N-Acetylation of p-Aminobenzoic Acid and p-Phenylenediamine in Primary Porcine Urinary Bladder Epithelial Cells and in the Human Urothelial Cell Line 5637

REFERENCES

• Alexander , M. , Behm , C. , Föllmann , W. and Kuhlmann , J. 2008 . Miniaturization of primary porcine urinary bladder epithelial cell cultures and application for gene expression studies after exposure to benzo[a]pyrene . J. Toxicol. Environ. Health A , 71 : 915 – 22 .
   PubMed Web of Science ®Google Scholar
• Bolt , H. M. and Golka , K. 2007 . The debate on carcinogenicity of permanent hair dyes . Crit. Rev. Toxicol. , 37 : 521 – 36 .
   PubMed Web of Science ®Google Scholar
• Bonifas , J. , Hennen , J. , Dierolf , D. , Kalmes , M. and Blömeke , B. 2010a . Evaluation of cytochrome P450 1 (CYP1) and N-acetyltransferase 1 (NAT1) activities in HaCaT cells: Implications for the development of in vitro techniques for predictive testing of contact sensitizers . Toxicol. In Vitro , 24 : 973 – 80 .
   PubMed Web of Science ®Google Scholar
• Bonifas , J. , Scheitza , S. , Clemens , J. and Blömeke , B. 2010b . Characterization of N-acetyl-transferase 1 activity in human keratinocytes and modulation by para-phenylenediamine . J. Pharmacol. Exp. Ther. , 334 : 318 – 26 .
   PubMed Web of Science ®Google Scholar
• Borza , A. , Plöttner , S. , Wolf , A. , Behm , C. , Selinski , S. , Hengstler , J. G. , Roos , P. H. , Bolt , H. M. , Kuhlmann , J. and Föllmann , W. 2008 . Synergism of aromatic amines and benzo[a]pyrene in induction of Ah receptor-dependent genes . Arch. Toxicol. , 82 : 973 – 80 .
   PubMed Web of Science ®Google Scholar
• Boukamp , P. , Petrussevska , R. T. , Breitkreutz , D. , Hornung , J. , Markham , A. and Fusenig , N. E. 1988 . Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line . J. Cell Biol. , 106 : 761 – 71 .
   PubMed Web of Science ®Google Scholar
• Bradford , M. M. 1976 . A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding . Anal. Biochem. , 72 : 248 – 54 .
   PubMed Web of Science ®Google Scholar
• Butcher , N. J. , Ilett , K. F. and Minchin , R. F. 2000 . Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells . Mol. Pharmacol. , 57 : 468 – 73 .
   PubMed Web of Science ®Google Scholar
• Degen , G. H. , Schlattjan , J. H. , Mahler , S. , Föllmann , W. and Golka , K. 2004 . Comparative metabolic activation of benzidine and N-acetylbenzidine by prostaglandin H synthase . Toxicol. Lett. , 151 : 135 – 42 .
   PubMed Web of Science ®Google Scholar
• Flieger , A. , Golka , K. , Schulze , H. and Föllmann , W. 2008 . Primary cultures of human urothelial cells for genotoxicity testing . J. Toxicol. Environ. Health A , 71 : 930 – 35 .
   PubMed Web of Science ®Google Scholar
• Föllmann , W. , Mähler , S. , Schuhmacher , U. S. and Guhe , C. 1997 . An in vitro model of the urinary bladder: Cultured porcine urinary bladder epithelial cells . Toxicol. In Vitro , 11 : 427 – 33 .
   PubMed Web of Science ®Google Scholar
• Föllmann , W. , Guhe , C. , Weber , S. , Birkner , S. and Mähler , S. 2000 . Cultured porcine urinary bladder epithelial cells as a screening model for genotoxic effects of aromatic amines: Characterisation and application of the cell culture model . Altern. Lab. Anim. , 28 : 833 – 54 .
   PubMed Web of Science ®Google Scholar
• Fogh , J. 1978 . Cultivation, characterization, and identification of human tumor cells with emphasis on kidney, testis, and bladder tumors . Natl. Cancer Inst. Monogr. , 49 : 5 – 9 .
   PubMedGoogle Scholar
• Fusenig , N. E. and Boukamp , P. 1998 . Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes . Mol. Carcinogen. , 23 : 144 – 58 .
   PubMed Web of Science ®Google Scholar
• Goebel , C. , Hewitt , N. J. , Kunze , G. , Wenker , M. , Hein , D. W. , Beck , H. and Skare , J. 2009 . Skin metabolism of aminophenols: Human keratinocytes as a suitable in vitro model to qualitatively predict the dermal transformation of 4-amino-2-hydroxytoluene in vivo . Toxicol. Appl. Pharmacol. , 235 : 114 – 23 .
   PubMed Web of Science ®Google Scholar
• Guhe , C. and Föllmann , W. 1994 . Growth and characterization of porcine urinary bladder epithelial cells in vitro . Am. J. Physiol. , 266 : F298 – F308 .
   PubMed Web of Science ®Google Scholar
• Guhe , C. , Degen , G. H. , Schuhmacher , U. S. , Kiefer , F. and Föllmann , W. 1996 . Drug metabolizing enzyme activities in porcine urinary bladder epithelial cell cultures (PUBEC) . Arch. Toxicol. , 70 : 599 – 606 .
   PubMed Web of Science ®Google Scholar
• Hein , D. W. 2002 . Molecular genetics and function of NAT1 and NAT2: Role in aromatic amine metabolism and carcinogenesis . Mutat. Res. , : 65 – 77 . 506 – 507 .
   PubMed Web of Science ®Google Scholar
• Hein , D. W. , Doll , M. A. , Rustan , T. D. , Gray , K. , Feng , Y. , Ferguson , R. J. and Grant , D. M. 1993 . Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases . Carcinogenesis , 14 : 1633 – 38 .
   PubMed Web of Science ®Google Scholar
• Herbst , K. , Föllmann , W. , Degen , G. H. and Roos , P. H. 2010 . Transcript-profiling for phase I and II-enzymes in 5637 urothelial cells: Basal expression pattern and modulation by xenobiotics . Naunyn-Schmiedeberg's Arch Pharmacol , 381 (suppl. 1): 61, abstr. 279 )
   Google Scholar
• Kawakubo , Y. , Merk , H. F. , Masaoudi , T. A. , Sieben , S. and Blömeke , B. 2000 . N-Acetylation of paraphenylenediamine in human skin and keratinocytes . J. Pharmacol. Exp. Ther. , 292 : 150 – 55 .
   PubMed Web of Science ®Google Scholar
• Kawamura , A. , Graham , J. , Mushtaq , A. , Tsiftsoglou , S. A. , Vath , G. M. , Hanna , P. E. , Wagner , C. R. and Sim , E. 2005 . Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening . Biochem. Pharmacol. , 69 : 347 – 59 .
   PubMed Web of Science ®Google Scholar
• Kloth , M. T. , Gee , R. L. , Messing , E. M. and Swaminathan , S. 1994 . Expression of N-acetyl-transferase (NAT) in cultured human uroepithelial cells . Carcinogenesis , 15 : 2781 – 87 .
   PubMed Web of Science ®Google Scholar
• Mähler , S. , Kinne-Saffran , E. , Fujisue , H. , Kinne , R. K. H. and Föllmann , W. 1998 . Regulation of sorbitol content in cultured porcine urinary bladder epithelial cells . Am. J. Physiol. Renal Physiol. , 274 : 342 – 47 .
   PubMed Web of Science ®Google Scholar
• Möller , R. , Lichter , J. and Blömeke , B. 2008 . Impact of para-phenylenediamine on cyclooxygenases expression and prostaglandin formation in human immortalized keratinocytes (HaCaT) . Toxicology , 249 : 167 – 75 .
   PubMed Web of Science ®Google Scholar
• Plöttner , S. , Borza , A. , Wolf , A. , Bolt , H. M , Kuhlmann , J. and Föllmann , W. 2008a . Evaluation of time dependence and interindividual differences in benzo[a]pyrene-mediated CYP1A1 induction and genotoxicity in porcine urinary bladder cell cultures . J. Toxicol. Environ. Health A , 71 : 969 – 75 .
   PubMed Web of Science ®Google Scholar
• Plöttner , S. , Degen , G. H. , Roos , P. H. and Föllmann , W. 2008b . Analysis of CYP1A1 induction in single cells of urothelial cell populations by flow cytometry . Anal. Bioanal. Chem. , 392 : 1149 – 58 .
   PubMed Web of Science ®Google Scholar
• Plöttner , S. , Selinski , S. , Bolt , H. M. , Degen , G. H. , Hengstler , J. G. , Roos , P. H. and Föllmann , W. 2009 . Distinct subtypes of urinary bladder epithelial cells with inducible and non-inducible cytochrome P450 1A1 . Arch. Toxicol. , 83 : 131 – 38 .
   PubMed Web of Science ®Google Scholar
• Roos , P. H. , Belik , R. , Föllmann , W. , Degen , G. H. , Knopf , H. J. , Bolt , H. M. and Golka , K. 2006 . Expression of cytochrome P450 enzymes CYP1A1, CYP1B1, CYP2E1 and CYP4B1 in cultured transitional cells from specimens of the human urinary tract and from urinary sediments . Arch. Toxicol. , 80 : 45 – 52 .
   PubMed Web of Science ®Google Scholar
• Sim , E. , Westwood , I. and Fullam , E. 2007 . Arylamine N-acetyltransferases . Expert Opin. Drug Metab. Toxicol. , 3 : 169 – 84 .
   PubMed Web of Science ®Google Scholar
• Vandebriel , R. J. , Pennings , J. L. , Baken , K. A. , Pronk , T. E. , Boorsma , A. , Gottschalk , R. and Van Loveren , H. 2010 . Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds . Toxicol. Sci. , 117 : 81 – 89 .
   PubMed Web of Science ®Google Scholar
• Verma , N. , Bäuerlein , C. , Pink , M. , Rettenmeier , A. W. and Schmitz-Spanke , S. 2011 . Proteome and phosphoproteome of primary cultured pig urothelial cells . Electrophoresis , 32 : 3600 – 11 .
   PubMed Web of Science ®Google Scholar
• Wolf , A. , Kutz , A. , Plöttner , S. , Behm , C. , Bolt , H. M. , Föllmann , W. and Kuhlmann , J. 2005 . The effect of benzo(a)pyrene on porcine urinary bladder epithelial cells analyzed for the expression of selected genes and cellular toxicological endpoints . Toxicology , 207 : 255 – 69 .
   PubMed Web of Science ®Google Scholar
• Zenser , T. V. , Lakshmi , V. M. , Hsu , F. F. and Davis , B. B. 2002 . Metabolism of N-acetyl-benzidine and initiation of bladder cancer . Mutat. Res. , 506–507 : 29 – 40 .
   PubMed Web of Science ®Google Scholar