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Original Articles

Hematological and Hepatic Alterations in Brazilian Population Heavily Exposed to Organochlorine Pesticides

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Pages 534-548 | Received 01 Jul 2014, Accepted 12 Dec 2014, Published online: 07 Apr 2015

REFERENCES

  • Agency for Toxic Substances and Disease Registry. 2002a. Toxicological profile for hexachlorobenzene. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. http://www.atsdr.cdc.gov/toxprofiles/tp90.html (accessed June 26, 2014).
  • Agency for Toxic Substances and Disease Registry. 2002b. Toxicological profile for DDT, DDE, and DDD. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. http://www.atsdr.cdc.gov/toxprofiles/tp35.html (accessed June 26, 2014).
  • Agency for Toxic Substances and Disease Registry. 2005. Toxicological profile for hexachlorocyclohexane. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. http://www.atsdr.cdc.gov/toxprofiles/tp43.html (accessed June 26, 2014).
  • Ahamed, M., Anand, M., Kumar, A., and Siddiqui, M. K. 2006. Childhood aplastic anaemia in Lucknow, India: Incidence, organochlorines in the blood and review of case reports following exposure to pesticides. Clin. Biochem. 39: 762–766.
  • Alegria-Torres, J. A., Díaz-Barriga, F., Gandolfi, A. J., and Pérez-Maldonado, I.N. 2009. Mechanisms of p,p’-DDE-induced apoptosis in human peripheral blood mononuclear cells. Toxicol. In Vitro 23: 1000–1003.
  • Antunes-Madeira, M. C., and Madeira, V. M. 1990. Membrane fluidity as affected by the organochlorine insecticide DDT. Biochim. Biophys. Acta 1023: 469–474.
  • Arrebola, J. P., Cuellar, M., Claure, E., Quevedo, M., Antelo, S. R., Mutch, E., Ramirez, E., Fernandez, M. F., Olea, N., and Mercado, L. A. 2012. Concentrations of organochlorine pesticides and polychlorinated biphenyls in human serum and adipose tissue from Bolivia. Environ. Res. 112: 40–47.
  • Asmus, C. I., Alonzo, H. G., Palácios, M., da Silva, A., Filhote, M. I., Buosi, D., and Câmara, V. 2008. Assessment of human health risk from organochlorine pesticide residues in Cidade dos Meninos, Duque de Caxias, Rio de Janeiro, Brazil. Cad. Saúde Pública 24: 755–766.
  • Bates, M. N., Buckland, S. J., Garrett, N., Ellis, H., Needham, L. L., Patterson, D. G., Turner, W. E., and Russell, P. G. 2004. Persistent organochlorines in the serum of the non-occupationally exposed New Zealand population. Chemosphere 54: 1431–1443.
  • Brassow, H. L., Baumann, K., and Lehnert, G. 1981. Occupational exposure to hexachlorocyclohexane. II. Health conditions of chronically exposed workers. Int. Arch. Environ. Health 48: 81–87.
  • Carvalho, F. M., Silvany Neto, A. M., Mendes, J. L., Cotrim, H. P., Nascimento, A. L., Lima Júnior, A. S., and Cunha, T. O. 2006. Liver enzyme abnormalities among oil refinery workers. Rev. Saude Publica 40: 92–98.
  • Casmo, V., Augusto, G., Nala, R., Sabonete, A., and Carvalho-Costa, F. A. 2014. The effect of hookworm infection and urinary schistosomiasis on blood hemoglobin concentration of schoolchildren living in northern Mozambique. Rev. Inst. Med. Trop. Sao Paulo. 56: 219–224.
  • Centers for Disease Control and Prevention, Department of Health and Human Services. 2009. Fourth national report on human exposure to environmental chemicals. Report no. 4. http://www.cdc.gov/exposurereport
  • Cocco, P. 2002. On the rumors about the silent spring. Review of the scientific evidence linking occupational and environmental pesticide exposure to endocrine disruption health effects. Cad. Saude Publica 18: 379–402.
  • Delgado, I. F., Barretto, H. H., Kussumi, T. A., Alleluia, I. B., Baggio Cde, A., and Paumgartten, F. J. 2002. Serum levels of organochlorine pesticides and polychlorinated biphenyls among inhabitants of Greater Metropolitan Rio de Janeiro, Brazil. Cad. Saúde Publica 18: 519–524.
  • Dexter, T. M., Whetton, A. D., and Spooner, E. 1985. The role of stromal cells and growth factors in haemopoiesis and modulation of their effects by the src oncogene. J. Cell Sci. 3: 83–95.
  • Fareed, M., Pathak, M. K., Bihari, V., Reddy, M. M. K., Patel, D. K., Mathura, N., Kuddusc, M., and Kesavachandrana, C. N. 2010. Hematological and biochemical alterations in sprayers occupationally exposed to mixture of pesticides at a mango plantation in Lucknow, India. Toxicol. Environ. Chem. 92: 1919–1928.
  • Fareed, M., Pathak, M. K., Bihari, V., Kamal, R., Srivastava, A. K., and Kesavachandran, C. N. 2013. Adverse respiratory health and hematological alterations among agricultural workers occupationally exposed to organophosphate pesticides: A cross-sectional study in North India. PLoS ONE 25: e69755.
  • Food and Agriculture Organization of the United Nations. 2014. Prevention and disposal of obsolete pesticides. http://www.fao.org/agriculture/crops/obsolete-pesticides ( accessed June 16, 2014)
  • Freire, C., Koifman, R.J., Sarcinelli, P., Rosa, A. C., Clapauch, R., and Koifman, S. 2012. Long term exposure to organochlorine pesticides and thyroid function in children from Cidade dos Meninos, Rio de Janeiro, Brazil. Environ. Res. 117: 68–74.
  • Freire, C., Koifman, R. J., Sarcinelli, P. N., Simões Rosa, A. C., Clapauch, R., and Koifman, S. 2013. Long-term exposure to organochlorine pesticides and thyroid status in adults in a heavily contaminated area in Brazil. Environ. Res. 127: 7–15.
  • Freire, C., Koifman, R.J., Sarcinelli, P. N., Rosa, A. C., Clapauch, R., and Koifman, S. 2014. Association between serum levels of organochlorine pesticides and sex hormones in adults living in a heavily contaminated area in Brazil. Int. J. Hyg. Environ. Health 217: 370–378.
  • Furie, B., and Trubowitz, S. 1976. Insecticides and blood dyscrasias. Chlordane exposure and self-limited refractory megaloblastic anemia. J. Am. Med. Assoc. 235: 1720–1722.
  • Furuta, G. T., Atkins, F. D., Lee, N. A., and Lee, J. J. 2014. Changing roles of eosinophils in health and disease. Ann. Allergy Asthma Immunol. 113: 3–8.
  • Gennari, P., Naldi, M., Motta, R., Nucci, M.C., Giacomini, C., Violante, F. S., and Raffi, G. 1992. Gamma-glutamyltransferase isoenzyme pattern in workers exposed to tetrachloroethylene. Am. J. Ind. Med. 21: 661–671.
  • Heukelbach, J., Poggensee, G., Winter, B., Wilcke, T., Kerr-Pontes, L. R., and Feldmeier, H. 2006. Leukocytosis and blood eosinophilia in a polyparasitised population in north-eastern Brazil. Trans. R. Soc. Trop. Med. Hyg. 100: 32–40.
  • Ho, S. F., Phoon, W. H., Gan, S. L., and Chan, Y. K. 1991. Persistent liver dysfunction among workers at a vinyl chloride monomer polymerization plant. J. Soc. Occup. Med. 41: 10–16.
  • Hodgson, M. J., Heyl, A. E., and Van Thiel, D. H. 1989. Liver disease associated with exposure to 1,1,1-trichloroethane. Arch. Intern. Med. 149: 1793–1798.
  • Issaragrisil, S., Chansung, K., Kaufman, D.W., Sirijirachai, J., Thamprasit, T., Young, N. S., and the Aplastic Anemia Study Group. 1997. Aplastic anemia in rural Thailand: Its association with grain farming and agricultural pesticide exposure. Am. J. Public Health. 87: 1551–1554.
  • Jaeschke, H., Gores, G., Cederbaum, A., Hinson, H., Pessayre, D., and Lemaster, J. 2002. Mechanisms of hepatotoxicity. Toxicol. Sci. 22: 166–176.
  • Long, G. L., and Wineffordener, J. D. 1983. Limit of detection. A closer look at the IUPAC definition. Anal. Chem. 55: 712–714.
  • McGlynn, K. A., Abnett, C. C., and Zhang, M. 2006. Serum concentration of DDT and DDE and risk of primary liver cancer. J. Natl. Cancer Inst. 9: 1005–1010.
  • Ministério da Saúde, Secretaria de Políticas de Saúde, Departamento de Ciência e Tecnologia em Saúde. 2003. Exposição Humana a Resíduos Organoclorados na Cidade dos Meninos, Município de Duque de Caxias, Rio de Janeiro. Relatório de Trabalho da Comissão Técnica Assessora ao Ministério da Saúde, Brasília, DF, Brazil.
  • Mnif, W., Hassine, A.I., Bouaziz, A., Bartegi, A., Thomas, O., and Roig, B. 2011. Effect of endocrine disruptor pesticides: A review. Int. J. Environ. Res. Public Health 8: 2265–2303.
  • Muir, K. R., Chilver, C. E. D., Harris, C., Coulson, L., Grainge, M., Darbyshire, P., Geary, C., Hows, J., Marsh, J., Rutherford, T., Taylor, M., and Gordon-Smith, E. C. 2003. The role of occupational and environmental exposures in the aetiology of acquired severe aplastic anemia: A case control investigation. Br. J. Haematol. 123: 906–914.
  • Nims, R. W., and Lubet, R. A. 1995. Induction of cytochrome P-450 in the Norway rat, Rattus norvegicus, following exposure to potential environmental contaminants. J. Toxicol. Environ. Health 46: 271–292.
  • Ozucelik, D. N., Karcioglu, O., Topacoglu, H., and Fouler, J. R. 2004. Toxicity following unintentional DDT ingestion. J. Toxicol. Clin. Toxicol. 42: 299–303.
  • Paumgartten, F. J. R., Delgado, I. F., Oliveira, E. S., Alleluia, I. B., Barretto, H. H. C., and Kussumi, T. A. 1998. Levels of organochlorine pesticides in the blood of agricultural workers from Rio de Janeiro State, Brazil. Cad. Saúde Pública 14: 33–39.
  • Pérez-Maldonado, I. N., Díaz-Barriga, F., de la Fuente, H., González-Amaro, R., Calderón, J., and Yáñez, R. 2004. DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children. Environ. Res. 94: 38–46.
  • Persson, E. C., Graubard, B. I., Evans, A. A., London, W. T., Weber, J. P., LeBlanc, A., Chen, G., Lin, W., and McGlynn, K. A. 2012. Dichlorodiphenyltrichloroethane and risk of hepatocellular carcinoma. Int. J. Cancer 131: 2078–2084.
  • Phillips, D. L., Pirkle, J. L., Burse, V. W., Bernert, J. T., Jr., Henderson, L. O., and Needham, L. L. 1989. Chlorinated hydrocarbon levels in human serum: Effects of fasting and feeding. Arch. Environ. Contam. Toxicol. 18: 495–500.
  • Prihartono, N., Kriebel, D., Woskie, S., Thetkhathuek, A., Sripaung, N., Padungtod, C., and Kaufman, D. 2011. Risk of aplastic anemia and pesticide and other chemical exposures. Asia Pacific J. Public Health 23: 369–377.
  • Rauch, A. E., Kowalsky, S. F., Lesar, T. S., Sauerbier, G. A., Burkart, P. T., and Scharfman, W. B. 1990. Lindane (Kwell)-induced aplastic anemia. Arch. Intern. Med. 150: 2393–2395.
  • Rugman, F. P., and Cosstick, R. 1990. Aplastic anaemia associated with organochlorine pesticide: Case reports and review of evidence. J. Clin. Pathol. 43: 98–101.
  • Sarcinelli, P. N., Pereira, A. C., Mesquita, S. A., Oliveira-Silva, J. J., Meyer, A., Menezes, M. A., Alves, S. R., Mattos, R. C., Moreira, J. C., and Wolff, M. 2003. Dietary and reproductive determinants of plasma organochlorine levels in pregnant women in Rio de Janeiro. Environ. Res. 91: 143–150.
  • Schaalan, M. F., Abdelraouf, S. M., Mohamed, W. A., and Hassanein, F. S. 2012. Correlation between maternal milk and infant serum levels of chlorinated pesticides (CP) and the impact of elevated CP on bleeding tendency and immune status in some infants in Egypt. J. Immunotoxicol. 9: 15–24.
  • Snyder, R., and Remmer, H. 1979. Classes of hepatic microsomal mixed function oxidase inducers. Pharmacol. Ther. 7: 203–244.
  • Tomita, M., Yoshida, T., Fukumori, J., Yamaguchi, S., Kojima, S., Fukuyama, T., Ohnuma-Koyama, A., Takahashi, N., Takeuchi-Kashimoto, Y., Kuwahara, M., Nakashima, N., Ohtsuka, R., Takeda, M., Kosaka, T., and Harada, T. 2013. p,p′-DDT induces microcytic anemia in rats. J. Toxicol. Sci. 38: 775–782.
  • United Nations Environment Programme. 2014. Stockholm Convention. http://www.unep.org/chemicalsandwaste/UNEPsWork/PersistentOrganicPollutansPOPs (accessed June 26, 2014).
  • Varona, M. E., Díaz-Criollo, S. M., Lancheros-Bernal, A. R., Murcia-Orjuela, A. M., Henao-Londoño, G. L., and Idrovo, A. J. 2010. Organochlorine pesticide exposure among agricultural workers in Colombian regions with illegal crops: An exploration in a hidden and dangerous world. Int. J. Environ. Health Res. 20: 407–414.
  • Wolff, M. S., Rivera, M., and Baker, D. B. 1991. Detection limits of organochlorine pesticides and related compounds in blood serum. Bull. Environ. Contam. Toxicol. 47: 499–503.
  • World Health Organization. 2001. Iron deficiency anemia: Assessment, prevention and control. A guide for programme managers. WHO/NDH/01.3. Geneva, Switzerland: WHO/NHD.
  • Zhao, B., Shen, H., Liu, F., Liu, S., Niu, J., Guo, F., and Sun, X. 2012. Exposure to organochlorine pesticides is an independent risk factor of hepatocellular carcinoma: A case-control study. J. Expos. Sci. Environ. Epidemiol. 22: 541–548.
  • Zumbado, M., Goethals, M., Alvarez-León, E. E., Luzardo, O. P., Cabrera, F., Serra-Majem, L., and Domínguez-Boada, L. 2005. Inadvertent exposure to organochlorine pesticides DDT and derivatives in people from the Canary Islands (Spain). Sci. Total Environ. 339: 49–62.

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