Metabonomics Biomarkers for Subacute Toxicity Screening for Benzene Exposure in Mice

REFERENCES

• Arakaki , A. K. , Skolnick , J. and McDonald , J. F. 2008 . Marker metabolites can be therapeutic targets as well . Nature , 456 : 443
   PubMed Web of Science ®Google Scholar
• Bittinger , M. A. , Nguyen , L. P. and Bradfield , C. A. 2003 . Aspartate aminotransferase generates proagonists of the aryl hydrocarbon receptor . Mol. Pharmacol. , 64 : 550 – 56 .
   PubMed Web of Science ®Google Scholar
• Bogdanov , M. , Matson , W. R. , Wang , L. , Matson , T. , Saunders-Pullman , R. , Bressman , S. S. and Flint Beal , M. 2008 . Metabolomic profiling to develop blood biomarkers for Parkinson’ disease . Brain , 131 : 389 – 96 .
   PubMed Web of Science ®Google Scholar
• Boudondk , K. J. , Mitchell , M. W. , Német , L. , Kereszte , L. , Nyska , A. , Shinar , D. and Rosenstock , M. 2009 . Discovery of metabolomics biomarkers for early detection of nephrotoxicity . Toxicol. Pathol. , 37 : 280 – 92 .
   PubMed Web of Science ®Google Scholar
• Castelao , J. E. , Bart , R. D. , DiPerna , C. A. , Sievers , E. M. and Bremner , R. M. 2003 . Lung cancer and cyclooxygenase-2 . Ann. Thorac. Surg. , 76 : 1327 – 35 .
   PubMed Web of Science ®Google Scholar
• Castro-Perez , J. , Plumb , R. , Liang , L. and Yang , E. 2005 . A high-throughput liqudid chromatography/tandem mass spectrometry method for screening glutanthione conjugates using exact mass neutral loss acquisition . Rapid. Commun. Mass. Spectrom. , 19 : 798 – 804 .
   PubMed Web of Science ®Google Scholar
• Cheng , J. and Hada , T. 2005 . The significance of COX-2 and COX-2 inhibitors in liver fibrosis and liver cancer . Curr. Med. Chem. Anti-Inflamm. Anti-Allergy Agents , 4 : 199 – 206 .
   Google Scholar
• Connor , M. J. , Pheasant , A. E. and Blair , J. A. 1979 . The identification of p-acetamidobenzoate as a folate degradation product in rat urine . Biochem. J. , 178 : 795 – 97 .
   PubMed Web of Science ®Google Scholar
• Denison , M. S. and Naqy , S. R. 2003 . Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals . Annu. Rev. Pharmacol. Toxocol. , 43 : 309 – 34 .
   PubMed Web of Science ®Google Scholar
• Denkert , C. , Kobel , M. , Pest , S. , Koch , I. , Berger , S. , Schwabe , M. , Siegert , A. , Reles , A. , Klosterhalfen , B. and Hauptmann , S. 2002 . Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma . Am. J. Pathol. , 160 : 893 – 903 .
   PubMed Web of Science ®Google Scholar
• Eisenberg , T. , Knauer , H. , Schauer , A. , Büttner , S. , Ruckenstuhl , C. , Carmona-Gutierrez , D. , Ring , J. , Schroeder , S. , Magnes , C. , Antonacci , L. , Fussi , H. , Deszcz , L. , Hartl , R. , Schraml , E. , Criollo , A. , Megalou , E. , Weiskopf , D. , Laun , P. , Heeren , G. , Breitenbach , M. , Grubeck-Loebenstein , B. , Herker , E. , Fahrenkrog , B. , Fröhlich , K. U. , Sinner , F. , Tavernarakis , N. , Minois , N. , Kroemer , G. and Madeo , F. 2009 . Induction of autophagy by spermidine promotes longevity . Nat. Cell. Biol. , 11 : 1305 – 14 .
   PubMed Web of Science ®Google Scholar
• Fiehn , O. , Kopka , J. , Trethewey , R. N. and Willmitzer , L. 2000 . Identification of uncommon plant metabolites based on calculation of elemental compositions using gas chromatography and quadrupole mass spectrometry . Anal. Chem. , 72 : 3573 – 80 .
   PubMed Web of Science ®Google Scholar
• Golding , B. T. and Watson , W. P. 1999 . Possible mechanisms of carcinogenesis after exposure to benzene . IARC. Sci. Publ. , 150 : 75 – 88 .
   PubMedGoogle Scholar
• Hayes , R. B. , Yin , R. , Rothman , N. , Dosemeci , M. , Li , G. , Travis , L.T. , Smith , M.T. and Linet , M.S. 2000 . Benzene and lymphohematopoietic malignancies in China . J. Toxicol. Environ. Health A , 61 : 419 – 32 .
   PubMed Web of Science ®Google Scholar
• Huff , J. 2007 . Benzene-induced cancers: Abridged history and occupational health impact . Int. Occup. Environ. Health , 13 : 213 – 21 .
   Web of Science ®Google Scholar
• IARC . 1982 . Benzene. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans: some industrial chemicals and dyestuffs . Lyon: International Agency for Research on Cancer , 29 : 93 – 148 .
   PubMed Web of Science ®Google Scholar
• Infante , P. F. , Rinsky , R. A. , Wagoner , J. K. and Young , R. J. 1977 . Leukemia in benzene workers . Lancet , 2 : 76 – 78 .
   PubMed Web of Science ®Google Scholar
• Jackson , J. E. 1991 . A user's guide to principal components , New York , NY : J. Wiley & Sons .
   Google Scholar
• Jonsson , P. , Johansson , A. I. , Gullberg , J. , Trygg , J. A J. , Grung , B. , Marklund , S. , Sjostrom , M. , Antti , H. and Moritz , T. 2005 . High-throughput data analysis for detecting and identifying differences between samples in GC/MS-based metabolomic analyses . Anal. Chem. , 77 : 5635 – 42 .
   PubMed Web of Science ®Google Scholar
• Kalir , A. , Bessler , H. , Braun , R. , Gitter , S. and Djaldetti , M. 1989 . Benzene-derived free radical-a possible mediator of its carcinogenicity. I. Ultrastructural and functional studies on the effect of benzene on human white blood cells and its possible prevention . Isr. J. Med. Sci. , 25 : 421 – 28 .
   PubMedGoogle Scholar
• Kase , S. , Osaki , M. , Honjo , S. , Hashimoto , K. , Adachi , H. , Tsujitani , S. and Ito , H. 2004 . Expression of cyclooxygenase-1 and cyclooxygenase-2 in human esophageal mucosa, dysplasia and carcinoma . Pathobiology , 71 : 84 – 92 .
   PubMed Web of Science ®Google Scholar
• Krewski , D. , Snyder , R. , Beatty , P. , Granville , G. , Meek , B. and Sonawane , B. 2000 . Assessing the health risks of benzene: A report on the benzene state-of-the-science workshop . J. Toxicol. Environ. Health A , 61 : 307 – 38 .
   PubMed Web of Science ®Google Scholar
• Kuang , S. and Liang , W. 2005 . Clinical analysis of 43 cases of chronic benzene poisoning . Chem. Biol. Interact , : 153 – 154 . 129 – 35 .
   PubMed Web of Science ®Google Scholar
• Lim , H. Y. , Joo , H. J. , Choi , J. H. , Yi , J. W. , Yang , M. S. , Cho , D. Y. , Kim , H. S. , Nam , D. K. , Lee , K. B. and Kim , H. C. 2000 . Increased expression of cyclooxygenase-2 protein in human gastric carcinoma . Clin. Cancer Res. , 6 : 519 – 25 .
   PubMed Web of Science ®Google Scholar
• Madl , A. K. and Paustenbach , D. J. 2002 . Airborne concentrations of benzene due to diesel locomotive exhaust in a roundhouse . J. Toxicol. Environ. Health A , 65 : 1945 – 64 .
   PubMed Web of Science ®Google Scholar
• Mitacek , E. J. , Brunnemann , K. D. , Polednak , A.P. , Limsila , T. , Bhothisuwan , K. and Hummel , C.F. 2002 . Rising leukemia rates in Thailand: The possible role of benzene and relate compounds in cigarette smoke . Oncol. Rep. , 9 : 1399 – 403 .
   PubMed Web of Science ®Google Scholar
• Mögel , I. , Baumann , S. , Böhme , A. , Kohajda , T. , von Bergen , M. , Simon , J. C. and Lehmann , I. 2011 . The aromatic volatile organic compounds toluene, benzene and styrene induce COX-2 and prostaglandins in human lung epithelial cells via oxidative stress and p38 MAPK activation . Toxicology , 289 : 28 – 37 .
   PubMed Web of Science ®Google Scholar
• Nicholson , J. K. , Lindon , J. C. and Holmes , E. 1999 . ‘Metabonomics’: Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data . Xenobiotica , 29 : 1181 – 89 .
   PubMed Web of Science ®Google Scholar
• Parker , M. T. and Gerner , E. W. 2002 . Polyamine-mediated post-transcriptional regulation of COX-2 . Biochimie , 84 : 815 – 19 .
   PubMed Web of Science ®Google Scholar
• Pieters , R. , Huismans , D. R. , Loonen , A. H. , Peter , G. J. , Hahlen , K. , van der Dose-van den Berq , A. , van Wering , E. R. and Veerman , A. J. 1992 . Hypoxanthine-guanine phosphoribosyltransferase in childhood leukemia: Relation with immunophenotype, in vitro drug resistance and clinical prognosis . Int. J. Cancer , 51 : 213 – 17 .
   PubMed Web of Science ®Google Scholar
• Pyatt , D. W. , Aylward , L. L. and Hays , S. M. 2007 . Is age an independent risk factor for chemically induced acute myelogenous leukemia in children? . J. Toxicol. Environ. Health B , 10 : 379 – 400 .
   PubMed Web of Science ®Google Scholar
• Reubi , F. C. 1953 . Glomerular filtration rate, renal blood flow and blood viscosity during and after diabetic coma . Circ. Res. , 1 : 410 – 13 .
   PubMed Web of Science ®Google Scholar
• Romano , M. , Cecco , L. , Cerra , M. , Montuori , R. and De Rosa , C. 1980 . Polyamines as biological markers of the effectiveness of therapy in acute leukemia . Tumori , 66 : 677 – 87 .
   PubMed Web of Science ®Google Scholar
• Roux , A. , Lison , D. , Junot , C. and Heilier , H. 2011 . Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review . Clin. Biochem. , 44 : 119 – 35 .
   PubMed Web of Science ®Google Scholar
• Shen , Y. , Shen , H. M. , Shi , C. Y. and Ong , C. N. 1996 . Benzene metabolites enhance reactive oxygen species generation in HL60 human leukemia cells . Hum. Exp. Toxicol. , 15 : 422 – 427 .
   PubMed Web of Science ®Google Scholar
• Smilde , A. K. , Jansen , J. J. , Hoefsloot , H. C. , Lamers , R. J. and van der Greef , J. 2005 . ANOVA-simultaneous component analysis (ASCA): A new tool for analyzing designed metabolomics data . Bioinformatics , 21 : 3043 – 48 .
   PubMed Web of Science ®Google Scholar
• Smith , M. T. 1996 . Overview of benzene-induced aplastic anaemia . Eur. J. Haematol. Suppl. , 60 : 107 – 10 .
   PubMedGoogle Scholar
• Snyder , R. 2000 . Overview of toxicology of benzene . J. Toxicol. Environ. Health A , 61 : 339 – 46 .
   PubMed Web of Science ®Google Scholar
• Sudbo , J. , Ristimaki , A. , Sondresen , J. E. , Kildal , W. , Boysen , M. , Koppang , H. S. , Reith , A. , Risberg , B. , Nesland , J. M. and Bryne , M. 2003 . Cyclooxygenase-2 (COX-2) expression in high-risk premalignant oral lesions . Oral Oncol. , 39 : 497 – 505 .
   PubMed Web of Science ®Google Scholar
• van Elswijk , D. A. , Diefenbach , O. , van der Berg , S. , Irth , H. , Tjaden , U. R. and van der Greef , J. 2003 . Rapid detection and identification of angiotensin-converting enzyme inhibitors by on-line liquid chromatography-biochemical detection, coupled to electrospray mass spectrometry . J. Chromatogr. A , 1020 : 45 – 58 .
   PubMed Web of Science ®Google Scholar
• Whysner , J. 2000 . Benzene-induced genotoxicity . J. Toxicol. Environ. Health A , 61 : 347 – 51 .
   PubMed Web of Science ®Google Scholar
• Whysner , J. , Reddy , M. V. , Rose , P. M. , Mohan , M. and Lax , E. A. 2004 . Genotoxicity of benzene and its metabolites . Mutat. Res. , 566 : 99 – 130 .
   PubMed Web of Science ®Google Scholar
• Williams , R. E. , Lenz , E. M. , Evans , J. A. , Wilson , I. D. , Granger , J. H. , Plumb , R. S. and Stumpf , C. L. 2005 . A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats . J. Pharm. Biomed. Anal. , 38 : 465 – 71 .
   PubMed Web of Science ®Google Scholar
• Wilson , I. D. , Plumb , R. , Granger , J. , Major , H. , Williams , R. and Lenz , E. M. 2005 . HPLC-MS–based methods for the study of metabonomics . J. Chromatogr. B , 817 : 67 – 76 .
   PubMed Web of Science ®Google Scholar
• Winn , L. M. 2003 . Homologous recombination initiated by benzene metabolites: A potential role of oxidative stress . Toxicol. Sci. , 72 : 143 – 49 .
   PubMed Web of Science ®Google Scholar
• Yang , J. , Xu , G. , Kong , H. , Zheng , Y. , Pang , T. and Yang , Q. 2002 . Artificial neural network classification based on high-performance liquid chromatography of urinary and serum nucleosides for the clinical diagnosis of cancer . J. Chromatogr. B , 780 : 27 – 33 .
   PubMed Web of Science ®Google Scholar
• Yang , J. , Xu , G. , Zheng , Y. , Kong , H. , Pang , T. , Lv , S. and Yang , Q. 2004 . Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases . J. Chromatogr. B Anal. Technol. Biomed. Life. Sci. , 813 : 59 – 65 .
   PubMed Web of Science ®Google Scholar
• Zaza , G. , Yang , W. , Kaqer , L. , Cheok , M. , Downing , J. , Pui , C. H. , Cheng , C. , Relling , M. V. and Evans , W. E. 2004 . Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis . Blood , 104 : 1435 – 41 .
   PubMed Web of Science ®Google Scholar