belanger , K. , Bracken , M. B. , Beckett , W. S. and Leaderer , B. P. 2003 . Association of low-level ozone and fine particles with respiratory symptoms in children . J. Am. Med. Assoc. , 290 : 1859 – 1867 .
  • Gilbert , R. , Auchincloss , J. H. , Brodsky , J. and Boden , W. 1972 . Changes in tidal volume, frequency, and ventilation induced by their measurement . J. Appl. Physiol. , 33 : 252 – 254 .
  • Graham , S. E. and McCurdy , T. 2005 . Revised ventilation rate (VE) equations for use in inhalation-oriented exposure models , Internal research report. U.S. Environmental Protection Agency : Office of Research and Development, National Exposure Laboratory, Human Exposure and Atmospheric Sciences Division, Exposure Modeling Research Branch, Research Triangle Park, NC .
  • Ha , E. H. , Hong , Y. C. , Lee , B. E. , Woo , B. H. , Schwartz , J. and Christiani , D. C. 2001 . Is air pollution a risk factor for low birth weight in Seoul? . Epidemiology , 12 : 643 – 648 .
  • Ha , E. H. , Lee , J. T. , Kim , H. , Hong , Y. C. , Lee , B. O. , Park , H. S. and Christiani , D. C. 2003 . Infant susceptibility of mortality to air pollution in Seoul, South Korea . Pediatrics , 111 : 284 – 290 .
  • Harding , R. , Pinkerton , K. E. and Plopper , C. G. , eds. 1994 . The lung: Development, aging, and the environment , San Diego : Elsevier Academic Press .
  • Hebestreit , H. , Kriemler , S. , Hughson , R. L. and Bar-Or , O. 1998 . Kinetics of oxygen uptake at the onset of exercise in boys and men . J. Appl. Physiol. , 85 : 1833 – 1841 .
  • Hebestreit , H. , Staschen , B. and Hebestreit , A. 2000 . Ventilatory threshold: A useful method to determine aerobic fitness in children? . Med. Sci. Sports Exer. , 32 : 1964 – 1969 .
  • Heinrich , J. , Hoelscher , B. and Wichman , H. E. 2000 . Decline of ambient air pollution and respiratory symptoms in children . Am. J. Respir. Crit. Care Med. , 161 : 1930 – 1936 .
  • Her Majesty's Public Health Service . 1954 . Mortality and morbidity during the London Fog of December 1952 , HMPHS. Report No 95 on Public Health and Medical Subjects. London : Her Majesty's Stationary Office .
  • Heyder , J. , Gebhart , J. and Scheuch , G. 1988 . Influence of human lung morphology on particle deposition . J. Aerosol Med. , 1 : 81 – 88 .
  • Holt , P. G. 1998 . Programming for responsiveness to environmental antigens that trigger allergic respiratory disease in adulthood is initiated in the perinatal period . Environ. Health Perspect. , 106 ( Suppl. 3 ) : 795 – 800 .
  • International Commission on Radiological Protection. 1994. Human respiratory tract for model for radiological protection. London: ICRP Pub. No. 66.
  • International Commission on Radiological Protection . 1995 . Age-dependent doses to members of the public from intake of radionuclides: Part 4 Inhalation dose coefficients. Pub. 71 . Ann. ICRP , 25 ( 3–4 ) : 11 – 405 .
  • Ishizaki , T. , Koisumi , K. , Ikemori , R. , Ishiyama , Y. and Kushibiki , E. 1987 . Studies of prevalence of Japanese cedar pollinosis among the residents of densely cultivated area . Ann. Allergy , 58 : 265 – 270 .
  • Jarabek , A. M. 1995 . Interspecies extrapolation based on mechanistic determinants of chemical disposition . J. Hum. Ecol. Risk Assess. , 1 : 641 – 662 .
  • James , D. S. , Lambert , W. E. , Mermier , C. E. , Stidley , C. A. , Chick , T. W. and Samet , J. M. 1997 . Oronasal distribution of ventilation at different ages . Arch. Environ. Health , 52 : 118 – 123 .
  • Jerrett , M. , Burnett , R. T. , Ma , R. , Pope , C. A. , Krewski , D. , Newbold , K. B. , Thurston , G. , Shi , Y. , Finkelstein , N. , Calle , E. E. and Thun , M. J. 2005 . Spatial analysis of air pollution and mortality in Los Angeles . Epidemiology , 16 : 727 – 736 .
  • Kesavanthan , J. , Bascom , R. and Swift , D. L. 1998 . The effect of nasal passage characteristics on particle deposition . J. Aerosol. Med. , 11 : 27 – 39 .
  • Kharrazi , M. , DeLorenze , G. N. , Kaufman , F. L. , Eskenazi , B. , Bernert , J. T. Jr. , Graham , S. , Pearl , M. and Pirkle , J. 2004 . Environmental tobacco smoke and pregnancy outcome . Epidemiology , 15 : 660 – 670 .
  • Kim , C. S. and Kang , T. C. 1997 . Comparative measurement of lung deposition of inhaled fine particles in normal subjects and patients with obstructive airway disease . Am.J. Respir. Crit. Care Med. , 155 : 899 – 905 .
  • Kim , J. J. , Smorodinsky , S. , Lipsett , M. , Singer , B. C. , Hodgson , A. T. and Ostro , B. 2004 . Traffic-related air pollution near busy roads: the East Bay Children's Respiratory Health Study . Am. J. Respir. Crit. Care Med. , 170 : 520 – 526 .
  • Kramer , U. , Koch , T. , Ranft , U. , Ring , J. and Behrendt , H. 2000 . Traffic related air pollution is associated with atopy in children living in urban areas . Epidemiology , 11 : 64 – 70 .
  • Kunzli , N. , Lurmann , F. , Segal , M. , Ngo , L. , Balmes , J. and Tager , I. B. 1997 . Association between lifetime ambient ozone exposure and pulmonary function in college freshman—Results of a pilot study . Environ. Res. , 72 : 8 – 23 .
  • Layton , D. W. 1993 . Metabolically consistent breathing rates for use in dose assessments . Health Phys. , 64 : 23 – 36 .
  • Lin , M. , Chen , Y. , Burnett , R. T. , Villeneuve , P. J. and Krewski , D. 2002 . The influence of ambient coarse particulate matter on asthma hospitalization in children: Case crossover and time series analyses . Environ. Health. Perspect. , 110 : 575 – 581 .
  • Lin , M. C. , Chiu , H. F. , Yu , H. S. , Tsai , S. S. , Cheng , B. H. , Wu , T. N. , Sung , F. C. and Yang , C. Y. 2001 . Increased risk of preterm delivery in areas with air pollution from a petroleum refinery plant in Taiwan . J. Toxicol. Environ. Health A , 64 : 37 – 44 .
  • Loomis , D. , Castillejos , M. , Gold , D. R. , McDonnell , W. and Borja-Aburto , V. H. 1999 . Air pollution and infant mortality in Mexico City . Epidemiology , 10 : 118 – 123 .
  • Maejima , K. , Tamura , K. , Nakajima , T. , Taniguchi , Y. , Saito , S. and Takenaka , H. 2001 . Effects of the inhalation of diesel exhaust, Kanto loam dust, or diesel exhaust without particles on immune responses in mice exposed to Japanese cedar (Cryptomeria japonica) pollen . Inhal. Toxicol. , 13 : 1047 – 1063 .
  • Mar , T. F. , Larson , T. V. , Stier , R. A. , Claiborn , C. and Koeniq , J. Q. 2004 . An analysis of the association between respiratory symptoms in subjects with asthma and daily air pollution in Spokane, Washington . Inhal. Toxicol. , 16 : 809 – 815 .
  • Marty , M. A. , Blaisdell , R. J. , Broadwin , R. , Hill , M. , Shimer , D. and Jenkins , M. 2002 . Distribution of daily breathing rates for use in California's air toxics hot spots program risk assessments . Hum. Ecol. Risk Assess. , 8 : 1723 – 1737 .
  • Mathieu-Nolf , M. 2002 . Poisons in the air: a cause of chronic disease in children . Clin. Toxicol. , 40 : 483
  • McConnell , R. , Berhane , K. , Gilliland , F. , London , S. J. , Vora , H. , Avol , E. , Gauderman , W. J. , Margolis , H. G. , Lurmann , F. , Thomas , D. C. and Peters , J. M. 1999 . Air pollution and bronchitic symptoms in Southern California children with asthma . Environ. Health Perspect. , 107 : 757 – 760 .
  • McCurdy , T. 2000 . Conceptual basis for multi-route intake dose modeling using an energy expenditure approach . J. Expos. Anal. Environ. Epidemiol , 10 : 86 – 97 .
  • McDonnell , W. F. 3rd , Horstmann , D. H. , Abdul-Salaam , S. and House , D. E. 1985 . Reproducibility of individual responses to ozone exposure . Am. Rev. Respir. Dis. , 131 : 36 – 40 .
  • Nel , A. , Diaz-Sanchez , D. , Ng , D. , Hiura , T. and Saxon , A. 1998 . Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system . J. Allergy Clin. Immunol. , 102 : 539 – 553 .
  • Niinimaa , V. , Cole , P. , Mintz , S. and Shephard , R. J. 1981 . Oronasal distribution of respiratory airflow . Respir. Physiol. , 43 : 69 – 75 .
  • Office of Environmental Health Hazard Assessment. 1999. Air Toxics Hot Spots Program risk assessment guidelines. Part I: Technical support document for the determination of acute reference exposure levels for airborne toxicants. OEHHA. http://www.oehha.ca.gov/air/acute_rels/acuterel.html#download
  • Office of Environmental Health Hazard Assessment. 2000a. Air Toxics Hot Spots Program risk assessment guidelines. Part III. Technical support document for the determination of noncancer chronic reference exposure levels. OEHHA. http://www.oehha.ca.gov/air/chronic_rels/pdf/relsP32k.pdf
  • Office of Environmental Health Hazard Assessment. 2000b. Air Toxics Hot Spots Program risk assessment guidelines. Part IV. Technical support document for exposure assessment and stochastic analysis. OEHHA. http://www.oehha.ca.gov/air/hot_spots/finalStoc.html#download
  • Office of Environmental Health Hazard Assessment. 2003. Air Toxics Hot Spots Program risk assessment guidelines. Air Toxics Hot Spots Program guidance manual for preparation of health and risk assessments. OEHHA. http://www.oehha.ca.gov/air/hot_spots/pdf/HRAfinalnoapp.pdf
  • Office of Environmental Health Hazard Assessment. 2005. Air Toxics Hot Spots Program risk assessment guidelines. Part II. Technical support document for describing cancer potency factors. OEHHA. http://www.oehha.ca.gov/air/hot_spots/pdf/May2005Hotspots.pdf
  • Oosterlee , A. , Drijver , M. , Lebret , E. and Brunekreef , B. 1996 . Chronic respiratory symptoms in children and adults living along streets with high traffic density . Occup. Environ. Med. , 53 : 241 – 247 .
  • Ostro , B. D. , Lipsett , M. J. , Mann , J. K. , Braxton-Owens , H. and White , M. C. 1995 . Air pollution and asthma exacerbations among African-American children in Los Angeles . Inhal. Toxicol. , 7 : 711 – 722 .
  • Ostro , B. , Lipsett , M. , Mann , J. , Braxton-Owens , H. and White , M. 2001 . Air pollution and exacerbation of asthma in African-American children in Los Angeles . Epidemiology , 12 : 200 – 208 .
  • Parker , J. D. , Woodruff , T. J. , Basu , R. and Schoendorf , K. C. 2005 . Air pollution and birth weight among term infants in California . Pediatrics , 115 : 121 – 128 .
  • Pereira , L. A. , Loomis , D. , Conceicao , G. M. , Braga , A. L. , Arcas , R. M. , Kishi , H. S. , Singer , J. M. , Bohm , G. M. and Saldiva , P. H. 1998 . Association between air pollution and intrauterine mortality in Sao Paulo, Brazil . Environ. Health Perspect. , 106 : 325 – 329 .
  • Phalen , R. F. , Oldham , M. J. and Mautz , W. J. 1989 . Aerosol deposition in the nose as a function of body size . Health Phys. , 57 ( Suppl. 1 ) : 299 – 305 .
  • Pope , C. A. and Dockery , D. W. 1992 . Acute health effects of PM10 pollution on symptomatic and asymptomatic children . Am. Rev. Respir. Dis. , 145 : 1123 – 1128 .
  • Rauh , V. A. , Whyatt , R. M. , Garfinkel , R. , Andrews , H. , Hoepner , L. , Reyes , A. , Diaz , D. , Camann , D. and Perera , F. P. 2004 . Developmental effects of exposure to environmental tobacco smoke and maternal hardship among inter-city children . Neurotoxicol. Teratol. , 26 : 373 – 385 .
  • Renwick , A. G. and Lazarus , N. R. 1998 . Human variability and noncancer risk assessment—An analysis of the default uncertainty factor . Regul. Toxicol. Pharmacol. , 27 : 3 – 20 .
  • Ritz , B. and Yu , F. 1999 . The effect of ambient carbon monoxide on low birth weight among children born in southern California between 1989 and 1993 . Environ. Health Perspect. , 107 : 17 – 25 .
  • Ritz , B. , Yu , F. , Chapa , G. and Fruin , S. 2000 . Effect of air pollution on preterm birth among children born in southern California between 1989 and 1993 . Epidemiology , 11 : 502 – 511 .
  • Romieu , I. , Sienra-Mongue , J. J. , Ramirez-Auiglar , M. , Moreno-Macias , H. , Reyes-Ruiz , N. I. , del Rio-Navarro , B. .E. , Hernandez-Avila , M. and London , S. .J. 2004 . Genetic polymorphism of GSTM 1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City . Thorax , 59 : 8 – 10 .
  • Sagiv , S. K. , Mendola , P. , Loomis , D. , Herring , A. H. , Neas , L. M. , Savitz , D. A. and Poole , C. A. 2005 . A time series analysis of air pollution and preterm birth in Pennsylvania, 1997–2001 . Environ. Health Perspect. , 113 : 602 – 606 .
  • Saldiva , P. H. N. , Lichtenfels , A. J. F. C. , Paiva , P. S. O. , Barone , I. A. , Martins , M. A. , Massad , E. , Pereira , J. C. R. , Xavier , V. P. , Singer , J. M. and Bohm , G. M. 1994 . Association between air pollution and mortality due to respiratory disease in children in Sao Paulo, Brazil . Environ. Res. , 65 : 218 – 225 .
  • Schiller-Scotland , C. H. F. , Hlawa , R. and Gebhart , J. 1994 . Total deposition of monodisperse aerosol particles in the respiratory tract of children . Toxicol. Lett. , 72 : 137 – 144 .
  • Schofield , W. N. 1985 . Predicting basal metabolic rate, new standards and review of previous work . Hum. Nutr. Clin. Nutr. , 39C ( Suppl. ) : 5 – 41 .
  • Schwartz , J. 1994 . What are people dying of on high air pollution days? . Environ. Res. , 64 : 26 – 35 .
  • Schwartz , J. , Dockery , D. W. , Neas , L. M. , Wypij , D. , Ware , J. H. , Spengler , J. D. , Koutrakis , P. , Speizer , F. E. and Ferris , B. G. 1994 . Acute effects of summer air pollution on respiratory symptom reporting in children . Am. J. Respir. Crit. Care Med. , 150 : 1234 – 1242 .
  • Schwartz , J. 2004 . Air pollution and children's health . Pediatrics , 113 : 1037
  • Sheppard , L. , Levy , D. , Norris , G. , Larson , T. V. and Koenig , J. Q. 1999 . Effects of ambient air pollution on nonelderly asthma hospital admissions in Seattle, Washington, 1987–1994 . Epidemiology , 10 : 23 – 30 .
  • Studnicka , M. , Hackl , E. , Pischinger , J. , Fangmeyer , C. , Haschke , N. , Kuhr , J. , Urbanek , R. , Neumann , M. and Frischer , T. 1997 . Traffic related NO2 and the prevalence of asthma and respiratory symptoms in seven year olds . Eur. Respir. J. , 10 : 2275 – 2278 .
  • Tabachnik , E. , Muller , N. , Toye , B. and Levison , H. 1981 . Measurement of ventilation in children using the respiratory inductive plethysmograph . J. Pediatr. , 99 : 895 – 899 .
  • Thurlbeck , W. M. 1997 . “ Morphology of the aging lung ” . In The lung: Scientific foundations , Edited by: Crystal , R. G. and West , J. B. Vol. 2 , 1743 – 1748 . New York : Raven Press .
  • Titanen , P. , Timonen , K. L. , Ruskanen , J. J. , Mirme , A. and Pekkanen , J. 1999 . Fine Particulate air pollution, resuspended road dust and respiratory health among symptomatic children . Eur. Respir. J. , 13 : 266 – 273 .
  • Tobin , M. J. , Chadha , T. S. , Jenouri , G. , Birch , S. J. , Gazeroglu , H. B. and Sackner , M. A. 1983 . Breathing patterns: 1. Normal subjects . Chest , 84 : 202 – 205 .
  • Transande , L. and Thurston , G. D. 2005 . The role of air pollution in asthma and other pediatric morbidities . J. Allergy Clin. Immunol. , 115 : 689
  • U.S. Environmental Protection Agency . 1994 . Methods for the derivation of inhalation reference concentrations and application of inhalation dosimetry , Washington, DC : U.S. EPA . EPA/600/8–90/066F
  • U.S. Environmental Protection Agency. 1995. Policy on evaluating health risks to children. U.S. Environmental Protection Agency, Science Policy Council. http://www.epa.gov/osa/spc/2poleval.htm
  • U.S. Environmental Protection Agency . 1996 . Dosimetry of inhaled particles in the respiratory tract. Air quality criteria for particulate matter , Washington, DC : U.S. EPA . Chapter 10. EPA/600/P-95/001aF
  • U.S. Environmental Protection Agency. 1997. Exposure factors handbook. Washington, DC: U.S. Environmental Protection Agency, Office of Research and Development. EPA/600/P-95/002Fa. http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=12464
  • U.S. Environmental Protection Agency. 2002. CHAD user's guide. U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory. http://oaspub.epa.gov/chad/CHAD_Datafiles$.startup#Manual (Accessed: 20 October 2006 ).
  • U.S. Environmental Protection Agency. 2005a. Guidance on selecting age groups for monitoring and assessing childhood exposures to environmental contaminants. EPA/630/P-03/003F. Washington, DC: U.S. EPA. http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=146583
  • U.S. Environmental Protection Agency. 2005b. Guidelines for carcinogen risk assessment. EPA/630/P-03/001F. Washington, DC: U.S. EPA. http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=116283
  • U.S. Environmental Protection Agency. 2005c. Supplemental guidance for assessing susceptibility from early life exposure to carcinogens. EPA/630/R-03/003F. http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=116283
  • U.S. Environmental Protection Agency . 2006a . Air quality criteria for ozone and related photochemical oxidants , Washington, DC : U.S. EPA. . Final draft. EPA/600/R-05/004aF-cF
  • U.S. Environmental Protection Agency. 2006b . Revision of the metabolically-derived ventilation rates within the Exposure Factors Handbook. External review draft. Washington, DC: Office of Research and Development. EPA/600/R-06/129A. http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=160065
  • U.S. Environmental Protection Agency. 2006c. Total Risk Integrated Methodology (TRIM)—Air pollutants exposure model documentation (TRIM.Expo/APEX, Version 4). Volume 1: User's guide. Research Triangle Park, NC: U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards. http://www.epa.gov/ttn/fera/human_apex.html
  • U.S. Environmental Protection Agency. 2006d. Total Risk Integrated Methodology (TRIM)—Air pollutants exposure model documentation (TRIM.Expo/APEX, Version 4). Volume 2: Technical support document. Research Triangle Park, NC: U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards. http://www.epa.gov/ttn/fera/human_apex.html
  • U.S. Environmental Protection Agency. 2006e. Ozone population exposure analysis for selected urban areas. Draft. Research Triangle Park, NC: U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards. http://www.epa.gov/ttn/naaqs/standards/ozone/s_o3_cr_td.html
  • U.S. Environmental Protection Agency. 2006f. Review of the National Ambient Air Quality Standards for Ozone: Policy assessment of scientific and technical information, OAQPS staff paper. Second draft. Research Triangle Park, NC: U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards. http://www.epa.gov/ttn/naaqs/standards/ozone/s_o3_cr_sp.html
  • van Vliet , P. , Knape , M. , de Hartog , J. , Janssen , N. , Harssema , H. and Brunekreef , B. 1997 . Motor vehicle exhaust and chronic respiratory symptoms in children living near freeways . Environ. Res. , 74 : 122 – 132 .
  • Wang , X. , Ding , H. , Ryan , L. and Xu , X. 1997 . Association between air pollution and low birth weight: A community based study . Environ. Health Perspect. , 105 : 514 – 520 .
  • Wilhelm , M. and Ritz , B. 2005 . Local variations in CO and particulate air pollution and adverse birth outcomes in Los Angeles County, California, USA . Environ. Health Perspect. , 113 : 1212 – 1221 .
  • Windham , G. C. , Eaton , A. and Hopkins , B. 1999 . Evidence for an association between environmental tobacco smoke exposure and birthweight: A meta-analysis and new data . Paediatr. Perinat. Epidemiol. , 13 : 35 – 57 .
  • Woodruff , T. J. , Grillo , J. and Schoendorf , C. 1997 . The relationship between selected causes of postneonatal infant mortality and particulate air pollution in the United States . Environ. Health Perspect. , 105 : 608 – 612 .
  • Woodruff , T. J. , Parker , J. D. and Schoendorf , K. C. 2006 . Fine particulate matter (PM2.5) air pollution and selected causes of postneonatal infant mortality in California. Environ . Health Perspect. , 114 : 786 – 790 .
  • Xu , X. , Ding , H. and Wang , X. 1995 . Acute effects of total suspended particles and sulfur dioxides on preterm delivery: A community-based cohort study . Arch. Environ. Health , 50 : 407 – 415 .
  • Yang , I. A. , Holz , O. , Jorres , R. , Magnussen , H. , Barton , S. J. , Rodriguez , S. , Cakebread , J. A. , Holloway , J. W. and Holgate , S. T. 2005 . Association of tumor necrosis factor-α polymorphisms and ozone-induced change in lung function . Am. J. Respir. Crit. Care Med. , 171 : 171 – 176 .
  • Yolton , K. , Dietrich , K. , Auinger , P. , Lanphear , B. P. and Hornung , R. 2005 . Exposure to environmental tobacco smoke and cognitive abilities among U.S. children and adolescents . Environ. Health Perspect. , 113 : 98 – 103 .
  • Yu , C. P. , Diu , C. K. and Soong , T. T. 1981 . Statistical analysis of aerosol deposition in nose and mouth . Am. Ind. Hyg. Assoc. J. , 42 : 726 – 733 .
  • Zeger , S. L. , Thomas , D. , Dominici , F. , Samet , J. M. , Schwartz , J. , Dockery , D. and Cohen , A. 2000 . Exposure measurement error in time-series studies of air pollution: Concepts and consequences . Environ. Health Perspect. , 108 : 419 – 426 .
  • Zeman , K. L. and Bennett , W. D. 2006 . Growth of the small airways and alveoli from childhood to the adult lung measured by aerosol-derived airway morphometry . J. Appl. Physiol. , 100 : 965 – 971 .

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